HIPHOP chemogenomics database
YEL058W / PCM1 
Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YEL058W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.153 | 4.67E-19 | YJR082C | EAF6 | hom | Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3 |
| 0.152 | 7.87E-19 | YKL050C | YKL050C | hom | Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p |
| 0.145 | 3.14E-17 | YLR011W | LOT6 | hom | FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions |
| 0.134 | 5.68E-15 | YDL174C | DLD1 | hom | D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane |
| 0.132 | 1.85E-14 | YJR116W_p | TDA4_p | hom | Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele |
| 0.128 | 8.13E-14 | YIL107C | PFK26 | hom | 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A |
| 0.126 | 2.26E-13 | YGR189C | CRH1 | hom | Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress |
| 0.116 | 1.63E-11 | YHR065C | RRP3 | het | Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity |
| 0.114 | 3.51E-11 | YNL245C | CWC25 | het | Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p |
| 0.111 | 1.36E-10 | YNR039C | ZRG17 | hom | Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency |
| 0.109 | 2.08E-10 | YLR272C | YCS4 | het | Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation |
| 0.105 | 9.10E-10 | YBR185C | MBA1 | hom | Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane |
| 0.100 | 6.36E-9 | YLL035W | GRC3 | het | Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated |
| 0.099 | 8.90E-9 | YOR062C_p | YOR062C_p | hom | Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS |
| 0.098 | 1.14E-8 | YOL046C_d | YOL046C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W |