YEL050C / RML2

Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL050C / RML2

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:5.43|P-value:3.00E-6 ID:SGTC_10|Compound:0279-0212|FD-Score:5.53|P-value:1.95E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:4.34|P-value:1.46E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.62|P-value:1.36E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:5.16|P-value:8.47E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:8.35|P-value:1.59E-12 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.32|P-value:1.58E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:6.78|P-value:7.49E-9 ID:SGTC_173|Compound:1273-0061|FD-Score:17.20|P-value:2.69E-47 ID:SGTC_236|Compound:1509-0011|FD-Score:10.70|P-value:1.68E-19 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.97|P-value:4.50E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.08|P-value:7.75E-12 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.06|P-value:3.36E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:7.79|P-value:4.00E-11 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.35|P-value:3.76E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:9.35|P-value:3.05E-15 ID:SGTC_314|Compound:1671-0008|FD-Score:3.90|P-value:5.67E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-5.15|P-value:8.35E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.01|P-value:4.00E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-4.71|P-value:4.04E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.95|P-value:5.00E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.70|P-value:6.05E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-5.11|P-value:9.73E-6 ID:SGTC_502|Compound:l-744,832|FD-Score:8.36|P-value:1.54E-12 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.71|P-value:9.85E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.76|P-value:8.47E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.31|P-value:1.64E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:4.72|P-value:4.07E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:6.29|P-value:7.73E-8 ID:SGTC_609|Compound:0986-0026|FD-Score:5.76|P-value:7.65E-7 ID:SGTC_612|Compound:0302-0167|FD-Score:-3.76|P-value:8.22E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:7.09|P-value:1.65E-9 ID:SGTC_735|Compound:3076-0345|FD-Score:6.77|P-value:7.94E-9 ID:SGTC_748|Compound:0136-0228|FD-Score:5.62|P-value:1.37E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:3.78|P-value:8.03E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:-5.29|P-value:4.84E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:7.64|P-value:9.06E-11 ID:SGTC_832|Compound:4083-0019|FD-Score:9.35|P-value:3.08E-15 ID:SGTC_908|Compound:3448-7491|FD-Score:5.33|P-value:4.35E-6 ID:SGTC_1015|Compound:4130-4525|FD-Score:-4.45|P-value:9.71E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:6.22|P-value:1.04E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:-5.69|P-value:9.67E-7 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.42|P-value:1.13E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.04|P-value:3.78E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.91|P-value:1.99E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.82|P-value:7.33E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.48|P-value:9.39E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.87|P-value:6.31E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.91|P-value:2.13E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.82|P-value:7.19E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:6.97|P-value:3.05E-9 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.85|P-value:6.67E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.06|P-value:1.21E-5 ID:SGTC_1622|Compound:st003707|FD-Score:4.78|P-value:3.34E-5 ID:SGTC_1623|Compound:st003709|FD-Score:5.31|P-value:4.63E-6 ID:SGTC_1624|Compound:st003710|FD-Score:4.10|P-value:3.10E-4 ID:SGTC_1656|Compound:st012921|FD-Score:-3.81|P-value:7.09E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-4.95|P-value:1.71E-5 ID:SGTC_1707|Compound:st032323|FD-Score:-4.01|P-value:3.93E-4 ID:SGTC_1722|Compound:st034304|FD-Score:4.21|P-value:2.21E-4 ID:SGTC_1742|Compound:st038235|FD-Score:7.65|P-value:8.62E-11 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.58|P-value:1.55E-6 ID:SGTC_1812|Compound:st052057|FD-Score:3.86|P-value:6.45E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.27|P-value:1.76E-4 ID:SGTC_1881|Compound:5652484|FD-Score:4.26|P-value:1.89E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.48|P-value:9.43E-5 ID:SGTC_1884|Compound:5633444|FD-Score:-3.78|P-value:7.86E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.88|P-value:6.06E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.87|P-value:6.09E-4 ID:SGTC_2183|Compound:6420625|FD-Score:6.00|P-value:2.76E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.96|P-value:4.74E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.03|P-value:1.37E-5 ID:SGTC_2329|Compound:6138490|FD-Score:-6.66|P-value:1.28E-8 ID:SGTC_2331|Compound:7980721|FD-Score:-8.18|P-value:4.06E-12 ID:SGTC_2338|Compound:7999974|FD-Score:3.88|P-value:6.13E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.81|P-value:3.05E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.97|P-value:1.71E-5 ID:SGTC_2441|Compound:5730946|FD-Score:3.74|P-value:9.09E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-5.34|P-value:3.93E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:3.78|P-value:8.12E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.78|P-value:3.17E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:14.20|P-value:1.53E-32 ID:SGTC_2691|Compound:st077356|FD-Score:6.02|P-value:2.53E-7 ID:SGTC_2858|Compound:9025781|FD-Score:-7.03|P-value:2.07E-9 ID:SGTC_2896|Compound:9052656|FD-Score:-7.07|P-value:1.72E-9 ID:SGTC_2918|Compound:7977171|FD-Score:-4.06|P-value:3.43E-4 ID:SGTC_2996|Compound:9066192|FD-Score:5.38|P-value:3.61E-6 ID:SGTC_3018|Compound:9082602|FD-Score:3.88|P-value:6.16E-4 ID:SGTC_3037|Compound:9091026|FD-Score:8.50|P-value:6.68E-13 ID:SGTC_3152|Compound:9099253|FD-Score:5.78|P-value:6.95E-7 ID:SGTC_3197|Compound:9113331|FD-Score:-3.89|P-value:5.66E-4 ID:SGTC_3225|Compound:9130819|FD-Score:4.18|P-value:2.42E-4 ID:SGTC_3247|Compound:9135149|FD-Score:-3.92|P-value:5.13E-4 ID:SGTC_5|Compound:0352-0601|FD-Score:5.43|P-value:3.00E-6 ID:SGTC_10|Compound:0279-0212|FD-Score:5.53|P-value:1.95E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:4.34|P-value:1.46E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.62|P-value:1.36E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:5.16|P-value:8.47E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:8.35|P-value:1.59E-12 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.32|P-value:1.58E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:6.78|P-value:7.49E-9 ID:SGTC_173|Compound:1273-0061|FD-Score:17.20|P-value:2.69E-47 ID:SGTC_236|Compound:1509-0011|FD-Score:10.70|P-value:1.68E-19 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.97|P-value:4.50E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.08|P-value:7.75E-12 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.06|P-value:3.36E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:7.79|P-value:4.00E-11 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.35|P-value:3.76E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:9.35|P-value:3.05E-15 ID:SGTC_314|Compound:1671-0008|FD-Score:3.90|P-value:5.67E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-5.15|P-value:8.35E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.01|P-value:4.00E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-4.71|P-value:4.04E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.95|P-value:5.00E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.70|P-value:6.05E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-5.11|P-value:9.73E-6 ID:SGTC_502|Compound:l-744,832|FD-Score:8.36|P-value:1.54E-12 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.71|P-value:9.85E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.76|P-value:8.47E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.31|P-value:1.64E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:4.72|P-value:4.07E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:6.29|P-value:7.73E-8 ID:SGTC_609|Compound:0986-0026|FD-Score:5.76|P-value:7.65E-7 ID:SGTC_612|Compound:0302-0167|FD-Score:-3.76|P-value:8.22E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:7.09|P-value:1.65E-9 ID:SGTC_735|Compound:3076-0345|FD-Score:6.77|P-value:7.94E-9 ID:SGTC_748|Compound:0136-0228|FD-Score:5.62|P-value:1.37E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:3.78|P-value:8.03E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:-5.29|P-value:4.84E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:7.64|P-value:9.06E-11 ID:SGTC_832|Compound:4083-0019|FD-Score:9.35|P-value:3.08E-15 ID:SGTC_908|Compound:3448-7491|FD-Score:5.33|P-value:4.35E-6 ID:SGTC_1015|Compound:4130-4525|FD-Score:-4.45|P-value:9.71E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:6.22|P-value:1.04E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:-5.69|P-value:9.67E-7 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.42|P-value:1.13E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.04|P-value:3.78E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.91|P-value:1.99E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.82|P-value:7.33E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.48|P-value:9.39E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.87|P-value:6.31E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.91|P-value:2.13E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.82|P-value:7.19E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:6.97|P-value:3.05E-9 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.85|P-value:6.67E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.06|P-value:1.21E-5 ID:SGTC_1622|Compound:st003707|FD-Score:4.78|P-value:3.34E-5 ID:SGTC_1623|Compound:st003709|FD-Score:5.31|P-value:4.63E-6 ID:SGTC_1624|Compound:st003710|FD-Score:4.10|P-value:3.10E-4 ID:SGTC_1656|Compound:st012921|FD-Score:-3.81|P-value:7.09E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-4.95|P-value:1.71E-5 ID:SGTC_1707|Compound:st032323|FD-Score:-4.01|P-value:3.93E-4 ID:SGTC_1722|Compound:st034304|FD-Score:4.21|P-value:2.21E-4 ID:SGTC_1742|Compound:st038235|FD-Score:7.65|P-value:8.62E-11 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.58|P-value:1.55E-6 ID:SGTC_1812|Compound:st052057|FD-Score:3.86|P-value:6.45E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.27|P-value:1.76E-4 ID:SGTC_1881|Compound:5652484|FD-Score:4.26|P-value:1.89E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.48|P-value:9.43E-5 ID:SGTC_1884|Compound:5633444|FD-Score:-3.78|P-value:7.86E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.88|P-value:6.06E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.87|P-value:6.09E-4 ID:SGTC_2183|Compound:6420625|FD-Score:6.00|P-value:2.76E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.96|P-value:4.74E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.03|P-value:1.37E-5 ID:SGTC_2329|Compound:6138490|FD-Score:-6.66|P-value:1.28E-8 ID:SGTC_2331|Compound:7980721|FD-Score:-8.18|P-value:4.06E-12 ID:SGTC_2338|Compound:7999974|FD-Score:3.88|P-value:6.13E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.81|P-value:3.05E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.97|P-value:1.71E-5 ID:SGTC_2441|Compound:5730946|FD-Score:3.74|P-value:9.09E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-5.34|P-value:3.93E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:3.78|P-value:8.12E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.78|P-value:3.17E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:14.20|P-value:1.53E-32 ID:SGTC_2691|Compound:st077356|FD-Score:6.02|P-value:2.53E-7 ID:SGTC_2858|Compound:9025781|FD-Score:-7.03|P-value:2.07E-9 ID:SGTC_2896|Compound:9052656|FD-Score:-7.07|P-value:1.72E-9 ID:SGTC_2918|Compound:7977171|FD-Score:-4.06|P-value:3.43E-4 ID:SGTC_2996|Compound:9066192|FD-Score:5.38|P-value:3.61E-6 ID:SGTC_3018|Compound:9082602|FD-Score:3.88|P-value:6.16E-4 ID:SGTC_3037|Compound:9091026|FD-Score:8.50|P-value:6.68E-13 ID:SGTC_3152|Compound:9099253|FD-Score:5.78|P-value:6.95E-7 ID:SGTC_3197|Compound:9113331|FD-Score:-3.89|P-value:5.66E-4 ID:SGTC_3225|Compound:9130819|FD-Score:4.18|P-value:2.42E-4 ID:SGTC_3247|Compound:9135149|FD-Score:-3.92|P-value:5.13E-4

Top fitness defect scores for YEL050C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 17.20 2.7 µM 2.69E-47 mitochondrial stress 3 6.40E-67
2 SGTC_2688 kanamycin b 14.20 96.7 µM 1.53E-32 calcium & mitochondrial duress 7 8.42E-46
3 SGTC_236 1509-0011 10.70 5.3 µM 1.68E-19 180 3.73E-27
4 SGTC_310 1273-0058 9.35 1.1 µM 3.05E-15 mitochondrial stress 55 4.53E-21
5 SGTC_832 4083-0019 9.35 164.0 µM 3.08E-15 translation 3 4.59E-21
6 SGTC_3037 9091026 8.50 49.5 µM 6.68E-13 NEO1-PIK1 12 9.88E-18
7 SGTC_502 l-744,832 8.36 89.3 µM 1.54E-12 calcium & mitochondrial duress 6 3.25E-17
8 SGTC_63 0099-0242 8.35 26.7 µM 1.59E-12 mitochondrial stress 6 3.41E-17
9 SGTC_275 trichlorophene 8.08 5.7 µM 7.75E-12 mitochondrial stress 74 3.26E-16
10 SGTC_298 1391-0729 7.79 10.0 µM 4.00E-11 calcium & mitochondrial duress 3 3.38E-15
11 SGTC_1742 st038235 7.65 28.9 µM 8.62E-11 mitochondrial stress 22 1.01E-14
12 SGTC_831 k061-1017 7.64 217.0 µM 9.06E-11 translation 1 1.08E-14
13 SGTC_614 0462-0418 7.09 107.0 µM 1.65E-9 4 6.74E-13
14 SGTC_1445 4239-0156 6.97 97.7 µM 3.05E-9 2 1.62E-12
15 SGTC_134 0269-0018 6.78 6.9 µM 7.49E-9 70 5.82E-12
16 SGTC_735 3076-0345 6.77 636.0 µM 7.94E-9 1 6.32E-12
17 SGTC_601 0986-0029 6.29 62.9 µM 7.73E-8 calcium & mitochondrial duress 7 1.61E-10
18 SGTC_1017 4239-0030 6.22 168.0 µM 1.04E-7 4 2.46E-10
19 SGTC_2691 st077356 6.02 60.2 µM 2.53E-7 8 8.65E-10
20 SGTC_2183 6420625 6.00 130.5 µM 2.76E-7 mitochondrial processes 13 9.77E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.465 5.84E-180 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.442 1.79E-160 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.440 2.79E-159 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.439 2.19E-158 YMR282C AEP2 hom Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.436 1.06E-155 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.434 4.16E-154 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.433 1.75E-153 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.422 1.96E-145 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.422 1.07E-144 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.422 3.76E-144 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.415 3.56E-140 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.415 8.66E-140 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.410 4.87E-136 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.408 3.38E-135 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.408 1.50E-134 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency