YEL024W / RIP1

Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL024W / RIP1

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:5.62|P-value:3.26E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:15.00|P-value:1.25E-40 ID:SGTC_141|Compound:0443-0274|FD-Score:3.59|P-value:7.40E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.78|P-value:4.11E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.29|P-value:7.14E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:7.81|P-value:2.35E-12 ID:SGTC_175|Compound:3793-3120|FD-Score:5.22|P-value:1.88E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:5.37|P-value:9.98E-7 ID:SGTC_195|Compound:4234-0266|FD-Score:3.80|P-value:3.77E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:7.02|P-value:2.57E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:16.10|P-value:2.28E-46 ID:SGTC_310|Compound:1273-0058|FD-Score:3.90|P-value:2.75E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-5.45|P-value:7.48E-7 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.29|P-value:7.49E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.59|P-value:7.45E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-4.73|P-value:1.46E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-4.13|P-value:1.33E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.63|P-value:6.81E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-4.38|P-value:5.48E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:4.50|P-value:3.35E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:4.71|P-value:1.55E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:4.22|P-value:9.33E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.94|P-value:2.43E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.51|P-value:9.62E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.73|P-value:4.76E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-4.22|P-value:9.74E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:-3.60|P-value:7.31E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.79|P-value:3.97E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:4.41|P-value:4.68E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:-3.69|P-value:5.62E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.27|P-value:1.51E-6 ID:SGTC_1635|Compound:st007035|FD-Score:10.00|P-value:3.14E-19 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.85|P-value:1.97E-12 ID:SGTC_1790|Compound:st045711|FD-Score:3.50|P-value:9.74E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-4.21|P-value:1.00E-4 ID:SGTC_1979|Compound:st071809|FD-Score:4.06|P-value:1.60E-4 ID:SGTC_2053|Compound:5265679|FD-Score:6.12|P-value:3.01E-8 ID:SGTC_2056|Compound:5235370|FD-Score:3.99|P-value:2.08E-4 ID:SGTC_2057|Compound:5236571|FD-Score:5.03|P-value:4.28E-6 ID:SGTC_2166|Compound:5933061|FD-Score:4.11|P-value:1.35E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.52|P-value:9.21E-4 ID:SGTC_2179|Compound:6298986|FD-Score:4.25|P-value:8.22E-5 ID:SGTC_2263|Compound:7948595|FD-Score:3.88|P-value:2.94E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.55|P-value:8.44E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.57|P-value:2.56E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.88|P-value:3.06E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.90|P-value:2.83E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.82|P-value:3.54E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.04|P-value:1.83E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.60|P-value:7.24E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.53|P-value:3.13E-5 ID:SGTC_2913|Compound:7966556|FD-Score:4.10|P-value:1.41E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-4.39|P-value:5.29E-5 ID:SGTC_3007|Compound:9078383|FD-Score:3.52|P-value:9.02E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.64|P-value:6.29E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.83|P-value:3.45E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-3.54|P-value:8.97E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:5.62|P-value:3.26E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:15.00|P-value:1.25E-40 ID:SGTC_141|Compound:0443-0274|FD-Score:3.59|P-value:7.40E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.78|P-value:4.11E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.29|P-value:7.14E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:7.81|P-value:2.35E-12 ID:SGTC_175|Compound:3793-3120|FD-Score:5.22|P-value:1.88E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:5.37|P-value:9.98E-7 ID:SGTC_195|Compound:4234-0266|FD-Score:3.80|P-value:3.77E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:7.02|P-value:2.57E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:16.10|P-value:2.28E-46 ID:SGTC_310|Compound:1273-0058|FD-Score:3.90|P-value:2.75E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-5.45|P-value:7.48E-7 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.29|P-value:7.49E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.59|P-value:7.45E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-4.73|P-value:1.46E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-4.13|P-value:1.33E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.63|P-value:6.81E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-4.38|P-value:5.48E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:4.50|P-value:3.35E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:4.71|P-value:1.55E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:4.22|P-value:9.33E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.94|P-value:2.43E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.51|P-value:9.62E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.73|P-value:4.76E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-4.22|P-value:9.74E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:-3.60|P-value:7.31E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.79|P-value:3.97E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:4.41|P-value:4.68E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:-3.69|P-value:5.62E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.27|P-value:1.51E-6 ID:SGTC_1635|Compound:st007035|FD-Score:10.00|P-value:3.14E-19 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.85|P-value:1.97E-12 ID:SGTC_1790|Compound:st045711|FD-Score:3.50|P-value:9.74E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-4.21|P-value:1.00E-4 ID:SGTC_1979|Compound:st071809|FD-Score:4.06|P-value:1.60E-4 ID:SGTC_2053|Compound:5265679|FD-Score:6.12|P-value:3.01E-8 ID:SGTC_2056|Compound:5235370|FD-Score:3.99|P-value:2.08E-4 ID:SGTC_2057|Compound:5236571|FD-Score:5.03|P-value:4.28E-6 ID:SGTC_2166|Compound:5933061|FD-Score:4.11|P-value:1.35E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.52|P-value:9.21E-4 ID:SGTC_2179|Compound:6298986|FD-Score:4.25|P-value:8.22E-5 ID:SGTC_2263|Compound:7948595|FD-Score:3.88|P-value:2.94E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.55|P-value:8.44E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.57|P-value:2.56E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.88|P-value:3.06E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.90|P-value:2.83E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.82|P-value:3.54E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.04|P-value:1.83E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.60|P-value:7.24E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.53|P-value:3.13E-5 ID:SGTC_2913|Compound:7966556|FD-Score:4.10|P-value:1.41E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-4.39|P-value:5.29E-5 ID:SGTC_3007|Compound:9078383|FD-Score:3.52|P-value:9.02E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.64|P-value:6.29E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.83|P-value:3.45E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-3.54|P-value:8.97E-4

Top fitness defect scores for YEL024W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 16.10 5.3 µM 2.28E-46 86 1.15E-58
2 SGTC_134 0269-0018 15.00 6.9 µM 1.25E-40 17 2.45E-51
3 SGTC_1635 st007035 10.00 42.4 µM 3.14E-19 73 4.92E-24
4 SGTC_173 1273-0061 7.81 2.7 µM 2.35E-12 mitochondrial stress 72 2.80E-15
5 SGTC_214 4373-3496 7.02 70.0 µM 2.57E-10 10 1.10E-12
6 SGTC_2053 5265679 6.12 138.0 µM 3.01E-8 1 4.66E-10
7 SGTC_87 0100-0052 5.62 35.5 µM 3.26E-7 40 9.57E-9
8 SGTC_184 1494-0393 5.37 24.7 µM 9.98E-7 22 3.95E-8
9 SGTC_1493 4348-0038 5.27 111.0 µM 1.51E-6 RSC complex & mRNA processing 5 6.66E-8
10 SGTC_175 3793-3120 5.22 23.7 µM 1.88E-6 3 8.79E-8
11 SGTC_2057 5236571 5.03 38.3 µM 4.28E-6 RPP1 & pyrimidine depletion 12 2.49E-7
12 SGTC_766 1391-0721 4.71 126.0 µM 1.55E-5 5 1.27E-6
13 SGTC_2361 9034121 4.57 116.0 µM 2.56E-5 RSC complex & mRNA processing 10 2.39E-6
14 SGTC_665 3914-0008 4.50 307.0 µM 3.35E-5 12 3.37E-6
15 SGTC_1306 1185-0270 4.41 9.0 µM 4.68E-5 Golgi 45 5.14E-6
16 SGTC_168 3970-0862 4.29 530.5 µM 7.14E-5 100 8.75E-6
17 SGTC_2179 6298986 4.25 200.0 µM 8.22E-5 heme requiring 16 1.05E-5
18 SGTC_921 1561-0023 4.22 372.0 µM 9.33E-5 12 1.23E-5
19 SGTC_2166 5933061 4.11 31.5 µM 1.35E-4 tubulin folding & SWR complex 38 1.96E-5
20 SGTC_2913 7966556 4.10 36.6 µM 1.41E-4 60S ribosome export 7 2.06E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.486 3.89E-198 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.465 1.77E-179 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.463 5.13E-178 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.459 8.66E-174 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.444 6.18E-162 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.440 5.76E-159 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.439 3.37E-158 YHL038C CBP2 hom Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
0.439 6.15E-158 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.436 5.23E-155 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.429 5.23E-150 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.426 1.45E-147 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.421 8.87E-144 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.421 8.52E-144 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.411 1.15E-136 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.409 3.36E-135 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20