YEL057C_p

Protein of unknown function involved in telomere maintenance; target of UME6 regulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL057C / YEL057C

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-4.44|P-value:3.51E-7 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-2.97|P-value:4.66E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:-2.94|P-value:5.21E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.86|P-value:7.60E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:6.19|P-value:2.07E-12 ID:SGTC_533|Compound:1222-0222|FD-Score:2.97|P-value:4.25E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.32|P-value:6.39E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:3.02|P-value:3.51E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.01|P-value:3.69E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.02|P-value:3.53E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:2.99|P-value:3.99E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.14|P-value:2.16E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:2.94|P-value:4.84E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-2.98|P-value:4.46E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.96|P-value:4.68E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.17|P-value:1.90E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.12|P-value:2.32E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.66|P-value:2.01E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.74|P-value:1.40E-5 ID:SGTC_1931|Compound:st074438|FD-Score:-3.11|P-value:2.59E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-2.93|P-value:5.29E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-3.12|P-value:2.51E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.92|P-value:5.52E-4 ID:SGTC_2483|Compound:5729050|FD-Score:2.89|P-value:5.90E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.20|P-value:1.76E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.87|P-value:7.63E-6 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.33|P-value:1.01E-4 ID:SGTC_2787|Compound:5284540|FD-Score:2.81|P-value:8.06E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-2.83|P-value:7.83E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.39|P-value:7.27E-5 ID:SGTC_2892|Compound:9047358|FD-Score:-3.73|P-value:1.59E-5 ID:SGTC_2897|Compound:9048598|FD-Score:-2.79|P-value:9.40E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.35|P-value:8.73E-5 ID:SGTC_2952|Compound:9073731|FD-Score:4.86|P-value:2.54E-8 ID:SGTC_3033|Compound:9090887|FD-Score:3.61|P-value:2.58E-5 ID:SGTC_3036|Compound:9090181|FD-Score:3.63|P-value:2.37E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-3.94|P-value:5.34E-6 ID:SGTC_3039|Compound:9090270|FD-Score:-3.83|P-value:9.60E-6 ID:SGTC_3042|Compound:9091578|FD-Score:4.38|P-value:4.63E-7 ID:SGTC_3075|Compound:9116269|FD-Score:6.17|P-value:2.39E-12 ID:SGTC_3087|Compound:9117406|FD-Score:-2.91|P-value:5.70E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-2.88|P-value:6.44E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.12|P-value:2.27E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.83|P-value:8.88E-6 ID:SGTC_3329|Compound:9141233|FD-Score:2.90|P-value:5.73E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.01|P-value:3.60E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.44|P-value:3.51E-7 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-2.97|P-value:4.66E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:-2.94|P-value:5.21E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.86|P-value:7.60E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:6.19|P-value:2.07E-12 ID:SGTC_533|Compound:1222-0222|FD-Score:2.97|P-value:4.25E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.32|P-value:6.39E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:3.02|P-value:3.51E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.01|P-value:3.69E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.02|P-value:3.53E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:2.99|P-value:3.99E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.14|P-value:2.16E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:2.94|P-value:4.84E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-2.98|P-value:4.46E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.96|P-value:4.68E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.17|P-value:1.90E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.12|P-value:2.32E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.66|P-value:2.01E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.74|P-value:1.40E-5 ID:SGTC_1931|Compound:st074438|FD-Score:-3.11|P-value:2.59E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-2.93|P-value:5.29E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-3.12|P-value:2.51E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.92|P-value:5.52E-4 ID:SGTC_2483|Compound:5729050|FD-Score:2.89|P-value:5.90E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.20|P-value:1.76E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.87|P-value:7.63E-6 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.33|P-value:1.01E-4 ID:SGTC_2787|Compound:5284540|FD-Score:2.81|P-value:8.06E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-2.83|P-value:7.83E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.39|P-value:7.27E-5 ID:SGTC_2892|Compound:9047358|FD-Score:-3.73|P-value:1.59E-5 ID:SGTC_2897|Compound:9048598|FD-Score:-2.79|P-value:9.40E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.35|P-value:8.73E-5 ID:SGTC_2952|Compound:9073731|FD-Score:4.86|P-value:2.54E-8 ID:SGTC_3033|Compound:9090887|FD-Score:3.61|P-value:2.58E-5 ID:SGTC_3036|Compound:9090181|FD-Score:3.63|P-value:2.37E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-3.94|P-value:5.34E-6 ID:SGTC_3039|Compound:9090270|FD-Score:-3.83|P-value:9.60E-6 ID:SGTC_3042|Compound:9091578|FD-Score:4.38|P-value:4.63E-7 ID:SGTC_3075|Compound:9116269|FD-Score:6.17|P-value:2.39E-12 ID:SGTC_3087|Compound:9117406|FD-Score:-2.91|P-value:5.70E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-2.88|P-value:6.44E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.12|P-value:2.27E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.83|P-value:8.88E-6 ID:SGTC_3329|Compound:9141233|FD-Score:2.90|P-value:5.73E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.01|P-value:3.60E-4

Top fitness defect scores for YEL057C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_435 c-PAF 6.19 6.7 µM 2.07E-12 6 3.09E-10
2 SGTC_3075 9116269 6.17 49.5 µM 2.39E-12 4 3.47E-10
3 SGTC_2952 9073731 4.86 13.8 µM 2.54E-8 tubulin folding & SWR complex 17 5.87E-7
4 SGTC_3042 9091578 4.38 49.5 µM 4.63E-7 ERG2 1 6.05E-6
5 SGTC_534 k292-0788 4.32 63.4 µM 6.39E-7 mitochondrial processes 24 7.83E-6
6 SGTC_427 1354-0053 3.86 47.3 µM 7.60E-6 24 5.74E-5
7 SGTC_3212 9128307 3.83 49.5 µM 8.88E-6 48 6.51E-5
8 SGTC_1860 st056228 3.74 74.6 µM 1.40E-5 30 9.37E-5
9 SGTC_1735 st034310 3.66 56.8 µM 2.01E-5 Golgi 39 1.26E-4
10 SGTC_3036 9090181 3.63 49.5 µM 2.37E-5 8 1.44E-4
11 SGTC_3033 9090887 3.61 49.5 µM 2.58E-5 fatty acid desaturase (OLE1) 39 1.54E-4
12 SGTC_2884 9058502 3.39 52.0 µM 7.27E-5 45 3.55E-4
13 SGTC_2913 7966556 3.35 36.6 µM 8.73E-5 60S ribosome export 28 4.11E-4
14 SGTC_1483 3453-0561 3.17 55.9 µM 1.90E-4 48 7.71E-4
15 SGTC_979 1426-2828 3.14 121.0 µM 2.16E-4 58 8.56E-4
16 SGTC_3193 9111931 3.12 49.5 µM 2.27E-4 56 8.91E-4
17 SGTC_1501 4491-0275 3.12 38.4 µM 2.32E-4 32 9.06E-4
18 SGTC_535 2293-4129 3.02 48.2 µM 3.51E-4 NEO1 124 0.00127
19 SGTC_911 3456-4043 3.02 236.0 µM 3.53E-4 mitochondrial processes 72 0.00127
20 SGTC_3330 9141424 3.01 71.4 µM 3.60E-4 amide catabolism 55 0.00129

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.217 7.20E-37 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.110 1.93E-10 YML060W OGG1 hom Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance
0.108 3.06E-10 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.107 5.71E-10 YPL079W RPL21B hom Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication
0.104 1.50E-9 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.099 8.38E-9 YCL033C MXR2 hom Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan
0.091 1.16E-7 YLR112W_d YLR112W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.091 1.24E-7 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.089 2.21E-7 YNL088W TOP2 het Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.089 2.31E-7 YOR272W YTM1 het Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
0.088 3.44E-7 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.088 3.59E-7 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.087 4.08E-7 YPL167C REV3 hom Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.083 1.46E-6 YDR476C_p YDR476C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
0.083 1.47E-6 YAL067C SEO1 hom Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide