YEL053C / MAK10

Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL053C / MAK10

Click on Significant Values for Screen Details ID:SGTC_91|Compound:0417-1751|FD-Score:3.33|P-value:2.83E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:9.68|P-value:4.27E-24 ID:SGTC_124|Compound:0136-0217|FD-Score:5.53|P-value:4.84E-9 ID:SGTC_188|Compound:3229-0966|FD-Score:5.56|P-value:4.03E-9 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.82|P-value:3.35E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.24|P-value:3.58E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:4.15|P-value:8.50E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.03|P-value:7.87E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.41|P-value:1.25E-11 ID:SGTC_455|Compound:paf C-16|FD-Score:-4.08|P-value:1.03E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:7.60|P-value:1.51E-15 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.34|P-value:2.48E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.57|P-value:9.74E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:-3.37|P-value:2.16E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.37|P-value:2.20E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.20|P-value:4.58E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.18|P-value:4.89E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.11|P-value:9.96E-6 ID:SGTC_814|Compound:3342-0569|FD-Score:3.35|P-value:2.61E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.55|P-value:1.16E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.79|P-value:4.22E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.55|P-value:1.18E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.29|P-value:3.25E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.16|P-value:4.93E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.40|P-value:2.15E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.06|P-value:7.53E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.18|P-value:4.95E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.90|P-value:2.43E-5 ID:SGTC_1567|Compound:st069303|FD-Score:3.07|P-value:7.26E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.47|P-value:1.64E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.83|P-value:3.58E-5 ID:SGTC_1687|Compound:st020778|FD-Score:4.03|P-value:1.49E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.44|P-value:1.67E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.23|P-value:5.27E-6 ID:SGTC_1760|Compound:st045453|FD-Score:3.65|P-value:7.72E-5 ID:SGTC_1767|Compound:st044992|FD-Score:3.52|P-value:1.31E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.57|P-value:1.08E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.25|P-value:3.51E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.30|P-value:3.13E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.17|P-value:4.73E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.89|P-value:2.50E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.10|P-value:6.21E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.65|P-value:7.81E-5 ID:SGTC_2242|Compound:6630449|FD-Score:3.53|P-value:1.27E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.67|P-value:5.56E-7 ID:SGTC_2311|Compound:7694451|FD-Score:3.22|P-value:4.31E-4 ID:SGTC_2314|Compound:7727897|FD-Score:4.37|P-value:2.86E-6 ID:SGTC_2363|Compound:9053361|FD-Score:3.76|P-value:4.75E-5 ID:SGTC_2387|Compound:9077560|FD-Score:3.60|P-value:9.51E-5 ID:SGTC_2389|Compound:9091542|FD-Score:3.40|P-value:2.12E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.79|P-value:4.26E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.04|P-value:7.71E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-4.45|P-value:1.77E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.74|P-value:4.75E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.12|P-value:6.17E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.76|P-value:4.45E-5 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:5.10|P-value:5.93E-8 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.87|P-value:2.98E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.80|P-value:3.13E-7 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.01|P-value:8.33E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.22|P-value:4.19E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.66|P-value:6.91E-5 ID:SGTC_2860|Compound:9025725|FD-Score:-3.25|P-value:3.52E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.15|P-value:5.17E-4 ID:SGTC_2914|Compound:7968218|FD-Score:3.53|P-value:1.24E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.21|P-value:4.47E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.10|P-value:6.18E-4 ID:SGTC_2954|Compound:9074818|FD-Score:4.49|P-value:1.63E-6 ID:SGTC_2989|Compound:9073649|FD-Score:4.06|P-value:1.29E-5 ID:SGTC_2994|Compound:9053520|FD-Score:3.65|P-value:7.72E-5 ID:SGTC_3106|Compound:9121286|FD-Score:-2.99|P-value:9.18E-4 ID:SGTC_3118|Compound:9124250|FD-Score:4.15|P-value:8.47E-6 ID:SGTC_3131|Compound:9127911|FD-Score:3.39|P-value:2.20E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.16|P-value:4.98E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-4.07|P-value:1.10E-5 ID:SGTC_3308|Compound:9128332|FD-Score:4.51|P-value:1.45E-6 ID:SGTC_91|Compound:0417-1751|FD-Score:3.33|P-value:2.83E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:9.68|P-value:4.27E-24 ID:SGTC_124|Compound:0136-0217|FD-Score:5.53|P-value:4.84E-9 ID:SGTC_188|Compound:3229-0966|FD-Score:5.56|P-value:4.03E-9 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.82|P-value:3.35E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.24|P-value:3.58E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:4.15|P-value:8.50E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.03|P-value:7.87E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.41|P-value:1.25E-11 ID:SGTC_455|Compound:paf C-16|FD-Score:-4.08|P-value:1.03E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:7.60|P-value:1.51E-15 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.34|P-value:2.48E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.57|P-value:9.74E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:-3.37|P-value:2.16E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.37|P-value:2.20E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.20|P-value:4.58E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.18|P-value:4.89E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.11|P-value:9.96E-6 ID:SGTC_814|Compound:3342-0569|FD-Score:3.35|P-value:2.61E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.55|P-value:1.16E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.79|P-value:4.22E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.55|P-value:1.18E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.29|P-value:3.25E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.16|P-value:4.93E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.40|P-value:2.15E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.06|P-value:7.53E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.18|P-value:4.95E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.90|P-value:2.43E-5 ID:SGTC_1567|Compound:st069303|FD-Score:3.07|P-value:7.26E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.47|P-value:1.64E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.83|P-value:3.58E-5 ID:SGTC_1687|Compound:st020778|FD-Score:4.03|P-value:1.49E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.44|P-value:1.67E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.23|P-value:5.27E-6 ID:SGTC_1760|Compound:st045453|FD-Score:3.65|P-value:7.72E-5 ID:SGTC_1767|Compound:st044992|FD-Score:3.52|P-value:1.31E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.57|P-value:1.08E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.25|P-value:3.51E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.30|P-value:3.13E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.17|P-value:4.73E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.89|P-value:2.50E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.10|P-value:6.21E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.65|P-value:7.81E-5 ID:SGTC_2242|Compound:6630449|FD-Score:3.53|P-value:1.27E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.67|P-value:5.56E-7 ID:SGTC_2311|Compound:7694451|FD-Score:3.22|P-value:4.31E-4 ID:SGTC_2314|Compound:7727897|FD-Score:4.37|P-value:2.86E-6 ID:SGTC_2363|Compound:9053361|FD-Score:3.76|P-value:4.75E-5 ID:SGTC_2387|Compound:9077560|FD-Score:3.60|P-value:9.51E-5 ID:SGTC_2389|Compound:9091542|FD-Score:3.40|P-value:2.12E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.79|P-value:4.26E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.04|P-value:7.71E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-4.45|P-value:1.77E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.74|P-value:4.75E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.12|P-value:6.17E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.76|P-value:4.45E-5 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:5.10|P-value:5.93E-8 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.87|P-value:2.98E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.80|P-value:3.13E-7 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.01|P-value:8.33E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.22|P-value:4.19E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.66|P-value:6.91E-5 ID:SGTC_2860|Compound:9025725|FD-Score:-3.25|P-value:3.52E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.15|P-value:5.17E-4 ID:SGTC_2914|Compound:7968218|FD-Score:3.53|P-value:1.24E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.21|P-value:4.47E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.10|P-value:6.18E-4 ID:SGTC_2954|Compound:9074818|FD-Score:4.49|P-value:1.63E-6 ID:SGTC_2989|Compound:9073649|FD-Score:4.06|P-value:1.29E-5 ID:SGTC_2994|Compound:9053520|FD-Score:3.65|P-value:7.72E-5 ID:SGTC_3106|Compound:9121286|FD-Score:-2.99|P-value:9.18E-4 ID:SGTC_3118|Compound:9124250|FD-Score:4.15|P-value:8.47E-6 ID:SGTC_3131|Compound:9127911|FD-Score:3.39|P-value:2.20E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.16|P-value:4.98E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-4.07|P-value:1.10E-5 ID:SGTC_3308|Compound:9128332|FD-Score:4.51|P-value:1.45E-6

Top fitness defect scores for YEL053C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_98 0074-0023 9.68 107.7 µM 4.27E-24 Golgi 3 1.77E-22
2 SGTC_528 3492-0019 7.60 172.0 µM 1.51E-15 calcium & mitochondrial duress 85 1.49E-14
3 SGTC_188 3229-0966 5.56 278.5 µM 4.03E-9 13 1.37E-8
4 SGTC_124 0136-0217 5.53 7.1 µM 4.84E-9 mitochondrial stress 27 1.63E-8
5 SGTC_2642 cholecalciferol 5.10 100.0 µM 5.93E-8 14 1.67E-7
6 SGTC_2737 bleomycin 4.80 30.5 nM 3.13E-7 Golgi 63 7.82E-7
7 SGTC_3308 9128332 4.51 17.6 µM 1.45E-6 plasma membrane duress 60 3.25E-6
8 SGTC_2954 9074818 4.49 52.7 µM 1.63E-6 25 3.63E-6
9 SGTC_2314 7727897 4.37 200.0 µM 2.86E-6 12 6.12E-6
10 SGTC_3118 9124250 4.15 49.5 µM 8.47E-6 11 1.68E-5
11 SGTC_337 1315-0038 4.15 354.0 µM 8.50E-6 amide catabolism 25 1.68E-5
12 SGTC_748 0136-0228 4.11 77.9 µM 9.96E-6 redox potentiating 73 1.95E-5
13 SGTC_2989 9073649 4.06 71.4 µM 1.29E-5 34 2.48E-5
14 SGTC_1687 st020778 4.03 55.4 µM 1.49E-5 171 2.83E-5
15 SGTC_2651 1327-0036 3.87 5.0 µM 2.98E-5 164 5.42E-5
16 SGTC_1679 4130-1276 3.83 6.7 µM 3.58E-5 Golgi 69 6.42E-5
17 SGTC_878 0828-0289 3.79 13.7 µM 4.22E-5 53 7.49E-5
18 SGTC_2474 5321570 3.79 43.3 µM 4.26E-5 17 7.54E-5
19 SGTC_2363 9053361 3.76 176.0 µM 4.75E-5 Golgi 35 8.36E-5
20 SGTC_2994 9053520 3.65 71.4 µM 7.72E-5 RPP1 & pyrimidine depletion 34 1.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.266 1.56E-55 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.234 4.64E-43 YPL051W ARL3 hom GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
0.206 1.71E-33 YPR050C_d YPR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W
0.200 1.74E-31 YBR164C ARL1 hom Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
0.182 2.78E-26 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.180 9.11E-26 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.173 6.34E-24 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.167 1.64E-22 YOR068C VAM10 hom Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering
0.167 2.22E-22 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.159 2.46E-20 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.158 3.25E-20 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.152 9.27E-19 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.148 7.27E-18 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.145 2.93E-17 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.143 6.56E-17 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress