YEL052W / AFG1

Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL052W / AFG1

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:-4.49|P-value:7.73E-7 ID:SGTC_63|Compound:0099-0242|FD-Score:3.31|P-value:2.07E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.25|P-value:2.57E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.04|P-value:5.84E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:4.66|P-value:3.27E-7 ID:SGTC_472|Compound:calcifediol|FD-Score:-3.11|P-value:4.33E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-4.30|P-value:2.15E-6 ID:SGTC_480|Compound:am 92016|FD-Score:-3.50|P-value:9.07E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:3.16|P-value:3.77E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.23|P-value:2.77E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.92|P-value:1.44E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.38|P-value:1.52E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.88|P-value:1.69E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.31|P-value:2.12E-6 ID:SGTC_1261|Compound:0712-0010|FD-Score:-3.11|P-value:4.44E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.33|P-value:1.90E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-3.54|P-value:7.70E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.91|P-value:1.49E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.64|P-value:5.04E-5 ID:SGTC_1518|Compound:st038567|FD-Score:-3.68|P-value:4.15E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-3.99|P-value:1.02E-5 ID:SGTC_1703|Compound:st026983|FD-Score:3.16|P-value:3.73E-4 ID:SGTC_1971|Compound:st069429|FD-Score:2.96|P-value:7.97E-4 ID:SGTC_1972|Compound:st070201|FD-Score:4.47|P-value:9.25E-7 ID:SGTC_2061|Compound:5245884|FD-Score:3.44|P-value:1.20E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.12|P-value:5.43E-6 ID:SGTC_2165|Compound:5727197|FD-Score:-4.94|P-value:6.55E-8 ID:SGTC_2210|Compound:7115885|FD-Score:2.98|P-value:7.21E-4 ID:SGTC_2264|Compound:7948757|FD-Score:2.94|P-value:8.45E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.12|P-value:4.39E-4 ID:SGTC_2326|Compound:6164455|FD-Score:4.53|P-value:6.47E-7 ID:SGTC_2331|Compound:7980721|FD-Score:-3.50|P-value:9.28E-5 ID:SGTC_2354|Compound:9060492|FD-Score:-3.68|P-value:4.08E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.54|P-value:7.56E-5 ID:SGTC_2394|Compound:5221648|FD-Score:-3.58|P-value:6.42E-5 ID:SGTC_2395|Compound:5646831|FD-Score:-4.11|P-value:5.56E-6 ID:SGTC_2456|Compound:5770359|FD-Score:-3.27|P-value:2.35E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.24|P-value:3.01E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.81|P-value:2.37E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.25|P-value:2.53E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.22|P-value:2.86E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.08|P-value:4.97E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-4.34|P-value:1.76E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.15|P-value:3.81E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:2.97|P-value:7.66E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.79|P-value:2.59E-5 ID:SGTC_2804|Compound:7954240|FD-Score:3.84|P-value:2.03E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.19|P-value:3.33E-4 ID:SGTC_2965|Compound:9082772|FD-Score:4.21|P-value:3.41E-6 ID:SGTC_3052|Compound:9092717|FD-Score:3.18|P-value:3.47E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.48|P-value:1.01E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:-4.49|P-value:7.73E-7 ID:SGTC_63|Compound:0099-0242|FD-Score:3.31|P-value:2.07E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.25|P-value:2.57E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.04|P-value:5.84E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:4.66|P-value:3.27E-7 ID:SGTC_472|Compound:calcifediol|FD-Score:-3.11|P-value:4.33E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-4.30|P-value:2.15E-6 ID:SGTC_480|Compound:am 92016|FD-Score:-3.50|P-value:9.07E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:3.16|P-value:3.77E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.23|P-value:2.77E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.92|P-value:1.44E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.38|P-value:1.52E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.88|P-value:1.69E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.31|P-value:2.12E-6 ID:SGTC_1261|Compound:0712-0010|FD-Score:-3.11|P-value:4.44E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.33|P-value:1.90E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-3.54|P-value:7.70E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.91|P-value:1.49E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.64|P-value:5.04E-5 ID:SGTC_1518|Compound:st038567|FD-Score:-3.68|P-value:4.15E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-3.99|P-value:1.02E-5 ID:SGTC_1703|Compound:st026983|FD-Score:3.16|P-value:3.73E-4 ID:SGTC_1971|Compound:st069429|FD-Score:2.96|P-value:7.97E-4 ID:SGTC_1972|Compound:st070201|FD-Score:4.47|P-value:9.25E-7 ID:SGTC_2061|Compound:5245884|FD-Score:3.44|P-value:1.20E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.12|P-value:5.43E-6 ID:SGTC_2165|Compound:5727197|FD-Score:-4.94|P-value:6.55E-8 ID:SGTC_2210|Compound:7115885|FD-Score:2.98|P-value:7.21E-4 ID:SGTC_2264|Compound:7948757|FD-Score:2.94|P-value:8.45E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.12|P-value:4.39E-4 ID:SGTC_2326|Compound:6164455|FD-Score:4.53|P-value:6.47E-7 ID:SGTC_2331|Compound:7980721|FD-Score:-3.50|P-value:9.28E-5 ID:SGTC_2354|Compound:9060492|FD-Score:-3.68|P-value:4.08E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.54|P-value:7.56E-5 ID:SGTC_2394|Compound:5221648|FD-Score:-3.58|P-value:6.42E-5 ID:SGTC_2395|Compound:5646831|FD-Score:-4.11|P-value:5.56E-6 ID:SGTC_2456|Compound:5770359|FD-Score:-3.27|P-value:2.35E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.24|P-value:3.01E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.81|P-value:2.37E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.25|P-value:2.53E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.22|P-value:2.86E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.08|P-value:4.97E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-4.34|P-value:1.76E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.15|P-value:3.81E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:2.97|P-value:7.66E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.79|P-value:2.59E-5 ID:SGTC_2804|Compound:7954240|FD-Score:3.84|P-value:2.03E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.19|P-value:3.33E-4 ID:SGTC_2965|Compound:9082772|FD-Score:4.21|P-value:3.41E-6 ID:SGTC_3052|Compound:9092717|FD-Score:3.18|P-value:3.47E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.48|P-value:1.01E-4

Top fitness defect scores for YEL052W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_334 1502-1024 4.66 68.5 µM 3.27E-7 3 1.59E-6
2 SGTC_2326 6164455 4.53 177.6 µM 6.47E-7 mitochondrial processes 13 2.91E-6
3 SGTC_1972 st070201 4.47 17.4 µM 9.25E-7 19 3.98E-6
4 SGTC_1198 1612-1005 4.31 86.7 µM 2.12E-6 4 8.27E-6
5 SGTC_2531 methyl deoxycholate 4.24 70.1 µM 3.01E-6 18 1.13E-5
6 SGTC_2965 9082772 4.21 38.6 µM 3.41E-6 mitochondrial response to ROS 32 1.26E-5
7 SGTC_1083 didemethylchlorpromazine sulfoxide 3.92 707.4 nM 1.44E-5 redox potentiating 84 4.47E-5
8 SGTC_1384 3089-0840 3.91 101.0 µM 1.49E-5 17 4.61E-5
9 SGTC_1125 tnp00248 3.88 1.3 µM 1.69E-5 28 5.15E-5
10 SGTC_2804 7954240 3.84 19.5 µM 2.03E-5 34 6.05E-5
11 SGTC_2702 st077768 3.79 96.8 µM 2.59E-5 18 7.52E-5
12 SGTC_2061 5245884 3.44 81.0 µM 1.20E-4 tubulin folding & SWR complex 38 2.90E-4
13 SGTC_1121 fusaric acid 3.38 630.5 nM 1.52E-4 59 3.58E-4
14 SGTC_1266 0828-0227 3.33 32.9 µM 1.90E-4 43 4.36E-4
15 SGTC_63 0099-0242 3.31 26.7 µM 2.07E-4 mitochondrial stress 127 4.72E-4
16 SGTC_87 0100-0052 3.25 35.5 µM 2.57E-4 180 5.71E-4
17 SGTC_2848 9016370 3.19 26.0 µM 3.33E-4 61 7.17E-4
18 SGTC_3052 9092717 3.18 49.5 µM 3.47E-4 72 7.43E-4
19 SGTC_1703 st026983 3.16 48.3 µM 3.73E-4 38 7.93E-4
20 SGTC_825 1988-2224 3.16 89.6 µM 3.77E-4 cell wall signaling 68 7.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 3.58E-15 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.124 5.28E-13 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.107 5.73E-10 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
0.106 7.08E-10 YJL064W_d YJL064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1
0.103 2.37E-9 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.103 2.43E-9 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.102 3.45E-9 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.097 1.82E-8 YOR040W GLO4 hom Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
0.092 8.32E-8 YOR314W_d YOR314W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.090 2.05E-7 YBR218C PYC2 hom Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication
0.089 2.35E-7 YKL005C BYE1 hom Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit
0.087 4.53E-7 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.085 7.44E-7 YER152C YER152C hom Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene
0.084 1.19E-6 YFL051C_p YFL051C_p hom Putative protein of unknown function; YFL051C is not an essential gene
0.083 1.49E-6 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins