YEL067C_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL067C / YEL067C

Click on Significant Values for Screen Details ID:SGTC_325|Compound:2810-4341|FD-Score:3.17|P-value:8.53E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.75|P-value:8.57E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:3.75|P-value:1.01E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.22|P-value:6.95E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:5.04|P-value:2.80E-7 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.67|P-value:1.17E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.40|P-value:3.69E-4 ID:SGTC_1796|Compound:st049173|FD-Score:3.49|P-value:2.65E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.83|P-value:6.19E-5 ID:SGTC_2022|Compound:5136654|FD-Score:3.15|P-value:9.04E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:7.40|P-value:9.16E-14 ID:SGTC_2104|Compound:5389443|FD-Score:7.02|P-value:1.47E-12 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.72|P-value:1.11E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.54|P-value:2.21E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.27|P-value:9.71E-6 ID:SGTC_2844|Compound:9010103|FD-Score:4.42|P-value:5.82E-6 ID:SGTC_2845|Compound:9003024|FD-Score:-4.69|P-value:1.33E-6 ID:SGTC_2859|Compound:9028643|FD-Score:-3.16|P-value:7.66E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.14|P-value:9.36E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.29|P-value:1.01E-5 ID:SGTC_2940|Compound:9060638|FD-Score:3.22|P-value:7.09E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.44|P-value:2.83E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.14|P-value:8.13E-4 ID:SGTC_3258|Compound:9138477|FD-Score:3.13|P-value:9.63E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:3.17|P-value:8.53E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.75|P-value:8.57E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:3.75|P-value:1.01E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.22|P-value:6.95E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:5.04|P-value:2.80E-7 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.67|P-value:1.17E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.40|P-value:3.69E-4 ID:SGTC_1796|Compound:st049173|FD-Score:3.49|P-value:2.65E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.83|P-value:6.19E-5 ID:SGTC_2022|Compound:5136654|FD-Score:3.15|P-value:9.04E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:7.40|P-value:9.16E-14 ID:SGTC_2104|Compound:5389443|FD-Score:7.02|P-value:1.47E-12 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.72|P-value:1.11E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.54|P-value:2.21E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.27|P-value:9.71E-6 ID:SGTC_2844|Compound:9010103|FD-Score:4.42|P-value:5.82E-6 ID:SGTC_2845|Compound:9003024|FD-Score:-4.69|P-value:1.33E-6 ID:SGTC_2859|Compound:9028643|FD-Score:-3.16|P-value:7.66E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.14|P-value:9.36E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.29|P-value:1.01E-5 ID:SGTC_2940|Compound:9060638|FD-Score:3.22|P-value:7.09E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.44|P-value:2.83E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.14|P-value:8.13E-4 ID:SGTC_3258|Compound:9138477|FD-Score:3.13|P-value:9.63E-4

Top fitness defect scores for YEL067C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2091 4-phenylthiadiazole 7.40 200.0 µM 9.16E-14 1 6.71E-14
2 SGTC_2104 5389443 7.02 200.0 µM 1.47E-12 2 1.10E-12
3 SGTC_1222 0366-0074 5.04 1.2 µM 2.80E-7 TSC3-RPN4 4 2.35E-7
4 SGTC_2844 9010103 4.42 26.0 µM 5.82E-6 19 5.02E-6
5 SGTC_2934 9036370 4.29 36.9 µM 1.01E-5 22 8.75E-6
6 SGTC_515 4092-1064 3.75 102.0 µM 1.01E-4 plasma membrane duress 65 9.01E-5
7 SGTC_2771 fluoxetine 3.72 41.0 µM 1.11E-4 28 9.87E-5
8 SGTC_2832 7992762 3.54 52.0 µM 2.21E-4 45 1.98E-4
9 SGTC_1796 st049173 3.49 110.4 µM 2.65E-4 25 2.38E-4
10 SGTC_1738 st035555 3.40 74.0 µM 3.69E-4 TSC3-RPN4 57 3.32E-4
11 SGTC_898 1000-0849 3.22 28.3 µM 6.95E-4 22 6.30E-4
12 SGTC_2940 9060638 3.22 45.9 µM 7.09E-4 amide catabolism 56 6.43E-4
13 SGTC_325 2810-4341 3.17 181.0 µM 8.53E-4 amide catabolism 23 7.75E-4
14 SGTC_2022 5136654 3.15 200.0 µM 9.04E-4 53 8.21E-4
15 SGTC_2930 9013230 3.14 14.9 µM 9.36E-4 heme biosynthesis & mitochondrial translocase 78 8.51E-4
16 SGTC_3258 9138477 3.13 49.5 µM 9.63E-4 26 8.76E-4
17 SGTC_1795 st049545 3.11 62.3 µM 0.00102 TSC3-RPN4 35 9.26E-4
18 SGTC_324 1315-0088 3.06 19.6 µM 0.00122 RSC & ERG11 30 0.00112
19 SGTC_448 monastrol 3.05 171.0 µM 0.00127 30 0.00116
20 SGTC_2757 clomiphene 2.96 4.2 µM 0.00168 fatty acid desaturase (OLE1) 101 0.00154

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.37E-20 YKL168C KKQ8 hom Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication
0.146 2.06E-17 YOR079C ATX2 hom Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation
0.138 8.96E-16 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.136 3.27E-15 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.112 7.11E-11 YLR107W REX3 hom RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases
0.111 1.40E-10 YGL021W ALK1 hom Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins
0.111 1.38E-10 YDR056C_p YDR056C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
0.107 5.48E-10 YLR026C SED5 het cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
0.101 5.15E-9 YOL137W BSC6 hom Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.101 5.47E-9 YOR090C PTC5 hom Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
0.098 1.18E-8 YIL113W SDP1 hom Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
0.098 1.33E-8 YDR415C_p YDR415C_p hom Putative aminopeptidase
0.094 5.39E-8 YJR128W_d YJR128W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
0.087 4.03E-7 YDR142C PEX7 hom Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)
0.087 4.99E-7 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins