YEL055C / POL5

DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YEL055C / POL5

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:3.05|P-value:2.69E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:2.79|P-value:7.61E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.07|P-value:2.46E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-4.10|P-value:1.54E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:-2.91|P-value:4.67E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:-2.80|P-value:7.20E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.89|P-value:4.98E-6 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.23|P-value:1.25E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.48|P-value:3.87E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-2.80|P-value:7.19E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:-3.22|P-value:1.26E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.08|P-value:2.37E-4 ID:SGTC_1713|Compound:st033146|FD-Score:5.21|P-value:1.68E-9 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.23|P-value:8.00E-7 ID:SGTC_1884|Compound:5633444|FD-Score:3.38|P-value:6.27E-5 ID:SGTC_2033|Compound:5192550|FD-Score:-3.84|P-value:6.27E-6 ID:SGTC_2046|Compound:4110841|FD-Score:4.22|P-value:8.42E-7 ID:SGTC_2076|Compound:5212012|FD-Score:3.41|P-value:5.40E-5 ID:SGTC_2078|Compound:5212016|FD-Score:6.10|P-value:2.11E-12 ID:SGTC_2159|Compound:5658611|FD-Score:-3.37|P-value:6.26E-5 ID:SGTC_2182|Compound:6325192|FD-Score:2.87|P-value:5.67E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-4.08|P-value:1.77E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.72|P-value:9.99E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.16|P-value:1.67E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.59|P-value:2.20E-5 ID:SGTC_2413|Compound:inermin|FD-Score:5.96|P-value:6.41E-12 ID:SGTC_2417|Compound:cerulenin|FD-Score:-4.29|P-value:5.29E-7 ID:SGTC_2483|Compound:5729050|FD-Score:2.91|P-value:4.76E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:2.77|P-value:8.23E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-2.72|P-value:9.96E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-2.74|P-value:9.28E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.64|P-value:1.83E-5 ID:SGTC_2947|Compound:9072639|FD-Score:7.92|P-value:1.18E-19 ID:SGTC_3043|Compound:9092303|FD-Score:3.11|P-value:2.04E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-3.14|P-value:1.78E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.33|P-value:7.79E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.22|P-value:1.28E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-3.34|P-value:7.40E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.13|P-value:1.94E-4 ID:SGTC_3193|Compound:9111931|FD-Score:4.95|P-value:9.83E-9 ID:SGTC_3316|Compound:9136639|FD-Score:3.56|P-value:2.61E-5 ID:SGTC_3327|Compound:9140648|FD-Score:3.67|P-value:1.59E-5 ID:SGTC_3333|Compound:9141820|FD-Score:3.53|P-value:3.10E-5 ID:SGTC_12|Compound:0849-0099|FD-Score:3.05|P-value:2.69E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:2.79|P-value:7.61E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.07|P-value:2.46E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-4.10|P-value:1.54E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:-2.91|P-value:4.67E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:-2.80|P-value:7.20E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.89|P-value:4.98E-6 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.23|P-value:1.25E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.48|P-value:3.87E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-2.80|P-value:7.19E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:-3.22|P-value:1.26E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.08|P-value:2.37E-4 ID:SGTC_1713|Compound:st033146|FD-Score:5.21|P-value:1.68E-9 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.23|P-value:8.00E-7 ID:SGTC_1884|Compound:5633444|FD-Score:3.38|P-value:6.27E-5 ID:SGTC_2033|Compound:5192550|FD-Score:-3.84|P-value:6.27E-6 ID:SGTC_2046|Compound:4110841|FD-Score:4.22|P-value:8.42E-7 ID:SGTC_2076|Compound:5212012|FD-Score:3.41|P-value:5.40E-5 ID:SGTC_2078|Compound:5212016|FD-Score:6.10|P-value:2.11E-12 ID:SGTC_2159|Compound:5658611|FD-Score:-3.37|P-value:6.26E-5 ID:SGTC_2182|Compound:6325192|FD-Score:2.87|P-value:5.67E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-4.08|P-value:1.77E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.72|P-value:9.99E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.16|P-value:1.67E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.59|P-value:2.20E-5 ID:SGTC_2413|Compound:inermin|FD-Score:5.96|P-value:6.41E-12 ID:SGTC_2417|Compound:cerulenin|FD-Score:-4.29|P-value:5.29E-7 ID:SGTC_2483|Compound:5729050|FD-Score:2.91|P-value:4.76E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:2.77|P-value:8.23E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-2.72|P-value:9.96E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-2.74|P-value:9.28E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.64|P-value:1.83E-5 ID:SGTC_2947|Compound:9072639|FD-Score:7.92|P-value:1.18E-19 ID:SGTC_3043|Compound:9092303|FD-Score:3.11|P-value:2.04E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-3.14|P-value:1.78E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.33|P-value:7.79E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.22|P-value:1.28E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-3.34|P-value:7.40E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.13|P-value:1.94E-4 ID:SGTC_3193|Compound:9111931|FD-Score:4.95|P-value:9.83E-9 ID:SGTC_3316|Compound:9136639|FD-Score:3.56|P-value:2.61E-5 ID:SGTC_3327|Compound:9140648|FD-Score:3.67|P-value:1.59E-5 ID:SGTC_3333|Compound:9141820|FD-Score:3.53|P-value:3.10E-5

Top fitness defect scores for YEL055C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2947 9072639 7.92 7.7 µM 1.18E-19 tubulin folding & SWR complex 1 1.17E-15 1.24
2 SGTC_2078 5212016 6.10 200.0 µM 2.11E-12 60S ribosome export 3 5.19E-10 0.73
3 SGTC_2413 inermin 5.96 26.1 µM 6.41E-12 9 1.24E-9 0.97
4 SGTC_1713 st033146 5.21 12.8 µM 1.68E-9 3 9.51E-8 0.37
5 SGTC_3193 9111931 4.95 49.5 µM 9.83E-9 3 3.79E-7 0.35
6 SGTC_1788 fluconazole 4.23 20.0 µM 8.00E-7 azole & statin 6 1.18E-5 0.07
7 SGTC_2046 4110841 4.22 106.0 µM 8.42E-7 iron homeostasis 7 1.23E-5 0.02
8 SGTC_3327 9140648 3.67 26.9 µM 1.59E-5 18 1.23E-4 0.01
9 SGTC_2943 9068529 3.64 45.3 µM 1.83E-5 13 1.38E-4 0.14
10 SGTC_3316 9136639 3.56 10.6 µM 2.61E-5 8 1.83E-4 0.20
11 SGTC_3333 9141820 3.53 12.1 µM 3.10E-5 9 2.09E-4 0.06
12 SGTC_1235 benzylparaben 3.48 21.5 µM 3.87E-5 3 2.49E-4 0.00
13 SGTC_2076 5212012 3.41 200.0 µM 5.40E-5 4 3.23E-4 0.37
14 SGTC_1884 5633444 3.38 25.0 µM 6.27E-5 redox potentiating 23 3.64E-4 0.03
15 SGTC_3140 9094243 3.33 49.5 µM 7.79E-5 11 4.31E-4 0.19
16 SGTC_1233 0325-0408 3.23 14.2 µM 1.25E-4 12 6.28E-4 0.11
17 SGTC_3154 9100113 3.22 49.5 µM 1.28E-4 19 6.37E-4 0.05
18 SGTC_3192 9110362 3.13 49.5 µM 1.94E-4 mitochondrial processes 14 8.84E-4 7.10E-4
19 SGTC_3043 9092303 3.11 49.5 µM 2.04E-4 11 9.20E-4 0.04
20 SGTC_1590 st077108 3.08 57.8 µM 2.37E-4 14 0.00104 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 7.47E-32 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.140 3.75E-16 YJL142C_d IRC9_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci
0.118 6.16E-12 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.115 2.34E-11 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.110 1.92E-10 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.108 2.96E-10 YJL116C NCA3 hom Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication
0.105 1.01E-9 YPR138C MEP3 hom Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease
0.104 1.77E-9 YGL113W SLD3 het Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress
0.104 1.82E-9 YOR076C SKI7 hom Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype
0.102 3.61E-9 YPL140C MKK2 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication
0.098 1.49E-8 YDL112W TRM3 hom 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
0.097 2.10E-8 YOR242C SSP2 hom Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis
0.094 4.38E-8 YPL092W SSU1 hom Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
0.094 5.35E-8 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.092 8.04E-8 YPL192C PRM3 hom Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body