YER002W / NOP16

Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YER002W / NOP16

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:4.01|P-value:7.94E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.63|P-value:3.07E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.55|P-value:4.11E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.33|P-value:8.20E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:4.37|P-value:1.93E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-4.18|P-value:4.04E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.08|P-value:6.03E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.76|P-value:3.63E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.79|P-value:2.42E-8 ID:SGTC_1264|Compound:0783-0040|FD-Score:5.25|P-value:3.90E-7 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.39|P-value:7.02E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.81|P-value:1.58E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.62|P-value:3.33E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.19|P-value:3.99E-5 ID:SGTC_1747|Compound:st037496|FD-Score:-3.46|P-value:5.49E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.30|P-value:9.27E-4 ID:SGTC_1825|Compound:st052143|FD-Score:4.20|P-value:3.77E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-3.35|P-value:7.84E-4 ID:SGTC_2206|Compound:7254556|FD-Score:-3.28|P-value:9.80E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.32|P-value:8.92E-4 ID:SGTC_2227|Compound:7312221|FD-Score:-4.43|P-value:1.47E-5 ID:SGTC_2273|Compound:7815444|FD-Score:3.67|P-value:2.71E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-4.15|P-value:4.42E-5 ID:SGTC_2326|Compound:6164455|FD-Score:-4.45|P-value:1.35E-5 ID:SGTC_2393|Compound:9031399|FD-Score:5.26|P-value:3.69E-7 ID:SGTC_2399|Compound:5884133|FD-Score:-3.52|P-value:4.46E-4 ID:SGTC_2403|Compound:6032726|FD-Score:6.14|P-value:3.66E-9 ID:SGTC_2458|Compound:5808907|FD-Score:3.59|P-value:3.57E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.36|P-value:7.45E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.29|P-value:9.47E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.53|P-value:4.39E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.67|P-value:2.76E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.77|P-value:1.86E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.79|P-value:1.78E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.67|P-value:2.77E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-4.19|P-value:3.85E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.43|P-value:6.04E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.22|P-value:3.57E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.89|P-value:1.27E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.01|P-value:7.94E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.63|P-value:3.07E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.55|P-value:4.11E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.33|P-value:8.20E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:4.37|P-value:1.93E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-4.18|P-value:4.04E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.08|P-value:6.03E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.76|P-value:3.63E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.79|P-value:2.42E-8 ID:SGTC_1264|Compound:0783-0040|FD-Score:5.25|P-value:3.90E-7 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.39|P-value:7.02E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.81|P-value:1.58E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.62|P-value:3.33E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.19|P-value:3.99E-5 ID:SGTC_1747|Compound:st037496|FD-Score:-3.46|P-value:5.49E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.30|P-value:9.27E-4 ID:SGTC_1825|Compound:st052143|FD-Score:4.20|P-value:3.77E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-3.35|P-value:7.84E-4 ID:SGTC_2206|Compound:7254556|FD-Score:-3.28|P-value:9.80E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.32|P-value:8.92E-4 ID:SGTC_2227|Compound:7312221|FD-Score:-4.43|P-value:1.47E-5 ID:SGTC_2273|Compound:7815444|FD-Score:3.67|P-value:2.71E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-4.15|P-value:4.42E-5 ID:SGTC_2326|Compound:6164455|FD-Score:-4.45|P-value:1.35E-5 ID:SGTC_2393|Compound:9031399|FD-Score:5.26|P-value:3.69E-7 ID:SGTC_2399|Compound:5884133|FD-Score:-3.52|P-value:4.46E-4 ID:SGTC_2403|Compound:6032726|FD-Score:6.14|P-value:3.66E-9 ID:SGTC_2458|Compound:5808907|FD-Score:3.59|P-value:3.57E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.36|P-value:7.45E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.29|P-value:9.47E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.53|P-value:4.39E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.67|P-value:2.76E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.77|P-value:1.86E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.79|P-value:1.78E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.67|P-value:2.77E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-4.19|P-value:3.85E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.43|P-value:6.04E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.22|P-value:3.57E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.89|P-value:1.27E-4

Top fitness defect scores for YER002W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2403 6032726 6.14 181.2 µM 3.66E-9 9 4.14E-10
2 SGTC_1263 0774-1208 5.79 64.8 µM 2.42E-8 7 3.44E-9
3 SGTC_2393 9031399 5.26 185.9 µM 3.69E-7 RNA processing & uracil transport 10 7.33E-8
4 SGTC_1264 0783-0040 5.25 158.0 µM 3.90E-7 7 7.80E-8
5 SGTC_1134 3477-0009 4.76 42.5 µM 3.63E-6 25 9.52E-7
6 SGTC_787 4152-0075 4.37 138.0 µM 1.93E-5 16 6.18E-6
7 SGTC_2932 9016711 4.22 44.5 µM 3.57E-5 40 1.23E-5
8 SGTC_1825 st052143 4.20 62.6 µM 3.77E-5 11 1.31E-5
9 SGTC_1743 st037606 4.19 46.4 µM 3.99E-5 18 1.40E-5
10 SGTC_1127 asiatic acid 4.08 681.4 nM 6.03E-5 21 2.22E-5
11 SGTC_87 0100-0052 4.01 35.5 µM 7.94E-5 102 3.02E-5
12 SGTC_2933 9026794 3.89 32.5 µM 1.27E-4 21 5.11E-5
13 SGTC_2651 1327-0036 3.79 5.0 µM 1.78E-4 171 7.46E-5
14 SGTC_2273 7815444 3.67 169.1 µM 2.71E-4 32 1.19E-4
15 SGTC_2605 digitonin 3.67 300.0 nM 2.76E-4 40 1.22E-4
16 SGTC_2691 st077356 3.67 60.2 µM 2.77E-4 39 1.22E-4
17 SGTC_1739 st037196 3.62 92.5 µM 3.33E-4 34 1.50E-4
18 SGTC_2458 5808907 3.59 16.4 µM 3.57E-4 10 1.62E-4
19 SGTC_453 enantio-paf c16 3.55 10.0 µM 4.11E-4 183 1.90E-4
20 SGTC_2567 aureobasidin a 3.53 60.0 nM 4.39E-4 112 2.05E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 9.36E-15 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.113 4.95E-11 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.101 4.88E-9 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.101 5.19E-9 YGL259W_p YPS5_p hom Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p
0.099 1.03E-8 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.099 1.07E-8 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.091 1.14E-7 YDL242W_d YDL242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.091 1.21E-7 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.090 1.53E-7 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.090 2.03E-7 YOL122C SMF1 hom Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
0.088 2.84E-7 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.084 1.13E-6 YER072W VTC1 hom Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress
0.082 1.83E-6 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.081 2.84E-6 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.080 3.83E-6 YDL002C NHP10 hom Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair