HIPHOP chemogenomics database

YEL059W_d / HHY1

Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking

Zygosity: Homozygous strain

fixedexpanded
Profile for YEL059W / HHY1

Click on Significant Values for Screen Details

Top fitness defect scores for YEL059W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1193	1488-0126	5.36	41.5 µM	6.42E-9		10	4.24E-8
2	SGTC_67	0335-0847	5.34	266.0 µM	7.28E-9	ubiquinone biosynthesis & proteasome	80	4.74E-8
3	SGTC_1837	st055472	5.10	66.5 µM	3.13E-8		10	1.74E-7
4	SGTC_1205	4161-2785	4.95	76.0 µM	7.52E-8		12	3.80E-7
5	SGTC_1840	st055363	4.63	71.0 µM	4.32E-7		3	1.81E-6
6	SGTC_2703	st077852	4.38	53.4 µM	1.64E-6		13	5.91E-6
7	SGTC_725	1497-0963	4.23	19.0 µM	3.46E-6	copper-dependent oxidative stress	16	1.15E-5
8	SGTC_2375	9072683	3.92	200.0 µM	1.57E-5	mitochondrial processes	20	4.44E-5
9	SGTC_2571	chrysanthemic acid	3.91	100.0 µM	1.62E-5		18	4.56E-5
10	SGTC_1913	st060213	3.91	96.1 µM	1.67E-5		31	4.69E-5
11	SGTC_86	0417-1630	3.87	471.9 µM	1.97E-5	ubiquinone biosynthesis & proteasome	159	5.45E-5
12	SGTC_1844	rapamycin	3.85	4.0 nM	2.17E-5		168	5.93E-5
13	SGTC_1304	1165-0502	3.68	251.0 µM	4.66E-5		70	1.17E-4
14	SGTC_768	0384-0033	3.66	77.3 µM	5.10E-5	fatty acid desaturase (OLE1)	95	1.27E-4
15	SGTC_3234	9132280	3.55	49.5 µM	8.12E-5		33	1.93E-4
16	SGTC_1212	0520-0165	3.53	585.0 µM	8.65E-5		49	2.04E-4
17	SGTC_2520	obtusaquinone	3.40	4.7 µM	1.51E-4		35	3.35E-4
18	SGTC_2920	7982904	3.29	15.8 µM	2.34E-4		43	4.96E-4
19	SGTC_1743	st037606	3.29	46.4 µM	2.40E-4		45	5.07E-4
20	SGTC_732	3970-1727	3.18	52.7 µM	3.64E-4		25	7.37E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.197	9.02E-31	YDR312W	SSF2	hom	Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.184	7.86E-27	YJL171C	YJL171C	hom	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.180	6.53E-26	YGR022C_d	YGR022C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.174	4.72E-24	YNL166C	BNI5	hom	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.171	2.34E-23	YOR213C	SAS5	hom	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
0.166	4.31E-22	YDR521W_d	YDR521W_d	hom	Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.159	1.50E-20	YMR322C_p	SNO4_p	hom	Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.155	1.33E-19	YLR213C	CRR1	hom	Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.155	1.54E-19	YGR077C	PEX8	hom	Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.154	2.89E-19	YDL157C_p	YDL157C_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.148	8.66E-18	YPR180W	AOS1	het	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.145	2.94E-17	YDL230W	PTP1	hom	Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.145	3.47E-17	YBL017C	PEP1	hom	Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.142	1.48E-16	YDL176W	YDL176W	hom	Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.140	4.00E-16	YFL014W	HSP12	hom	Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension