YEL035C_p / UTR5

Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions

Zygosity: Heterozygous strain
fixedexpanded
Profile for YEL035C / UTR5

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.57|P-value:4.95E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.45|P-value:2.74E-7 ID:SGTC_42|Compound:0133-0086|FD-Score:4.13|P-value:7.13E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:-4.69|P-value:9.03E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:10.70|P-value:4.07E-23 ID:SGTC_63|Compound:0099-0242|FD-Score:4.92|P-value:2.97E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:3.92|P-value:1.55E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:5.35|P-value:4.39E-7 ID:SGTC_113|Compound:0099-0221|FD-Score:4.22|P-value:5.19E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:5.28|P-value:5.97E-7 ID:SGTC_259|Compound:usnic acid|FD-Score:5.70|P-value:7.77E-8 ID:SGTC_264|Compound:promethazine|FD-Score:4.68|P-value:8.40E-6 ID:SGTC_288|Compound:1315-0019|FD-Score:5.43|P-value:2.97E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:4.32|P-value:3.50E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:5.10|P-value:1.33E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:3.68|P-value:3.46E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.96|P-value:1.32E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.47|P-value:7.64E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.92|P-value:1.01E-10 ID:SGTC_520|Compound:3584-0023|FD-Score:3.58|P-value:4.89E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.98|P-value:1.95E-8 ID:SGTC_576|Compound:1073-0113|FD-Score:7.30|P-value:9.64E-12 ID:SGTC_586|Compound:0957-0265|FD-Score:9.22|P-value:1.19E-17 ID:SGTC_673|Compound:1082-0474|FD-Score:5.97|P-value:1.98E-8 ID:SGTC_742|Compound:0kpi-0133|FD-Score:5.99|P-value:1.79E-8 ID:SGTC_745|Compound:0469-0705|FD-Score:5.22|P-value:7.70E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:4.44|P-value:2.21E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.99|P-value:2.20E-6 ID:SGTC_842|Compound:0271-0008|FD-Score:3.70|P-value:3.29E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:6.43|P-value:1.71E-9 ID:SGTC_853|Compound:0419-0306|FD-Score:4.23|P-value:5.01E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:4.33|P-value:3.33E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:3.67|P-value:3.59E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.56|P-value:5.23E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.99|P-value:1.19E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.00|P-value:1.17E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.98|P-value:1.25E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:6.38|P-value:2.28E-9 ID:SGTC_1478|Compound:0453-0656|FD-Score:4.54|P-value:1.47E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.51|P-value:2.05E-7 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.46|P-value:2.02E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.81|P-value:2.25E-4 ID:SGTC_1567|Compound:st069303|FD-Score:4.72|P-value:7.02E-6 ID:SGTC_1707|Compound:st032323|FD-Score:7.46|P-value:3.53E-12 ID:SGTC_2004|Compound:4023728|FD-Score:3.79|P-value:2.43E-4 ID:SGTC_2149|Compound:5554786|FD-Score:6.09|P-value:1.08E-8 ID:SGTC_2158|Compound:5657123|FD-Score:3.39|P-value:8.95E-4 ID:SGTC_2161|Compound:5662504|FD-Score:4.37|P-value:2.85E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:5.53|P-value:1.86E-7 ID:SGTC_2172|Compound:5754775|FD-Score:4.33|P-value:3.39E-5 ID:SGTC_2178|Compound:5812956|FD-Score:-3.64|P-value:4.41E-4 ID:SGTC_2256|Compound:7954252|FD-Score:4.47|P-value:1.93E-5 ID:SGTC_2326|Compound:6164455|FD-Score:6.06|P-value:1.24E-8 ID:SGTC_2344|Compound:7990960|FD-Score:3.52|P-value:5.92E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.24|P-value:4.66E-5 ID:SGTC_2442|Compound:5158906|FD-Score:3.81|P-value:2.26E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:4.95|P-value:2.61E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.58|P-value:4.85E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.08|P-value:8.70E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-4.49|P-value:2.02E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.97|P-value:2.38E-6 ID:SGTC_2912|Compound:7964298|FD-Score:5.60|P-value:1.29E-7 ID:SGTC_2930|Compound:9013230|FD-Score:6.42|P-value:1.77E-9 ID:SGTC_2938|Compound:9059746|FD-Score:3.99|P-value:1.18E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.34|P-value:4.60E-7 ID:SGTC_3142|Compound:9086498|FD-Score:-5.94|P-value:2.78E-8 ID:SGTC_3272|Compound:9137413|FD-Score:3.77|P-value:2.58E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.57|P-value:4.95E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.45|P-value:2.74E-7 ID:SGTC_42|Compound:0133-0086|FD-Score:4.13|P-value:7.13E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:-4.69|P-value:9.03E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:10.70|P-value:4.07E-23 ID:SGTC_63|Compound:0099-0242|FD-Score:4.92|P-value:2.97E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:3.92|P-value:1.55E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:5.35|P-value:4.39E-7 ID:SGTC_113|Compound:0099-0221|FD-Score:4.22|P-value:5.19E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:5.28|P-value:5.97E-7 ID:SGTC_259|Compound:usnic acid|FD-Score:5.70|P-value:7.77E-8 ID:SGTC_264|Compound:promethazine|FD-Score:4.68|P-value:8.40E-6 ID:SGTC_288|Compound:1315-0019|FD-Score:5.43|P-value:2.97E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:4.32|P-value:3.50E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:5.10|P-value:1.33E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:3.68|P-value:3.46E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.96|P-value:1.32E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.47|P-value:7.64E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.92|P-value:1.01E-10 ID:SGTC_520|Compound:3584-0023|FD-Score:3.58|P-value:4.89E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.98|P-value:1.95E-8 ID:SGTC_576|Compound:1073-0113|FD-Score:7.30|P-value:9.64E-12 ID:SGTC_586|Compound:0957-0265|FD-Score:9.22|P-value:1.19E-17 ID:SGTC_673|Compound:1082-0474|FD-Score:5.97|P-value:1.98E-8 ID:SGTC_742|Compound:0kpi-0133|FD-Score:5.99|P-value:1.79E-8 ID:SGTC_745|Compound:0469-0705|FD-Score:5.22|P-value:7.70E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:4.44|P-value:2.21E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.99|P-value:2.20E-6 ID:SGTC_842|Compound:0271-0008|FD-Score:3.70|P-value:3.29E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:6.43|P-value:1.71E-9 ID:SGTC_853|Compound:0419-0306|FD-Score:4.23|P-value:5.01E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:4.33|P-value:3.33E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:3.67|P-value:3.59E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.56|P-value:5.23E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.99|P-value:1.19E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.00|P-value:1.17E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.98|P-value:1.25E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:6.38|P-value:2.28E-9 ID:SGTC_1478|Compound:0453-0656|FD-Score:4.54|P-value:1.47E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.51|P-value:2.05E-7 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.46|P-value:2.02E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.81|P-value:2.25E-4 ID:SGTC_1567|Compound:st069303|FD-Score:4.72|P-value:7.02E-6 ID:SGTC_1707|Compound:st032323|FD-Score:7.46|P-value:3.53E-12 ID:SGTC_2004|Compound:4023728|FD-Score:3.79|P-value:2.43E-4 ID:SGTC_2149|Compound:5554786|FD-Score:6.09|P-value:1.08E-8 ID:SGTC_2158|Compound:5657123|FD-Score:3.39|P-value:8.95E-4 ID:SGTC_2161|Compound:5662504|FD-Score:4.37|P-value:2.85E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:5.53|P-value:1.86E-7 ID:SGTC_2172|Compound:5754775|FD-Score:4.33|P-value:3.39E-5 ID:SGTC_2178|Compound:5812956|FD-Score:-3.64|P-value:4.41E-4 ID:SGTC_2256|Compound:7954252|FD-Score:4.47|P-value:1.93E-5 ID:SGTC_2326|Compound:6164455|FD-Score:6.06|P-value:1.24E-8 ID:SGTC_2344|Compound:7990960|FD-Score:3.52|P-value:5.92E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.24|P-value:4.66E-5 ID:SGTC_2442|Compound:5158906|FD-Score:3.81|P-value:2.26E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:4.95|P-value:2.61E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.58|P-value:4.85E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.08|P-value:8.70E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-4.49|P-value:2.02E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.97|P-value:2.38E-6 ID:SGTC_2912|Compound:7964298|FD-Score:5.60|P-value:1.29E-7 ID:SGTC_2930|Compound:9013230|FD-Score:6.42|P-value:1.77E-9 ID:SGTC_2938|Compound:9059746|FD-Score:3.99|P-value:1.18E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.34|P-value:4.60E-7 ID:SGTC_3142|Compound:9086498|FD-Score:-5.94|P-value:2.78E-8 ID:SGTC_3272|Compound:9137413|FD-Score:3.77|P-value:2.58E-4

Top fitness defect scores for YEL035C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_58 0957-0393 10.70 9.0 µM 4.07E-23 cell wall 7 4.79E-27 0.05
2 SGTC_586 0957-0265 9.22 8.2 µM 1.19E-17 cell wall 8 1.44E-20 0.05
3 SGTC_1707 st032323 7.46 6.3 µM 3.53E-12 DNA damage response 11 4.32E-14 0.26
4 SGTC_576 1073-0113 7.30 22.7 µM 9.64E-12 redox potentiating 11 1.42E-13 0.03
5 SGTC_514 4466-0038 6.92 2.6 nM 1.01E-10 cell wall 9 2.27E-12 0.15
6 SGTC_851 0394-0702 6.43 453.0 µM 1.71E-9 mitochondrial processes 7 6.45E-11 0.18
7 SGTC_2930 9013230 6.42 14.9 µM 1.77E-9 heme biosynthesis & mitochondrial translocase 11 6.71E-11 1.63
8 SGTC_1371 2421-0008 6.38 32.7 µM 2.28E-9 mitochondrial processes 7 9.10E-11 0.50
9 SGTC_2149 5554786 6.09 194.8 µM 1.08E-8 cell wall signaling 2 5.68E-10 0.11
10 SGTC_2326 6164455 6.06 177.6 µM 1.24E-8 mitochondrial processes 3 6.74E-10 0.15
11 SGTC_742 0kpi-0133 5.99 140.0 µM 1.79E-8 ERG2 2 1.03E-9 1.16
12 SGTC_525 k781-2675 5.98 26.7 µM 1.95E-8 redox potentiating 20 1.14E-9 0.02
13 SGTC_673 1082-0474 5.97 110.0 µM 1.98E-8 RSC complex & mRNA processing 28 1.16E-9 0.19
14 SGTC_259 usnic acid 5.70 108.9 µM 7.77E-8 2 5.85E-9 0.40
15 SGTC_2912 7964298 5.60 10.9 µM 1.29E-7 cell wall 24 1.06E-8 0.07
16 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 5.53 49.5 µM 1.86E-7 7 1.64E-8 0.25
17 SGTC_1493 4348-0038 5.51 111.0 µM 2.05E-7 RSC complex & mRNA processing 21 1.84E-8 0.02
18 SGTC_36 0335-0881 5.45 14.2 µM 2.74E-7 ubiquinone biosynthesis & proteasome 16 2.58E-8 0.05
19 SGTC_288 1315-0019 5.43 35.1 µM 2.97E-7 RSC & ERG11 9 2.84E-8 0.18
20 SGTC_69 0096-0274 5.35 206.7 µM 4.39E-7 mitochondrial processes 26 4.51E-8 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.332 5.55E-87 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.280 2.44E-61 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.253 7.37E-50 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.234 5.88E-43 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.231 9.73E-42 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.230 1.44E-41 YBR143C SUP45 het Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
0.227 2.12E-40 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.220 9.56E-38 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.220 9.56E-38 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.217 5.39E-37 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.216 1.42E-36 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.206 2.48E-33 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.205 4.69E-33 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.197 1.34E-30 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.194 1.34E-29 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress