HIPHOP chemogenomics database

YER016W / BIM1

Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally

Zygosity: Homozygous strain

fixedexpanded
Profile for YER016W / BIM1

Click on Significant Values for Screen Details

Top fitness defect scores for YER016W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_625	k213-0058	12.40	121.0 µM	5.38E-38	translation	2	1.66E-35
2	SGTC_2040	5100729	9.84	123.0 µM	1.08E-24		3	3.96E-23
3	SGTC_2406	ethylparaben	8.17	405.7 µM	1.32E-17		2	1.57E-16
4	SGTC_2054	5233173	6.78	129.0 µM	1.10E-12	mitochondrial response to ROS	12	6.05E-12
5	SGTC_241	5hr heat shock (37°C) + cantharidin	6.30	155.4 µM	3.47E-11	cell wall signaling	29	1.50E-10
6	SGTC_268	camptothecin	6.16	39.6 µM	8.79E-11	DNA damage response	27	3.57E-10
7	SGTC_159	3970-0959	6.02	50.0 µM	2.26E-10		24	8.62E-10
8	SGTC_619	1652-1634	5.34	108.0 µM	1.65E-8	PDR1	4	4.71E-8
9	SGTC_2810	7959871	5.23	45.5 µM	3.07E-8	copper-dependent oxidative stress	16	8.40E-8
10	SGTC_1232	0279-0259	5.08	161.0 µM	7.13E-8		3	1.85E-7
11	SGTC_372	0155-0182	5.03	15.9 µM	9.64E-8	mitochondrial response to ROS	14	2.45E-7
12	SGTC_1707	st032323	5.02	6.3 µM	1.00E-7	DNA damage response	35	2.53E-7
13	SGTC_935	2996-0153	4.43	430.0 µM	2.31E-6	PDR1	13	4.75E-6
14	SGTC_956	1185-0240	4.12	191.0 µM	1.02E-5		21	1.91E-5
15	SGTC_634	1611-4317	4.06	11.2 µM	1.32E-5	ERG2	13	2.43E-5
16	SGTC_3058	9093861	4.05	49.5 µM	1.40E-5		14	2.57E-5
17	SGTC_1491	4138-0063	4.00	26.5 µM	1.74E-5		11	3.14E-5
18	SGTC_1238	0333-0287	4.00	48.8 µM	1.77E-5	Golgi	28	3.19E-5
19	SGTC_2400	5203494	3.99	178.7 µM	1.80E-5	RSC complex & mRNA processing	25	3.24E-5
20	SGTC_632	0781-2353	3.99	4.7 µM	1.83E-5	Golgi	43	3.28E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.163	2.15E-21	YDR281C	PHM6	hom	Protein of unknown function, expression is regulated by phosphate levels
0.146	2.01E-17	YPL017C	IRC15	hom	Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci
0.143	8.37E-17	YHR209W	CRG1	hom	S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.137	1.72E-15	YDR318W	MCM21	hom	Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2
0.133	9.36E-15	YPL047W	SGF11	hom	Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
0.131	2.12E-14	YLR027C	AAT2	hom	Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.117	1.29E-11	YDR381W	YRA1	het	RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.116	1.59E-11	YDR516C	EMI2	hom	Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.114	3.16E-11	YDR260C	SWM1	hom	Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.110	1.69E-10	YOR078W	BUD21	hom	Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
0.110	1.89E-10	YJR145C	RPS4A	hom	Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.110	1.99E-10	YDL059C	RAD59	hom	Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.109	2.45E-10	YBR098W	MMS4	hom	Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.108	3.99E-10	YMR048W	CSM3	hom	Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
0.104	1.44E-9	YIR021W-A_p	YIR021W-A_p	hom	Putative protein of unknown function; identified by expression profiling and mass spectrometry