YER016W / BIM1

Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally

Zygosity: Homozygous strain
fixedexpanded
Profile for YER016W / BIM1

Click on Significant Values for Screen Details ID:SGTC_60|Compound:0986-0278|FD-Score:3.18|P-value:5.11E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.20|P-value:4.22E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:6.02|P-value:2.26E-10 ID:SGTC_175|Compound:3793-3120|FD-Score:3.87|P-value:3.14E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.11|P-value:6.49E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:6.30|P-value:3.47E-11 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.05|P-value:8.13E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.66|P-value:7.55E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.28|P-value:3.49E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.63|P-value:8.71E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.06|P-value:7.89E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:6.16|P-value:8.79E-11 ID:SGTC_274|Compound:sirtinol|FD-Score:3.62|P-value:8.98E-5 ID:SGTC_283|Compound:0987-0079|FD-Score:3.04|P-value:8.37E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.09|P-value:6.52E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:5.03|P-value:9.64E-8 ID:SGTC_422|Compound:cantharidin|FD-Score:3.63|P-value:8.88E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.28|P-value:3.16E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.25|P-value:3.97E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-3.44|P-value:1.68E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:5.34|P-value:1.65E-8 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.51|P-value:1.29E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:-3.17|P-value:4.79E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:12.40|P-value:5.38E-38 ID:SGTC_632|Compound:0781-2353|FD-Score:3.99|P-value:1.83E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:4.06|P-value:1.32E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:4.43|P-value:2.31E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:4.12|P-value:1.02E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.36|P-value:2.54E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.98|P-value:1.94E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.41|P-value:2.11E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.13|P-value:6.03E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.13|P-value:6.20E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:-4.33|P-value:3.30E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.72|P-value:6.01E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:5.08|P-value:7.13E-8 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.00|P-value:1.77E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:-6.27|P-value:3.53E-11 ID:SGTC_1491|Compound:4138-0063|FD-Score:4.00|P-value:1.74E-5 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.14|P-value:5.85E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-8.33|P-value:2.41E-18 ID:SGTC_1642|Compound:st009582|FD-Score:3.19|P-value:4.88E-4 ID:SGTC_1707|Compound:st032323|FD-Score:5.02|P-value:1.00E-7 ID:SGTC_1745|Compound:st081495|FD-Score:-3.24|P-value:3.72E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-2.97|P-value:9.75E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.25|P-value:3.93E-4 ID:SGTC_2040|Compound:5100729|FD-Score:9.84|P-value:1.08E-24 ID:SGTC_2054|Compound:5233173|FD-Score:6.78|P-value:1.10E-12 ID:SGTC_2108|Compound:5365811|FD-Score:3.00|P-value:9.80E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.16|P-value:5.37E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.33|P-value:2.94E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-2.99|P-value:9.10E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-3.40|P-value:1.96E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.99|P-value:1.80E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:8.17|P-value:1.32E-17 ID:SGTC_2810|Compound:7959871|FD-Score:5.23|P-value:3.07E-8 ID:SGTC_2857|Compound:9024691|FD-Score:-3.51|P-value:1.27E-4 ID:SGTC_3058|Compound:9093861|FD-Score:4.05|P-value:1.40E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:3.18|P-value:5.11E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.20|P-value:4.22E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:6.02|P-value:2.26E-10 ID:SGTC_175|Compound:3793-3120|FD-Score:3.87|P-value:3.14E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.11|P-value:6.49E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:6.30|P-value:3.47E-11 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.05|P-value:8.13E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.66|P-value:7.55E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.28|P-value:3.49E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.63|P-value:8.71E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.06|P-value:7.89E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:6.16|P-value:8.79E-11 ID:SGTC_274|Compound:sirtinol|FD-Score:3.62|P-value:8.98E-5 ID:SGTC_283|Compound:0987-0079|FD-Score:3.04|P-value:8.37E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.09|P-value:6.52E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:5.03|P-value:9.64E-8 ID:SGTC_422|Compound:cantharidin|FD-Score:3.63|P-value:8.88E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.28|P-value:3.16E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.25|P-value:3.97E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-3.44|P-value:1.68E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:5.34|P-value:1.65E-8 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.51|P-value:1.29E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:-3.17|P-value:4.79E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:12.40|P-value:5.38E-38 ID:SGTC_632|Compound:0781-2353|FD-Score:3.99|P-value:1.83E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:4.06|P-value:1.32E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:4.43|P-value:2.31E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:4.12|P-value:1.02E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.36|P-value:2.54E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.98|P-value:1.94E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.41|P-value:2.11E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.13|P-value:6.03E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.13|P-value:6.20E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:-4.33|P-value:3.30E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.72|P-value:6.01E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:5.08|P-value:7.13E-8 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.00|P-value:1.77E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:-6.27|P-value:3.53E-11 ID:SGTC_1491|Compound:4138-0063|FD-Score:4.00|P-value:1.74E-5 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.14|P-value:5.85E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-8.33|P-value:2.41E-18 ID:SGTC_1642|Compound:st009582|FD-Score:3.19|P-value:4.88E-4 ID:SGTC_1707|Compound:st032323|FD-Score:5.02|P-value:1.00E-7 ID:SGTC_1745|Compound:st081495|FD-Score:-3.24|P-value:3.72E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-2.97|P-value:9.75E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.25|P-value:3.93E-4 ID:SGTC_2040|Compound:5100729|FD-Score:9.84|P-value:1.08E-24 ID:SGTC_2054|Compound:5233173|FD-Score:6.78|P-value:1.10E-12 ID:SGTC_2108|Compound:5365811|FD-Score:3.00|P-value:9.80E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.16|P-value:5.37E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.33|P-value:2.94E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-2.99|P-value:9.10E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-3.40|P-value:1.96E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.99|P-value:1.80E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:8.17|P-value:1.32E-17 ID:SGTC_2810|Compound:7959871|FD-Score:5.23|P-value:3.07E-8 ID:SGTC_2857|Compound:9024691|FD-Score:-3.51|P-value:1.27E-4 ID:SGTC_3058|Compound:9093861|FD-Score:4.05|P-value:1.40E-5

Top fitness defect scores for YER016W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_625 k213-0058 12.40 121.0 µM 5.38E-38 translation 2 1.66E-35
2 SGTC_2040 5100729 9.84 123.0 µM 1.08E-24 3 3.96E-23
3 SGTC_2406 ethylparaben 8.17 405.7 µM 1.32E-17 2 1.57E-16
4 SGTC_2054 5233173 6.78 129.0 µM 1.10E-12 mitochondrial response to ROS 12 6.05E-12
5 SGTC_241 5hr heat shock (37°C) + cantharidin 6.30 155.4 µM 3.47E-11 cell wall signaling 29 1.50E-10
6 SGTC_268 camptothecin 6.16 39.6 µM 8.79E-11 DNA damage response 27 3.57E-10
7 SGTC_159 3970-0959 6.02 50.0 µM 2.26E-10 24 8.62E-10
8 SGTC_619 1652-1634 5.34 108.0 µM 1.65E-8 PDR1 4 4.71E-8
9 SGTC_2810 7959871 5.23 45.5 µM 3.07E-8 copper-dependent oxidative stress 16 8.40E-8
10 SGTC_1232 0279-0259 5.08 161.0 µM 7.13E-8 3 1.85E-7
11 SGTC_372 0155-0182 5.03 15.9 µM 9.64E-8 mitochondrial response to ROS 14 2.45E-7
12 SGTC_1707 st032323 5.02 6.3 µM 1.00E-7 DNA damage response 35 2.53E-7
13 SGTC_935 2996-0153 4.43 430.0 µM 2.31E-6 PDR1 13 4.75E-6
14 SGTC_956 1185-0240 4.12 191.0 µM 1.02E-5 21 1.91E-5
15 SGTC_634 1611-4317 4.06 11.2 µM 1.32E-5 ERG2 13 2.43E-5
16 SGTC_3058 9093861 4.05 49.5 µM 1.40E-5 14 2.57E-5
17 SGTC_1491 4138-0063 4.00 26.5 µM 1.74E-5 11 3.14E-5
18 SGTC_1238 0333-0287 4.00 48.8 µM 1.77E-5 Golgi 28 3.19E-5
19 SGTC_2400 5203494 3.99 178.7 µM 1.80E-5 RSC complex & mRNA processing 25 3.24E-5
20 SGTC_632 0781-2353 3.99 4.7 µM 1.83E-5 Golgi 43 3.28E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 2.15E-21 YDR281C PHM6 hom Protein of unknown function, expression is regulated by phosphate levels
0.146 2.01E-17 YPL017C IRC15 hom Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci
0.143 8.37E-17 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.137 1.72E-15 YDR318W MCM21 hom Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2
0.133 9.36E-15 YPL047W SGF11 hom Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
0.131 2.12E-14 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.117 1.29E-11 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.116 1.59E-11 YDR516C EMI2 hom Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.114 3.16E-11 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.110 1.69E-10 YOR078W BUD21 hom Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
0.110 1.89E-10 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.110 1.99E-10 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.109 2.45E-10 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.108 3.99E-10 YMR048W CSM3 hom Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
0.104 1.44E-9 YIR021W-A_p YIR021W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry