Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YEL025C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.224 | 3.00E-39 | YEL001C | IRC22 | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci |
0.166 | 3.41E-22 | YGR292W | MAL12 | hom | Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose |
0.155 | 1.90E-19 | YDR358W | GGA1 | hom | Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi |
0.144 | 4.31E-17 | YER009W | NTF2 | het | Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport |
0.137 | 1.79E-15 | YBR258C | SHG1 | hom | Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres |
0.132 | 1.76E-14 | YIL058W_d | YIL058W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.132 | 1.98E-14 | YGL017W | ATE1 | hom | Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway |
0.116 | 1.76E-11 | YLL006W-A_p | YLL006W-A_p | hom | Putative protein of unknown function; identified by fungal homology and RT-PCR |
0.115 | 2.87E-11 | YPL264C_p | YPL264C_p | hom | Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene |
0.112 | 6.69E-11 | YGR050C_p | YGR050C_p | hom | Protein of unknown function; mRNA identified as translated by ribosome profiling data |
0.112 | 7.64E-11 | YMR025W | CSI1 | hom | Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome |
0.111 | 1.36E-10 | YDR379W | RGA2 | hom | GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p |
0.109 | 2.07E-10 | YCL076W_d | YCL076W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
0.109 | 2.76E-10 | YOR302W | YOR302W | hom | CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA |
0.107 | 4.46E-10 | YIL009W | FAA3 | hom | Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |