YEL036C / ANP1

Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL036C / ANP1

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:4.21|P-value:1.19E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.52|P-value:8.05E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.45|P-value:3.52E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:6.13|P-value:3.96E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:4.46|P-value:5.04E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.53|P-value:7.78E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:8.73|P-value:9.24E-15 ID:SGTC_445|Compound:e6 berbamine|FD-Score:8.05|P-value:8.19E-13 ID:SGTC_663|Compound:1486-0733|FD-Score:4.48|P-value:4.62E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:3.61|P-value:8.36E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.75|P-value:5.38E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.98|P-value:2.62E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:-3.86|P-value:2.73E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:3.56|P-value:9.81E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:5.73|P-value:2.67E-7 ID:SGTC_881|Compound:0833-0569|FD-Score:3.70|P-value:6.40E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.61|P-value:2.85E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.56|P-value:9.80E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.63|P-value:5.69E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.37|P-value:6.77E-5 ID:SGTC_1236|Compound:0330-0013|FD-Score:7.68|P-value:7.96E-12 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.58|P-value:6.60E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.22|P-value:1.16E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:5.95|P-value:9.53E-8 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.99|P-value:6.42E-6 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.83|P-value:4.24E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.70|P-value:2.03E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.48|P-value:4.68E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.60|P-value:6.35E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.99|P-value:2.53E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.93|P-value:3.08E-4 ID:SGTC_1778|Compound:st046819|FD-Score:-4.14|P-value:1.07E-4 ID:SGTC_1814|Compound:st052110|FD-Score:-3.79|P-value:3.48E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.81|P-value:1.81E-7 ID:SGTC_1870|Compound:st057514|FD-Score:3.82|P-value:4.41E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.40|P-value:6.18E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.63|P-value:7.95E-4 ID:SGTC_2007|Compound:4011539|FD-Score:5.74|P-value:2.55E-7 ID:SGTC_2009|Compound:4012297|FD-Score:6.95|P-value:5.71E-10 ID:SGTC_2067|Compound:5224629|FD-Score:3.95|P-value:2.87E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.59|P-value:8.78E-4 ID:SGTC_2118|Compound:5526350|FD-Score:-4.47|P-value:3.21E-5 ID:SGTC_2125|Compound:5246583|FD-Score:-3.92|P-value:2.22E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.66|P-value:7.24E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-3.97|P-value:1.88E-4 ID:SGTC_2242|Compound:6630449|FD-Score:5.29|P-value:1.83E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.83|P-value:4.20E-4 ID:SGTC_2366|Compound:9070441|FD-Score:5.45|P-value:9.16E-7 ID:SGTC_2399|Compound:5884133|FD-Score:5.86|P-value:1.46E-7 ID:SGTC_2415|Compound:st077333|FD-Score:4.48|P-value:4.60E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-4.27|P-value:6.72E-5 ID:SGTC_2451|Compound:5856223|FD-Score:4.44|P-value:5.35E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.71|P-value:4.52E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.72|P-value:1.91E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:9.92|P-value:1.49E-18 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.78|P-value:4.95E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.80|P-value:4.68E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.99|P-value:2.52E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.70|P-value:6.39E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.83|P-value:3.07E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.58|P-value:9.16E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.78|P-value:3.52E-4 ID:SGTC_2994|Compound:9053520|FD-Score:4.97|P-value:7.13E-6 ID:SGTC_14|Compound:0354-0009|FD-Score:4.21|P-value:1.19E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.52|P-value:8.05E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.45|P-value:3.52E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:6.13|P-value:3.96E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:4.46|P-value:5.04E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.53|P-value:7.78E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:8.73|P-value:9.24E-15 ID:SGTC_445|Compound:e6 berbamine|FD-Score:8.05|P-value:8.19E-13 ID:SGTC_663|Compound:1486-0733|FD-Score:4.48|P-value:4.62E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:3.61|P-value:8.36E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.75|P-value:5.38E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.98|P-value:2.62E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:-3.86|P-value:2.73E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:3.56|P-value:9.81E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:5.73|P-value:2.67E-7 ID:SGTC_881|Compound:0833-0569|FD-Score:3.70|P-value:6.40E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.61|P-value:2.85E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.56|P-value:9.80E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.63|P-value:5.69E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.37|P-value:6.77E-5 ID:SGTC_1236|Compound:0330-0013|FD-Score:7.68|P-value:7.96E-12 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.58|P-value:6.60E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.22|P-value:1.16E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:5.95|P-value:9.53E-8 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.99|P-value:6.42E-6 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.83|P-value:4.24E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.70|P-value:2.03E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.48|P-value:4.68E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.60|P-value:6.35E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.99|P-value:2.53E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.93|P-value:3.08E-4 ID:SGTC_1778|Compound:st046819|FD-Score:-4.14|P-value:1.07E-4 ID:SGTC_1814|Compound:st052110|FD-Score:-3.79|P-value:3.48E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.81|P-value:1.81E-7 ID:SGTC_1870|Compound:st057514|FD-Score:3.82|P-value:4.41E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.40|P-value:6.18E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.63|P-value:7.95E-4 ID:SGTC_2007|Compound:4011539|FD-Score:5.74|P-value:2.55E-7 ID:SGTC_2009|Compound:4012297|FD-Score:6.95|P-value:5.71E-10 ID:SGTC_2067|Compound:5224629|FD-Score:3.95|P-value:2.87E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.59|P-value:8.78E-4 ID:SGTC_2118|Compound:5526350|FD-Score:-4.47|P-value:3.21E-5 ID:SGTC_2125|Compound:5246583|FD-Score:-3.92|P-value:2.22E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.66|P-value:7.24E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-3.97|P-value:1.88E-4 ID:SGTC_2242|Compound:6630449|FD-Score:5.29|P-value:1.83E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.83|P-value:4.20E-4 ID:SGTC_2366|Compound:9070441|FD-Score:5.45|P-value:9.16E-7 ID:SGTC_2399|Compound:5884133|FD-Score:5.86|P-value:1.46E-7 ID:SGTC_2415|Compound:st077333|FD-Score:4.48|P-value:4.60E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-4.27|P-value:6.72E-5 ID:SGTC_2451|Compound:5856223|FD-Score:4.44|P-value:5.35E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.71|P-value:4.52E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.72|P-value:1.91E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:9.92|P-value:1.49E-18 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.78|P-value:4.95E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.80|P-value:4.68E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.99|P-value:2.52E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.70|P-value:6.39E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.83|P-value:3.07E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.58|P-value:9.16E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.78|P-value:3.52E-4 ID:SGTC_2994|Compound:9053520|FD-Score:4.97|P-value:7.13E-6

Top fitness defect scores for YEL036C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2583 asiatic acid 9.92 100.0 µM 1.49E-18 1 1.75E-23
2 SGTC_351 caspofungin 8.73 25.0 nM 9.24E-15 cell wall 12 1.31E-18
3 SGTC_445 e6 berbamine 8.05 66.0 µM 8.19E-13 NEO1-PIK1 12 4.18E-16
4 SGTC_1236 0330-0013 7.68 258.0 µM 7.96E-12 1 7.77E-15
5 SGTC_2009 4012297 6.95 12.1 µM 5.71E-10 cell wall signaling 19 1.88E-12
6 SGTC_121 0557-0495 6.13 61.3 µM 3.96E-8 calcium & mitochondrial duress 18 4.35E-10
7 SGTC_1264 0783-0040 5.95 158.0 µM 9.53E-8 4 1.34E-9
8 SGTC_2399 5884133 5.86 200.0 µM 1.46E-7 cell wall signaling 29 2.32E-9
9 SGTC_1844 rapamycin 5.81 4.0 nM 1.81E-7 93 3.08E-9
10 SGTC_2007 4011539 5.74 71.8 µM 2.55E-7 cell wall signaling 27 4.76E-9
11 SGTC_878 0828-0289 5.73 13.7 µM 2.67E-7 17 5.04E-9
12 SGTC_2366 9070441 5.45 60.6 µM 9.16E-7 6 2.45E-8
13 SGTC_2242 6630449 5.29 61.3 µM 1.83E-6 Golgi 22 5.99E-8
14 SGTC_1495 4469-0029 4.99 237.0 µM 6.42E-6 70 2.98E-7
15 SGTC_2994 9053520 4.97 71.4 µM 7.13E-6 RPP1 & pyrimidine depletion 10 3.42E-7
16 SGTC_2582 agaric acid 4.72 100.0 µM 1.91E-5 redox potentiating 240 1.21E-6
17 SGTC_1597 7-benzyloxygramine 4.70 47.5 µM 2.03E-5 calcium & mitochondrial duress 76 1.30E-6
18 SGTC_908 3448-7491 4.61 47.7 µM 2.85E-5 mitochondrial stress 90 2.02E-6
19 SGTC_2415 st077333 4.48 57.7 µM 4.60E-5 30 3.72E-6
20 SGTC_663 1486-0733 4.48 13.9 µM 4.62E-5 cell wall signaling 39 3.75E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.205 4.47E-33 YJL183W MNN11 hom Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
0.201 7.58E-32 YGL027C CWH41 hom Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress
0.192 3.18E-29 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.179 1.58E-25 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.173 5.12E-24 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.172 8.94E-24 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.169 8.48E-23 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.167 1.83E-22 YDR245W MNN10 hom Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family
0.163 1.97E-21 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.163 2.55E-21 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.158 3.28E-20 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.157 7.69E-20 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.149 3.89E-18 YMR238W DFG5 hom Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p
0.148 6.19E-18 YML115C VAN1 hom Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant
0.139 6.82E-16 YOR002W ALG6 hom Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease