YEL030W / ECM10

Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; ECM10 has a paralog, SSC1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL030W / ECM10

Click on Significant Values for Screen Details ID:SGTC_127|Compound:0180-0333|FD-Score:3.19|P-value:3.91E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:2.93|P-value:9.88E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:2.95|P-value:9.32E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:4.21|P-value:4.64E-6 ID:SGTC_790|Compound:1575-0012|FD-Score:3.13|P-value:4.90E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.01|P-value:9.22E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:2.94|P-value:9.74E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.04|P-value:8.22E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.81|P-value:2.98E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.03|P-value:8.74E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:4.54|P-value:8.98E-7 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.48|P-value:1.21E-6 ID:SGTC_1194|Compound:1488-0194|FD-Score:2.95|P-value:9.42E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.14|P-value:4.59E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.17|P-value:5.15E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.76|P-value:3.84E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.84|P-value:2.68E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.56|P-value:8.83E-5 ID:SGTC_1656|Compound:st012921|FD-Score:3.00|P-value:7.68E-4 ID:SGTC_1828|Compound:st055811|FD-Score:5.21|P-value:2.22E-8 ID:SGTC_1841|Compound:st054148|FD-Score:3.73|P-value:4.26E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.72|P-value:5.83E-5 ID:SGTC_1946|Compound:st076057|FD-Score:3.26|P-value:2.97E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.61|P-value:7.28E-5 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.43|P-value:1.48E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.46|P-value:1.33E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-3.60|P-value:9.55E-5 ID:SGTC_2469|Compound:5655019|FD-Score:5.62|P-value:1.78E-9 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.24|P-value:4.04E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-4.50|P-value:1.54E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.91|P-value:2.58E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.06|P-value:6.26E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-5.08|P-value:6.86E-8 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.24|P-value:3.21E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.42|P-value:1.55E-4 ID:SGTC_2707|Compound:st078556|FD-Score:3.26|P-value:2.97E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.44|P-value:1.52E-6 ID:SGTC_2853|Compound:9015042|FD-Score:-3.99|P-value:1.75E-5 ID:SGTC_2935|Compound:9038016|FD-Score:3.39|P-value:1.79E-4 ID:SGTC_3010|Compound:9080089|FD-Score:4.29|P-value:3.19E-6 ID:SGTC_3081|Compound:9117243|FD-Score:2.97|P-value:8.73E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.23|P-value:3.28E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.19|P-value:3.91E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:2.93|P-value:9.88E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:2.95|P-value:9.32E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:4.21|P-value:4.64E-6 ID:SGTC_790|Compound:1575-0012|FD-Score:3.13|P-value:4.90E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.01|P-value:9.22E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:2.94|P-value:9.74E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.04|P-value:8.22E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.81|P-value:2.98E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.03|P-value:8.74E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:4.54|P-value:8.98E-7 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.48|P-value:1.21E-6 ID:SGTC_1194|Compound:1488-0194|FD-Score:2.95|P-value:9.42E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.14|P-value:4.59E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.17|P-value:5.15E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.76|P-value:3.84E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.84|P-value:2.68E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.56|P-value:8.83E-5 ID:SGTC_1656|Compound:st012921|FD-Score:3.00|P-value:7.68E-4 ID:SGTC_1828|Compound:st055811|FD-Score:5.21|P-value:2.22E-8 ID:SGTC_1841|Compound:st054148|FD-Score:3.73|P-value:4.26E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.72|P-value:5.83E-5 ID:SGTC_1946|Compound:st076057|FD-Score:3.26|P-value:2.97E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.61|P-value:7.28E-5 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.43|P-value:1.48E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.46|P-value:1.33E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-3.60|P-value:9.55E-5 ID:SGTC_2469|Compound:5655019|FD-Score:5.62|P-value:1.78E-9 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.24|P-value:4.04E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-4.50|P-value:1.54E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.91|P-value:2.58E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.06|P-value:6.26E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-5.08|P-value:6.86E-8 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.24|P-value:3.21E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.42|P-value:1.55E-4 ID:SGTC_2707|Compound:st078556|FD-Score:3.26|P-value:2.97E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.44|P-value:1.52E-6 ID:SGTC_2853|Compound:9015042|FD-Score:-3.99|P-value:1.75E-5 ID:SGTC_2935|Compound:9038016|FD-Score:3.39|P-value:1.79E-4 ID:SGTC_3010|Compound:9080089|FD-Score:4.29|P-value:3.19E-6 ID:SGTC_3081|Compound:9117243|FD-Score:2.97|P-value:8.73E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.23|P-value:3.28E-4

Top fitness defect scores for YEL030W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2469 5655019 5.62 90.8 µM 1.78E-9 3 9.41E-9
2 SGTC_1828 st055811 5.21 49.0 µM 2.22E-8 2 9.46E-8
3 SGTC_1152 3909-8331 4.54 15.9 µM 8.98E-7 3 2.79E-6
4 SGTC_1153 4055-0057 4.48 267.0 µM 1.21E-6 13 3.65E-6
5 SGTC_2781 5567276 4.44 71.4 µM 1.52E-6 33 4.51E-6
6 SGTC_3010 9080089 4.29 71.4 µM 3.19E-6 9 8.88E-6
7 SGTC_653 0203-0016 4.21 55.2 µM 4.64E-6 10 1.25E-5
8 SGTC_1395 3486-0190 3.84 4.3 µM 2.68E-5 14 6.21E-5
9 SGTC_1022 4477-0945 3.81 21.3 µM 2.98E-5 28 6.84E-5
10 SGTC_1284 0929-0043 3.76 16.0 µM 3.84E-5 27 8.64E-5
11 SGTC_1841 st054148 3.73 70.0 µM 4.26E-5 14 9.49E-5
12 SGTC_2187 6125751 3.61 200.0 µM 7.28E-5 RSC complex & mRNA processing 27 1.55E-4
13 SGTC_1401 3807-4679 3.56 7.6 µM 8.83E-5 tubulin folding & SWR complex 27 1.85E-4
14 SGTC_2294 7971431 3.46 200.0 µM 1.33E-4 28 2.69E-4
15 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 3.43 122.8 µM 1.48E-4 21 2.96E-4
16 SGTC_2698 st077697 3.42 67.5 µM 1.55E-4 27 3.10E-4
17 SGTC_2935 9038016 3.39 30.0 µM 1.79E-4 34 3.54E-4
18 SGTC_1946 st076057 3.26 65.1 µM 2.97E-4 17 5.61E-4
19 SGTC_2707 st078556 3.26 66.6 µM 2.97E-4 25 5.62E-4
20 SGTC_2642 cholecalciferol 3.24 100.0 µM 3.21E-4 32 6.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.097 1.70E-8 YLR063W_p YLR063W_p hom Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
0.078 5.90E-6 YJR039W_p YJR039W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.078 6.73E-6 YOR003W YSP3 hom Putative precursor to the subtilisin-like protease III
0.067 1.07E-4 YOR251C TUM1 hom Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized
0.067 1.08E-4 YFL015C_d YFL015C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
0.066 1.18E-4 YKL074C MUD2 hom Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
0.066 1.27E-4 YFL045C SEC53 het Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen
0.066 1.28E-4 YKL012W PRP40 het U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex
0.066 1.38E-4 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.065 1.49E-4 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.064 1.95E-4 YBR073W RDH54 hom DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p
0.062 3.36E-4 YIR020W-A_d YIR020W-A_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.060 4.57E-4 YDR283C GCN2 hom Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
0.060 5.02E-4 YDR426C_d YDR426C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41
0.060 5.07E-4 YCR043C_p YCR043C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene