HIPHOP chemogenomics database
YEL028W_d 
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YEL028W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.110 | 1.67E-10 | YKL099C | UTP11 | het | Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit |
| 0.107 | 4.33E-10 | YCR075C | ERS1 | hom | Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains |
| 0.102 | 2.69E-9 | YDR294C | DPL1 | hom | Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate |
| 0.087 | 4.14E-7 | YPR155C | NCA2 | hom | Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p |
| 0.084 | 1.18E-6 | YDL154W | MSH5 | hom | Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans |
| 0.080 | 3.79E-6 | YOR266W | PNT1 | hom | Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine |
| 0.078 | 5.56E-6 | YER172C | BRR2 | het | RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD |
| 0.077 | 7.28E-6 | YCL033C | MXR2 | hom | Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan |
| 0.076 | 1.13E-5 | YIL072W | HOP1 | hom | Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments |
| 0.074 | 1.69E-5 | YNL065W | AQR1 | hom | Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress |
| 0.074 | 1.71E-5 | YNL247W | YNL247W | het | Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments |
| 0.073 | 2.51E-5 | YDL242W_d | YDL242W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.072 | 2.65E-5 | YGR093W_p | YGR093W_p | hom | Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus |
| 0.071 | 4.21E-5 | YGR121C | MEP1 | hom | Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation |
| 0.070 | 5.41E-5 | YCR098C | GIT1 | hom | Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability |