YEL058W / PCM1

Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors

Zygosity: Heterozygous strain
fixedexpanded
Profile for YEL058W / PCM1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.02|P-value:5.13E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:3.05|P-value:5.22E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:2.71|P-value:2.82E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-2.61|P-value:3.96E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:2.60|P-value:4.72E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:-2.69|P-value:2.70E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:-2.66|P-value:3.17E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:2.64|P-value:3.94E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.49|P-value:4.48E-6 ID:SGTC_650|Compound:1328-0195|FD-Score:2.64|P-value:3.87E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.18|P-value:2.65E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:3.71|P-value:1.15E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:-2.45|P-value:7.98E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-4.25|P-value:2.43E-8 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.84|P-value:1.30E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:2.98|P-value:7.46E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.07|P-value:3.91E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:-2.87|P-value:1.12E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.02|P-value:6.01E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:2.90|P-value:1.14E-4 ID:SGTC_1115|Compound:galangin|FD-Score:4.23|P-value:3.54E-8 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.94|P-value:9.23E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:2.49|P-value:7.94E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.82|P-value:1.69E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.00|P-value:6.88E-5 ID:SGTC_1307|Compound:1187-1599|FD-Score:-2.52|P-value:6.02E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.75|P-value:9.24E-7 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.83|P-value:1.60E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:2.52|P-value:6.69E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:2.76|P-value:2.28E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.25|P-value:1.46E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:2.79|P-value:1.98E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-2.41|P-value:9.71E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.34|P-value:1.04E-5 ID:SGTC_1633|Compound:st005664|FD-Score:-3.13|P-value:2.84E-5 ID:SGTC_1646|Compound:st011709|FD-Score:-2.41|P-value:9.66E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-2.63|P-value:3.61E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.34|P-value:9.12E-6 ID:SGTC_2093|Compound:5331342|FD-Score:3.36|P-value:9.24E-6 ID:SGTC_2128|Compound:5255449|FD-Score:-5.55|P-value:5.40E-13 ID:SGTC_2134|Compound:5324836|FD-Score:-2.48|P-value:7.23E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-2.98|P-value:6.57E-5 ID:SGTC_2172|Compound:5754775|FD-Score:-2.73|P-value:2.27E-4 ID:SGTC_2182|Compound:6325192|FD-Score:2.99|P-value:7.02E-5 ID:SGTC_2184|Compound:6075246|FD-Score:3.11|P-value:3.78E-5 ID:SGTC_2245|Compound:6637752|FD-Score:-3.11|P-value:3.31E-5 ID:SGTC_2270|Compound:7924575|FD-Score:2.71|P-value:2.84E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.06|P-value:5.08E-5 ID:SGTC_2378|Compound:9074213|FD-Score:2.63|P-value:4.14E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.61|P-value:2.14E-9 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.40|P-value:7.69E-6 ID:SGTC_2415|Compound:st077333|FD-Score:5.61|P-value:4.18E-13 ID:SGTC_2474|Compound:5321570|FD-Score:3.33|P-value:1.13E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:2.55|P-value:5.88E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.16|P-value:2.86E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-2.41|P-value:9.64E-4 ID:SGTC_3042|Compound:9091578|FD-Score:2.91|P-value:1.09E-4 ID:SGTC_3125|Compound:9127534|FD-Score:2.71|P-value:2.85E-4 ID:SGTC_3133|Compound:9127736|FD-Score:2.56|P-value:5.79E-4 ID:SGTC_3134|Compound:9127454|FD-Score:-2.81|P-value:1.51E-4 ID:SGTC_3226|Compound:9131256|FD-Score:2.69|P-value:3.14E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.02|P-value:5.13E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:3.05|P-value:5.22E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:2.71|P-value:2.82E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-2.61|P-value:3.96E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:2.60|P-value:4.72E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:-2.69|P-value:2.70E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:-2.66|P-value:3.17E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:2.64|P-value:3.94E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.49|P-value:4.48E-6 ID:SGTC_650|Compound:1328-0195|FD-Score:2.64|P-value:3.87E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.18|P-value:2.65E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:3.71|P-value:1.15E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:-2.45|P-value:7.98E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-4.25|P-value:2.43E-8 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.84|P-value:1.30E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:2.98|P-value:7.46E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.07|P-value:3.91E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:-2.87|P-value:1.12E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.02|P-value:6.01E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:2.90|P-value:1.14E-4 ID:SGTC_1115|Compound:galangin|FD-Score:4.23|P-value:3.54E-8 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.94|P-value:9.23E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:2.49|P-value:7.94E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.82|P-value:1.69E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.00|P-value:6.88E-5 ID:SGTC_1307|Compound:1187-1599|FD-Score:-2.52|P-value:6.02E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.75|P-value:9.24E-7 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.83|P-value:1.60E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:2.52|P-value:6.69E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:2.76|P-value:2.28E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.25|P-value:1.46E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:2.79|P-value:1.98E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-2.41|P-value:9.71E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.34|P-value:1.04E-5 ID:SGTC_1633|Compound:st005664|FD-Score:-3.13|P-value:2.84E-5 ID:SGTC_1646|Compound:st011709|FD-Score:-2.41|P-value:9.66E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-2.63|P-value:3.61E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.34|P-value:9.12E-6 ID:SGTC_2093|Compound:5331342|FD-Score:3.36|P-value:9.24E-6 ID:SGTC_2128|Compound:5255449|FD-Score:-5.55|P-value:5.40E-13 ID:SGTC_2134|Compound:5324836|FD-Score:-2.48|P-value:7.23E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-2.98|P-value:6.57E-5 ID:SGTC_2172|Compound:5754775|FD-Score:-2.73|P-value:2.27E-4 ID:SGTC_2182|Compound:6325192|FD-Score:2.99|P-value:7.02E-5 ID:SGTC_2184|Compound:6075246|FD-Score:3.11|P-value:3.78E-5 ID:SGTC_2245|Compound:6637752|FD-Score:-3.11|P-value:3.31E-5 ID:SGTC_2270|Compound:7924575|FD-Score:2.71|P-value:2.84E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.06|P-value:5.08E-5 ID:SGTC_2378|Compound:9074213|FD-Score:2.63|P-value:4.14E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.61|P-value:2.14E-9 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.40|P-value:7.69E-6 ID:SGTC_2415|Compound:st077333|FD-Score:5.61|P-value:4.18E-13 ID:SGTC_2474|Compound:5321570|FD-Score:3.33|P-value:1.13E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:2.55|P-value:5.88E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.16|P-value:2.86E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-2.41|P-value:9.64E-4 ID:SGTC_3042|Compound:9091578|FD-Score:2.91|P-value:1.09E-4 ID:SGTC_3125|Compound:9127534|FD-Score:2.71|P-value:2.85E-4 ID:SGTC_3133|Compound:9127736|FD-Score:2.56|P-value:5.79E-4 ID:SGTC_3134|Compound:9127454|FD-Score:-2.81|P-value:1.51E-4 ID:SGTC_3226|Compound:9131256|FD-Score:2.69|P-value:3.14E-4

Top fitness defect scores for YEL058W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2415 st077333 5.61 57.7 µM 4.18E-13 4 1.00E-8 0.09
2 SGTC_2407 paclitaxel 4.61 400.0 µM 2.14E-9 2 2.02E-6 0.11
3 SGTC_1115 galangin 4.23 695.7 nM 3.54E-8 RPP1 & pyrimidine depletion 3 1.17E-5 0.75
4 SGTC_1309 pyrazolanthrone 3.75 13.4 µM 9.24E-7 11 9.00E-5 0.09
5 SGTC_808 0711-0032 3.71 135.0 µM 1.15E-6 12 1.03E-4 0.21
6 SGTC_612 0302-0167 3.49 22.4 µM 4.48E-6 copper-dependent oxidative stress 11 2.43E-4 0.12
7 SGTC_2409 alverine citrate 3.40 64.0 µM 7.69E-6 20 3.41E-4 0.05
8 SGTC_2093 5331342 3.36 194.4 µM 9.24E-6 10 3.83E-4 0.12
9 SGTC_1573 oleylamine 3.34 1.1 µM 1.04E-5 8 4.14E-4 0.01
10 SGTC_2474 5321570 3.33 43.3 µM 1.13E-5 7 4.35E-4 0.02
11 SGTC_784 4579-0127 3.18 173.0 µM 2.65E-5 8 7.44E-4 0.14
12 SGTC_2918 7977171 3.16 22.1 µM 2.86E-5 9 7.82E-4 0.03
13 SGTC_2184 6075246 3.11 200.0 µM 3.78E-5 5 9.32E-4 0.07
14 SGTC_2328 6201408 3.06 200.0 µM 5.08E-5 22 0.00112 0.01
15 SGTC_39 0986-0283 3.05 58.4 µM 5.22E-5 calcium & mitochondrial duress 17 0.00114 0.03
16 SGTC_1073 triclabendazole 3.02 3.1 µM 6.01E-5 11 0.00125 0.06
17 SGTC_1295 1013-0063 3.00 9.8 µM 6.88E-5 3 0.00136 0.01
18 SGTC_2182 6325192 2.99 200.0 µM 7.02E-5 Golgi 6 0.00138 0.12
19 SGTC_1012 4112-3522 2.98 18.0 µM 7.46E-5 10 0.00143 0.04
20 SGTC_1246 0422-0085 2.94 105.0 µM 9.23E-5 22 0.00164 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 4.67E-19 YJR082C EAF6 hom Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3
0.152 7.87E-19 YKL050C YKL050C hom Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p
0.145 3.14E-17 YLR011W LOT6 hom FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions
0.134 5.68E-15 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.132 1.85E-14 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.128 8.13E-14 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.126 2.26E-13 YGR189C CRH1 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress
0.116 1.63E-11 YHR065C RRP3 het Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
0.114 3.51E-11 YNL245C CWC25 het Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p
0.111 1.36E-10 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.109 2.08E-10 YLR272C YCS4 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.105 9.10E-10 YBR185C MBA1 hom Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane
0.100 6.36E-9 YLL035W GRC3 het Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated
0.099 8.90E-9 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.098 1.14E-8 YOL046C_d YOL046C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W