YEL039C / CYC7

Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL039C / CYC7

Click on Significant Values for Screen Details ID:SGTC_101|Compound:0490-5701|FD-Score:-3.63|P-value:4.43E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:6.00|P-value:2.03E-8 ID:SGTC_181|Compound:1447-1644|FD-Score:-4.54|P-value:1.63E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:3.49|P-value:7.12E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.72|P-value:3.30E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.65|P-value:4.28E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:3.68|P-value:3.78E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:-4.27|P-value:4.75E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:4.69|P-value:9.04E-6 ID:SGTC_452|Compound:diindolylmethane|FD-Score:4.15|P-value:7.54E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.77|P-value:2.82E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-4.11|P-value:8.62E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:3.91|P-value:1.78E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:6.58|P-value:8.77E-10 ID:SGTC_639|Compound:0833-0042|FD-Score:-4.61|P-value:1.24E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.56|P-value:5.72E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:4.11|P-value:8.50E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.55|P-value:5.94E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:4.14|P-value:7.70E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:3.92|P-value:1.71E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.63|P-value:4.48E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.44|P-value:8.27E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.14|P-value:7.81E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.27|P-value:4.67E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:-5.53|P-value:2.08E-7 ID:SGTC_1376|Compound:2910-0861|FD-Score:5.56|P-value:1.87E-7 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.45|P-value:8.16E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:4.03|P-value:1.13E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:4.87|P-value:4.26E-6 ID:SGTC_1555|Compound:citronellol|FD-Score:-3.54|P-value:6.01E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.41|P-value:2.77E-5 ID:SGTC_2041|Compound:5107442|FD-Score:3.98|P-value:1.35E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.42|P-value:8.93E-4 ID:SGTC_2242|Compound:6630449|FD-Score:5.19|P-value:1.04E-6 ID:SGTC_2336|Compound:9001819|FD-Score:-3.46|P-value:7.70E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.66|P-value:4.13E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.94|P-value:1.60E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.54|P-value:5.97E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.75|P-value:3.06E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.42|P-value:8.76E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.68|P-value:3.78E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.72|P-value:3.35E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:4.05|P-value:1.08E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.50|P-value:6.79E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.49|P-value:7.18E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.71|P-value:3.42E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:5.22|P-value:9.30E-7 ID:SGTC_2836|Compound:9010338|FD-Score:-4.60|P-value:1.30E-5 ID:SGTC_2840|Compound:9008771|FD-Score:5.21|P-value:9.70E-7 ID:SGTC_2844|Compound:9010103|FD-Score:-5.28|P-value:6.85E-7 ID:SGTC_2880|Compound:9042983|FD-Score:-4.97|P-value:2.72E-6 ID:SGTC_2896|Compound:9052656|FD-Score:4.35|P-value:3.45E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-3.66|P-value:4.10E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.58|P-value:5.33E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.63|P-value:4.43E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:6.00|P-value:2.03E-8 ID:SGTC_181|Compound:1447-1644|FD-Score:-4.54|P-value:1.63E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:3.49|P-value:7.12E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.72|P-value:3.30E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.65|P-value:4.28E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:3.68|P-value:3.78E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:-4.27|P-value:4.75E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:4.69|P-value:9.04E-6 ID:SGTC_452|Compound:diindolylmethane|FD-Score:4.15|P-value:7.54E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.77|P-value:2.82E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-4.11|P-value:8.62E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:3.91|P-value:1.78E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:6.58|P-value:8.77E-10 ID:SGTC_639|Compound:0833-0042|FD-Score:-4.61|P-value:1.24E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.56|P-value:5.72E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:4.11|P-value:8.50E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.55|P-value:5.94E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:4.14|P-value:7.70E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:3.92|P-value:1.71E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.63|P-value:4.48E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.44|P-value:8.27E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.14|P-value:7.81E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.27|P-value:4.67E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:-5.53|P-value:2.08E-7 ID:SGTC_1376|Compound:2910-0861|FD-Score:5.56|P-value:1.87E-7 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.45|P-value:8.16E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:4.03|P-value:1.13E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:4.87|P-value:4.26E-6 ID:SGTC_1555|Compound:citronellol|FD-Score:-3.54|P-value:6.01E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.41|P-value:2.77E-5 ID:SGTC_2041|Compound:5107442|FD-Score:3.98|P-value:1.35E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.42|P-value:8.93E-4 ID:SGTC_2242|Compound:6630449|FD-Score:5.19|P-value:1.04E-6 ID:SGTC_2336|Compound:9001819|FD-Score:-3.46|P-value:7.70E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.66|P-value:4.13E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.94|P-value:1.60E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.54|P-value:5.97E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.75|P-value:3.06E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.42|P-value:8.76E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.68|P-value:3.78E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.72|P-value:3.35E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:4.05|P-value:1.08E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.50|P-value:6.79E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.49|P-value:7.18E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.71|P-value:3.42E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:5.22|P-value:9.30E-7 ID:SGTC_2836|Compound:9010338|FD-Score:-4.60|P-value:1.30E-5 ID:SGTC_2840|Compound:9008771|FD-Score:5.21|P-value:9.70E-7 ID:SGTC_2844|Compound:9010103|FD-Score:-5.28|P-value:6.85E-7 ID:SGTC_2880|Compound:9042983|FD-Score:-4.97|P-value:2.72E-6 ID:SGTC_2896|Compound:9052656|FD-Score:4.35|P-value:3.45E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-3.66|P-value:4.10E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.58|P-value:5.33E-4

Top fitness defect scores for YEL039C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_638 3970-0837 6.58 4.1 µM 8.77E-10 11 2.30E-11
2 SGTC_178 4092-0806 6.00 87.5 µM 2.03E-8 ergosterol depletion effects on membrane 38 9.71E-10
3 SGTC_1376 2910-0861 5.56 41.3 µM 1.87E-7 5 1.37E-8
4 SGTC_2760 etidronate 5.22 98.0 µM 9.30E-7 8 9.18E-8
5 SGTC_2840 9008771 5.21 71.4 µM 9.70E-7 1 9.66E-8
6 SGTC_2242 6630449 5.19 61.3 µM 1.04E-6 Golgi 23 1.05E-7
7 SGTC_1504 k297-0033 4.87 30.0 µM 4.26E-6 3 5.61E-7
8 SGTC_322 k048-0136 4.69 19.3 µM 9.04E-6 RSC & ERG11 7 1.37E-6
9 SGTC_1672 st016598 4.41 6.5 µM 2.77E-5 endomembrane recycling 53 5.18E-6
10 SGTC_2896 9052656 4.35 71.4 µM 3.45E-5 endomembrane recycling 87 6.71E-6
11 SGTC_1281 0884-0031 4.27 11.8 µM 4.67E-5 fatty acid desaturase (OLE1) 19 9.63E-6
12 SGTC_452 diindolylmethane 4.15 8.0 µM 7.54E-5 RNA processing & uracil transport 7 1.70E-5
13 SGTC_854 0422-0053 4.14 192.0 µM 7.70E-5 PDR1 14 1.74E-5
14 SGTC_1176 0848-0131 4.14 83.3 µM 7.81E-5 Golgi 19 1.77E-5
15 SGTC_729 4092-0585 4.11 94.1 µM 8.50E-5 22 1.96E-5
16 SGTC_2718 lomofungin 4.05 53.0 µM 1.08E-4 mitochondrial processes 7 2.59E-5
17 SGTC_1438 4092-1045 4.03 4.0 µM 1.13E-4 7 2.74E-5
18 SGTC_2041 5107442 3.98 45.3 µM 1.35E-4 RSC complex & mRNA processing 29 3.39E-5
19 SGTC_2426 5582046 3.94 32.2 µM 1.60E-4 31 4.15E-5
20 SGTC_952 1185-0122 3.92 232.0 µM 1.71E-4 21 4.47E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.086 5.72E-7 YDL073W_p YDL073W_p hom Putative protein of unknown function; YDL073W is not an essential gene
0.082 1.89E-6 YDR248C_p YDR248C_p hom Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1
0.077 7.12E-6 YIL112W HOS4 hom Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate
0.075 1.41E-5 YOL131W_p YOL131W_p hom Putative protein of unknown function
0.073 2.07E-5 YHR135C YCK1 hom Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication
0.073 2.39E-5 YDL167C NRP1 hom Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis
0.072 3.21E-5 YBR116C_d YBR116C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
0.070 5.25E-5 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.068 7.93E-5 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.067 9.58E-5 YCR001W_d YCR001W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene
0.065 1.49E-4 YMR043W MCM1 het Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes
0.065 1.62E-4 YBL012C_d YBL012C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.064 2.09E-4 YJL076W NET1 het Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication
0.064 2.34E-4 YHR066W SSF1 hom Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication
0.063 2.65E-4 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation