YEL025C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL025C / YEL025C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:2.80|P-value:5.29E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:2.86|P-value:4.14E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-2.73|P-value:8.12E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.46|P-value:2.76E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:-2.82|P-value:5.52E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.18|P-value:1.03E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:2.91|P-value:3.35E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.06|P-value:1.76E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:2.66|P-value:9.64E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.13|P-value:1.29E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.53|P-value:1.89E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.11|P-value:8.32E-7 ID:SGTC_1021|Compound:4476-0760|FD-Score:-3.56|P-value:1.92E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:2.75|P-value:6.51E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.54|P-value:1.87E-5 ID:SGTC_1871|Compound:st057448|FD-Score:3.02|P-value:2.14E-4 ID:SGTC_2297|Compound:7971671|FD-Score:2.74|P-value:6.86E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.24|P-value:9.13E-5 ID:SGTC_2334|Compound:9017922|FD-Score:3.77|P-value:5.64E-6 ID:SGTC_2338|Compound:7999974|FD-Score:4.20|P-value:4.99E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.47|P-value:2.97E-5 ID:SGTC_2817|Compound:7995342|FD-Score:-2.73|P-value:8.06E-4 ID:SGTC_2839|Compound:9003951|FD-Score:6.52|P-value:1.54E-14 ID:SGTC_2843|Compound:9000894|FD-Score:4.73|P-value:1.77E-8 ID:SGTC_2844|Compound:9010103|FD-Score:5.88|P-value:3.88E-12 ID:SGTC_2847|Compound:9005661|FD-Score:3.93|P-value:2.29E-6 ID:SGTC_2849|Compound:9019321|FD-Score:5.46|P-value:1.05E-10 ID:SGTC_2850|Compound:9015429|FD-Score:5.02|P-value:2.48E-9 ID:SGTC_2855|Compound:9016525|FD-Score:-4.85|P-value:9.75E-9 ID:SGTC_2876|Compound:9059903|FD-Score:4.21|P-value:4.58E-7 ID:SGTC_3012|Compound:9080433|FD-Score:3.05|P-value:1.86E-4 ID:SGTC_3080|Compound:9117754|FD-Score:4.06|P-value:1.08E-6 ID:SGTC_6|Compound:0844-0013|FD-Score:2.80|P-value:5.29E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:2.86|P-value:4.14E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-2.73|P-value:8.12E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.46|P-value:2.76E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:-2.82|P-value:5.52E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.18|P-value:1.03E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:2.91|P-value:3.35E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.06|P-value:1.76E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:2.66|P-value:9.64E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.13|P-value:1.29E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.53|P-value:1.89E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.11|P-value:8.32E-7 ID:SGTC_1021|Compound:4476-0760|FD-Score:-3.56|P-value:1.92E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:2.75|P-value:6.51E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.54|P-value:1.87E-5 ID:SGTC_1871|Compound:st057448|FD-Score:3.02|P-value:2.14E-4 ID:SGTC_2297|Compound:7971671|FD-Score:2.74|P-value:6.86E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.24|P-value:9.13E-5 ID:SGTC_2334|Compound:9017922|FD-Score:3.77|P-value:5.64E-6 ID:SGTC_2338|Compound:7999974|FD-Score:4.20|P-value:4.99E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.47|P-value:2.97E-5 ID:SGTC_2817|Compound:7995342|FD-Score:-2.73|P-value:8.06E-4 ID:SGTC_2839|Compound:9003951|FD-Score:6.52|P-value:1.54E-14 ID:SGTC_2843|Compound:9000894|FD-Score:4.73|P-value:1.77E-8 ID:SGTC_2844|Compound:9010103|FD-Score:5.88|P-value:3.88E-12 ID:SGTC_2847|Compound:9005661|FD-Score:3.93|P-value:2.29E-6 ID:SGTC_2849|Compound:9019321|FD-Score:5.46|P-value:1.05E-10 ID:SGTC_2850|Compound:9015429|FD-Score:5.02|P-value:2.48E-9 ID:SGTC_2855|Compound:9016525|FD-Score:-4.85|P-value:9.75E-9 ID:SGTC_2876|Compound:9059903|FD-Score:4.21|P-value:4.58E-7 ID:SGTC_3012|Compound:9080433|FD-Score:3.05|P-value:1.86E-4 ID:SGTC_3080|Compound:9117754|FD-Score:4.06|P-value:1.08E-6

Top fitness defect scores for YEL025C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2839 9003951 6.52 26.0 µM 1.54E-14 1 3.40E-11
2 SGTC_2844 9010103 5.88 26.0 µM 3.88E-12 3 2.09E-9
3 SGTC_2849 9019321 5.46 13.0 µM 1.05E-10 10 2.43E-8
4 SGTC_2850 9015429 5.02 58.4 µM 2.48E-9 3 2.57E-7
5 SGTC_2843 9000894 4.73 45.5 µM 1.77E-8 2 1.11E-6
6 SGTC_2876 9059903 4.21 26.0 µM 4.58E-7 6 1.27E-5
7 SGTC_2338 7999974 4.20 200.0 µM 4.99E-7 16 1.35E-5
8 SGTC_1008 4106-0037 4.11 6.0 µM 8.32E-7 PDR1 18 1.98E-5
9 SGTC_3080 9117754 4.06 49.5 µM 1.08E-6 16 2.41E-5
10 SGTC_2847 9005661 3.93 71.4 µM 2.29E-6 9 4.22E-5
11 SGTC_2334 9017922 3.77 200.0 µM 5.64E-6 28 8.29E-5
12 SGTC_1603 st002045 3.54 67.8 µM 1.87E-5 TSC3-RPN4 26 2.03E-4
13 SGTC_916 4466-0038 3.53 42.0 nM 1.89E-5 cell wall 91 2.06E-4
14 SGTC_306 1672-3436 3.46 11.6 µM 2.76E-5 Golgi 26 2.73E-4
15 SGTC_418 lividomycin a 3.18 100.0 µM 1.03E-4 36 7.35E-4
16 SGTC_910 3454-3003 3.13 490.0 µM 1.29E-4 52 8.70E-4
17 SGTC_650 1328-0195 3.06 38.0 µM 1.76E-4 55 0.00110
18 SGTC_3012 9080433 3.05 71.4 µM 1.86E-4 40 0.00114
19 SGTC_1871 st057448 3.02 67.3 µM 2.14E-4 67 0.00128
20 SGTC_503 tyrphostin 8 2.91 294.0 µM 3.35E-4 TSC3-RPN4 82 0.00178

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.224 3.00E-39 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.166 3.41E-22 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.155 1.90E-19 YDR358W GGA1 hom Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
0.144 4.31E-17 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.137 1.79E-15 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.132 1.76E-14 YIL058W_d YIL058W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.132 1.98E-14 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.116 1.76E-11 YLL006W-A_p YLL006W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.115 2.87E-11 YPL264C_p YPL264C_p hom Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene
0.112 6.69E-11 YGR050C_p YGR050C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.112 7.64E-11 YMR025W CSI1 hom Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome
0.111 1.36E-10 YDR379W RGA2 hom GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p
0.109 2.07E-10 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.109 2.76E-10 YOR302W YOR302W hom CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA
0.107 4.46E-10 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery