YEL059W_d / HHY1

Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL059W / HHY1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:-3.98|P-value:1.23E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-2.92|P-value:9.92E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:5.34|P-value:7.28E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:3.04|P-value:6.25E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.87|P-value:1.97E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:-3.22|P-value:3.30E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.03|P-value:6.48E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.58|P-value:7.44E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:4.23|P-value:3.46E-6 ID:SGTC_732|Compound:3970-1727|FD-Score:3.18|P-value:3.64E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.09|P-value:5.16E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:2.96|P-value:8.36E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.66|P-value:5.10E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:-4.77|P-value:2.15E-7 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.40|P-value:1.57E-6 ID:SGTC_985|Compound:1493-0307|FD-Score:3.06|P-value:5.64E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:2.92|P-value:9.61E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:5.36|P-value:6.42E-9 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.12|P-value:4.61E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.95|P-value:7.52E-8 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.53|P-value:8.65E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.07|P-value:5.43E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.68|P-value:4.66E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:-3.59|P-value:7.08E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.58|P-value:6.07E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.86|P-value:1.33E-7 ID:SGTC_1518|Compound:st038567|FD-Score:-3.34|P-value:2.02E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.24|P-value:2.95E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.05|P-value:5.99E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.29|P-value:2.40E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-2.94|P-value:9.22E-4 ID:SGTC_1837|Compound:st055472|FD-Score:5.10|P-value:3.13E-8 ID:SGTC_1840|Compound:st055363|FD-Score:4.63|P-value:4.32E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.85|P-value:2.17E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.91|P-value:1.67E-5 ID:SGTC_2075|Compound:5212009|FD-Score:-3.81|P-value:2.70E-5 ID:SGTC_2375|Compound:9072683|FD-Score:3.92|P-value:1.57E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.40|P-value:1.51E-4 ID:SGTC_2556|Compound:citropten|FD-Score:-3.76|P-value:3.35E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.91|P-value:1.62E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.17|P-value:3.85E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.38|P-value:1.64E-6 ID:SGTC_2761|Compound:levamisole|FD-Score:-2.94|P-value:9.17E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.17|P-value:3.77E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-3.33|P-value:2.07E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.29|P-value:2.34E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.95|P-value:1.41E-5 ID:SGTC_2982|Compound:9019404|FD-Score:2.95|P-value:8.49E-4 ID:SGTC_3020|Compound:9089140|FD-Score:-4.08|P-value:7.73E-6 ID:SGTC_3027|Compound:9089541|FD-Score:-4.79|P-value:1.97E-7 ID:SGTC_3029|Compound:9088683|FD-Score:-2.93|P-value:9.50E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.08|P-value:5.24E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.55|P-value:8.12E-5 ID:SGTC_3331|Compound:9141060|FD-Score:2.97|P-value:8.05E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:-3.98|P-value:1.23E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-2.92|P-value:9.92E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:5.34|P-value:7.28E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:3.04|P-value:6.25E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.87|P-value:1.97E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:-3.22|P-value:3.30E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.03|P-value:6.48E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.58|P-value:7.44E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:4.23|P-value:3.46E-6 ID:SGTC_732|Compound:3970-1727|FD-Score:3.18|P-value:3.64E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.09|P-value:5.16E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:2.96|P-value:8.36E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.66|P-value:5.10E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:-4.77|P-value:2.15E-7 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.40|P-value:1.57E-6 ID:SGTC_985|Compound:1493-0307|FD-Score:3.06|P-value:5.64E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:2.92|P-value:9.61E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:5.36|P-value:6.42E-9 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.12|P-value:4.61E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.95|P-value:7.52E-8 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.53|P-value:8.65E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.07|P-value:5.43E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.68|P-value:4.66E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:-3.59|P-value:7.08E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.58|P-value:6.07E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.86|P-value:1.33E-7 ID:SGTC_1518|Compound:st038567|FD-Score:-3.34|P-value:2.02E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.24|P-value:2.95E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.05|P-value:5.99E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.29|P-value:2.40E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-2.94|P-value:9.22E-4 ID:SGTC_1837|Compound:st055472|FD-Score:5.10|P-value:3.13E-8 ID:SGTC_1840|Compound:st055363|FD-Score:4.63|P-value:4.32E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.85|P-value:2.17E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.91|P-value:1.67E-5 ID:SGTC_2075|Compound:5212009|FD-Score:-3.81|P-value:2.70E-5 ID:SGTC_2375|Compound:9072683|FD-Score:3.92|P-value:1.57E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.40|P-value:1.51E-4 ID:SGTC_2556|Compound:citropten|FD-Score:-3.76|P-value:3.35E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.91|P-value:1.62E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.17|P-value:3.85E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.38|P-value:1.64E-6 ID:SGTC_2761|Compound:levamisole|FD-Score:-2.94|P-value:9.17E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.17|P-value:3.77E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-3.33|P-value:2.07E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.29|P-value:2.34E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.95|P-value:1.41E-5 ID:SGTC_2982|Compound:9019404|FD-Score:2.95|P-value:8.49E-4 ID:SGTC_3020|Compound:9089140|FD-Score:-4.08|P-value:7.73E-6 ID:SGTC_3027|Compound:9089541|FD-Score:-4.79|P-value:1.97E-7 ID:SGTC_3029|Compound:9088683|FD-Score:-2.93|P-value:9.50E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.08|P-value:5.24E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.55|P-value:8.12E-5 ID:SGTC_3331|Compound:9141060|FD-Score:2.97|P-value:8.05E-4

Top fitness defect scores for YEL059W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1193 1488-0126 5.36 41.5 µM 6.42E-9 10 4.24E-8
2 SGTC_67 0335-0847 5.34 266.0 µM 7.28E-9 ubiquinone biosynthesis & proteasome 80 4.74E-8
3 SGTC_1837 st055472 5.10 66.5 µM 3.13E-8 10 1.74E-7
4 SGTC_1205 4161-2785 4.95 76.0 µM 7.52E-8 12 3.80E-7
5 SGTC_1840 st055363 4.63 71.0 µM 4.32E-7 3 1.81E-6
6 SGTC_2703 st077852 4.38 53.4 µM 1.64E-6 13 5.91E-6
7 SGTC_725 1497-0963 4.23 19.0 µM 3.46E-6 copper-dependent oxidative stress 16 1.15E-5
8 SGTC_2375 9072683 3.92 200.0 µM 1.57E-5 mitochondrial processes 20 4.44E-5
9 SGTC_2571 chrysanthemic acid 3.91 100.0 µM 1.62E-5 18 4.56E-5
10 SGTC_1913 st060213 3.91 96.1 µM 1.67E-5 31 4.69E-5
11 SGTC_86 0417-1630 3.87 471.9 µM 1.97E-5 ubiquinone biosynthesis & proteasome 159 5.45E-5
12 SGTC_1844 rapamycin 3.85 4.0 nM 2.17E-5 168 5.93E-5
13 SGTC_1304 1165-0502 3.68 251.0 µM 4.66E-5 70 1.17E-4
14 SGTC_768 0384-0033 3.66 77.3 µM 5.10E-5 fatty acid desaturase (OLE1) 95 1.27E-4
15 SGTC_3234 9132280 3.55 49.5 µM 8.12E-5 33 1.93E-4
16 SGTC_1212 0520-0165 3.53 585.0 µM 8.65E-5 49 2.04E-4
17 SGTC_2520 obtusaquinone 3.40 4.7 µM 1.51E-4 35 3.35E-4
18 SGTC_2920 7982904 3.29 15.8 µM 2.34E-4 43 4.96E-4
19 SGTC_1743 st037606 3.29 46.4 µM 2.40E-4 45 5.07E-4
20 SGTC_732 3970-1727 3.18 52.7 µM 3.64E-4 25 7.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.197 9.02E-31 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.184 7.86E-27 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.180 6.53E-26 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.174 4.72E-24 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.171 2.34E-23 YOR213C SAS5 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
0.166 4.31E-22 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.159 1.50E-20 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.155 1.33E-19 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.155 1.54E-19 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.154 2.89E-19 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.148 8.66E-18 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.145 2.94E-17 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.145 3.47E-17 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.142 1.48E-16 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.140 4.00E-16 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension