YER010C

Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction

Zygosity: Homozygous strain
fixedexpanded
Profile for YER010C / YER010C

Click on Significant Values for Screen Details ID:SGTC_27|Compound:0485-0001|FD-Score:3.51|P-value:3.21E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:5.44|P-value:6.36E-8 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.35|P-value:6.11E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.78|P-value:1.19E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.56|P-value:2.72E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.72|P-value:1.50E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:4.13|P-value:2.92E-5 ID:SGTC_389|Compound:tpck|FD-Score:-3.39|P-value:5.41E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.40|P-value:5.23E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-4.29|P-value:1.71E-5 ID:SGTC_500|Compound:h-89|FD-Score:5.15|P-value:2.82E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:3.36|P-value:5.43E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.52|P-value:3.06E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.19|P-value:2.36E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:3.39|P-value:4.87E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.61|P-value:2.24E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.30|P-value:7.40E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.64|P-value:2.21E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.15|P-value:2.76E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.98|P-value:5.46E-5 ID:SGTC_1734|Compound:st037168|FD-Score:-3.31|P-value:7.12E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.57|P-value:2.60E-4 ID:SGTC_1826|Compound:st055655|FD-Score:5.16|P-value:2.66E-7 ID:SGTC_1862|Compound:st057513|FD-Score:3.63|P-value:2.10E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.42|P-value:4.37E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.58|P-value:2.47E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.28|P-value:7.03E-4 ID:SGTC_2097|Compound:5376186|FD-Score:-3.43|P-value:4.64E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.56|P-value:2.98E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.29|P-value:6.83E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.16|P-value:2.67E-5 ID:SGTC_2473|Compound:5854593|FD-Score:3.68|P-value:1.75E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.26|P-value:7.47E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-3.33|P-value:6.52E-4 ID:SGTC_3159|Compound:9100096|FD-Score:4.04|P-value:4.33E-5 ID:SGTC_3163|Compound:9099914|FD-Score:3.29|P-value:6.91E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:3.51|P-value:3.21E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:5.44|P-value:6.36E-8 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.35|P-value:6.11E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.78|P-value:1.19E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.56|P-value:2.72E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.72|P-value:1.50E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:4.13|P-value:2.92E-5 ID:SGTC_389|Compound:tpck|FD-Score:-3.39|P-value:5.41E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.40|P-value:5.23E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-4.29|P-value:1.71E-5 ID:SGTC_500|Compound:h-89|FD-Score:5.15|P-value:2.82E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:3.36|P-value:5.43E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.52|P-value:3.06E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.19|P-value:2.36E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:3.39|P-value:4.87E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.61|P-value:2.24E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.30|P-value:7.40E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.64|P-value:2.21E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.15|P-value:2.76E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.98|P-value:5.46E-5 ID:SGTC_1734|Compound:st037168|FD-Score:-3.31|P-value:7.12E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.57|P-value:2.60E-4 ID:SGTC_1826|Compound:st055655|FD-Score:5.16|P-value:2.66E-7 ID:SGTC_1862|Compound:st057513|FD-Score:3.63|P-value:2.10E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.42|P-value:4.37E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.58|P-value:2.47E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.28|P-value:7.03E-4 ID:SGTC_2097|Compound:5376186|FD-Score:-3.43|P-value:4.64E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.56|P-value:2.98E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.29|P-value:6.83E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.16|P-value:2.67E-5 ID:SGTC_2473|Compound:5854593|FD-Score:3.68|P-value:1.75E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.26|P-value:7.47E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-3.33|P-value:6.52E-4 ID:SGTC_3159|Compound:9100096|FD-Score:4.04|P-value:4.33E-5 ID:SGTC_3163|Compound:9099914|FD-Score:3.29|P-value:6.91E-4

Top fitness defect scores for YER010C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_98 0074-0023 5.44 107.7 µM 6.36E-8 Golgi 16 2.68E-8
2 SGTC_1826 st055655 5.16 41.6 µM 2.66E-7 ERG2 20 1.22E-7
3 SGTC_500 h-89 5.15 112.0 µM 2.82E-7 cell wall signaling 16 1.30E-7
4 SGTC_651 3253-0966 4.19 34.4 µM 2.36E-5 calcium & mitochondrial duress 27 1.42E-5
5 SGTC_2467 5474540 4.16 200.0 µM 2.67E-5 13 1.62E-5
6 SGTC_1017 4239-0030 4.15 168.0 µM 2.76E-5 24 1.67E-5
7 SGTC_338 4055-0136 4.13 114.0 µM 2.92E-5 6 1.78E-5
8 SGTC_3159 9100096 4.04 49.5 µM 4.33E-5 17 2.70E-5
9 SGTC_1248 0469-0687 3.98 58.6 µM 5.46E-5 29 3.45E-5
10 SGTC_176 1486-1328 3.78 72.8 µM 1.19E-4 61 7.87E-5
11 SGTC_196 k015-0023 3.72 18.1 µM 1.50E-4 PDR1 28 1.00E-4
12 SGTC_2473 5854593 3.68 8.9 µM 1.75E-4 17 1.19E-4
13 SGTC_1862 st057513 3.63 3.8 µM 2.10E-4 18 1.43E-4
14 SGTC_711 k292-0785 3.61 179.0 µM 2.24E-4 DNA intercalators 32 1.54E-4
15 SGTC_1993 st073995 3.58 70.8 µM 2.47E-4 30 1.70E-4
16 SGTC_1737 st035557 3.57 69.7 µM 2.60E-4 22 1.80E-4
17 SGTC_188 3229-0966 3.56 278.5 µM 2.72E-4 36 1.88E-4
18 SGTC_646 4092-0839 3.52 27.3 µM 3.06E-4 plasma membrane duress 38 2.14E-4
19 SGTC_27 0485-0001 3.51 32.6 µM 3.21E-4 RPP1 & pyrimidine depletion 9 2.25E-4
20 SGTC_1966 st070145 3.42 16.1 µM 4.37E-4 41 3.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.087 4.40E-7 YKL174C TPO5 hom Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles
0.083 1.65E-6 YLR459W GAB1 het GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI
0.079 4.17E-6 YIL037C PRM2 hom Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion
0.074 1.67E-5 YEL053C MAK10 hom Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
0.071 4.01E-5 YJR021C REC107 hom Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation
0.071 4.05E-5 YML038C YMD8 hom Putative nucleotide sugar transporter, has similarity to Vrg4p
0.068 7.63E-5 YLR403W SFP1 hom Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion
0.067 1.01E-4 YOR276W CAF20 hom Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
0.067 1.07E-4 YOR325W_d YOR325W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1
0.067 1.08E-4 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.065 1.54E-4 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
0.065 1.75E-4 YIL127C_p RRT14_p hom Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.064 2.25E-4 YLR174W IDP2 hom Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication
0.063 2.42E-4 YOR361C PRT1 het eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
0.063 2.49E-4 YDR304C CPR5 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER