YEL043W

Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL043W / YEL043W

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:5.28|P-value:5.57E-8 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:6.06|P-value:5.88E-10 ID:SGTC_36|Compound:0335-0881|FD-Score:3.21|P-value:6.25E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.55|P-value:1.83E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:6.94|P-value:1.60E-12 ID:SGTC_86|Compound:0417-1630|FD-Score:3.73|P-value:8.96E-5 ID:SGTC_91|Compound:0417-1751|FD-Score:5.24|P-value:7.29E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:8.45|P-value:1.09E-17 ID:SGTC_137|Compound:0438-0332|FD-Score:5.20|P-value:9.00E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:4.28|P-value:8.71E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:6.03|P-value:6.82E-10 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.97|P-value:3.13E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.25|P-value:5.63E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.09|P-value:9.42E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.11|P-value:8.84E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.18|P-value:1.37E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:-3.16|P-value:7.60E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:5.08|P-value:1.70E-7 ID:SGTC_852|Compound:0418-0143|FD-Score:4.05|P-value:2.36E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:3.37|P-value:3.55E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.36|P-value:3.68E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.54|P-value:1.87E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.62|P-value:1.40E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.12|P-value:8.84E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:4.46|P-value:3.80E-6 ID:SGTC_1423|Compound:4048-0112|FD-Score:-3.22|P-value:6.36E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.22|P-value:6.01E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.09|P-value:9.76E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.08|P-value:9.96E-4 ID:SGTC_1723|Compound:st034307|FD-Score:6.21|P-value:2.26E-10 ID:SGTC_1754|Compound:st042065|FD-Score:-5.34|P-value:4.32E-8 ID:SGTC_1767|Compound:st044992|FD-Score:3.41|P-value:3.02E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.14|P-value:1.61E-5 ID:SGTC_1980|Compound:st071811|FD-Score:3.60|P-value:1.51E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.88|P-value:4.93E-5 ID:SGTC_1985|Compound:st071382|FD-Score:-3.54|P-value:1.95E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.27|P-value:5.05E-4 ID:SGTC_2000|Compound:st075254|FD-Score:4.31|P-value:7.51E-6 ID:SGTC_2204|Compound:7233102|FD-Score:-3.16|P-value:7.75E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.79|P-value:7.20E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.74|P-value:9.82E-7 ID:SGTC_2396|Compound:5342950|FD-Score:-3.27|P-value:5.21E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-3.69|P-value:1.08E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.20|P-value:1.20E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:5.46|P-value:2.11E-8 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.42|P-value:2.96E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.85|P-value:1.65E-15 ID:SGTC_2744|Compound:captopril|FD-Score:3.34|P-value:3.96E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.43|P-value:2.84E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.77|P-value:7.56E-5 ID:SGTC_2844|Compound:9010103|FD-Score:-3.15|P-value:8.07E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.30|P-value:4.53E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.34|P-value:4.06E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.22|P-value:6.06E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.06|P-value:2.22E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-5.33|P-value:4.52E-8 ID:SGTC_3222|Compound:9128301|FD-Score:4.67|P-value:1.35E-6 ID:SGTC_3283|Compound:9109332|FD-Score:3.55|P-value:1.80E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.46|P-value:2.53E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:5.28|P-value:5.57E-8 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:6.06|P-value:5.88E-10 ID:SGTC_36|Compound:0335-0881|FD-Score:3.21|P-value:6.25E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.55|P-value:1.83E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:6.94|P-value:1.60E-12 ID:SGTC_86|Compound:0417-1630|FD-Score:3.73|P-value:8.96E-5 ID:SGTC_91|Compound:0417-1751|FD-Score:5.24|P-value:7.29E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:8.45|P-value:1.09E-17 ID:SGTC_137|Compound:0438-0332|FD-Score:5.20|P-value:9.00E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:4.28|P-value:8.71E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:6.03|P-value:6.82E-10 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.97|P-value:3.13E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.25|P-value:5.63E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.09|P-value:9.42E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.11|P-value:8.84E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.18|P-value:1.37E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:-3.16|P-value:7.60E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:5.08|P-value:1.70E-7 ID:SGTC_852|Compound:0418-0143|FD-Score:4.05|P-value:2.36E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:3.37|P-value:3.55E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.36|P-value:3.68E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.54|P-value:1.87E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.62|P-value:1.40E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.12|P-value:8.84E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:4.46|P-value:3.80E-6 ID:SGTC_1423|Compound:4048-0112|FD-Score:-3.22|P-value:6.36E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.22|P-value:6.01E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.09|P-value:9.76E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.08|P-value:9.96E-4 ID:SGTC_1723|Compound:st034307|FD-Score:6.21|P-value:2.26E-10 ID:SGTC_1754|Compound:st042065|FD-Score:-5.34|P-value:4.32E-8 ID:SGTC_1767|Compound:st044992|FD-Score:3.41|P-value:3.02E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.14|P-value:1.61E-5 ID:SGTC_1980|Compound:st071811|FD-Score:3.60|P-value:1.51E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.88|P-value:4.93E-5 ID:SGTC_1985|Compound:st071382|FD-Score:-3.54|P-value:1.95E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.27|P-value:5.05E-4 ID:SGTC_2000|Compound:st075254|FD-Score:4.31|P-value:7.51E-6 ID:SGTC_2204|Compound:7233102|FD-Score:-3.16|P-value:7.75E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.79|P-value:7.20E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.74|P-value:9.82E-7 ID:SGTC_2396|Compound:5342950|FD-Score:-3.27|P-value:5.21E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-3.69|P-value:1.08E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.20|P-value:1.20E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:5.46|P-value:2.11E-8 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.42|P-value:2.96E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.85|P-value:1.65E-15 ID:SGTC_2744|Compound:captopril|FD-Score:3.34|P-value:3.96E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.43|P-value:2.84E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.77|P-value:7.56E-5 ID:SGTC_2844|Compound:9010103|FD-Score:-3.15|P-value:8.07E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.30|P-value:4.53E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.34|P-value:4.06E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.22|P-value:6.06E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.06|P-value:2.22E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-5.33|P-value:4.52E-8 ID:SGTC_3222|Compound:9128301|FD-Score:4.67|P-value:1.35E-6 ID:SGTC_3283|Compound:9109332|FD-Score:3.55|P-value:1.80E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.46|P-value:2.53E-4

Top fitness defect scores for YEL043W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 8.45 51.8 µM 1.09E-17 ERAD & cell cycle 45 1.45E-17
2 SGTC_2688 kanamycin b 7.85 96.7 µM 1.65E-15 calcium & mitochondrial duress 69 2.13E-15
3 SGTC_64 000l-0018 6.94 272.1 µM 1.60E-12 ubiquinone biosynthesis & proteasome 59 1.96E-12
4 SGTC_1723 st034307 6.21 2.5 µM 2.26E-10 mitochondrial processes 3 2.67E-10
5 SGTC_28 pentachloropyridine N-oxide 6.06 1.6 µM 5.88E-10 TSC3-RPN4 16 6.89E-10
6 SGTC_158 k038-0087 6.03 26.4 µM 6.82E-10 ubiquinone biosynthesis & proteasome 66 7.99E-10
7 SGTC_2645 abamectin 5.46 100.0 µM 2.11E-8 heme requiring 15 2.41E-8
8 SGTC_16 erodoxin 5.28 22.8 µM 5.57E-8 unfolded protein response 33 6.32E-8
9 SGTC_91 0417-1751 5.24 58.4 µM 7.29E-8 Golgi 20 8.25E-8
10 SGTC_137 0438-0332 5.20 85.4 µM 9.00E-8 ubiquinone biosynthesis & proteasome 73 1.02E-7
11 SGTC_676 falcarinol 5.08 140.0 µM 1.70E-7 27 1.91E-7
12 SGTC_3222 9128301 4.67 49.5 µM 1.35E-6 60S ribosome export 11 1.49E-6
13 SGTC_1414 3917-0015 4.46 5.4 µM 3.80E-6 6 4.18E-6
14 SGTC_2000 st075254 4.31 36.4 µM 7.51E-6 4 8.20E-6
15 SGTC_142 0335-0849 4.28 62.7 µM 8.71E-6 ubiquinone biosynthesis & proteasome 109 9.50E-6
16 SGTC_2620 irigenin 4.20 100.0 µM 1.20E-5 30 1.31E-5
17 SGTC_1926 methyl fluorone black 4.14 53.6 µM 1.61E-5 DNA intercalators 52 1.75E-5
18 SGTC_3200 9114385 4.06 49.5 µM 2.22E-5 31 2.40E-5
19 SGTC_852 0418-0143 4.05 439.0 µM 2.36E-5 calcium & mitochondrial duress 65 2.55E-5
20 SGTC_1982 st072467 3.88 71.9 µM 4.93E-5 39 5.31E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.347 1.72E-95 YGR089W NNF2 hom Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation
0.320 1.46E-80 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.300 6.09E-71 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.293 2.87E-67 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.286 2.77E-64 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.286 4.22E-64 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.277 3.75E-60 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.266 1.59E-55 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.258 3.38E-52 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.256 1.58E-51 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.253 3.50E-50 YPL144W POC4 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.253 4.96E-50 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.249 1.47E-48 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.249 1.91E-48 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.237 5.80E-44 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells