HIPHOP chemogenomics database

YER007C-A / TMA20

Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YER007C-A / TMA20

Click on Significant Values for Screen Details

Top fitness defect scores for YER007C-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_3224	9130643	6.64	49.5 µM	9.10E-12	RPP1 & pyrimidine depletion	4	1.62E-11
2	SGTC_152	4469-0003	5.70	551.2 µM	3.88E-9		6	6.11E-9
3	SGTC_3190	9110366	5.06	49.5 µM	1.41E-7		4	2.07E-7
4	SGTC_1994	st072947	4.99	40.9 µM	2.06E-7		5	2.99E-7
5	SGTC_2832	7992762	4.98	52.0 µM	2.18E-7		12	3.16E-7
6	SGTC_3218	9131285	4.74	49.5 µM	7.74E-7	endomembrane recycling	22	1.09E-6
7	SGTC_2550	chrysin dimethyl ether	4.71	71.9 µM	8.84E-7		5	1.24E-6
8	SGTC_1849	st056239	4.67	19.2 µM	1.07E-6	RPP1 & pyrimidine depletion	10	1.50E-6
9	SGTC_151	3013-0144	4.50	2.3 µM	2.45E-6	iron homeostasis	13	3.38E-6
10	SGTC_791	1348-1292	4.50	225.0 µM	2.52E-6		24	3.47E-6
11	SGTC_2819	7996655	4.33	46.4 µM	5.44E-6		16	7.38E-6
12	SGTC_1516	st013856	4.28	110.0 µM	7.00E-6		10	9.43E-6
13	SGTC_1671	st016596	4.26	74.5 µM	7.70E-6		13	1.04E-5
14	SGTC_1848	st056003	4.21	16.4 µM	9.53E-6		9	1.28E-5
15	SGTC_1010	4112-3296	4.04	15.2 µM	2.05E-5		16	2.70E-5
16	SGTC_2187	6125751	4.00	200.0 µM	2.42E-5	RSC complex & mRNA processing	16	3.18E-5
17	SGTC_1367	1812-0510	3.87	76.9 µM	4.22E-5		23	5.47E-5
18	SGTC_2800	7887935	3.86	81.8 µM	4.37E-5	RPP1 & pyrimidine depletion	38	5.66E-5
19	SGTC_146	3448-8650	3.86	53.1 µM	4.44E-5	NEO1-PIK1	143	5.75E-5
20	SGTC_1552	6-methylflavone	3.77	10.6 µM	6.49E-5	superoxide	18	8.33E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.117	1.18E-11	YER034W	YER034W	hom	Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress
0.116	1.78E-11	YDR372C	VPS74	hom	Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.109	2.40E-10	YOR293W	RPS10A	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.097	2.05E-8	YPR126C_d	YPR126C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096	2.75E-8	YNL038W	GPI15	het	Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein
0.090	1.51E-7	YHL047C	ARN2	hom	Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
0.089	2.15E-7	YDR163W	CWC15	hom	Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p
0.086	6.35E-7	YDR229W	IVY1	hom	Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase
0.081	2.62E-6	YJR035W	RAD26	hom	Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
0.080	3.08E-6	YNL067W	RPL9B	hom	Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.080	3.53E-6	YOR073W	SGO1	hom	Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.080	3.58E-6	YPL208W	RKM1	hom	SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)
0.079	4.39E-6	YML115C	VAN1	hom	Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant
0.079	4.45E-6	YOR234C	RPL33B	hom	Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.079	4.89E-6	YLR315W	NKP2	hom	Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2