YEL033W_p / MTC7

Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL033W / MTC7

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:4.64|P-value:2.14E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:4.10|P-value:1.52E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:-3.91|P-value:1.74E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.76|P-value:4.70E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.89|P-value:3.12E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:4.58|P-value:2.70E-5 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.88|P-value:3.22E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.19|P-value:2.22E-6 ID:SGTC_565|Compound:1418-0001|FD-Score:3.59|P-value:8.04E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.95|P-value:2.58E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.08|P-value:1.67E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.67|P-value:6.36E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-4.16|P-value:7.24E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:4.46|P-value:4.16E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:4.28|P-value:8.19E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.70|P-value:1.68E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:4.36|P-value:6.17E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.81|P-value:4.12E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.68|P-value:6.13E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.50|P-value:6.80E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.48|P-value:7.10E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-4.34|P-value:3.72E-5 ID:SGTC_1652|Compound:st011932|FD-Score:-3.53|P-value:6.12E-4 ID:SGTC_1783|Compound:st039459|FD-Score:5.45|P-value:7.35E-7 ID:SGTC_1843|Compound:st055809|FD-Score:3.96|P-value:2.47E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.98|P-value:1.39E-4 ID:SGTC_2050|Compound:5263056|FD-Score:5.45|P-value:7.15E-7 ID:SGTC_2053|Compound:5265679|FD-Score:4.39|P-value:5.52E-5 ID:SGTC_2059|Compound:5238311|FD-Score:4.28|P-value:8.06E-5 ID:SGTC_2146|Compound:5545642|FD-Score:4.21|P-value:1.06E-4 ID:SGTC_2178|Compound:5812956|FD-Score:4.10|P-value:1.52E-4 ID:SGTC_2183|Compound:6420625|FD-Score:5.41|P-value:8.65E-7 ID:SGTC_2274|Compound:7947094|FD-Score:3.59|P-value:8.24E-4 ID:SGTC_2294|Compound:7971431|FD-Score:4.24|P-value:9.50E-5 ID:SGTC_2303|Compound:7774051|FD-Score:-4.10|P-value:9.06E-5 ID:SGTC_2332|Compound:7982454|FD-Score:5.25|P-value:1.75E-6 ID:SGTC_2382|Compound:9035899|FD-Score:-3.93|P-value:1.62E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.72|P-value:1.57E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.32|P-value:4.05E-5 ID:SGTC_2434|Compound:5670830|FD-Score:3.83|P-value:3.83E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.77|P-value:2.82E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.66|P-value:6.59E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.00|P-value:2.15E-4 ID:SGTC_2706|Compound:st078239|FD-Score:4.31|P-value:7.44E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.40|P-value:9.07E-7 ID:SGTC_2801|Compound:7907800|FD-Score:5.01|P-value:4.88E-6 ID:SGTC_2806|Compound:7952793|FD-Score:3.72|P-value:5.34E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.21|P-value:1.05E-4 ID:SGTC_2813|Compound:7971799|FD-Score:4.90|P-value:7.62E-6 ID:SGTC_3275|Compound:9138069|FD-Score:3.57|P-value:8.58E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.83|P-value:3.78E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.63|P-value:4.40E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.64|P-value:2.14E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:4.10|P-value:1.52E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:-3.91|P-value:1.74E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.76|P-value:4.70E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.89|P-value:3.12E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:4.58|P-value:2.70E-5 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.88|P-value:3.22E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.19|P-value:2.22E-6 ID:SGTC_565|Compound:1418-0001|FD-Score:3.59|P-value:8.04E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.95|P-value:2.58E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.08|P-value:1.67E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.67|P-value:6.36E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-4.16|P-value:7.24E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:4.46|P-value:4.16E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:4.28|P-value:8.19E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.70|P-value:1.68E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:4.36|P-value:6.17E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.81|P-value:4.12E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.68|P-value:6.13E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.50|P-value:6.80E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.48|P-value:7.10E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-4.34|P-value:3.72E-5 ID:SGTC_1652|Compound:st011932|FD-Score:-3.53|P-value:6.12E-4 ID:SGTC_1783|Compound:st039459|FD-Score:5.45|P-value:7.35E-7 ID:SGTC_1843|Compound:st055809|FD-Score:3.96|P-value:2.47E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.98|P-value:1.39E-4 ID:SGTC_2050|Compound:5263056|FD-Score:5.45|P-value:7.15E-7 ID:SGTC_2053|Compound:5265679|FD-Score:4.39|P-value:5.52E-5 ID:SGTC_2059|Compound:5238311|FD-Score:4.28|P-value:8.06E-5 ID:SGTC_2146|Compound:5545642|FD-Score:4.21|P-value:1.06E-4 ID:SGTC_2178|Compound:5812956|FD-Score:4.10|P-value:1.52E-4 ID:SGTC_2183|Compound:6420625|FD-Score:5.41|P-value:8.65E-7 ID:SGTC_2274|Compound:7947094|FD-Score:3.59|P-value:8.24E-4 ID:SGTC_2294|Compound:7971431|FD-Score:4.24|P-value:9.50E-5 ID:SGTC_2303|Compound:7774051|FD-Score:-4.10|P-value:9.06E-5 ID:SGTC_2332|Compound:7982454|FD-Score:5.25|P-value:1.75E-6 ID:SGTC_2382|Compound:9035899|FD-Score:-3.93|P-value:1.62E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.72|P-value:1.57E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.32|P-value:4.05E-5 ID:SGTC_2434|Compound:5670830|FD-Score:3.83|P-value:3.83E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.77|P-value:2.82E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.66|P-value:6.59E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.00|P-value:2.15E-4 ID:SGTC_2706|Compound:st078239|FD-Score:4.31|P-value:7.44E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.40|P-value:9.07E-7 ID:SGTC_2801|Compound:7907800|FD-Score:5.01|P-value:4.88E-6 ID:SGTC_2806|Compound:7952793|FD-Score:3.72|P-value:5.34E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.21|P-value:1.05E-4 ID:SGTC_2813|Compound:7971799|FD-Score:4.90|P-value:7.62E-6 ID:SGTC_3275|Compound:9138069|FD-Score:3.57|P-value:8.58E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.83|P-value:3.78E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.63|P-value:4.40E-4

Top fitness defect scores for YEL033W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2050 5263056 5.45 171.0 µM 7.15E-7 fatty acid desaturase (OLE1) 15 2.49E-8
2 SGTC_1783 st039459 5.45 87.5 µM 7.35E-7 Golgi 8 2.58E-8
3 SGTC_2183 6420625 5.41 130.5 µM 8.65E-7 mitochondrial processes 22 3.17E-8
4 SGTC_2757 clomiphene 5.40 4.2 µM 9.07E-7 fatty acid desaturase (OLE1) 15 3.36E-8
5 SGTC_2332 7982454 5.25 138.9 µM 1.75E-6 26 7.62E-8
6 SGTC_451 chloral hydrate 5.19 100.0 µM 2.22E-6 24 1.03E-7
7 SGTC_2801 7907800 5.01 81.8 µM 4.88E-6 13 2.76E-7
8 SGTC_2813 7971799 4.90 71.4 µM 7.62E-6 9 4.82E-7
9 SGTC_2407 paclitaxel 4.72 400.0 µM 1.57E-5 20 1.19E-6
10 SGTC_916 4466-0038 4.70 42.0 nM 1.68E-5 cell wall 45 1.29E-6
11 SGTC_118 0083-0097 4.64 135.3 µM 2.14E-5 translation 77 1.76E-6
12 SGTC_399 oxolinic acid 4.58 75.0 µM 2.70E-5 2 2.35E-6
13 SGTC_907 3448-6986 4.46 75.5 µM 4.16E-5 15 4.02E-6
14 SGTC_2053 5265679 4.39 138.0 µM 5.52E-5 15 5.73E-6
15 SGTC_946 3434-1334 4.36 87.4 µM 6.17E-5 21 6.59E-6
16 SGTC_2706 st078239 4.31 82.5 µM 7.44E-5 4 8.33E-6
17 SGTC_2059 5238311 4.28 157.0 µM 8.06E-5 15 9.20E-6
18 SGTC_909 3448-9333 4.28 149.0 µM 8.19E-5 14 9.39E-6
19 SGTC_2294 7971431 4.24 200.0 µM 9.50E-5 9 1.13E-5
20 SGTC_2809 7964133 4.21 13.0 µM 1.05E-4 60S ribosome export 31 1.27E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 3.32E-14 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.103 2.30E-9 YOL121C RPS19A hom Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication
0.102 3.04E-9 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.099 9.92E-9 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.096 3.01E-8 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.093 8.00E-8 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.092 9.33E-8 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.091 1.34E-7 YLL044W_d YLL044W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
0.090 2.11E-7 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.089 2.61E-7 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.088 3.44E-7 YDL105W NSE4 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.087 4.63E-7 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.086 5.85E-7 YGL240W DOC1 hom Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain
0.086 6.49E-7 YNL328C MDJ2 hom Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain
0.086 6.66E-7 YER122C GLO3 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p