YEL031W / SPF1

P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL031W / SPF1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:6.19|P-value:2.55E-7 ID:SGTC_16|Compound:erodoxin|FD-Score:4.52|P-value:1.31E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:6.20|P-value:2.37E-7 ID:SGTC_55|Compound:0767-0285|FD-Score:4.82|P-value:4.86E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.83|P-value:6.46E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:8.38|P-value:4.39E-12 ID:SGTC_61|Compound:0978-8327|FD-Score:3.92|P-value:7.90E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.46|P-value:4.76E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:5.55|P-value:3.41E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:7.12|P-value:3.43E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:5.83|P-value:1.15E-6 ID:SGTC_79|Compound:0052-0007|FD-Score:4.16|P-value:3.99E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:7.62|P-value:2.84E-10 ID:SGTC_137|Compound:0438-0332|FD-Score:6.85|P-value:1.29E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:4.35|P-value:2.22E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.27|P-value:2.81E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:6.19|P-value:2.48E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:7.45|P-value:6.76E-10 ID:SGTC_200|Compound:k038-0079|FD-Score:6.72|P-value:2.31E-8 ID:SGTC_216|Compound:k038-0035|FD-Score:4.09|P-value:4.88E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:12.10|P-value:1.90E-23 ID:SGTC_279|Compound:1273-0055|FD-Score:8.16|P-value:1.48E-11 ID:SGTC_294|Compound:k038-0071|FD-Score:5.68|P-value:2.05E-6 ID:SGTC_305|Compound:1682-2595|FD-Score:4.89|P-value:3.85E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.54|P-value:1.22E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:5.18|P-value:1.36E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:7.33|P-value:1.22E-9 ID:SGTC_327|Compound:1273-0057|FD-Score:4.36|P-value:2.16E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.13|P-value:2.63E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:4.46|P-value:1.56E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:5.21|P-value:1.21E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:4.86|P-value:4.17E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.37|P-value:3.60E-6 ID:SGTC_444|Compound:curcumin|FD-Score:-4.20|P-value:2.16E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:8.42|P-value:3.49E-12 ID:SGTC_545|Compound:4218-0007|FD-Score:4.37|P-value:2.08E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:6.64|P-value:3.36E-8 ID:SGTC_625|Compound:k213-0058|FD-Score:14.30|P-value:6.94E-32 ID:SGTC_635|Compound:k038-0028|FD-Score:4.21|P-value:3.36E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.05|P-value:5.53E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:6.14|P-value:3.04E-7 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.05|P-value:2.14E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:4.04|P-value:5.59E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:4.21|P-value:3.39E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:11.50|P-value:3.20E-21 ID:SGTC_796|Compound:1234-0020|FD-Score:5.26|P-value:1.04E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:14.90|P-value:2.05E-34 ID:SGTC_802|Compound:4112-3352|FD-Score:4.28|P-value:2.73E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:7.30|P-value:1.44E-9 ID:SGTC_831|Compound:k061-1017|FD-Score:4.98|P-value:2.78E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:5.87|P-value:9.46E-7 ID:SGTC_862|Compound:0452-0056|FD-Score:5.55|P-value:3.47E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:6.49|P-value:6.79E-8 ID:SGTC_985|Compound:1493-0307|FD-Score:7.23|P-value:1.99E-9 ID:SGTC_990|Compound:3985-0011|FD-Score:4.32|P-value:2.46E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:9.46|P-value:5.83E-15 ID:SGTC_1019|Compound:4262-0212|FD-Score:8.87|P-value:2.44E-13 ID:SGTC_1081|Compound:sertraline|FD-Score:-3.96|P-value:4.41E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.42|P-value:1.80E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:7.81|P-value:1.04E-10 ID:SGTC_1226|Compound:3909-7979|FD-Score:6.03|P-value:5.02E-7 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.48|P-value:1.48E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.63|P-value:9.09E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.87|P-value:4.13E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:-7.11|P-value:1.64E-9 ID:SGTC_1261|Compound:0712-0010|FD-Score:7.88|P-value:6.95E-11 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.04|P-value:5.55E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.56|P-value:1.13E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-4.35|P-value:1.35E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:5.40|P-value:6.01E-6 ID:SGTC_1471|Compound:k673-0312|FD-Score:4.42|P-value:1.80E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.14|P-value:4.18E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.87|P-value:1.18E-8 ID:SGTC_1672|Compound:st016598|FD-Score:4.83|P-value:4.63E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.70|P-value:7.35E-5 ID:SGTC_1696|Compound:st025591|FD-Score:5.16|P-value:1.47E-5 ID:SGTC_1706|Compound:st031321|FD-Score:3.84|P-value:0.00100 ID:SGTC_1745|Compound:st081495|FD-Score:9.45|P-value:6.30E-15 ID:SGTC_1750|Compound:st081859|FD-Score:5.84|P-value:1.09E-6 ID:SGTC_1774|Compound:st048371|FD-Score:3.87|P-value:9.15E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:6.98|P-value:6.93E-9 ID:SGTC_1834|Compound:st055981|FD-Score:-5.34|P-value:4.16E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.18|P-value:7.66E-6 ID:SGTC_1923|Compound:st058458|FD-Score:4.69|P-value:7.55E-5 ID:SGTC_2063|Compound:5246145|FD-Score:-3.72|P-value:8.93E-4 ID:SGTC_2077|Compound:5212015|FD-Score:5.15|P-value:1.52E-5 ID:SGTC_2082|Compound:5219693|FD-Score:4.87|P-value:4.02E-5 ID:SGTC_2122|Compound:5258151|FD-Score:4.32|P-value:2.41E-4 ID:SGTC_2151|Compound:5563267|FD-Score:5.09|P-value:1.87E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.99|P-value:6.45E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.94|P-value:7.44E-4 ID:SGTC_2312|Compound:7706453|FD-Score:4.40|P-value:1.90E-4 ID:SGTC_2342|Compound:7990637|FD-Score:5.08|P-value:1.95E-5 ID:SGTC_2365|Compound:9042475|FD-Score:4.70|P-value:7.18E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.90|P-value:3.70E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:6.40|P-value:1.01E-7 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.67|P-value:2.11E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.76|P-value:5.84E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.76|P-value:5.97E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:11.60|P-value:1.27E-21 ID:SGTC_2679|Compound:rapamycin|FD-Score:-6.01|P-value:2.72E-7 ID:SGTC_2701|Compound:st077767|FD-Score:6.07|P-value:4.25E-7 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.89|P-value:8.67E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:9.73|P-value:1.02E-15 ID:SGTC_2778|Compound:tioconazole|FD-Score:6.94|P-value:8.36E-9 ID:SGTC_2790|Compound:5423970|FD-Score:4.39|P-value:1.93E-4 ID:SGTC_2807|Compound:7945238|FD-Score:6.20|P-value:2.37E-7 ID:SGTC_3021|Compound:9087658|FD-Score:4.99|P-value:2.69E-5 ID:SGTC_3022|Compound:9087993|FD-Score:3.89|P-value:8.64E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-5.49|P-value:2.31E-6 ID:SGTC_3043|Compound:9092303|FD-Score:4.19|P-value:3.63E-4 ID:SGTC_3093|Compound:9117344|FD-Score:-4.22|P-value:2.00E-4 ID:SGTC_3110|Compound:9122132|FD-Score:4.55|P-value:1.18E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.62|P-value:9.33E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:6.19|P-value:2.55E-7 ID:SGTC_16|Compound:erodoxin|FD-Score:4.52|P-value:1.31E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:6.20|P-value:2.37E-7 ID:SGTC_55|Compound:0767-0285|FD-Score:4.82|P-value:4.86E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.83|P-value:6.46E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:8.38|P-value:4.39E-12 ID:SGTC_61|Compound:0978-8327|FD-Score:3.92|P-value:7.90E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.46|P-value:4.76E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:5.55|P-value:3.41E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:7.12|P-value:3.43E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:5.83|P-value:1.15E-6 ID:SGTC_79|Compound:0052-0007|FD-Score:4.16|P-value:3.99E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:7.62|P-value:2.84E-10 ID:SGTC_137|Compound:0438-0332|FD-Score:6.85|P-value:1.29E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:4.35|P-value:2.22E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.27|P-value:2.81E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:6.19|P-value:2.48E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:7.45|P-value:6.76E-10 ID:SGTC_200|Compound:k038-0079|FD-Score:6.72|P-value:2.31E-8 ID:SGTC_216|Compound:k038-0035|FD-Score:4.09|P-value:4.88E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:12.10|P-value:1.90E-23 ID:SGTC_279|Compound:1273-0055|FD-Score:8.16|P-value:1.48E-11 ID:SGTC_294|Compound:k038-0071|FD-Score:5.68|P-value:2.05E-6 ID:SGTC_305|Compound:1682-2595|FD-Score:4.89|P-value:3.85E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.54|P-value:1.22E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:5.18|P-value:1.36E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:7.33|P-value:1.22E-9 ID:SGTC_327|Compound:1273-0057|FD-Score:4.36|P-value:2.16E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.13|P-value:2.63E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:4.46|P-value:1.56E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:5.21|P-value:1.21E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:4.86|P-value:4.17E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.37|P-value:3.60E-6 ID:SGTC_444|Compound:curcumin|FD-Score:-4.20|P-value:2.16E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:8.42|P-value:3.49E-12 ID:SGTC_545|Compound:4218-0007|FD-Score:4.37|P-value:2.08E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:6.64|P-value:3.36E-8 ID:SGTC_625|Compound:k213-0058|FD-Score:14.30|P-value:6.94E-32 ID:SGTC_635|Compound:k038-0028|FD-Score:4.21|P-value:3.36E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.05|P-value:5.53E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:6.14|P-value:3.04E-7 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.05|P-value:2.14E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:4.04|P-value:5.59E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:4.21|P-value:3.39E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:11.50|P-value:3.20E-21 ID:SGTC_796|Compound:1234-0020|FD-Score:5.26|P-value:1.04E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:14.90|P-value:2.05E-34 ID:SGTC_802|Compound:4112-3352|FD-Score:4.28|P-value:2.73E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:7.30|P-value:1.44E-9 ID:SGTC_831|Compound:k061-1017|FD-Score:4.98|P-value:2.78E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:5.87|P-value:9.46E-7 ID:SGTC_862|Compound:0452-0056|FD-Score:5.55|P-value:3.47E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:6.49|P-value:6.79E-8 ID:SGTC_985|Compound:1493-0307|FD-Score:7.23|P-value:1.99E-9 ID:SGTC_990|Compound:3985-0011|FD-Score:4.32|P-value:2.46E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:9.46|P-value:5.83E-15 ID:SGTC_1019|Compound:4262-0212|FD-Score:8.87|P-value:2.44E-13 ID:SGTC_1081|Compound:sertraline|FD-Score:-3.96|P-value:4.41E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.42|P-value:1.80E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:7.81|P-value:1.04E-10 ID:SGTC_1226|Compound:3909-7979|FD-Score:6.03|P-value:5.02E-7 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.48|P-value:1.48E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.63|P-value:9.09E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.87|P-value:4.13E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:-7.11|P-value:1.64E-9 ID:SGTC_1261|Compound:0712-0010|FD-Score:7.88|P-value:6.95E-11 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.04|P-value:5.55E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.56|P-value:1.13E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-4.35|P-value:1.35E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:5.40|P-value:6.01E-6 ID:SGTC_1471|Compound:k673-0312|FD-Score:4.42|P-value:1.80E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.14|P-value:4.18E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.87|P-value:1.18E-8 ID:SGTC_1672|Compound:st016598|FD-Score:4.83|P-value:4.63E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.70|P-value:7.35E-5 ID:SGTC_1696|Compound:st025591|FD-Score:5.16|P-value:1.47E-5 ID:SGTC_1706|Compound:st031321|FD-Score:3.84|P-value:0.00100 ID:SGTC_1745|Compound:st081495|FD-Score:9.45|P-value:6.30E-15 ID:SGTC_1750|Compound:st081859|FD-Score:5.84|P-value:1.09E-6 ID:SGTC_1774|Compound:st048371|FD-Score:3.87|P-value:9.15E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:6.98|P-value:6.93E-9 ID:SGTC_1834|Compound:st055981|FD-Score:-5.34|P-value:4.16E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.18|P-value:7.66E-6 ID:SGTC_1923|Compound:st058458|FD-Score:4.69|P-value:7.55E-5 ID:SGTC_2063|Compound:5246145|FD-Score:-3.72|P-value:8.93E-4 ID:SGTC_2077|Compound:5212015|FD-Score:5.15|P-value:1.52E-5 ID:SGTC_2082|Compound:5219693|FD-Score:4.87|P-value:4.02E-5 ID:SGTC_2122|Compound:5258151|FD-Score:4.32|P-value:2.41E-4 ID:SGTC_2151|Compound:5563267|FD-Score:5.09|P-value:1.87E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.99|P-value:6.45E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.94|P-value:7.44E-4 ID:SGTC_2312|Compound:7706453|FD-Score:4.40|P-value:1.90E-4 ID:SGTC_2342|Compound:7990637|FD-Score:5.08|P-value:1.95E-5 ID:SGTC_2365|Compound:9042475|FD-Score:4.70|P-value:7.18E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.90|P-value:3.70E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:6.40|P-value:1.01E-7 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.67|P-value:2.11E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.76|P-value:5.84E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.76|P-value:5.97E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:11.60|P-value:1.27E-21 ID:SGTC_2679|Compound:rapamycin|FD-Score:-6.01|P-value:2.72E-7 ID:SGTC_2701|Compound:st077767|FD-Score:6.07|P-value:4.25E-7 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.89|P-value:8.67E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:9.73|P-value:1.02E-15 ID:SGTC_2778|Compound:tioconazole|FD-Score:6.94|P-value:8.36E-9 ID:SGTC_2790|Compound:5423970|FD-Score:4.39|P-value:1.93E-4 ID:SGTC_2807|Compound:7945238|FD-Score:6.20|P-value:2.37E-7 ID:SGTC_3021|Compound:9087658|FD-Score:4.99|P-value:2.69E-5 ID:SGTC_3022|Compound:9087993|FD-Score:3.89|P-value:8.64E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-5.49|P-value:2.31E-6 ID:SGTC_3043|Compound:9092303|FD-Score:4.19|P-value:3.63E-4 ID:SGTC_3093|Compound:9117344|FD-Score:-4.22|P-value:2.00E-4 ID:SGTC_3110|Compound:9122132|FD-Score:4.55|P-value:1.18E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.62|P-value:9.33E-5

Top fitness defect scores for YEL031W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_800 3448-7362 14.90 155.0 µM 2.05E-34 translation 1 2.11E-50
2 SGTC_625 k213-0058 14.30 121.0 µM 6.94E-32 translation 1 1.19E-46
3 SGTC_255 tunicamycin 12.10 200.5 nM 1.90E-23 unfolded protein response 8 3.84E-34
4 SGTC_2659 sanguinarine 11.60 24.2 µM 1.27E-21 2 1.95E-31
5 SGTC_794 k038-0031 11.50 316.0 µM 3.20E-21 ubiquinone biosynthesis & proteasome 10 7.70E-31
6 SGTC_2737 bleomycin 9.73 30.5 nM 1.02E-15 Golgi 13 1.11E-22
7 SGTC_1011 4112-3381 9.46 17.4 µM 5.83E-15 6 1.47E-21
8 SGTC_1745 st081495 9.45 74.0 µM 6.30E-15 RNA processing & uracil transport 9 1.65E-21
9 SGTC_1019 4262-0212 8.87 3.4 µM 2.44E-13 ergosterol depletion effects on membrane 11 3.74E-19
10 SGTC_513 4245-1575 8.42 41.7 µM 3.49E-12 unfolded protein response 24 1.92E-17
11 SGTC_59 0330-0160 8.38 1.3 µM 4.39E-12 14 2.71E-17
12 SGTC_279 1273-0055 8.16 2.9 µM 1.48E-11 azole & statin 3 1.63E-16
13 SGTC_1261 0712-0010 7.88 12.7 µM 6.95E-11 RNA processing & uracil transport 1 1.62E-15
14 SGTC_1218 1348-1416 7.81 30.7 µM 1.04E-10 SWF1 & branched chain AA biosynthesis 2 2.95E-15
15 SGTC_86 0417-1630 7.62 471.9 µM 2.84E-10 ubiquinone biosynthesis & proteasome 63 1.30E-14
16 SGTC_178 4092-0806 7.45 87.5 µM 6.76E-10 ergosterol depletion effects on membrane 21 4.72E-14
17 SGTC_315 k915-0449 7.33 187.0 µM 1.22E-9 12 1.13E-13
18 SGTC_830 4076-0286 7.30 57.8 µM 1.44E-9 translation 4 1.45E-13
19 SGTC_985 1493-0307 7.23 8.7 µM 1.99E-9 TSC3-RPN4 3 2.34E-13
20 SGTC_67 0335-0847 7.12 266.0 µM 3.43E-9 ubiquinone biosynthesis & proteasome 48 5.24E-13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.296 1.62E-68 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.286 3.62E-64 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.249 1.16E-48 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.242 1.02E-45 YDL020C RPN4 hom Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
0.224 3.06E-39 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.222 8.34E-39 YHR079C IRE1 hom Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
0.222 9.59E-39 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.220 5.58E-38 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.219 1.36E-37 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.218 3.35E-37 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.216 1.55E-36 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.213 7.86E-36 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.210 1.45E-34 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.207 1.06E-33 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.205 5.90E-33 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication