YEL046C / GLY1

Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL046C / GLY1

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:-4.03|P-value:2.11E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.84|P-value:4.58E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-10.30|P-value:1.90E-19 ID:SGTC_231|Compound:b-estradiol|FD-Score:4.96|P-value:9.19E-6 ID:SGTC_290|Compound:2043-6722|FD-Score:4.17|P-value:1.61E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.29|P-value:1.87E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-8.54|P-value:4.75E-14 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.60|P-value:8.03E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:4.60|P-value:3.55E-5 ID:SGTC_459|Compound:nigericin|FD-Score:3.65|P-value:8.33E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.84|P-value:4.58E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-4.30|P-value:8.28E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.79|P-value:4.59E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:4.22|P-value:1.33E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.87|P-value:4.20E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:6.93|P-value:9.70E-10 ID:SGTC_853|Compound:0419-0306|FD-Score:3.64|P-value:8.46E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:8.41|P-value:1.62E-13 ID:SGTC_912|Compound:3474-0017|FD-Score:3.84|P-value:4.66E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.90|P-value:3.23E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.66|P-value:7.93E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-3.85|P-value:3.74E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:4.71|P-value:2.39E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:3.85|P-value:4.54E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:7.31|P-value:1.23E-10 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.90|P-value:3.82E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:-4.21|P-value:1.13E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.31|P-value:9.89E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.76|P-value:5.88E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.59|P-value:8.42E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.68|P-value:6.36E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.34|P-value:7.37E-5 ID:SGTC_1724|Compound:st037281|FD-Score:3.99|P-value:2.84E-4 ID:SGTC_1736|Compound:st036774|FD-Score:-3.66|P-value:6.74E-4 ID:SGTC_1814|Compound:st052110|FD-Score:-5.48|P-value:8.53E-7 ID:SGTC_1853|Compound:st056710|FD-Score:-5.74|P-value:2.67E-7 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.61|P-value:7.79E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-4.01|P-value:2.27E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.82|P-value:4.98E-4 ID:SGTC_2177|Compound:5811945|FD-Score:-5.47|P-value:8.92E-7 ID:SGTC_2179|Compound:6298986|FD-Score:-5.52|P-value:7.00E-7 ID:SGTC_2277|Compound:7947813|FD-Score:-4.60|P-value:2.91E-5 ID:SGTC_2304|Compound:7443016|FD-Score:7.85|P-value:5.35E-12 ID:SGTC_2307|Compound:7538926|FD-Score:-4.51|P-value:3.93E-5 ID:SGTC_2427|Compound:5545055|FD-Score:3.68|P-value:7.57E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.88|P-value:1.23E-5 ID:SGTC_2452|Compound:5863136|FD-Score:3.59|P-value:9.81E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.74|P-value:5.32E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.65|P-value:8.31E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:-3.68|P-value:6.34E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:5.05|P-value:6.27E-6 ID:SGTC_2710|Compound:st078562|FD-Score:4.07|P-value:2.24E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.70|P-value:7.03E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.33|P-value:9.27E-5 ID:SGTC_2880|Compound:9042983|FD-Score:-4.72|P-value:1.86E-5 ID:SGTC_2889|Compound:9059656|FD-Score:4.36|P-value:8.45E-5 ID:SGTC_2895|Compound:9054447|FD-Score:4.86|P-value:1.36E-5 ID:SGTC_2920|Compound:7982904|FD-Score:4.10|P-value:2.03E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.23|P-value:1.07E-4 ID:SGTC_3318|Compound:9139014|FD-Score:4.97|P-value:8.74E-6 ID:SGTC_3325|Compound:9138760|FD-Score:4.05|P-value:2.40E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-4.03|P-value:2.11E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.84|P-value:4.58E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-10.30|P-value:1.90E-19 ID:SGTC_231|Compound:b-estradiol|FD-Score:4.96|P-value:9.19E-6 ID:SGTC_290|Compound:2043-6722|FD-Score:4.17|P-value:1.61E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.29|P-value:1.87E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-8.54|P-value:4.75E-14 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.60|P-value:8.03E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:4.60|P-value:3.55E-5 ID:SGTC_459|Compound:nigericin|FD-Score:3.65|P-value:8.33E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.84|P-value:4.58E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-4.30|P-value:8.28E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.79|P-value:4.59E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:4.22|P-value:1.33E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.87|P-value:4.20E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:6.93|P-value:9.70E-10 ID:SGTC_853|Compound:0419-0306|FD-Score:3.64|P-value:8.46E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:8.41|P-value:1.62E-13 ID:SGTC_912|Compound:3474-0017|FD-Score:3.84|P-value:4.66E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.90|P-value:3.23E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.66|P-value:7.93E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-3.85|P-value:3.74E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:4.71|P-value:2.39E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:3.85|P-value:4.54E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:7.31|P-value:1.23E-10 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.90|P-value:3.82E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:-4.21|P-value:1.13E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.31|P-value:9.89E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.76|P-value:5.88E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.59|P-value:8.42E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.68|P-value:6.36E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.34|P-value:7.37E-5 ID:SGTC_1724|Compound:st037281|FD-Score:3.99|P-value:2.84E-4 ID:SGTC_1736|Compound:st036774|FD-Score:-3.66|P-value:6.74E-4 ID:SGTC_1814|Compound:st052110|FD-Score:-5.48|P-value:8.53E-7 ID:SGTC_1853|Compound:st056710|FD-Score:-5.74|P-value:2.67E-7 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.61|P-value:7.79E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-4.01|P-value:2.27E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.82|P-value:4.98E-4 ID:SGTC_2177|Compound:5811945|FD-Score:-5.47|P-value:8.92E-7 ID:SGTC_2179|Compound:6298986|FD-Score:-5.52|P-value:7.00E-7 ID:SGTC_2277|Compound:7947813|FD-Score:-4.60|P-value:2.91E-5 ID:SGTC_2304|Compound:7443016|FD-Score:7.85|P-value:5.35E-12 ID:SGTC_2307|Compound:7538926|FD-Score:-4.51|P-value:3.93E-5 ID:SGTC_2427|Compound:5545055|FD-Score:3.68|P-value:7.57E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.88|P-value:1.23E-5 ID:SGTC_2452|Compound:5863136|FD-Score:3.59|P-value:9.81E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.74|P-value:5.32E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.65|P-value:8.31E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:-3.68|P-value:6.34E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:5.05|P-value:6.27E-6 ID:SGTC_2710|Compound:st078562|FD-Score:4.07|P-value:2.24E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.70|P-value:7.03E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.33|P-value:9.27E-5 ID:SGTC_2880|Compound:9042983|FD-Score:-4.72|P-value:1.86E-5 ID:SGTC_2889|Compound:9059656|FD-Score:4.36|P-value:8.45E-5 ID:SGTC_2895|Compound:9054447|FD-Score:4.86|P-value:1.36E-5 ID:SGTC_2920|Compound:7982904|FD-Score:4.10|P-value:2.03E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.23|P-value:1.07E-4 ID:SGTC_3318|Compound:9139014|FD-Score:4.97|P-value:8.74E-6 ID:SGTC_3325|Compound:9138760|FD-Score:4.05|P-value:2.40E-4

Top fitness defect scores for YEL046C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_858 0438-0351 8.41 2.8 µM 1.62E-13 copper-dependent oxidative stress 2 2.08E-17
2 SGTC_2304 7443016 7.85 91.4 µM 5.35E-12 4 2.11E-15
3 SGTC_1087 pterostilbene 7.31 9.1 µM 1.23E-10 2 1.34E-13
4 SGTC_852 0418-0143 6.93 439.0 µM 9.70E-10 calcium & mitochondrial duress 16 2.03E-12
5 SGTC_2687 chenodiol 5.05 100.0 µM 6.27E-6 7 2.16E-7
6 SGTC_3318 9139014 4.97 38.6 µM 8.74E-6 7 3.35E-7
7 SGTC_231 b-estradiol 4.96 524.0 µM 9.19E-6 1 3.58E-7
8 SGTC_2430 5571206 4.88 200.0 µM 1.23E-5 34 5.24E-7
9 SGTC_2895 9054447 4.86 58.4 µM 1.36E-5 1 6.00E-7
10 SGTC_1073 triclabendazole 4.71 3.1 µM 2.39E-5 15 1.26E-6
11 SGTC_368 fentichlor 4.60 4.6 µM 3.55E-5 17 2.12E-6
12 SGTC_2889 9059656 4.36 52.0 µM 8.45E-5 5 6.62E-6
13 SGTC_2816 7982706 4.33 58.4 µM 9.27E-5 azole & statin 42 7.48E-6
14 SGTC_1153 4055-0057 4.31 267.0 µM 9.89E-5 17 8.15E-6
15 SGTC_696 1560-0013 4.22 611.0 µM 1.33E-4 17 1.20E-5
16 SGTC_290 2043-6722 4.17 48.1 µM 1.61E-4 6 1.55E-5
17 SGTC_2920 7982904 4.10 15.8 µM 2.03E-4 20 2.10E-5
18 SGTC_2710 st078562 4.07 53.7 µM 2.24E-4 14 2.38E-5
19 SGTC_3325 9138760 4.05 55.2 µM 2.40E-4 Golgi 23 2.60E-5
20 SGTC_1724 st037281 3.99 8.3 µM 2.84E-4 44 3.26E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.22E-21 YEL045C_d YEL045C_d hom Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress
0.103 2.26E-9 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.099 9.79E-9 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.096 2.33E-8 YFL001W DEG1 hom tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability
0.095 3.59E-8 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.085 8.00E-7 YNL274C GOR1 hom Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.084 1.28E-6 YGL084C GUP1 hom Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport
0.083 1.49E-6 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.082 1.78E-6 YNL139C THO2 hom Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids
0.082 1.97E-6 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.080 3.14E-6 YDR363W-A SEM1 hom Component of lid subcomplex of the 26S proteasome regulatory subunit; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; protein abundance increases in response to DNA replication stress
0.080 3.55E-6 YGL188C-A_p YGL188C-A_p hom Putative protein of unknown function
0.080 3.96E-6 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.079 4.25E-6 YDR161W_p YDR161W_p hom Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
0.078 5.92E-6 YJL029C VPS53 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting