Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YER024W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.150 | 2.45E-18 | YKL202W_d | YKL202W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.122 | 1.17E-12 | YJR128W_d | YJR128W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2 |
0.108 | 2.99E-10 | YEL023C_p | YEL023C_p | hom | Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene |
0.107 | 4.78E-10 | YOR321W | PMT3 | hom | Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication |
0.105 | 9.13E-10 | YOR090C | PTC5 | hom | Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p |
0.103 | 1.94E-9 | YBL086C_p | YBL086C_p | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
0.098 | 1.21E-8 | YLR210W | CLB4 | hom | B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation |
0.096 | 2.21E-8 | YER076C_p | YER076C_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization |
0.096 | 2.43E-8 | YBL002W | HTB2 | hom | Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation |
0.093 | 7.94E-8 | YPL082C | MOT1 | het | Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA |
0.091 | 1.28E-7 | YBR029C | CDS1 | het | Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids |
0.089 | 2.79E-7 | YGL126W | SCS3 | hom | Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol |
0.087 | 4.48E-7 | YOR111W_p | YOR111W_p | hom | Putative protein of unknown function |
0.086 | 6.19E-7 | YKL129C | MYO3 | hom | One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization |
0.083 | 1.63E-6 | YPL168W_p | YPL168W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated |