YER022W / SRB4

Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination

Zygosity: Heterozygous strain
fixedexpanded
Profile for YER022W / SRB4

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.26|P-value:2.67E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.73|P-value:2.66E-7 ID:SGTC_157|Compound:1348-1695|FD-Score:4.49|P-value:9.09E-7 ID:SGTC_293|Compound:4049-0273|FD-Score:4.24|P-value:3.36E-6 ID:SGTC_302|Compound:1094-0063|FD-Score:5.15|P-value:2.23E-8 ID:SGTC_335|Compound:4077-0256|FD-Score:2.94|P-value:8.78E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.11|P-value:4.79E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.49|P-value:9.86E-7 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.75|P-value:3.36E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.12|P-value:4.81E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.33|P-value:1.99E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.23|P-value:3.17E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.36|P-value:1.80E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:9.75|P-value:2.05E-25 ID:SGTC_683|Compound:panaxydol|FD-Score:3.32|P-value:2.04E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:3.34|P-value:1.95E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:5.61|P-value:1.29E-9 ID:SGTC_759|Compound:3486-0358|FD-Score:3.84|P-value:2.22E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:3.41|P-value:1.43E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:2.91|P-value:9.74E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:-2.96|P-value:8.66E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:2.92|P-value:9.33E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.70|P-value:4.45E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:4.80|P-value:1.67E-7 ID:SGTC_839|Compound:0122-0028|FD-Score:3.84|P-value:2.22E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:3.21|P-value:3.19E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:-4.14|P-value:5.91E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:-6.22|P-value:2.23E-11 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.04|P-value:6.46E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.38|P-value:1.64E-6 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.38|P-value:1.65E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:5.13|P-value:2.55E-8 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.44|P-value:4.12E-9 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.31|P-value:2.20E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.38|P-value:1.64E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:5.39|P-value:5.28E-9 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:4.12|P-value:6.07E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.07|P-value:5.77E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.84|P-value:2.40E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:-3.02|P-value:7.07E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.18|P-value:3.61E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.56|P-value:7.84E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.13|P-value:2.53E-8 ID:SGTC_1520|Compound:flindersine|FD-Score:-4.10|P-value:6.95E-6 ID:SGTC_1687|Compound:st020778|FD-Score:4.04|P-value:8.76E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.33|P-value:2.09E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.04|P-value:6.44E-4 ID:SGTC_1909|Compound:st060837|FD-Score:6.70|P-value:5.38E-13 ID:SGTC_1910|Compound:st062352|FD-Score:3.71|P-value:3.98E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-2.97|P-value:8.33E-4 ID:SGTC_2015|Compound:5119600|FD-Score:2.94|P-value:8.96E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-3.68|P-value:4.98E-5 ID:SGTC_2023|Compound:5144124|FD-Score:-5.73|P-value:6.49E-10 ID:SGTC_2053|Compound:5265679|FD-Score:-3.36|P-value:1.85E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-4.34|P-value:2.11E-6 ID:SGTC_2105|Compound:5350118|FD-Score:-3.30|P-value:2.35E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.84|P-value:2.23E-5 ID:SGTC_2158|Compound:5657123|FD-Score:3.63|P-value:5.58E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.42|P-value:1.29E-6 ID:SGTC_2396|Compound:5342950|FD-Score:7.54|P-value:5.68E-16 ID:SGTC_2399|Compound:5884133|FD-Score:4.20|P-value:4.04E-6 ID:SGTC_2428|Compound:5615643|FD-Score:3.40|P-value:1.53E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.18|P-value:3.63E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.16|P-value:4.11E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.49|P-value:1.11E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.17|P-value:5.06E-6 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.22|P-value:3.23E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.10|P-value:7.09E-6 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.07|P-value:5.73E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.30|P-value:2.25E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.46|P-value:3.42E-12 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.46|P-value:1.26E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:-4.15|P-value:5.58E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:3.88|P-value:1.84E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.84|P-value:2.24E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.78|P-value:3.09E-5 ID:SGTC_2784|Compound:7567673|FD-Score:-3.11|P-value:4.96E-4 ID:SGTC_2787|Compound:5284540|FD-Score:9.44|P-value:5.84E-24 ID:SGTC_2789|Compound:5281112|FD-Score:6.68|P-value:6.62E-13 ID:SGTC_2791|Compound:5663188|FD-Score:4.95|P-value:7.22E-8 ID:SGTC_2833|Compound:9001315|FD-Score:-3.48|P-value:1.15E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-4.33|P-value:2.24E-6 ID:SGTC_2925|Compound:9010536|FD-Score:-7.56|P-value:5.51E-16 ID:SGTC_2997|Compound:9067075|FD-Score:4.27|P-value:2.78E-6 ID:SGTC_3073|Compound:9114972|FD-Score:3.73|P-value:3.63E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-3.36|P-value:1.86E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.42|P-value:1.49E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.26|P-value:2.67E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.73|P-value:2.66E-7 ID:SGTC_157|Compound:1348-1695|FD-Score:4.49|P-value:9.09E-7 ID:SGTC_293|Compound:4049-0273|FD-Score:4.24|P-value:3.36E-6 ID:SGTC_302|Compound:1094-0063|FD-Score:5.15|P-value:2.23E-8 ID:SGTC_335|Compound:4077-0256|FD-Score:2.94|P-value:8.78E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.11|P-value:4.79E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.49|P-value:9.86E-7 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.75|P-value:3.36E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.12|P-value:4.81E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.33|P-value:1.99E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.23|P-value:3.17E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.36|P-value:1.80E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:9.75|P-value:2.05E-25 ID:SGTC_683|Compound:panaxydol|FD-Score:3.32|P-value:2.04E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:3.34|P-value:1.95E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:5.61|P-value:1.29E-9 ID:SGTC_759|Compound:3486-0358|FD-Score:3.84|P-value:2.22E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:3.41|P-value:1.43E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:2.91|P-value:9.74E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:-2.96|P-value:8.66E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:2.92|P-value:9.33E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.70|P-value:4.45E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:4.80|P-value:1.67E-7 ID:SGTC_839|Compound:0122-0028|FD-Score:3.84|P-value:2.22E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:3.21|P-value:3.19E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:-4.14|P-value:5.91E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:-6.22|P-value:2.23E-11 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.04|P-value:6.46E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.38|P-value:1.64E-6 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.38|P-value:1.65E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:5.13|P-value:2.55E-8 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.44|P-value:4.12E-9 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.31|P-value:2.20E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.38|P-value:1.64E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:5.39|P-value:5.28E-9 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:4.12|P-value:6.07E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.07|P-value:5.77E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.84|P-value:2.40E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:-3.02|P-value:7.07E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.18|P-value:3.61E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.56|P-value:7.84E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.13|P-value:2.53E-8 ID:SGTC_1520|Compound:flindersine|FD-Score:-4.10|P-value:6.95E-6 ID:SGTC_1687|Compound:st020778|FD-Score:4.04|P-value:8.76E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.33|P-value:2.09E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.04|P-value:6.44E-4 ID:SGTC_1909|Compound:st060837|FD-Score:6.70|P-value:5.38E-13 ID:SGTC_1910|Compound:st062352|FD-Score:3.71|P-value:3.98E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-2.97|P-value:8.33E-4 ID:SGTC_2015|Compound:5119600|FD-Score:2.94|P-value:8.96E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-3.68|P-value:4.98E-5 ID:SGTC_2023|Compound:5144124|FD-Score:-5.73|P-value:6.49E-10 ID:SGTC_2053|Compound:5265679|FD-Score:-3.36|P-value:1.85E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-4.34|P-value:2.11E-6 ID:SGTC_2105|Compound:5350118|FD-Score:-3.30|P-value:2.35E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.84|P-value:2.23E-5 ID:SGTC_2158|Compound:5657123|FD-Score:3.63|P-value:5.58E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.42|P-value:1.29E-6 ID:SGTC_2396|Compound:5342950|FD-Score:7.54|P-value:5.68E-16 ID:SGTC_2399|Compound:5884133|FD-Score:4.20|P-value:4.04E-6 ID:SGTC_2428|Compound:5615643|FD-Score:3.40|P-value:1.53E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.18|P-value:3.63E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.16|P-value:4.11E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.49|P-value:1.11E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.17|P-value:5.06E-6 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.22|P-value:3.23E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.10|P-value:7.09E-6 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.07|P-value:5.73E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.30|P-value:2.25E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.46|P-value:3.42E-12 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.46|P-value:1.26E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:-4.15|P-value:5.58E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:3.88|P-value:1.84E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.84|P-value:2.24E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.78|P-value:3.09E-5 ID:SGTC_2784|Compound:7567673|FD-Score:-3.11|P-value:4.96E-4 ID:SGTC_2787|Compound:5284540|FD-Score:9.44|P-value:5.84E-24 ID:SGTC_2789|Compound:5281112|FD-Score:6.68|P-value:6.62E-13 ID:SGTC_2791|Compound:5663188|FD-Score:4.95|P-value:7.22E-8 ID:SGTC_2833|Compound:9001315|FD-Score:-3.48|P-value:1.15E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-4.33|P-value:2.24E-6 ID:SGTC_2925|Compound:9010536|FD-Score:-7.56|P-value:5.51E-16 ID:SGTC_2997|Compound:9067075|FD-Score:4.27|P-value:2.78E-6 ID:SGTC_3073|Compound:9114972|FD-Score:3.73|P-value:3.63E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-3.36|P-value:1.86E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.42|P-value:1.49E-4

Top fitness defect scores for YER022W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_673 1082-0474 9.75 110.0 µM 2.05E-25 RSC complex & mRNA processing 12 9.12E-23 0.03
2 SGTC_2787 5284540 9.44 71.4 µM 5.84E-24 1 1.79E-21 4.25
3 SGTC_2396 5342950 7.54 42.8 µM 5.68E-16 RSC complex & mRNA processing 10 2.27E-14 0.27
4 SGTC_1909 st060837 6.70 51.5 µM 5.38E-13 2 1.01E-11 0.72
5 SGTC_2789 5281112 6.68 71.4 µM 6.62E-13 1 1.21E-11 0.82
6 SGTC_2651 1327-0036 6.46 5.0 µM 3.42E-12 28 5.23E-11 0.14
7 SGTC_730 1436-0052 5.61 41.2 µM 1.29E-9 mitochondrial processes 8 1.03E-8 0.03
8 SGTC_1252 0493-0875 5.39 34.8 µM 5.28E-9 2 3.60E-8 0.51
9 SGTC_302 1094-0063 5.15 18.9 µM 2.23E-8 8 1.30E-7 0.30
10 SGTC_1493 4348-0038 5.13 111.0 µM 2.53E-8 RSC complex & mRNA processing 25 1.45E-7 0.08
11 SGTC_1105 epirubicin 5.13 18.1 µM 2.55E-8 anthracycline transcription coupled DNA repair 4 1.46E-7 0.20
12 SGTC_2791 5663188 4.95 71.4 µM 7.22E-8 RPP1 & pyrimidine depletion 6 3.70E-7 0.33
13 SGTC_808 0711-0032 4.80 135.0 µM 1.67E-7 3 7.81E-7 0.22
14 SGTC_157 1348-1695 4.49 65.8 µM 9.09E-7 iron homeostasis 25 3.53E-6 0.11
15 SGTC_2249 haloperidol 4.42 116.4 µM 1.29E-6 ergosterol depletion effects on membrane 30 4.84E-6 0.06
16 SGTC_908 3448-7491 4.38 47.7 µM 1.64E-6 mitochondrial stress 7 5.97E-6 0.29
17 SGTC_2997 9067075 4.27 71.4 µM 2.78E-6 unfolded protein response 19 9.58E-6 0.08
18 SGTC_293 4049-0273 4.24 38.5 µM 3.36E-6 2 1.13E-5 0.24
19 SGTC_2399 5884133 4.20 200.0 µM 4.04E-6 cell wall signaling 17 1.34E-5 0.07
20 SGTC_1301 naphtanilide LB 4.12 4.8 µM 6.07E-6 heme requiring 7 1.92E-5 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.192 3.07E-29 YHR058C MED6 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress
0.143 1.06E-16 YNR017W TIM23 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
0.142 1.32E-16 YMR277W FCP1 het Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
0.141 2.36E-16 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.140 3.58E-16 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.134 6.74E-15 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.126 2.49E-13 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.125 3.23E-13 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.122 1.14E-12 YPL055C LGE1 hom Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division
0.119 5.41E-12 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.117 9.12E-12 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.117 9.13E-12 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.115 2.03E-11 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.112 7.30E-11 YGL150C INO80 het ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription
0.112 7.51E-11 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP