YER007C-A / TMA20

Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YER007C-A / TMA20

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-4.58|P-value:2.32E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.44|P-value:2.92E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.08|P-value:8.54E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.86|P-value:4.44E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:4.50|P-value:2.45E-6 ID:SGTC_152|Compound:4469-0003|FD-Score:5.70|P-value:3.88E-9 ID:SGTC_196|Compound:k015-0023|FD-Score:3.07|P-value:8.80E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.33|P-value:7.47E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:-3.51|P-value:2.26E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.32|P-value:7.77E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:-4.18|P-value:1.44E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:3.14|P-value:6.83E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.20|P-value:5.58E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:4.50|P-value:2.52E-6 ID:SGTC_812|Compound:4251-0442|FD-Score:3.11|P-value:7.67E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.19|P-value:7.27E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.47|P-value:2.05E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:4.04|P-value:2.05E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.41|P-value:2.63E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.07|P-value:8.78E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.21|P-value:5.41E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.47|P-value:2.08E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.26|P-value:5.73E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.25|P-value:4.75E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.53|P-value:1.64E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.87|P-value:4.22E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.52|P-value:2.16E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.35|P-value:3.21E-4 ID:SGTC_1516|Compound:st013856|FD-Score:4.28|P-value:7.00E-6 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.48|P-value:2.02E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.77|P-value:6.49E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.39|P-value:2.81E-4 ID:SGTC_1671|Compound:st016596|FD-Score:4.26|P-value:7.70E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.09|P-value:8.37E-4 ID:SGTC_1848|Compound:st056003|FD-Score:4.21|P-value:9.53E-6 ID:SGTC_1849|Compound:st056239|FD-Score:4.67|P-value:1.07E-6 ID:SGTC_1957|Compound:st077035|FD-Score:-3.27|P-value:5.44E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.06|P-value:9.23E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.36|P-value:3.11E-4 ID:SGTC_1994|Compound:st072947|FD-Score:4.99|P-value:2.06E-7 ID:SGTC_2023|Compound:5144124|FD-Score:3.48|P-value:1.97E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.55|P-value:1.53E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.71|P-value:8.23E-5 ID:SGTC_2092|Compound:5303694|FD-Score:-3.63|P-value:1.45E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.46|P-value:2.17E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.71|P-value:8.22E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.29|P-value:4.01E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-4.09|P-value:2.15E-5 ID:SGTC_2187|Compound:6125751|FD-Score:4.00|P-value:2.42E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-4.22|P-value:1.20E-5 ID:SGTC_2287|Compound:7945887|FD-Score:-3.36|P-value:3.95E-4 ID:SGTC_2438|Compound:5259590|FD-Score:-3.11|P-value:9.66E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.17|P-value:6.33E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:4.71|P-value:8.84E-7 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.33|P-value:7.47E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.72|P-value:7.80E-5 ID:SGTC_2800|Compound:7887935|FD-Score:3.86|P-value:4.37E-5 ID:SGTC_2819|Compound:7996655|FD-Score:4.33|P-value:5.44E-6 ID:SGTC_2821|Compound:7996764|FD-Score:-3.85|P-value:6.02E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-4.89|P-value:4.99E-7 ID:SGTC_2832|Compound:7992762|FD-Score:4.98|P-value:2.18E-7 ID:SGTC_2968|Compound:9090663|FD-Score:3.65|P-value:1.03E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.64|P-value:1.06E-4 ID:SGTC_3190|Compound:9110366|FD-Score:5.06|P-value:1.41E-7 ID:SGTC_3218|Compound:9131285|FD-Score:4.74|P-value:7.74E-7 ID:SGTC_3224|Compound:9130643|FD-Score:6.64|P-value:9.10E-12 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.58|P-value:2.32E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.44|P-value:2.92E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.08|P-value:8.54E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.86|P-value:4.44E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:4.50|P-value:2.45E-6 ID:SGTC_152|Compound:4469-0003|FD-Score:5.70|P-value:3.88E-9 ID:SGTC_196|Compound:k015-0023|FD-Score:3.07|P-value:8.80E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.33|P-value:7.47E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:-3.51|P-value:2.26E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.32|P-value:7.77E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:-4.18|P-value:1.44E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:3.14|P-value:6.83E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.20|P-value:5.58E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:4.50|P-value:2.52E-6 ID:SGTC_812|Compound:4251-0442|FD-Score:3.11|P-value:7.67E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.19|P-value:7.27E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.47|P-value:2.05E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:4.04|P-value:2.05E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.41|P-value:2.63E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.07|P-value:8.78E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.21|P-value:5.41E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.47|P-value:2.08E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.26|P-value:5.73E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.25|P-value:4.75E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.53|P-value:1.64E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.87|P-value:4.22E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.52|P-value:2.16E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.35|P-value:3.21E-4 ID:SGTC_1516|Compound:st013856|FD-Score:4.28|P-value:7.00E-6 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.48|P-value:2.02E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.77|P-value:6.49E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.39|P-value:2.81E-4 ID:SGTC_1671|Compound:st016596|FD-Score:4.26|P-value:7.70E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.09|P-value:8.37E-4 ID:SGTC_1848|Compound:st056003|FD-Score:4.21|P-value:9.53E-6 ID:SGTC_1849|Compound:st056239|FD-Score:4.67|P-value:1.07E-6 ID:SGTC_1957|Compound:st077035|FD-Score:-3.27|P-value:5.44E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.06|P-value:9.23E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.36|P-value:3.11E-4 ID:SGTC_1994|Compound:st072947|FD-Score:4.99|P-value:2.06E-7 ID:SGTC_2023|Compound:5144124|FD-Score:3.48|P-value:1.97E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.55|P-value:1.53E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.71|P-value:8.23E-5 ID:SGTC_2092|Compound:5303694|FD-Score:-3.63|P-value:1.45E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.46|P-value:2.17E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.71|P-value:8.22E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.29|P-value:4.01E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-4.09|P-value:2.15E-5 ID:SGTC_2187|Compound:6125751|FD-Score:4.00|P-value:2.42E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-4.22|P-value:1.20E-5 ID:SGTC_2287|Compound:7945887|FD-Score:-3.36|P-value:3.95E-4 ID:SGTC_2438|Compound:5259590|FD-Score:-3.11|P-value:9.66E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.17|P-value:6.33E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:4.71|P-value:8.84E-7 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.33|P-value:7.47E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.72|P-value:7.80E-5 ID:SGTC_2800|Compound:7887935|FD-Score:3.86|P-value:4.37E-5 ID:SGTC_2819|Compound:7996655|FD-Score:4.33|P-value:5.44E-6 ID:SGTC_2821|Compound:7996764|FD-Score:-3.85|P-value:6.02E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-4.89|P-value:4.99E-7 ID:SGTC_2832|Compound:7992762|FD-Score:4.98|P-value:2.18E-7 ID:SGTC_2968|Compound:9090663|FD-Score:3.65|P-value:1.03E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.64|P-value:1.06E-4 ID:SGTC_3190|Compound:9110366|FD-Score:5.06|P-value:1.41E-7 ID:SGTC_3218|Compound:9131285|FD-Score:4.74|P-value:7.74E-7 ID:SGTC_3224|Compound:9130643|FD-Score:6.64|P-value:9.10E-12

Top fitness defect scores for YER007C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3224 9130643 6.64 49.5 µM 9.10E-12 RPP1 & pyrimidine depletion 4 1.62E-11
2 SGTC_152 4469-0003 5.70 551.2 µM 3.88E-9 6 6.11E-9
3 SGTC_3190 9110366 5.06 49.5 µM 1.41E-7 4 2.07E-7
4 SGTC_1994 st072947 4.99 40.9 µM 2.06E-7 5 2.99E-7
5 SGTC_2832 7992762 4.98 52.0 µM 2.18E-7 12 3.16E-7
6 SGTC_3218 9131285 4.74 49.5 µM 7.74E-7 endomembrane recycling 22 1.09E-6
7 SGTC_2550 chrysin dimethyl ether 4.71 71.9 µM 8.84E-7 5 1.24E-6
8 SGTC_1849 st056239 4.67 19.2 µM 1.07E-6 RPP1 & pyrimidine depletion 10 1.50E-6
9 SGTC_151 3013-0144 4.50 2.3 µM 2.45E-6 iron homeostasis 13 3.38E-6
10 SGTC_791 1348-1292 4.50 225.0 µM 2.52E-6 24 3.47E-6
11 SGTC_2819 7996655 4.33 46.4 µM 5.44E-6 16 7.38E-6
12 SGTC_1516 st013856 4.28 110.0 µM 7.00E-6 10 9.43E-6
13 SGTC_1671 st016596 4.26 74.5 µM 7.70E-6 13 1.04E-5
14 SGTC_1848 st056003 4.21 16.4 µM 9.53E-6 9 1.28E-5
15 SGTC_1010 4112-3296 4.04 15.2 µM 2.05E-5 16 2.70E-5
16 SGTC_2187 6125751 4.00 200.0 µM 2.42E-5 RSC complex & mRNA processing 16 3.18E-5
17 SGTC_1367 1812-0510 3.87 76.9 µM 4.22E-5 23 5.47E-5
18 SGTC_2800 7887935 3.86 81.8 µM 4.37E-5 RPP1 & pyrimidine depletion 38 5.66E-5
19 SGTC_146 3448-8650 3.86 53.1 µM 4.44E-5 NEO1-PIK1 143 5.75E-5
20 SGTC_1552 6-methylflavone 3.77 10.6 µM 6.49E-5 superoxide 18 8.33E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.18E-11 YER034W YER034W hom Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress
0.116 1.78E-11 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.109 2.40E-10 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.097 2.05E-8 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096 2.75E-8 YNL038W GPI15 het Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein
0.090 1.51E-7 YHL047C ARN2 hom Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
0.089 2.15E-7 YDR163W CWC15 hom Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p
0.086 6.35E-7 YDR229W IVY1 hom Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase
0.081 2.62E-6 YJR035W RAD26 hom Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
0.080 3.08E-6 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.080 3.53E-6 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.080 3.58E-6 YPL208W RKM1 hom SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)
0.079 4.39E-6 YML115C VAN1 hom Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant
0.079 4.45E-6 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.079 4.89E-6 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2