HIPHOP chemogenomics database

YER006W / NUG1

GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus

Zygosity: Heterozygous strain

fixedexpanded
Profile for YER006W / NUG1

Click on Significant Values for Screen Details

Top fitness defect scores for YER006W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_969	1313-0238	10.20	134.0 µM	3.10E-26	mitochondrial processes	2	1.22E-24	1.43
2	SGTC_2586	curcumin	6.56	80.0 µM	5.62E-12	iron homeostasis	2	2.66E-11	0.65
3	SGTC_2964	9083345	5.93	53.4 µM	4.27E-10		4	1.53E-9	0.19
4	SGTC_2896	9052656	5.48	71.4 µM	7.19E-9	endomembrane recycling	13	2.16E-8	0.08
5	SGTC_1635	st007035	5.41	42.4 µM	1.10E-8		10	3.22E-8	0.14
6	SGTC_146	3448-8650	5.38	53.1 µM	1.31E-8	NEO1-PIK1	6	3.78E-8	0.29
7	SGTC_3207	9114163	5.29	49.5 µM	2.22E-8		4	6.18E-8	0.45
8	SGTC_2959	9079155	5.06	11.0 µM	8.02E-8		5	2.06E-7	0.26
9	SGTC_1330	1469-0054	5.00	61.8 µM	1.15E-7	iron homeostasis	2	2.88E-7	0.26
10	SGTC_431	k089-0097	4.89	107.0 µM	2.09E-7	iron homeostasis	6	5.05E-7	0.26
11	SGTC_1810	st050138	4.85	53.0 µM	2.62E-7	PDR1	2	6.25E-7	0.86
12	SGTC_2131	toluylene red	4.82	5.3 µM	3.10E-7	60S ribosome export	10	7.30E-7	0.33
13	SGTC_2530	3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene	4.75	92.6 µM	4.30E-7		6	9.93E-7	0.06
14	SGTC_2458	5808907	4.56	16.4 µM	1.18E-6		1	2.56E-6	0.32
15	SGTC_2376	9072922	4.52	81.3 µM	1.43E-6		2	3.07E-6	0.46
16	SGTC_2757	clomiphene	4.41	4.2 µM	2.45E-6	fatty acid desaturase (OLE1)	5	5.07E-6	0.00
17	SGTC_3208	9114115	4.30	49.5 µM	4.22E-6		7	8.44E-6	0.11
18	SGTC_3061	glucosamine	4.07	200.0 µM	1.25E-5		1	2.33E-5	0.38
19	SGTC_706	4262-0057	3.88	46.9 µM	2.90E-5	fatty acid desaturase (OLE1)	10	5.14E-5	0.39
20	SGTC_1524	corynanthine	3.77	62.1 µM	4.74E-5		6	8.14E-5	0.02

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.131	2.13E-14	YNR018W	RCF2	hom	Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.120	3.21E-12	YMR151W_d	YIM2_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.112	7.03E-11	YAL037W_p	YAL037W_p	hom	Putative protein of unknown function; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication
0.111	9.82E-11	YEL059C-A	SOM1	hom	Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.110	1.72E-10	YML062C	MFT1	hom	Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.110	1.72E-10	YLL009C	COX17	hom	Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.107	5.80E-10	YNL044W	YIP3	hom	Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
0.101	3.93E-9	YNL183C	NPR1	hom	Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.100	5.73E-9	YPL189C-A	COA2	hom	Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.100	6.50E-9	YMR043W	MCM1	het	Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes
0.100	6.61E-9	YIL105C	SLM1	hom	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.097	1.69E-8	YDR256C	CTA1	hom	Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation
0.097	1.86E-8	YHL019C	APM2	hom	Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.097	2.12E-8	YJL094C	KHA1	hom	Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.095	3.33E-8	YDR289C	RTT103	hom	Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition