YEL063C / CAN1

Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL063C / CAN1

Click on Significant Values for Screen Details ID:SGTC_84|Compound:0443-0269|FD-Score:3.52|P-value:6.32E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:-3.56|P-value:6.39E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:12.90|P-value:1.79E-32 ID:SGTC_127|Compound:0180-0333|FD-Score:5.31|P-value:6.08E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.47|P-value:2.53E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.42|P-value:2.67E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.53|P-value:1.68E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:4.06|P-value:1.00E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:3.42|P-value:8.61E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.68|P-value:3.75E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:7.08|P-value:5.06E-11 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.58|P-value:6.02E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:5.08|P-value:1.69E-6 ID:SGTC_397|Compound:arbidol|FD-Score:3.77|P-value:2.83E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.61|P-value:4.76E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:5.29|P-value:6.64E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:8.92|P-value:2.01E-16 ID:SGTC_584|Compound:0986-0246|FD-Score:3.53|P-value:6.13E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.33|P-value:3.71E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:6.84|P-value:2.06E-10 ID:SGTC_769|Compound:0302-0231|FD-Score:4.68|P-value:9.21E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.79|P-value:3.00E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.72|P-value:7.90E-6 ID:SGTC_1092|Compound:toremifene|FD-Score:4.65|P-value:1.05E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.13|P-value:7.78E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.38|P-value:9.90E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:4.33|P-value:3.67E-5 ID:SGTC_1392|Compound:3455-1037|FD-Score:4.48|P-value:2.06E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.44|P-value:8.01E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.50|P-value:7.65E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-4.42|P-value:3.02E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-3.68|P-value:4.23E-4 ID:SGTC_1802|Compound:st050112|FD-Score:4.66|P-value:1.01E-5 ID:SGTC_1808|Compound:st050063|FD-Score:3.40|P-value:9.19E-4 ID:SGTC_1810|Compound:st050138|FD-Score:3.57|P-value:5.37E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.55|P-value:5.80E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.44|P-value:8.16E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-3.81|P-value:2.76E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.77|P-value:2.80E-4 ID:SGTC_2104|Compound:5389443|FD-Score:-4.77|P-value:7.59E-6 ID:SGTC_2106|Compound:5357045|FD-Score:-3.69|P-value:4.11E-4 ID:SGTC_2180|Compound:6301957|FD-Score:-3.43|P-value:9.36E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.90|P-value:1.78E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.86|P-value:2.36E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.42|P-value:9.88E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.68|P-value:4.22E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:-4.22|P-value:6.57E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:31.40|P-value:2.12E-180 ID:SGTC_2769|Compound:toremifene|FD-Score:5.23|P-value:8.87E-7 ID:SGTC_2804|Compound:7954240|FD-Score:4.20|P-value:6.13E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.67|P-value:3.84E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.87|P-value:2.26E-4 ID:SGTC_3048|Compound:9093155|FD-Score:4.08|P-value:9.28E-5 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.41|P-value:8.84E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.76|P-value:6.65E-6 ID:SGTC_3212|Compound:9128307|FD-Score:8.79|P-value:5.10E-16 ID:SGTC_3232|Compound:9132874|FD-Score:-3.63|P-value:5.11E-4 ID:SGTC_3249|Compound:9135183|FD-Score:6.91|P-value:1.40E-10 ID:SGTC_84|Compound:0443-0269|FD-Score:3.52|P-value:6.32E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:-3.56|P-value:6.39E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:12.90|P-value:1.79E-32 ID:SGTC_127|Compound:0180-0333|FD-Score:5.31|P-value:6.08E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.47|P-value:2.53E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.42|P-value:2.67E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.53|P-value:1.68E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:4.06|P-value:1.00E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:3.42|P-value:8.61E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.68|P-value:3.75E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:7.08|P-value:5.06E-11 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.58|P-value:6.02E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:5.08|P-value:1.69E-6 ID:SGTC_397|Compound:arbidol|FD-Score:3.77|P-value:2.83E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.61|P-value:4.76E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:5.29|P-value:6.64E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:8.92|P-value:2.01E-16 ID:SGTC_584|Compound:0986-0246|FD-Score:3.53|P-value:6.13E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.33|P-value:3.71E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:6.84|P-value:2.06E-10 ID:SGTC_769|Compound:0302-0231|FD-Score:4.68|P-value:9.21E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.79|P-value:3.00E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.72|P-value:7.90E-6 ID:SGTC_1092|Compound:toremifene|FD-Score:4.65|P-value:1.05E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.13|P-value:7.78E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.38|P-value:9.90E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:4.33|P-value:3.67E-5 ID:SGTC_1392|Compound:3455-1037|FD-Score:4.48|P-value:2.06E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.44|P-value:8.01E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.50|P-value:7.65E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-4.42|P-value:3.02E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-3.68|P-value:4.23E-4 ID:SGTC_1802|Compound:st050112|FD-Score:4.66|P-value:1.01E-5 ID:SGTC_1808|Compound:st050063|FD-Score:3.40|P-value:9.19E-4 ID:SGTC_1810|Compound:st050138|FD-Score:3.57|P-value:5.37E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.55|P-value:5.80E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.44|P-value:8.16E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-3.81|P-value:2.76E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.77|P-value:2.80E-4 ID:SGTC_2104|Compound:5389443|FD-Score:-4.77|P-value:7.59E-6 ID:SGTC_2106|Compound:5357045|FD-Score:-3.69|P-value:4.11E-4 ID:SGTC_2180|Compound:6301957|FD-Score:-3.43|P-value:9.36E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.90|P-value:1.78E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.86|P-value:2.36E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.42|P-value:9.88E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.68|P-value:4.22E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:-4.22|P-value:6.57E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:31.40|P-value:2.12E-180 ID:SGTC_2769|Compound:toremifene|FD-Score:5.23|P-value:8.87E-7 ID:SGTC_2804|Compound:7954240|FD-Score:4.20|P-value:6.13E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.67|P-value:3.84E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.87|P-value:2.26E-4 ID:SGTC_3048|Compound:9093155|FD-Score:4.08|P-value:9.28E-5 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.41|P-value:8.84E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.76|P-value:6.65E-6 ID:SGTC_3212|Compound:9128307|FD-Score:8.79|P-value:5.10E-16 ID:SGTC_3232|Compound:9132874|FD-Score:-3.63|P-value:5.11E-4 ID:SGTC_3249|Compound:9135183|FD-Score:6.91|P-value:1.40E-10

Top fitness defect scores for YEL063C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2697 mebhydrolin 31.40 72.4 µM 2.12E-180 NEO1 1 1.03E-216
2 SGTC_120 rhodamine 6G 12.90 52.3 µM 1.79E-32 mitochondrial processes 2 1.27E-38
3 SGTC_535 2293-4129 8.92 48.2 µM 2.01E-16 NEO1 10 2.43E-19
4 SGTC_3212 9128307 8.79 49.5 µM 5.10E-16 4 7.44E-19
5 SGTC_366 0181-0206 7.08 4.3 µM 5.06E-11 Golgi 5 7.29E-13
6 SGTC_3249 9135183 6.91 49.5 µM 1.40E-10 60S ribosome export 1 2.47E-12
7 SGTC_696 1560-0013 6.84 611.0 µM 2.06E-10 5 3.92E-12
8 SGTC_127 0180-0333 5.31 59.1 µM 6.08E-7 mitochondrial response to ROS 11 5.52E-8
9 SGTC_520 3584-0023 5.29 682.0 µM 6.64E-7 7 6.14E-8
10 SGTC_2769 toremifene 5.23 3.7 µM 8.87E-7 8 8.68E-8
11 SGTC_368 fentichlor 5.08 4.6 µM 1.69E-6 10 1.87E-7
12 SGTC_3189 9110682 4.76 49.5 µM 6.65E-6 17 9.60E-7
13 SGTC_1043 0916-0009 4.72 19.3 µM 7.90E-6 11 1.18E-6
14 SGTC_769 0302-0231 4.68 76.0 µM 9.21E-6 21 1.41E-6
15 SGTC_1802 st050112 4.66 57.9 µM 1.01E-5 3 1.58E-6
16 SGTC_1092 toremifene 4.65 6.3 µM 1.05E-5 10 1.64E-6
17 SGTC_275 trichlorophene 4.53 5.7 µM 1.68E-5 mitochondrial stress 198 2.90E-6
18 SGTC_1392 3455-1037 4.48 33.9 µM 2.06E-5 7 3.70E-6
19 SGTC_221 trifluoperazine 4.42 10.3 µM 2.67E-5 NEO1-PIK1 186 5.02E-6
20 SGTC_1382 3002-2117 4.33 298.0 µM 3.67E-5 6 7.34E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.271 2.20E-57 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.228 8.70E-41 YAL059W ECM1 hom Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
0.214 5.84E-36 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.201 5.25E-32 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.200 1.80E-31 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.195 3.46E-30 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.186 1.54E-27 YJR041C URB2 het Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.181 4.12E-26 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.177 6.26E-25 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.172 1.10E-23 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.167 1.70E-22 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.152 6.85E-19 YKR012C_d YKR012C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
0.151 1.88E-18 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.145 3.89E-17 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.142 1.12E-16 YDR026C NSI1 hom RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication