YEL048C / TCA17

Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL048C / TCA17

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:5.47|P-value:6.71E-9 ID:SGTC_201|Compound:4262-0159|FD-Score:3.42|P-value:1.82E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.46|P-value:1.55E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:2.96|P-value:9.88E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.46|P-value:2.21E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:5.06|P-value:7.40E-8 ID:SGTC_320|Compound:4092-0846|FD-Score:4.85|P-value:2.33E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:3.14|P-value:5.23E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.90|P-value:1.74E-7 ID:SGTC_513|Compound:4245-1575|FD-Score:3.45|P-value:1.60E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.53|P-value:1.16E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.54|P-value:1.13E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.32|P-value:2.62E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.61|P-value:1.22E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:4.24|P-value:5.19E-6 ID:SGTC_961|Compound:1252-1571|FD-Score:3.70|P-value:5.73E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.87|P-value:2.76E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.05|P-value:7.29E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.20|P-value:5.74E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-4.72|P-value:7.51E-7 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.23|P-value:3.71E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.53|P-value:1.18E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.71|P-value:7.95E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:3.13|P-value:5.35E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.32|P-value:2.68E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.06|P-value:9.62E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.23|P-value:5.39E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.95|P-value:1.31E-7 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.15|P-value:6.91E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.65|P-value:7.09E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.02|P-value:7.91E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.08|P-value:6.38E-8 ID:SGTC_1800|Compound:st050079|FD-Score:3.31|P-value:2.71E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.88|P-value:1.99E-7 ID:SGTC_1803|Compound:st050068|FD-Score:4.84|P-value:2.41E-7 ID:SGTC_1805|Compound:st050013|FD-Score:3.98|P-value:1.73E-5 ID:SGTC_1818|Compound:st052136|FD-Score:5.29|P-value:1.92E-8 ID:SGTC_2006|Compound:4011487|FD-Score:5.50|P-value:5.58E-9 ID:SGTC_2071|Compound:5230951|FD-Score:-3.62|P-value:1.17E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.33|P-value:2.53E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.44|P-value:2.39E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.00|P-value:2.28E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.75|P-value:6.75E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-6.14|P-value:1.76E-10 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.39|P-value:2.04E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-4.62|P-value:1.23E-6 ID:SGTC_2678|Compound:equilin|FD-Score:3.27|P-value:3.21E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.38|P-value:2.09E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.11|P-value:7.94E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.01|P-value:8.32E-4 ID:SGTC_2896|Compound:9052656|FD-Score:8.54|P-value:4.54E-19 ID:SGTC_2957|Compound:9076800|FD-Score:-3.43|P-value:2.43E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-3.88|P-value:3.86E-5 ID:SGTC_3037|Compound:9091026|FD-Score:5.24|P-value:2.60E-8 ID:SGTC_3137|Compound:9097352|FD-Score:7.24|P-value:3.13E-14 ID:SGTC_3138|Compound:9097216|FD-Score:3.18|P-value:4.41E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.50|P-value:1.41E-6 ID:SGTC_3162|Compound:9099653|FD-Score:3.04|P-value:7.45E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-3.17|P-value:6.53E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:5.47|P-value:6.71E-9 ID:SGTC_201|Compound:4262-0159|FD-Score:3.42|P-value:1.82E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.46|P-value:1.55E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:2.96|P-value:9.88E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.46|P-value:2.21E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:5.06|P-value:7.40E-8 ID:SGTC_320|Compound:4092-0846|FD-Score:4.85|P-value:2.33E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:3.14|P-value:5.23E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.90|P-value:1.74E-7 ID:SGTC_513|Compound:4245-1575|FD-Score:3.45|P-value:1.60E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.53|P-value:1.16E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.54|P-value:1.13E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.32|P-value:2.62E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.61|P-value:1.22E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:4.24|P-value:5.19E-6 ID:SGTC_961|Compound:1252-1571|FD-Score:3.70|P-value:5.73E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.87|P-value:2.76E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.05|P-value:7.29E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.20|P-value:5.74E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-4.72|P-value:7.51E-7 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.23|P-value:3.71E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.53|P-value:1.18E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.71|P-value:7.95E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:3.13|P-value:5.35E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.32|P-value:2.68E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.06|P-value:9.62E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.23|P-value:5.39E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.95|P-value:1.31E-7 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.15|P-value:6.91E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.65|P-value:7.09E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.02|P-value:7.91E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.08|P-value:6.38E-8 ID:SGTC_1800|Compound:st050079|FD-Score:3.31|P-value:2.71E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.88|P-value:1.99E-7 ID:SGTC_1803|Compound:st050068|FD-Score:4.84|P-value:2.41E-7 ID:SGTC_1805|Compound:st050013|FD-Score:3.98|P-value:1.73E-5 ID:SGTC_1818|Compound:st052136|FD-Score:5.29|P-value:1.92E-8 ID:SGTC_2006|Compound:4011487|FD-Score:5.50|P-value:5.58E-9 ID:SGTC_2071|Compound:5230951|FD-Score:-3.62|P-value:1.17E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.33|P-value:2.53E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.44|P-value:2.39E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.00|P-value:2.28E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.75|P-value:6.75E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-6.14|P-value:1.76E-10 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.39|P-value:2.04E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-4.62|P-value:1.23E-6 ID:SGTC_2678|Compound:equilin|FD-Score:3.27|P-value:3.21E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.38|P-value:2.09E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.11|P-value:7.94E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.01|P-value:8.32E-4 ID:SGTC_2896|Compound:9052656|FD-Score:8.54|P-value:4.54E-19 ID:SGTC_2957|Compound:9076800|FD-Score:-3.43|P-value:2.43E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-3.88|P-value:3.86E-5 ID:SGTC_3037|Compound:9091026|FD-Score:5.24|P-value:2.60E-8 ID:SGTC_3137|Compound:9097352|FD-Score:7.24|P-value:3.13E-14 ID:SGTC_3138|Compound:9097216|FD-Score:3.18|P-value:4.41E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.50|P-value:1.41E-6 ID:SGTC_3162|Compound:9099653|FD-Score:3.04|P-value:7.45E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-3.17|P-value:6.53E-4

Top fitness defect scores for YEL048C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2896 9052656 8.54 71.4 µM 4.54E-19 endomembrane recycling 13 6.51E-18
2 SGTC_3137 9097352 7.24 49.5 µM 3.13E-14 1 2.25E-13
3 SGTC_2006 4011487 5.50 200.0 µM 5.58E-9 endomembrane recycling 51 1.89E-8
4 SGTC_15 0266-0086 5.47 27.1 µM 6.71E-9 endomembrane recycling 26 2.24E-8
5 SGTC_1818 st052136 5.29 56.3 µM 1.92E-8 NEO1-PIK1 20 6.00E-8
6 SGTC_3037 9091026 5.24 49.5 µM 2.60E-8 NEO1-PIK1 63 7.98E-8
7 SGTC_1754 st042065 5.08 16.1 µM 6.38E-8 NEO1-PIK1 122 1.85E-7
8 SGTC_312 4092-0653 5.06 6.8 µM 7.40E-8 ergosterol depletion effects on membrane 56 2.12E-7
9 SGTC_1230 0170-0365 4.95 3.8 µM 1.31E-7 endomembrane recycling 39 3.63E-7
10 SGTC_449 xestospongin c 4.90 11.2 µM 1.74E-7 NEO1-PIK1 32 4.74E-7
11 SGTC_1801 st050089 4.88 28.4 µM 1.99E-7 NEO1-PIK1 79 5.36E-7
12 SGTC_320 4092-0846 4.85 5.3 µM 2.33E-7 ergosterol depletion effects on membrane 28 6.21E-7
13 SGTC_1803 st050068 4.84 52.4 µM 2.41E-7 NEO1-PIK1 121 6.43E-7
14 SGTC_3152 9099253 4.50 49.5 µM 1.41E-6 NEO1-PIK1 104 3.35E-6
15 SGTC_937 3122-0005 4.24 46.7 µM 5.19E-6 21 1.14E-5
16 SGTC_1130 3454-2858 4.23 15.9 µM 5.39E-6 NEO1 74 1.18E-5
17 SGTC_1805 st050013 3.98 60.3 µM 1.73E-5 6 3.50E-5
18 SGTC_967 1306-0166 3.87 352.0 µM 2.76E-5 37 5.42E-5
19 SGTC_961 1252-1571 3.70 372.0 µM 5.73E-5 37 1.08E-4
20 SGTC_1510 1123-0200 3.65 71.5 µM 7.09E-5 55 1.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.423 1.28E-145 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.388 9.54E-121 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.383 6.21E-118 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.381 5.38E-116 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.313 7.01E-77 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.303 4.32E-72 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.299 2.45E-70 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.283 5.89E-63 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.276 1.73E-59 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.274 1.14E-58 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.272 5.93E-58 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.260 3.89E-53 YGL199C_d YGL199C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
0.250 5.72E-49 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.246 1.55E-47 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.246 1.97E-47 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases