YER001W / MNN1

Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family

Zygosity: Homozygous strain
fixedexpanded
Profile for YER001W / MNN1

Click on Significant Values for Screen Details ID:SGTC_179|Compound:1273-0063|FD-Score:-2.90|P-value:6.99E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.38|P-value:9.13E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.08|P-value:3.40E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:2.91|P-value:6.34E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:2.88|P-value:7.36E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.53|P-value:4.66E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:4.02|P-value:4.50E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:3.38|P-value:9.26E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:3.65|P-value:2.69E-5 ID:SGTC_579|Compound:4491-1009|FD-Score:-2.83|P-value:8.83E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.27|P-value:1.49E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.39|P-value:8.85E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:5.26|P-value:3.04E-9 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.15|P-value:2.49E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-2.97|P-value:5.15E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.01|P-value:4.38E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.90|P-value:8.23E-6 ID:SGTC_1540|Compound:guanosine|FD-Score:3.03|P-value:4.02E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.51|P-value:3.19E-7 ID:SGTC_1732|Compound:st034308|FD-Score:-2.95|P-value:5.64E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.13|P-value:2.55E-6 ID:SGTC_1845|Compound:st056753|FD-Score:-3.86|P-value:1.02E-5 ID:SGTC_1847|Compound:st056231|FD-Score:-3.23|P-value:1.84E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-2.97|P-value:5.23E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.93|P-value:7.13E-6 ID:SGTC_2285|Compound:7945142|FD-Score:-3.07|P-value:3.54E-4 ID:SGTC_2305|Compound:7443522|FD-Score:2.92|P-value:6.29E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-2.85|P-value:8.21E-4 ID:SGTC_2646|Compound:retinol|FD-Score:2.90|P-value:6.78E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:-3.04|P-value:4.03E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-2.84|P-value:8.52E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.20|P-value:1.69E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-3.44|P-value:7.45E-5 ID:SGTC_2839|Compound:9003951|FD-Score:2.87|P-value:7.60E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.87|P-value:9.50E-6 ID:SGTC_3006|Compound:9075424|FD-Score:3.08|P-value:3.29E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.14|P-value:2.61E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.77|P-value:1.59E-5 ID:SGTC_3154|Compound:9100113|FD-Score:-3.24|P-value:1.71E-4 ID:SGTC_3205|Compound:9113483|FD-Score:8.94|P-value:2.68E-23 ID:SGTC_3213|Compound:9129884|FD-Score:-2.87|P-value:7.71E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.00|P-value:4.99E-6 ID:SGTC_3290|Compound:9121031|FD-Score:3.45|P-value:6.73E-5 ID:SGTC_3338|Compound:9144300|FD-Score:-2.93|P-value:6.01E-4 ID:SGTC_3341|Compound:9147222|FD-Score:-4.13|P-value:2.54E-6 ID:SGTC_3356|Compound:9151811|FD-Score:-3.17|P-value:2.36E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-2.90|P-value:6.99E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.38|P-value:9.13E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.08|P-value:3.40E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:2.91|P-value:6.34E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:2.88|P-value:7.36E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.53|P-value:4.66E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:4.02|P-value:4.50E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:3.38|P-value:9.26E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:3.65|P-value:2.69E-5 ID:SGTC_579|Compound:4491-1009|FD-Score:-2.83|P-value:8.83E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.27|P-value:1.49E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.39|P-value:8.85E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:5.26|P-value:3.04E-9 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.15|P-value:2.49E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-2.97|P-value:5.15E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.01|P-value:4.38E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.90|P-value:8.23E-6 ID:SGTC_1540|Compound:guanosine|FD-Score:3.03|P-value:4.02E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.51|P-value:3.19E-7 ID:SGTC_1732|Compound:st034308|FD-Score:-2.95|P-value:5.64E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.13|P-value:2.55E-6 ID:SGTC_1845|Compound:st056753|FD-Score:-3.86|P-value:1.02E-5 ID:SGTC_1847|Compound:st056231|FD-Score:-3.23|P-value:1.84E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-2.97|P-value:5.23E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.93|P-value:7.13E-6 ID:SGTC_2285|Compound:7945142|FD-Score:-3.07|P-value:3.54E-4 ID:SGTC_2305|Compound:7443522|FD-Score:2.92|P-value:6.29E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-2.85|P-value:8.21E-4 ID:SGTC_2646|Compound:retinol|FD-Score:2.90|P-value:6.78E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:-3.04|P-value:4.03E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-2.84|P-value:8.52E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.20|P-value:1.69E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-3.44|P-value:7.45E-5 ID:SGTC_2839|Compound:9003951|FD-Score:2.87|P-value:7.60E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.87|P-value:9.50E-6 ID:SGTC_3006|Compound:9075424|FD-Score:3.08|P-value:3.29E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.14|P-value:2.61E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.77|P-value:1.59E-5 ID:SGTC_3154|Compound:9100113|FD-Score:-3.24|P-value:1.71E-4 ID:SGTC_3205|Compound:9113483|FD-Score:8.94|P-value:2.68E-23 ID:SGTC_3213|Compound:9129884|FD-Score:-2.87|P-value:7.71E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.00|P-value:4.99E-6 ID:SGTC_3290|Compound:9121031|FD-Score:3.45|P-value:6.73E-5 ID:SGTC_3338|Compound:9144300|FD-Score:-2.93|P-value:6.01E-4 ID:SGTC_3341|Compound:9147222|FD-Score:-4.13|P-value:2.54E-6 ID:SGTC_3356|Compound:9151811|FD-Score:-3.17|P-value:2.36E-4

Top fitness defect scores for YER001W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3205 9113483 8.94 49.5 µM 2.68E-23 2 2.04E-19
2 SGTC_807 1315-0151 5.26 48.0 µM 3.04E-9 11 7.20E-8
3 SGTC_2774 tamoxifen 4.20 10.9 µM 1.69E-6 11 1.32E-5
4 SGTC_1772 st048439 4.13 82.2 µM 2.55E-6 34 1.85E-5
5 SGTC_515 4092-1064 4.02 102.0 µM 4.50E-6 plasma membrane duress 60 2.96E-5
6 SGTC_2123 5259487 3.93 200.0 µM 7.13E-6 18 4.34E-5
7 SGTC_2957 9076800 3.87 11.5 µM 9.50E-6 22 5.49E-5
8 SGTC_541 4513-1321 3.65 94.0 µM 2.69E-5 30 1.30E-4
9 SGTC_408 cantharidin 3.53 100.0 µM 4.66E-5 cell wall signaling 34 2.05E-4
10 SGTC_3290 9121031 3.45 71.4 µM 6.73E-5 25 2.78E-4
11 SGTC_713 1488-1073 3.39 324.0 µM 8.85E-5 ERG2 25 3.48E-4
12 SGTC_231 b-estradiol 3.38 524.0 µM 9.13E-5 14 3.57E-4
13 SGTC_521 r062-0005 3.38 13.8 µM 9.26E-5 28 3.62E-4
14 SGTC_584 0986-0246 3.27 15.4 µM 1.49E-4 heme requiring 34 5.36E-4
15 SGTC_3014 9081533 3.14 49.5 µM 2.61E-4 29 8.53E-4
16 SGTC_3006 9075424 3.08 71.4 µM 3.29E-4 43 0.00103
17 SGTC_1540 guanosine 3.03 70.6 µM 4.02E-4 32 0.00122
18 SGTC_2305 7443522 2.92 69.2 µM 6.29E-4 54 0.00177
19 SGTC_370 0180-0345 2.91 38.7 µM 6.34E-4 DNA intercalators 47 0.00178
20 SGTC_2646 retinol 2.90 96.8 µM 6.78E-4 51 0.00188

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.20E-20 YER183C FAU1 hom 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
0.140 4.36E-16 YFR056C_d YFR056C_d hom Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
0.136 3.24E-15 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.129 5.49E-14 YKR032W_d YKR032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.127 1.55E-13 YDR214W AHA1 hom Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress
0.117 9.44E-12 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.115 2.80E-11 YNL261W ORC5 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.114 4.15E-11 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.113 4.52E-11 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.110 1.55E-10 YGR160W_d YGR160W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.108 3.83E-10 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.108 3.79E-10 YGR045C_d YGR045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.103 1.97E-9 YCL024W KCC4 hom Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication
0.103 2.42E-9 YDL004W ATP16 het Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.100 5.94E-9 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene