YEL028W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL028W / YEL028W

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:-3.82|P-value:2.67E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.52|P-value:7.03E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.54|P-value:6.58E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.56|P-value:6.18E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.47|P-value:8.15E-4 ID:SGTC_433|Compound:pimozide|FD-Score:5.30|P-value:7.54E-7 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.79|P-value:6.90E-6 ID:SGTC_438|Compound:sphingosine|FD-Score:5.14|P-value:1.59E-6 ID:SGTC_607|Compound:4491-0986|FD-Score:4.14|P-value:8.75E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:4.57|P-value:1.74E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:3.65|P-value:4.65E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.63|P-value:4.98E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.81|P-value:2.76E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.41|P-value:9.86E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.90|P-value:2.05E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.22|P-value:6.41E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:-3.82|P-value:2.70E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.85|P-value:5.48E-6 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.94|P-value:3.74E-6 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.61|P-value:5.33E-4 ID:SGTC_1805|Compound:st050013|FD-Score:4.23|P-value:6.16E-5 ID:SGTC_1813|Compound:st051246|FD-Score:-3.98|P-value:1.51E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.67|P-value:4.40E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.36|P-value:3.84E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.59|P-value:5.62E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.79|P-value:2.93E-4 ID:SGTC_1989|Compound:st071868|FD-Score:4.13|P-value:9.06E-5 ID:SGTC_2295|Compound:7971645|FD-Score:5.73|P-value:1.03E-7 ID:SGTC_2507|Compound:purpurin|FD-Score:3.92|P-value:1.88E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.38|P-value:3.54E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:4.94|P-value:3.75E-6 ID:SGTC_2537|Compound:larixol|FD-Score:-5.99|P-value:2.78E-8 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.88|P-value:2.17E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.77|P-value:7.77E-6 ID:SGTC_2820|Compound:7989630|FD-Score:4.40|P-value:3.26E-5 ID:SGTC_2825|Compound:7998094|FD-Score:4.44|P-value:2.80E-5 ID:SGTC_2949|Compound:9072542|FD-Score:4.09|P-value:1.03E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-4.04|P-value:1.23E-4 ID:SGTC_2960|Compound:9079389|FD-Score:7.99|P-value:2.14E-13 ID:SGTC_2962|Compound:9082311|FD-Score:-7.64|P-value:2.12E-12 ID:SGTC_3024|Compound:9090631|FD-Score:4.96|P-value:3.47E-6 ID:SGTC_3030|Compound:9087619|FD-Score:5.70|P-value:1.18E-7 ID:SGTC_3141|Compound:9094609|FD-Score:-3.56|P-value:6.28E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.47|P-value:8.27E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.76|P-value:3.27E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:-3.82|P-value:2.67E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.52|P-value:7.03E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.54|P-value:6.58E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.56|P-value:6.18E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.47|P-value:8.15E-4 ID:SGTC_433|Compound:pimozide|FD-Score:5.30|P-value:7.54E-7 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.79|P-value:6.90E-6 ID:SGTC_438|Compound:sphingosine|FD-Score:5.14|P-value:1.59E-6 ID:SGTC_607|Compound:4491-0986|FD-Score:4.14|P-value:8.75E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:4.57|P-value:1.74E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:3.65|P-value:4.65E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.63|P-value:4.98E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.81|P-value:2.76E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.41|P-value:9.86E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.90|P-value:2.05E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.22|P-value:6.41E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:-3.82|P-value:2.70E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.85|P-value:5.48E-6 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.94|P-value:3.74E-6 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.61|P-value:5.33E-4 ID:SGTC_1805|Compound:st050013|FD-Score:4.23|P-value:6.16E-5 ID:SGTC_1813|Compound:st051246|FD-Score:-3.98|P-value:1.51E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.67|P-value:4.40E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.36|P-value:3.84E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.59|P-value:5.62E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.79|P-value:2.93E-4 ID:SGTC_1989|Compound:st071868|FD-Score:4.13|P-value:9.06E-5 ID:SGTC_2295|Compound:7971645|FD-Score:5.73|P-value:1.03E-7 ID:SGTC_2507|Compound:purpurin|FD-Score:3.92|P-value:1.88E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.38|P-value:3.54E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:4.94|P-value:3.75E-6 ID:SGTC_2537|Compound:larixol|FD-Score:-5.99|P-value:2.78E-8 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.88|P-value:2.17E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.77|P-value:7.77E-6 ID:SGTC_2820|Compound:7989630|FD-Score:4.40|P-value:3.26E-5 ID:SGTC_2825|Compound:7998094|FD-Score:4.44|P-value:2.80E-5 ID:SGTC_2949|Compound:9072542|FD-Score:4.09|P-value:1.03E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-4.04|P-value:1.23E-4 ID:SGTC_2960|Compound:9079389|FD-Score:7.99|P-value:2.14E-13 ID:SGTC_2962|Compound:9082311|FD-Score:-7.64|P-value:2.12E-12 ID:SGTC_3024|Compound:9090631|FD-Score:4.96|P-value:3.47E-6 ID:SGTC_3030|Compound:9087619|FD-Score:5.70|P-value:1.18E-7 ID:SGTC_3141|Compound:9094609|FD-Score:-3.56|P-value:6.28E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.47|P-value:8.27E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.76|P-value:3.27E-4

Top fitness defect scores for YEL028W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2960 9079389 7.99 6.0 µM 2.14E-13 1 6.64E-16
2 SGTC_2295 7971645 5.73 200.0 µM 1.03E-7 7 5.09E-9
3 SGTC_3030 9087619 5.70 49.5 µM 1.18E-7 2 6.00E-9
4 SGTC_433 pimozide 5.30 108.0 µM 7.54E-7 6 5.64E-8
5 SGTC_438 sphingosine 5.14 6.7 µM 1.59E-6 8 1.39E-7
6 SGTC_3024 9090631 4.96 49.5 µM 3.47E-6 3 3.56E-7
7 SGTC_1338 1486-1223 4.94 76.0 µM 3.74E-6 4 3.90E-7
8 SGTC_2533 agelasine 4.94 13.7 µM 3.75E-6 ERG2 25 3.92E-7
9 SGTC_1261 0712-0010 4.85 12.7 µM 5.48E-6 RNA processing & uracil transport 11 6.19E-7
10 SGTC_436 n,n-dimethylsphingosine 4.79 3.3 µM 6.90E-6 15 8.16E-7
11 SGTC_2789 5281112 4.77 71.4 µM 7.77E-6 15 9.43E-7
12 SGTC_610 4215-0184 4.57 155.0 µM 1.74E-5 exosome 5 2.49E-6
13 SGTC_2825 7998094 4.44 58.4 µM 2.80E-5 fatty acid desaturase (OLE1) 21 4.42E-6
14 SGTC_2820 7989630 4.40 71.4 µM 3.26E-5 ERG2 11 5.31E-6
15 SGTC_1868 st057644 4.36 42.7 µM 3.84E-5 25 6.48E-6
16 SGTC_1805 st050013 4.23 60.3 µM 6.16E-5 5 1.14E-5
17 SGTC_1031 k035-0009 4.22 16.0 µM 6.41E-5 17 1.20E-5
18 SGTC_607 4491-0986 4.14 66.8 µM 8.75E-5 heme requiring 24 1.75E-5
19 SGTC_1989 st071868 4.13 50.2 µM 9.06E-5 9 1.82E-5
20 SGTC_2949 9072542 4.09 2.2 µM 1.03E-4 TSC3-RPN4 35 2.13E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.67E-10 YKL099C UTP11 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.107 4.33E-10 YCR075C ERS1 hom Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains
0.102 2.69E-9 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.087 4.14E-7 YPR155C NCA2 hom Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p
0.084 1.18E-6 YDL154W MSH5 hom Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans
0.080 3.79E-6 YOR266W PNT1 hom Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine
0.078 5.56E-6 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.077 7.28E-6 YCL033C MXR2 hom Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan
0.076 1.13E-5 YIL072W HOP1 hom Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments
0.074 1.69E-5 YNL065W AQR1 hom Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.074 1.71E-5 YNL247W YNL247W het Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments
0.073 2.51E-5 YDL242W_d YDL242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.072 2.65E-5 YGR093W_p YGR093W_p hom Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.071 4.21E-5 YGR121C MEP1 hom Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
0.070 5.41E-5 YCR098C GIT1 hom Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability