YEL062W / NPR2

Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL062W / NPR2

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-3.52|P-value:4.20E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.13|P-value:4.55E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.35|P-value:8.24E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:6.15|P-value:3.59E-9 ID:SGTC_150|Compound:3970-0969|FD-Score:4.25|P-value:3.27E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.67|P-value:5.63E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:3.46|P-value:5.73E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.93|P-value:1.11E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.69|P-value:2.65E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-3.65|P-value:2.69E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.35|P-value:7.59E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:-3.55|P-value:3.87E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.95|P-value:9.15E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-6.81|P-value:6.06E-11 ID:SGTC_315|Compound:k915-0449|FD-Score:4.55|P-value:9.60E-6 ID:SGTC_393|Compound:acivicin|FD-Score:8.37|P-value:1.61E-15 ID:SGTC_435|Compound:c-PAF|FD-Score:3.40|P-value:7.02E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.49|P-value:6.99E-13 ID:SGTC_513|Compound:4245-1575|FD-Score:5.20|P-value:4.96E-7 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.74|P-value:3.69E-6 ID:SGTC_607|Compound:4491-0986|FD-Score:4.25|P-value:3.23E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:-5.03|P-value:9.57E-7 ID:SGTC_663|Compound:1486-0733|FD-Score:3.48|P-value:5.33E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.56|P-value:4.08E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.35|P-value:7.58E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.70|P-value:2.52E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.55|P-value:4.32E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:5.05|P-value:1.03E-6 ID:SGTC_930|Compound:2810-3379|FD-Score:3.50|P-value:5.05E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.83|P-value:1.63E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:6.74|P-value:1.15E-10 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.53|P-value:9.84E-8 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.40|P-value:7.10E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.94|P-value:1.05E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:-3.36|P-value:7.37E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:-3.40|P-value:6.32E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.60|P-value:3.65E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.30|P-value:2.70E-5 ID:SGTC_1652|Compound:st011932|FD-Score:3.60|P-value:3.56E-4 ID:SGTC_1656|Compound:st012921|FD-Score:4.08|P-value:6.32E-5 ID:SGTC_1687|Compound:st020778|FD-Score:7.39|P-value:1.71E-12 ID:SGTC_1712|Compound:st032288|FD-Score:-4.46|P-value:1.20E-5 ID:SGTC_1714|Compound:st033236|FD-Score:3.57|P-value:3.97E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.58|P-value:3.90E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.74|P-value:4.10E-6 ID:SGTC_1800|Compound:st050079|FD-Score:-3.41|P-value:6.23E-4 ID:SGTC_1816|Compound:st051957|FD-Score:4.01|P-value:8.30E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.71|P-value:4.22E-6 ID:SGTC_1819|Compound:st053448|FD-Score:6.05|P-value:6.42E-9 ID:SGTC_1846|Compound:st056244|FD-Score:3.51|P-value:4.87E-4 ID:SGTC_1852|Compound:st056254|FD-Score:3.41|P-value:6.80E-4 ID:SGTC_1859|Compound:st055998|FD-Score:4.61|P-value:7.25E-6 ID:SGTC_2081|Compound:5214970|FD-Score:3.46|P-value:5.70E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.28|P-value:9.39E-4 ID:SGTC_2248|Compound:tofa|FD-Score:7.22|P-value:5.31E-12 ID:SGTC_2273|Compound:7815444|FD-Score:3.83|P-value:1.58E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.88|P-value:1.35E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.69|P-value:2.66E-4 ID:SGTC_2416|Compound:tofa|FD-Score:12.80|P-value:1.22E-33 ID:SGTC_2428|Compound:5615643|FD-Score:5.70|P-value:4.13E-8 ID:SGTC_2434|Compound:5670830|FD-Score:5.88|P-value:1.58E-8 ID:SGTC_2482|Compound:5981709|FD-Score:3.66|P-value:2.97E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.62|P-value:2.99E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.28|P-value:9.50E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.98|P-value:9.36E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:9.03|P-value:9.30E-18 ID:SGTC_2864|Compound:9034755|FD-Score:-3.38|P-value:6.82E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.49|P-value:4.68E-4 ID:SGTC_3088|Compound:9117578|FD-Score:3.34|P-value:8.64E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-3.51|P-value:4.37E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.52|P-value:4.23E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.04|P-value:7.37E-5 ID:SGTC_3302|Compound:9125395|FD-Score:-5.34|P-value:2.20E-7 ID:SGTC_3307|Compound:9126885|FD-Score:5.31|P-value:2.92E-7 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.52|P-value:4.20E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.13|P-value:4.55E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.35|P-value:8.24E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:6.15|P-value:3.59E-9 ID:SGTC_150|Compound:3970-0969|FD-Score:4.25|P-value:3.27E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.67|P-value:5.63E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:3.46|P-value:5.73E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.93|P-value:1.11E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.69|P-value:2.65E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-3.65|P-value:2.69E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.35|P-value:7.59E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:-3.55|P-value:3.87E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.95|P-value:9.15E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-6.81|P-value:6.06E-11 ID:SGTC_315|Compound:k915-0449|FD-Score:4.55|P-value:9.60E-6 ID:SGTC_393|Compound:acivicin|FD-Score:8.37|P-value:1.61E-15 ID:SGTC_435|Compound:c-PAF|FD-Score:3.40|P-value:7.02E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.49|P-value:6.99E-13 ID:SGTC_513|Compound:4245-1575|FD-Score:5.20|P-value:4.96E-7 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.74|P-value:3.69E-6 ID:SGTC_607|Compound:4491-0986|FD-Score:4.25|P-value:3.23E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:-5.03|P-value:9.57E-7 ID:SGTC_663|Compound:1486-0733|FD-Score:3.48|P-value:5.33E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.56|P-value:4.08E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.35|P-value:7.58E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.70|P-value:2.52E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.55|P-value:4.32E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:5.05|P-value:1.03E-6 ID:SGTC_930|Compound:2810-3379|FD-Score:3.50|P-value:5.05E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.83|P-value:1.63E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:6.74|P-value:1.15E-10 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.53|P-value:9.84E-8 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.40|P-value:7.10E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.94|P-value:1.05E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:-3.36|P-value:7.37E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:-3.40|P-value:6.32E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.60|P-value:3.65E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.30|P-value:2.70E-5 ID:SGTC_1652|Compound:st011932|FD-Score:3.60|P-value:3.56E-4 ID:SGTC_1656|Compound:st012921|FD-Score:4.08|P-value:6.32E-5 ID:SGTC_1687|Compound:st020778|FD-Score:7.39|P-value:1.71E-12 ID:SGTC_1712|Compound:st032288|FD-Score:-4.46|P-value:1.20E-5 ID:SGTC_1714|Compound:st033236|FD-Score:3.57|P-value:3.97E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.58|P-value:3.90E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.74|P-value:4.10E-6 ID:SGTC_1800|Compound:st050079|FD-Score:-3.41|P-value:6.23E-4 ID:SGTC_1816|Compound:st051957|FD-Score:4.01|P-value:8.30E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.71|P-value:4.22E-6 ID:SGTC_1819|Compound:st053448|FD-Score:6.05|P-value:6.42E-9 ID:SGTC_1846|Compound:st056244|FD-Score:3.51|P-value:4.87E-4 ID:SGTC_1852|Compound:st056254|FD-Score:3.41|P-value:6.80E-4 ID:SGTC_1859|Compound:st055998|FD-Score:4.61|P-value:7.25E-6 ID:SGTC_2081|Compound:5214970|FD-Score:3.46|P-value:5.70E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.28|P-value:9.39E-4 ID:SGTC_2248|Compound:tofa|FD-Score:7.22|P-value:5.31E-12 ID:SGTC_2273|Compound:7815444|FD-Score:3.83|P-value:1.58E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.88|P-value:1.35E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.69|P-value:2.66E-4 ID:SGTC_2416|Compound:tofa|FD-Score:12.80|P-value:1.22E-33 ID:SGTC_2428|Compound:5615643|FD-Score:5.70|P-value:4.13E-8 ID:SGTC_2434|Compound:5670830|FD-Score:5.88|P-value:1.58E-8 ID:SGTC_2482|Compound:5981709|FD-Score:3.66|P-value:2.97E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.62|P-value:2.99E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.28|P-value:9.50E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.98|P-value:9.36E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:9.03|P-value:9.30E-18 ID:SGTC_2864|Compound:9034755|FD-Score:-3.38|P-value:6.82E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.49|P-value:4.68E-4 ID:SGTC_3088|Compound:9117578|FD-Score:3.34|P-value:8.64E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-3.51|P-value:4.37E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.52|P-value:4.23E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.04|P-value:7.37E-5 ID:SGTC_3302|Compound:9125395|FD-Score:-5.34|P-value:2.20E-7 ID:SGTC_3307|Compound:9126885|FD-Score:5.31|P-value:2.92E-7

Top fitness defect scores for YEL062W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2416 tofa 12.80 880.0 nM 1.22E-33 sphingolipid biosynthesis & PDR1 7 1.22E-37
2 SGTC_2645 abamectin 9.03 100.0 µM 9.30E-18 heme requiring 1 8.69E-20
3 SGTC_393 acivicin 8.37 6.2 µM 1.61E-15 3 2.86E-17
4 SGTC_1687 st020778 7.39 55.4 µM 1.71E-12 79 7.18E-14
5 SGTC_2248 tofa 7.22 1.1 µM 5.31E-12 sphingolipid biosynthesis & PDR1 13 2.57E-13
6 SGTC_1129 3453-1384 6.74 223.0 µM 1.15E-10 7 8.14E-12
7 SGTC_149 3970-0822 6.15 46.1 µM 3.59E-9 tubulin folding & SWR complex 36 3.88E-10
8 SGTC_1819 st053448 6.05 58.6 µM 6.42E-9 amide catabolism 2 7.45E-10
9 SGTC_2434 5670830 5.88 169.9 µM 1.58E-8 3 2.05E-9
10 SGTC_2428 5615643 5.70 7.8 µM 4.13E-8 13 6.03E-9
11 SGTC_1133 3473-0247 5.53 50.0 µM 9.84E-8 RSC complex & mRNA processing 12 1.60E-8
12 SGTC_3307 9126885 5.31 69.3 µM 2.92E-7 10 5.41E-8
13 SGTC_513 4245-1575 5.20 41.7 µM 4.96E-7 unfolded protein response 67 9.82E-8
14 SGTC_922 1866-0035 5.05 480.0 µM 1.03E-6 excess fatty acid 31 2.24E-7
15 SGTC_1750 st081859 4.74 2.4 µM 4.10E-6 endomembrane recycling 144 1.05E-6
16 SGTC_158 k038-0087 4.67 26.4 µM 5.63E-6 ubiquinone biosynthesis & proteasome 103 1.50E-6
17 SGTC_1859 st055998 4.61 20.0 µM 7.25E-6 14 1.99E-6
18 SGTC_315 k915-0449 4.55 187.0 µM 9.60E-6 42 2.73E-6
19 SGTC_1635 st007035 4.30 42.4 µM 2.70E-5 197 8.70E-6
20 SGTC_607 4491-0986 4.25 66.8 µM 3.23E-5 heme requiring 22 1.06E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.244 9.23E-47 YHL023C NPR3 hom Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair
0.242 8.51E-46 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.182 2.62E-26 YGR037C ACB1 hom Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress
0.177 6.64E-25 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.157 7.53E-20 YDR203W_d YDR203W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.144 7.39E-17 YAL012W CYS3 hom Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress
0.142 1.66E-16 YLR420W URA4 hom Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
0.136 2.86E-15 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.134 7.61E-15 YLR372W SUR4 hom Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
0.132 1.37E-14 YJR059W PTK2 hom Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
0.129 7.12E-14 YKL216W URA1 hom Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
0.127 2.03E-13 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.124 7.90E-13 YNL323W LEM3 hom Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
0.122 1.39E-12 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.122 1.62E-12 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate