YER014W / HEM14

Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides

Zygosity: Homozygous strain
fixedexpanded
Profile for YER014W / HEM14

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:5.08|P-value:2.73E-6 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.85|P-value:2.81E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.79|P-value:3.49E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:-3.50|P-value:8.72E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-8.27|P-value:6.95E-14 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.53|P-value:7.97E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.68|P-value:1.39E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:-3.56|P-value:7.29E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.31|P-value:5.72E-5 ID:SGTC_466|Compound:geldanamycin|FD-Score:4.94|P-value:4.95E-6 ID:SGTC_489|Compound:paxilline|FD-Score:-3.92|P-value:2.30E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-7.99|P-value:4.31E-13 ID:SGTC_779|Compound:1360-0071|FD-Score:-4.07|P-value:1.34E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:5.18|P-value:1.80E-6 ID:SGTC_954|Compound:1189-0853|FD-Score:4.08|P-value:1.31E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:8.00|P-value:4.20E-13 ID:SGTC_995|Compound:3931-2021|FD-Score:-4.60|P-value:1.93E-5 ID:SGTC_1081|Compound:sertraline|FD-Score:4.01|P-value:1.68E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.82|P-value:3.13E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:5.35|P-value:8.77E-7 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.66|P-value:5.31E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.62|P-value:6.11E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.65|P-value:5.57E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.98|P-value:1.86E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:-4.11|P-value:1.17E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-4.08|P-value:1.30E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.83|P-value:3.09E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.56|P-value:7.26E-4 ID:SGTC_1826|Compound:st055655|FD-Score:4.92|P-value:5.36E-6 ID:SGTC_1848|Compound:st056003|FD-Score:3.91|P-value:2.35E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-4.64|P-value:1.67E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-4.57|P-value:2.16E-5 ID:SGTC_2008|Compound:4012253|FD-Score:3.62|P-value:5.98E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-3.64|P-value:5.71E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.54|P-value:7.73E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.59|P-value:6.67E-4 ID:SGTC_2273|Compound:7815444|FD-Score:4.32|P-value:5.72E-5 ID:SGTC_2310|Compound:7668677|FD-Score:4.25|P-value:7.26E-5 ID:SGTC_2341|Compound:7987486|FD-Score:-3.58|P-value:6.79E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.27|P-value:1.24E-6 ID:SGTC_2413|Compound:inermin|FD-Score:-5.87|P-value:7.47E-8 ID:SGTC_2424|Compound:5537928|FD-Score:4.06|P-value:1.41E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-3.53|P-value:8.02E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-3.87|P-value:2.71E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.56|P-value:7.30E-4 ID:SGTC_2505|Compound:galangin|FD-Score:4.27|P-value:6.85E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.47|P-value:9.53E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.01|P-value:1.67E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.83|P-value:3.04E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-4.17|P-value:9.43E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.67|P-value:5.25E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:5.16|P-value:2.01E-6 ID:SGTC_2780|Compound:5215298|FD-Score:4.37|P-value:4.71E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-6.38|P-value:5.87E-9 ID:SGTC_2875|Compound:9039966|FD-Score:3.63|P-value:5.84E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.25|P-value:7.15E-5 ID:SGTC_2910|Compound:7948405|FD-Score:5.14|P-value:2.13E-6 ID:SGTC_3019|Compound:9081971|FD-Score:5.23|P-value:1.43E-6 ID:SGTC_3033|Compound:9090887|FD-Score:4.45|P-value:3.48E-5 ID:SGTC_3099|Compound:9120367|FD-Score:4.18|P-value:9.46E-5 ID:SGTC_3128|Compound:9127691|FD-Score:3.96|P-value:2.03E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-4.21|P-value:8.34E-5 ID:SGTC_3173|Compound:9105693|FD-Score:-3.51|P-value:8.32E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-4.52|P-value:2.60E-5 ID:SGTC_3259|Compound:9138485|FD-Score:-3.52|P-value:8.20E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.50|P-value:8.87E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:5.08|P-value:2.73E-6 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.85|P-value:2.81E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.79|P-value:3.49E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:-3.50|P-value:8.72E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-8.27|P-value:6.95E-14 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.53|P-value:7.97E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.68|P-value:1.39E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:-3.56|P-value:7.29E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.31|P-value:5.72E-5 ID:SGTC_466|Compound:geldanamycin|FD-Score:4.94|P-value:4.95E-6 ID:SGTC_489|Compound:paxilline|FD-Score:-3.92|P-value:2.30E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-7.99|P-value:4.31E-13 ID:SGTC_779|Compound:1360-0071|FD-Score:-4.07|P-value:1.34E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:5.18|P-value:1.80E-6 ID:SGTC_954|Compound:1189-0853|FD-Score:4.08|P-value:1.31E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:8.00|P-value:4.20E-13 ID:SGTC_995|Compound:3931-2021|FD-Score:-4.60|P-value:1.93E-5 ID:SGTC_1081|Compound:sertraline|FD-Score:4.01|P-value:1.68E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.82|P-value:3.13E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:5.35|P-value:8.77E-7 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.66|P-value:5.31E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.62|P-value:6.11E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.65|P-value:5.57E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.98|P-value:1.86E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:-4.11|P-value:1.17E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-4.08|P-value:1.30E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.83|P-value:3.09E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.56|P-value:7.26E-4 ID:SGTC_1826|Compound:st055655|FD-Score:4.92|P-value:5.36E-6 ID:SGTC_1848|Compound:st056003|FD-Score:3.91|P-value:2.35E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-4.64|P-value:1.67E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-4.57|P-value:2.16E-5 ID:SGTC_2008|Compound:4012253|FD-Score:3.62|P-value:5.98E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-3.64|P-value:5.71E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.54|P-value:7.73E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.59|P-value:6.67E-4 ID:SGTC_2273|Compound:7815444|FD-Score:4.32|P-value:5.72E-5 ID:SGTC_2310|Compound:7668677|FD-Score:4.25|P-value:7.26E-5 ID:SGTC_2341|Compound:7987486|FD-Score:-3.58|P-value:6.79E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.27|P-value:1.24E-6 ID:SGTC_2413|Compound:inermin|FD-Score:-5.87|P-value:7.47E-8 ID:SGTC_2424|Compound:5537928|FD-Score:4.06|P-value:1.41E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-3.53|P-value:8.02E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-3.87|P-value:2.71E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.56|P-value:7.30E-4 ID:SGTC_2505|Compound:galangin|FD-Score:4.27|P-value:6.85E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.47|P-value:9.53E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.01|P-value:1.67E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.83|P-value:3.04E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-4.17|P-value:9.43E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.67|P-value:5.25E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:5.16|P-value:2.01E-6 ID:SGTC_2780|Compound:5215298|FD-Score:4.37|P-value:4.71E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-6.38|P-value:5.87E-9 ID:SGTC_2875|Compound:9039966|FD-Score:3.63|P-value:5.84E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.25|P-value:7.15E-5 ID:SGTC_2910|Compound:7948405|FD-Score:5.14|P-value:2.13E-6 ID:SGTC_3019|Compound:9081971|FD-Score:5.23|P-value:1.43E-6 ID:SGTC_3033|Compound:9090887|FD-Score:4.45|P-value:3.48E-5 ID:SGTC_3099|Compound:9120367|FD-Score:4.18|P-value:9.46E-5 ID:SGTC_3128|Compound:9127691|FD-Score:3.96|P-value:2.03E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-4.21|P-value:8.34E-5 ID:SGTC_3173|Compound:9105693|FD-Score:-3.51|P-value:8.32E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-4.52|P-value:2.60E-5 ID:SGTC_3259|Compound:9138485|FD-Score:-3.52|P-value:8.20E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.50|P-value:8.87E-4

Top fitness defect scores for YER014W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_992 3909-8734 8.00 162.0 µM 4.20E-13 1 6.16E-16
2 SGTC_1381 2324-0066 5.35 62.1 µM 8.77E-7 9 4.50E-8
3 SGTC_2406 ethylparaben 5.27 405.7 µM 1.24E-6 16 6.92E-8
4 SGTC_3019 9081971 5.23 49.5 µM 1.43E-6 5 8.27E-8
5 SGTC_928 2764-0428 5.18 58.7 µM 1.80E-6 cell wall 25 1.10E-7
6 SGTC_2626 ethyl orsellinate 5.16 100.0 µM 2.01E-6 12 1.26E-7
7 SGTC_2910 7948405 5.14 26.0 µM 2.13E-6 plasma membrane duress 12 1.35E-7
8 SGTC_18 0111-0177 5.08 500.0 nM 2.73E-6 33 1.84E-7
9 SGTC_466 geldanamycin 4.94 89.2 µM 4.95E-6 RPP1 & pyrimidine depletion 2 3.84E-7
10 SGTC_1826 st055655 4.92 41.6 µM 5.36E-6 ERG2 25 4.24E-7
11 SGTC_3033 9090887 4.45 49.5 µM 3.48E-5 fatty acid desaturase (OLE1) 16 4.31E-6
12 SGTC_2780 5215298 4.37 71.4 µM 4.71E-5 26 6.27E-6
13 SGTC_2273 7815444 4.32 169.1 µM 5.72E-5 14 7.98E-6
14 SGTC_2505 galangin 4.27 7.9 µM 6.85E-5 RPP1 & pyrimidine depletion 6 9.96E-6
15 SGTC_2900 5328528 4.25 85.3 µM 7.15E-5 Golgi 25 1.05E-5
16 SGTC_2310 7668677 4.25 200.0 µM 7.26E-5 20 1.07E-5
17 SGTC_3099 9120367 4.18 49.5 µM 9.46E-5 14 1.49E-5
18 SGTC_954 1189-0853 4.08 2.9 µM 1.31E-4 endomembrane recycling 37 2.22E-5
19 SGTC_2424 5537928 4.06 59.2 µM 1.41E-4 35 2.43E-5
20 SGTC_1081 sertraline 4.01 6.0 µM 1.68E-4 60S ribosome export 34 3.03E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 2.47E-24 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.172 9.59E-24 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.139 7.52E-16 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.137 1.60E-15 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.134 6.14E-15 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.134 6.64E-15 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.133 8.69E-15 YLR440C SEC39 het Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
0.129 5.99E-14 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.125 4.55E-13 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.122 1.33E-12 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.121 2.03E-12 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.117 9.09E-12 YKL034W TUL1 hom Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1
0.117 1.04E-11 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.116 1.61E-11 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.115 2.10E-11 YCR015C_p YCR015C_p hom Putative protein of unknown function; YCR015C is not an essential gene