YER024W / YAT2

Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YER024W / YAT2

Click on Significant Values for Screen Details ID:SGTC_406|Compound:estrone|FD-Score:2.98|P-value:9.32E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:-2.91|P-value:9.73E-4 ID:SGTC_510|Compound:ag-490|FD-Score:2.96|P-value:9.80E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.17|P-value:4.64E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.00|P-value:8.67E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:5.66|P-value:1.42E-9 ID:SGTC_686|Compound:1319-0111|FD-Score:5.30|P-value:1.32E-8 ID:SGTC_723|Compound:4182-0001|FD-Score:3.63|P-value:7.23E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:-2.91|P-value:9.47E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.24|P-value:2.80E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.10|P-value:5.98E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:-4.49|P-value:9.22E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.04|P-value:5.90E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.57|P-value:9.25E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.25|P-value:3.34E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.04|P-value:7.45E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.20|P-value:3.31E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-2.90|P-value:9.85E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-3.63|P-value:5.53E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.81|P-value:3.31E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:4.22|P-value:4.79E-6 ID:SGTC_1407|Compound:3909-7909|FD-Score:-3.07|P-value:5.33E-4 ID:SGTC_1516|Compound:st013856|FD-Score:3.02|P-value:8.02E-4 ID:SGTC_1725|Compound:st036284|FD-Score:2.97|P-value:9.64E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-5.98|P-value:1.10E-10 ID:SGTC_1889|Compound:st059080|FD-Score:3.54|P-value:1.05E-4 ID:SGTC_1911|Compound:st060208|FD-Score:5.16|P-value:3.02E-8 ID:SGTC_1993|Compound:st073995|FD-Score:3.04|P-value:7.54E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:-3.43|P-value:1.31E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.21|P-value:3.10E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.47|P-value:1.10E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.62|P-value:7.44E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.17|P-value:3.64E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-5.42|P-value:4.51E-9 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.31|P-value:3.13E-6 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:5.00|P-value:8.02E-8 ID:SGTC_2834|Compound:9001755|FD-Score:-4.23|P-value:3.38E-6 ID:SGTC_2967|Compound:9089538|FD-Score:4.09|P-value:9.18E-6 ID:SGTC_2974|Compound:9094440|FD-Score:4.11|P-value:8.28E-6 ID:SGTC_3056|Compound:9094900|FD-Score:2.98|P-value:9.28E-4 ID:SGTC_3067|Compound:9117431|FD-Score:4.13|P-value:7.55E-6 ID:SGTC_3338|Compound:9144300|FD-Score:-3.78|P-value:2.86E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-3.07|P-value:5.44E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.34|P-value:1.91E-4 ID:SGTC_406|Compound:estrone|FD-Score:2.98|P-value:9.32E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:-2.91|P-value:9.73E-4 ID:SGTC_510|Compound:ag-490|FD-Score:2.96|P-value:9.80E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.17|P-value:4.64E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.00|P-value:8.67E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:5.66|P-value:1.42E-9 ID:SGTC_686|Compound:1319-0111|FD-Score:5.30|P-value:1.32E-8 ID:SGTC_723|Compound:4182-0001|FD-Score:3.63|P-value:7.23E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:-2.91|P-value:9.47E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.24|P-value:2.80E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.10|P-value:5.98E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:-4.49|P-value:9.22E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.04|P-value:5.90E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.57|P-value:9.25E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.25|P-value:3.34E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.04|P-value:7.45E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.20|P-value:3.31E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-2.90|P-value:9.85E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-3.63|P-value:5.53E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.81|P-value:3.31E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:4.22|P-value:4.79E-6 ID:SGTC_1407|Compound:3909-7909|FD-Score:-3.07|P-value:5.33E-4 ID:SGTC_1516|Compound:st013856|FD-Score:3.02|P-value:8.02E-4 ID:SGTC_1725|Compound:st036284|FD-Score:2.97|P-value:9.64E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-5.98|P-value:1.10E-10 ID:SGTC_1889|Compound:st059080|FD-Score:3.54|P-value:1.05E-4 ID:SGTC_1911|Compound:st060208|FD-Score:5.16|P-value:3.02E-8 ID:SGTC_1993|Compound:st073995|FD-Score:3.04|P-value:7.54E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:-3.43|P-value:1.31E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.21|P-value:3.10E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.47|P-value:1.10E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.62|P-value:7.44E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.17|P-value:3.64E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-5.42|P-value:4.51E-9 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.31|P-value:3.13E-6 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:5.00|P-value:8.02E-8 ID:SGTC_2834|Compound:9001755|FD-Score:-4.23|P-value:3.38E-6 ID:SGTC_2967|Compound:9089538|FD-Score:4.09|P-value:9.18E-6 ID:SGTC_2974|Compound:9094440|FD-Score:4.11|P-value:8.28E-6 ID:SGTC_3056|Compound:9094900|FD-Score:2.98|P-value:9.28E-4 ID:SGTC_3067|Compound:9117431|FD-Score:4.13|P-value:7.55E-6 ID:SGTC_3338|Compound:9144300|FD-Score:-3.78|P-value:2.86E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-3.07|P-value:5.44E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.34|P-value:1.91E-4

Top fitness defect scores for YER024W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_632 0781-2353 5.66 4.7 µM 1.42E-9 Golgi 11 7.60E-9
2 SGTC_686 1319-0111 5.30 510.0 µM 1.32E-8 60S ribosome export 5 5.73E-8
3 SGTC_1911 st060208 5.16 74.3 µM 3.02E-8 13 1.21E-7
4 SGTC_2580 diallyl disulphide 5.00 81.4 µM 8.02E-8 10 2.93E-7
5 SGTC_2546 rhodinyl acetate 4.31 100.0 µM 3.13E-6 8 8.14E-6
6 SGTC_1404 3909-7820 4.22 48.3 µM 4.79E-6 60S ribosome export 7 1.20E-5
7 SGTC_3067 9117431 4.13 49.5 µM 7.55E-6 6 1.81E-5
8 SGTC_2974 9094440 4.11 9.7 µM 8.28E-6 ergosterol biosynthesis 43 1.97E-5
9 SGTC_2967 9089538 4.09 49.9 µM 9.18E-6 29 2.16E-5
10 SGTC_1375 2910-0797 3.81 186.0 µM 3.31E-5 29 6.93E-5
11 SGTC_723 4182-0001 3.63 115.0 µM 7.23E-5 33 1.41E-4
12 SGTC_2487 5918373 3.62 44.0 µM 7.44E-5 23 1.45E-4
13 SGTC_1189 1431-2119 3.57 7.3 µM 9.25E-5 41 1.77E-4
14 SGTC_1889 st059080 3.54 5.2 µM 1.05E-4 32 1.97E-4
15 SGTC_1197 1601-0112 3.25 267.0 µM 3.34E-4 48 5.68E-4
16 SGTC_549 1661-1316 3.17 519.0 µM 4.64E-4 45 7.68E-4
17 SGTC_1023 4482-3888 3.10 16.0 µM 5.98E-4 TSC3-RPN4 52 9.67E-4
18 SGTC_1224 0823-0416 3.04 294.0 µM 7.45E-4 53 0.00118
19 SGTC_1993 st073995 3.04 70.8 µM 7.54E-4 50 0.00120
20 SGTC_1516 st013856 3.02 110.0 µM 8.02E-4 38 0.00126

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.45E-18 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.122 1.17E-12 YJR128W_d YJR128W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
0.108 2.99E-10 YEL023C_p YEL023C_p hom Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
0.107 4.78E-10 YOR321W PMT3 hom Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication
0.105 9.13E-10 YOR090C PTC5 hom Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
0.103 1.94E-9 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.098 1.21E-8 YLR210W CLB4 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
0.096 2.21E-8 YER076C_p YER076C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization
0.096 2.43E-8 YBL002W HTB2 hom Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.093 7.94E-8 YPL082C MOT1 het Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA
0.091 1.28E-7 YBR029C CDS1 het Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids
0.089 2.79E-7 YGL126W SCS3 hom Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol
0.087 4.48E-7 YOR111W_p YOR111W_p hom Putative protein of unknown function
0.086 6.19E-7 YKL129C MYO3 hom One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.083 1.63E-6 YPL168W_p YPL168W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated