YEL064C / AVT2

Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL064C / AVT2

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.09|P-value:2.62E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:2.94|P-value:4.86E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.21|P-value:1.56E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.47|P-value:4.89E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:4.95|P-value:1.41E-8 ID:SGTC_125|Compound:0133-0007|FD-Score:3.69|P-value:1.69E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:3.98|P-value:4.01E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:4.80|P-value:3.65E-8 ID:SGTC_143|Compound:4032-1194|FD-Score:3.16|P-value:1.98E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.14|P-value:2.13E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:6.33|P-value:6.36E-13 ID:SGTC_184|Compound:1494-0393|FD-Score:3.36|P-value:8.16E-5 ID:SGTC_281|Compound:1672-3440|FD-Score:2.79|P-value:8.76E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:-3.20|P-value:1.78E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:2.92|P-value:5.28E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.33|P-value:9.84E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:2.82|P-value:7.71E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:5.53|P-value:2.80E-10 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.35|P-value:8.42E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.71|P-value:1.56E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.94|P-value:4.87E-6 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.08|P-value:2.74E-4 ID:SGTC_1516|Compound:st013856|FD-Score:3.54|P-value:3.61E-5 ID:SGTC_1829|Compound:berberine|FD-Score:2.84|P-value:7.00E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.62|P-value:5.92E-14 ID:SGTC_2022|Compound:5136654|FD-Score:-2.89|P-value:6.30E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.93|P-value:5.11E-6 ID:SGTC_2159|Compound:5658611|FD-Score:3.49|P-value:4.57E-5 ID:SGTC_2287|Compound:7945887|FD-Score:3.32|P-value:9.67E-5 ID:SGTC_2340|Compound:7987427|FD-Score:-3.79|P-value:1.14E-5 ID:SGTC_2346|Compound:9031566|FD-Score:-3.00|P-value:4.08E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.11|P-value:2.36E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.66|P-value:1.98E-5 ID:SGTC_2427|Compound:5545055|FD-Score:3.24|P-value:1.39E-4 ID:SGTC_2436|Compound:5633522|FD-Score:2.94|P-value:4.81E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.03|P-value:3.60E-4 ID:SGTC_2517|Compound:totarol|FD-Score:2.95|P-value:4.61E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:5.98|P-value:1.04E-11 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:2.77|P-value:9.22E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.15|P-value:2.17E-4 ID:SGTC_2699|Compound:st077704|FD-Score:2.82|P-value:7.69E-4 ID:SGTC_2706|Compound:st078239|FD-Score:2.93|P-value:4.97E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-4.32|P-value:7.06E-7 ID:SGTC_2716|Compound:st080858|FD-Score:-3.24|P-value:1.46E-4 ID:SGTC_2795|Compound:7780010|FD-Score:2.82|P-value:7.61E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.06|P-value:3.13E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.54|P-value:3.62E-5 ID:SGTC_2890|Compound:9046729|FD-Score:-3.20|P-value:1.77E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.03|P-value:3.37E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.46|P-value:5.10E-5 ID:SGTC_3212|Compound:9128307|FD-Score:3.13|P-value:2.23E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-2.83|P-value:7.84E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.09|P-value:2.62E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:2.94|P-value:4.86E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.21|P-value:1.56E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.47|P-value:4.89E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:4.95|P-value:1.41E-8 ID:SGTC_125|Compound:0133-0007|FD-Score:3.69|P-value:1.69E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:3.98|P-value:4.01E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:4.80|P-value:3.65E-8 ID:SGTC_143|Compound:4032-1194|FD-Score:3.16|P-value:1.98E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.14|P-value:2.13E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:6.33|P-value:6.36E-13 ID:SGTC_184|Compound:1494-0393|FD-Score:3.36|P-value:8.16E-5 ID:SGTC_281|Compound:1672-3440|FD-Score:2.79|P-value:8.76E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:-3.20|P-value:1.78E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:2.92|P-value:5.28E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.33|P-value:9.84E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:2.82|P-value:7.71E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:5.53|P-value:2.80E-10 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.35|P-value:8.42E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.71|P-value:1.56E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.94|P-value:4.87E-6 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.08|P-value:2.74E-4 ID:SGTC_1516|Compound:st013856|FD-Score:3.54|P-value:3.61E-5 ID:SGTC_1829|Compound:berberine|FD-Score:2.84|P-value:7.00E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.62|P-value:5.92E-14 ID:SGTC_2022|Compound:5136654|FD-Score:-2.89|P-value:6.30E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.93|P-value:5.11E-6 ID:SGTC_2159|Compound:5658611|FD-Score:3.49|P-value:4.57E-5 ID:SGTC_2287|Compound:7945887|FD-Score:3.32|P-value:9.67E-5 ID:SGTC_2340|Compound:7987427|FD-Score:-3.79|P-value:1.14E-5 ID:SGTC_2346|Compound:9031566|FD-Score:-3.00|P-value:4.08E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.11|P-value:2.36E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.66|P-value:1.98E-5 ID:SGTC_2427|Compound:5545055|FD-Score:3.24|P-value:1.39E-4 ID:SGTC_2436|Compound:5633522|FD-Score:2.94|P-value:4.81E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.03|P-value:3.60E-4 ID:SGTC_2517|Compound:totarol|FD-Score:2.95|P-value:4.61E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:5.98|P-value:1.04E-11 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:2.77|P-value:9.22E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.15|P-value:2.17E-4 ID:SGTC_2699|Compound:st077704|FD-Score:2.82|P-value:7.69E-4 ID:SGTC_2706|Compound:st078239|FD-Score:2.93|P-value:4.97E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-4.32|P-value:7.06E-7 ID:SGTC_2716|Compound:st080858|FD-Score:-3.24|P-value:1.46E-4 ID:SGTC_2795|Compound:7780010|FD-Score:2.82|P-value:7.61E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.06|P-value:3.13E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.54|P-value:3.62E-5 ID:SGTC_2890|Compound:9046729|FD-Score:-3.20|P-value:1.77E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.03|P-value:3.37E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.46|P-value:5.10E-5 ID:SGTC_3212|Compound:9128307|FD-Score:3.13|P-value:2.23E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-2.83|P-value:7.84E-4

Top fitness defect scores for YEL064C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1926 methyl fluorone black 6.62 53.6 µM 5.92E-14 DNA intercalators 16 1.82E-11
2 SGTC_145 3737-0113 6.33 38.4 µM 6.36E-13 DNA intercalators 25 1.22E-10
3 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 5.98 100.0 µM 1.04E-11 2 1.14E-9
4 SGTC_1030 k029-0042 5.53 36.7 µM 2.80E-10 TSC3-RPN4 8 1.59E-8
5 SGTC_115 0527-0192 4.95 112.0 µM 1.41E-8 35 3.68E-7
6 SGTC_131 0141-0277 4.80 33.9 µM 3.65E-8 17 7.92E-7
7 SGTC_126 0417-1624 3.98 672.5 µM 4.01E-6 DNA intercalators 32 3.45E-5
8 SGTC_1044 1222-0021 3.94 1.8 µM 4.87E-6 heme biosynthesis & mitochondrial translocase 36 4.03E-5
9 SGTC_2117 5521686 3.93 200.0 µM 5.11E-6 12 4.19E-5
10 SGTC_1042 0350-0096 3.71 82.0 µM 1.56E-5 TSC3-RPN4 31 1.03E-4
11 SGTC_125 0133-0007 3.69 11.8 µM 1.69E-5 DNA intercalators 14 1.10E-4
12 SGTC_2419 paclitaxel 3.66 166.5 µM 1.98E-5 55 1.25E-4
13 SGTC_1516 st013856 3.54 110.0 µM 3.61E-5 22 2.02E-4
14 SGTC_2889 9059656 3.54 52.0 µM 3.62E-5 16 2.03E-4
15 SGTC_2159 5658611 3.49 73.8 µM 4.57E-5 16 2.45E-4
16 SGTC_113 0099-0221 3.47 2.5 µM 4.89E-5 46 2.59E-4
17 SGTC_3178 9107506 3.46 49.5 µM 5.10E-5 24 2.67E-4
18 SGTC_184 1494-0393 3.36 24.7 µM 8.16E-5 91 3.91E-4
19 SGTC_1036 k216-0215 3.35 33.5 µM 8.42E-5 mitochondrial response to ROS 78 4.01E-4
20 SGTC_2287 7945887 3.32 168.8 µM 9.67E-5 18 4.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.341 4.66E-92 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.295 4.04E-68 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.275 3.96E-59 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.259 2.66E-52 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.252 1.89E-49 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.237 4.14E-44 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.225 8.81E-40 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.218 3.36E-37 YER125W RSP5 het E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; ubiquitylates Sec23p
0.213 7.83E-36 YGL075C MPS2 het Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
0.211 3.60E-35 YBL008W-A_p YBL008W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.202 4.15E-32 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.201 8.87E-32 YDR054C CDC34 het Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress
0.195 4.37E-30 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.192 3.13E-29 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.190 1.67E-28 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm