YEL026W / SNU13

RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein

Zygosity: Heterozygous strain
fixedexpanded
Profile for YEL026W / SNU13

Click on Significant Values for Screen Details ID:SGTC_127|Compound:0180-0333|FD-Score:-2.93|P-value:5.72E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.09|P-value:2.93E-6 ID:SGTC_519|Compound:k048-0011|FD-Score:2.90|P-value:6.78E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.50|P-value:5.42E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.02|P-value:4.12E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.11|P-value:2.77E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:2.92|P-value:6.10E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.92|P-value:6.09E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.77|P-value:1.52E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.34|P-value:1.08E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.88|P-value:8.48E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:2.99|P-value:4.73E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.17|P-value:2.30E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.04|P-value:3.83E-4 ID:SGTC_1666|Compound:st014829|FD-Score:4.04|P-value:3.92E-6 ID:SGTC_1737|Compound:st035557|FD-Score:2.83|P-value:8.78E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-3.38|P-value:9.00E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:-2.92|P-value:5.98E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-3.42|P-value:7.39E-5 ID:SGTC_2353|Compound:9059630|FD-Score:-3.13|P-value:2.57E-4 ID:SGTC_2356|Compound:9061756|FD-Score:-3.30|P-value:1.28E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:2.93|P-value:5.98E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.30|P-value:1.30E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-2.96|P-value:5.17E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-2.99|P-value:4.66E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.70|P-value:2.10E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:-2.93|P-value:5.72E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.09|P-value:2.93E-6 ID:SGTC_519|Compound:k048-0011|FD-Score:2.90|P-value:6.78E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.50|P-value:5.42E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.02|P-value:4.12E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.11|P-value:2.77E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:2.92|P-value:6.10E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.92|P-value:6.09E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.77|P-value:1.52E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.34|P-value:1.08E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.88|P-value:8.48E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:2.99|P-value:4.73E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.17|P-value:2.30E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.04|P-value:3.83E-4 ID:SGTC_1666|Compound:st014829|FD-Score:4.04|P-value:3.92E-6 ID:SGTC_1737|Compound:st035557|FD-Score:2.83|P-value:8.78E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-3.38|P-value:9.00E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:-2.92|P-value:5.98E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-3.42|P-value:7.39E-5 ID:SGTC_2353|Compound:9059630|FD-Score:-3.13|P-value:2.57E-4 ID:SGTC_2356|Compound:9061756|FD-Score:-3.30|P-value:1.28E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:2.93|P-value:5.98E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.30|P-value:1.30E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-2.96|P-value:5.17E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-2.99|P-value:4.66E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.70|P-value:2.10E-5

Top fitness defect scores for YEL026W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_518 1021-0119 4.09 62.6 µM 2.93E-6 ERG2 7 2.12E-5 0.08
2 SGTC_1666 st014829 4.04 29.0 µM 3.92E-6 calcium & mitochondrial duress 5 2.69E-5 0.20
3 SGTC_953 1188-0045 3.77 9.7 µM 1.52E-5 60S ribosome export 7 8.24E-5 0.09
4 SGTC_2808 7946468 3.70 45.5 µM 2.10E-5 7 1.07E-4 0.04
5 SGTC_584 0986-0246 3.50 15.4 µM 5.42E-5 heme requiring 30 2.35E-4 0.00
6 SGTC_1079 idarubicin 3.34 2.4 µM 1.08E-4 DNA damage response 11 4.13E-4 0.21
7 SGTC_2608 thymoquinone 3.30 42.7 µM 1.30E-4 9 4.84E-4 0.10
8 SGTC_1370 2001-0092 3.17 44.6 µM 2.30E-4 11 7.73E-4 0.17
9 SGTC_1381 2324-0066 3.04 62.1 µM 3.83E-4 19 0.00118 0.02
10 SGTC_669 0108-0021 3.02 26.2 µM 4.12E-4 fatty acid desaturase (OLE1) 23 0.00125 0.05
11 SGTC_1153 4055-0057 2.99 267.0 µM 4.73E-4 22 0.00141 0.05
12 SGTC_2573 2',4'-dihydroxychalcone 2.93 15.0 µM 5.98E-4 23 0.00171 0.02
13 SGTC_891 0929-0073 2.92 133.0 µM 6.10E-4 14 0.00173 0.01
14 SGTC_519 k048-0011 2.90 62.8 µM 6.78E-4 23 0.00189 0.02
15 SGTC_1737 st035557 2.83 69.7 µM 8.78E-4 22 0.00235 0.08
16 SGTC_1714 st033236 2.78 13.6 µM 0.00106 22 0.00275 6.45E-4
17 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 2.75 15.3 µM 0.00117 18 0.00298 0.03
18 SGTC_2289 7946404 2.74 165.1 µM 0.00122 41 0.00309 0.07
19 SGTC_1296 1068-0102 2.72 11.9 µM 0.00129 9 0.00323 0.00
20 SGTC_2616 abietic acid 2.70 100.0 µM 0.00138 15 0.00342 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 6.59E-32 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.161 5.96E-21 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.155 1.67E-19 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.145 2.45E-17 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.144 5.84E-17 YBR090C_p YBR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.142 1.57E-16 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.140 4.79E-16 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.138 9.84E-16 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.134 6.19E-15 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.133 8.69E-15 YNL042W-B_p YNL042W-B_p hom Putative protein of unknown function
0.133 9.21E-15 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.129 7.37E-14 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.128 1.00E-13 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.126 2.22E-13 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.123 8.85E-13 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p