YEL045C_d

Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL045C / YEL045C

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:4.22|P-value:1.21E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-6.05|P-value:5.36E-8 ID:SGTC_195|Compound:4234-0266|FD-Score:3.83|P-value:4.31E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.46|P-value:4.30E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.65|P-value:3.41E-7 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.70|P-value:5.69E-4 ID:SGTC_389|Compound:tpck|FD-Score:4.92|P-value:9.25E-6 ID:SGTC_393|Compound:acivicin|FD-Score:-3.56|P-value:8.50E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-5.06|P-value:4.40E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.10|P-value:1.83E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:4.18|P-value:1.37E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.61|P-value:8.55E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-6.17|P-value:2.96E-8 ID:SGTC_795|Compound:0685-0265|FD-Score:4.72|P-value:1.99E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-6.26|P-value:1.95E-8 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.83|P-value:4.33E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:-4.98|P-value:5.91E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:-5.30|P-value:1.58E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.60|P-value:8.85E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.73|P-value:1.89E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.85|P-value:4.09E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.03|P-value:1.96E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.05|P-value:2.13E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.56|P-value:8.68E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.57|P-value:9.47E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.36|P-value:7.41E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.68|P-value:5.95E-4 ID:SGTC_1748|Compound:st037455|FD-Score:4.94|P-value:8.42E-6 ID:SGTC_1870|Compound:st057514|FD-Score:4.30|P-value:9.20E-5 ID:SGTC_1950|Compound:st077106|FD-Score:-5.91|P-value:1.02E-7 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-5.11|P-value:3.48E-6 ID:SGTC_1964|Compound:st076914|FD-Score:4.99|P-value:6.86E-6 ID:SGTC_1970|Compound:st070122|FD-Score:4.66|P-value:2.52E-5 ID:SGTC_1972|Compound:st070201|FD-Score:4.54|P-value:3.93E-5 ID:SGTC_2023|Compound:5144124|FD-Score:-3.80|P-value:4.09E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.17|P-value:1.44E-4 ID:SGTC_2139|Compound:5578692|FD-Score:-4.94|P-value:7.11E-6 ID:SGTC_2225|Compound:6654152|FD-Score:-3.93|P-value:2.73E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.56|P-value:8.68E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.29|P-value:9.33E-5 ID:SGTC_2351|Compound:9026858|FD-Score:-3.66|P-value:6.32E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.92|P-value:3.26E-4 ID:SGTC_2476|Compound:5806916|FD-Score:4.58|P-value:3.28E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:4.31|P-value:8.77E-5 ID:SGTC_2738|Compound:aclarubicin|FD-Score:6.19|P-value:3.46E-8 ID:SGTC_2743|Compound:auranofin|FD-Score:-5.83|P-value:1.53E-7 ID:SGTC_2781|Compound:5567276|FD-Score:5.29|P-value:2.02E-6 ID:SGTC_2789|Compound:5281112|FD-Score:4.87|P-value:1.09E-5 ID:SGTC_2934|Compound:9036370|FD-Score:8.62|P-value:2.65E-14 ID:SGTC_2937|Compound:9044753|FD-Score:-4.06|P-value:1.78E-4 ID:SGTC_3137|Compound:9097352|FD-Score:5.83|P-value:1.86E-7 ID:SGTC_3308|Compound:9128332|FD-Score:-3.56|P-value:8.45E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:4.22|P-value:1.21E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-6.05|P-value:5.36E-8 ID:SGTC_195|Compound:4234-0266|FD-Score:3.83|P-value:4.31E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.46|P-value:4.30E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.65|P-value:3.41E-7 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.70|P-value:5.69E-4 ID:SGTC_389|Compound:tpck|FD-Score:4.92|P-value:9.25E-6 ID:SGTC_393|Compound:acivicin|FD-Score:-3.56|P-value:8.50E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-5.06|P-value:4.40E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.10|P-value:1.83E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:4.18|P-value:1.37E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.61|P-value:8.55E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-6.17|P-value:2.96E-8 ID:SGTC_795|Compound:0685-0265|FD-Score:4.72|P-value:1.99E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-6.26|P-value:1.95E-8 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.83|P-value:4.33E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:-4.98|P-value:5.91E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:-5.30|P-value:1.58E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.60|P-value:8.85E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.73|P-value:1.89E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.85|P-value:4.09E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.03|P-value:1.96E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.05|P-value:2.13E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.56|P-value:8.68E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.57|P-value:9.47E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.36|P-value:7.41E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.68|P-value:5.95E-4 ID:SGTC_1748|Compound:st037455|FD-Score:4.94|P-value:8.42E-6 ID:SGTC_1870|Compound:st057514|FD-Score:4.30|P-value:9.20E-5 ID:SGTC_1950|Compound:st077106|FD-Score:-5.91|P-value:1.02E-7 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-5.11|P-value:3.48E-6 ID:SGTC_1964|Compound:st076914|FD-Score:4.99|P-value:6.86E-6 ID:SGTC_1970|Compound:st070122|FD-Score:4.66|P-value:2.52E-5 ID:SGTC_1972|Compound:st070201|FD-Score:4.54|P-value:3.93E-5 ID:SGTC_2023|Compound:5144124|FD-Score:-3.80|P-value:4.09E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.17|P-value:1.44E-4 ID:SGTC_2139|Compound:5578692|FD-Score:-4.94|P-value:7.11E-6 ID:SGTC_2225|Compound:6654152|FD-Score:-3.93|P-value:2.73E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.56|P-value:8.68E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.29|P-value:9.33E-5 ID:SGTC_2351|Compound:9026858|FD-Score:-3.66|P-value:6.32E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.92|P-value:3.26E-4 ID:SGTC_2476|Compound:5806916|FD-Score:4.58|P-value:3.28E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:4.31|P-value:8.77E-5 ID:SGTC_2738|Compound:aclarubicin|FD-Score:6.19|P-value:3.46E-8 ID:SGTC_2743|Compound:auranofin|FD-Score:-5.83|P-value:1.53E-7 ID:SGTC_2781|Compound:5567276|FD-Score:5.29|P-value:2.02E-6 ID:SGTC_2789|Compound:5281112|FD-Score:4.87|P-value:1.09E-5 ID:SGTC_2934|Compound:9036370|FD-Score:8.62|P-value:2.65E-14 ID:SGTC_2937|Compound:9044753|FD-Score:-4.06|P-value:1.78E-4 ID:SGTC_3137|Compound:9097352|FD-Score:5.83|P-value:1.86E-7 ID:SGTC_3308|Compound:9128332|FD-Score:-3.56|P-value:8.45E-4

Top fitness defect scores for YEL045C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2934 9036370 8.62 36.9 µM 2.65E-14 2 3.29E-18
2 SGTC_2738 aclarubicin 6.19 5.5 µM 3.46E-8 RNA pol III & RNase P/MRP 2 3.08E-10
3 SGTC_3137 9097352 5.83 49.5 µM 1.86E-7 7 2.75E-9
4 SGTC_2781 5567276 5.29 71.4 µM 2.02E-6 19 6.09E-8
5 SGTC_1964 st076914 4.99 61.0 µM 6.86E-6 RPP1 & pyrimidine depletion 5 2.99E-7
6 SGTC_1748 st037455 4.94 53.6 µM 8.42E-6 11 3.89E-7
7 SGTC_389 tpck 4.92 16.7 µM 9.25E-6 17 4.40E-7
8 SGTC_2789 5281112 4.87 71.4 µM 1.09E-5 14 5.47E-7
9 SGTC_1359 1582-0056 4.73 520.0 nM 1.89E-5 8 1.11E-6
10 SGTC_795 0685-0265 4.72 78.0 µM 1.99E-5 excess fatty acid 12 1.19E-6
11 SGTC_1970 st070122 4.66 35.8 µM 2.52E-5 TSC3-RPN4 15 1.62E-6
12 SGTC_2476 5806916 4.58 10.5 µM 3.28E-5 6 2.28E-6
13 SGTC_1972 st070201 4.54 17.4 µM 3.93E-5 18 2.87E-6
14 SGTC_1633 st005664 4.36 67.9 µM 7.41E-5 20 6.53E-6
15 SGTC_2736 butenafine 4.31 14.7 µM 8.77E-5 21 8.13E-6
16 SGTC_1870 st057514 4.30 26.5 µM 9.20E-5 RSC & ERG11 18 8.65E-6
17 SGTC_2320 7373003 4.29 200.0 µM 9.33E-5 21 8.80E-6
18 SGTC_41 0478-0632 4.22 82.6 µM 1.21E-4 24 1.23E-5
19 SGTC_492 tmb-8 4.18 126.0 µM 1.37E-4 5 1.45E-5
20 SGTC_2126 5251174 4.17 33.9 µM 1.44E-4 24 1.55E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.22E-21 YEL046C GLY1 hom Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis
0.079 4.18E-6 YKR019C IRS4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.077 7.18E-6 YDR132C YDR132C hom Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication
0.076 1.18E-5 YPL113C_p YPL113C_p hom Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
0.075 1.31E-5 YEL008W_d YEL008W_d hom Hypothetical protein predicted to be involved in metabolism
0.074 1.65E-5 YBL071W-A KTI11 hom Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs
0.074 1.76E-5 YHR060W VMA22 hom Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
0.073 2.46E-5 YNL051W COG5 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.072 3.06E-5 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.071 3.95E-5 YNL194C YNL194C hom Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate
0.071 4.09E-5 YDR028C REG1 hom Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p
0.070 4.43E-5 YPR181C SEC23 het GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p
0.070 5.05E-5 YJL029C VPS53 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
0.070 5.46E-5 YMR216C SKY1 hom SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
0.068 7.81E-5 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain