YER026C / CHO1

Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline

Zygosity: Homozygous strain
fixedexpanded
Profile for YER026C / CHO1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.39|P-value:6.13E-4 ID:SGTC_251|Compound:melphalan|FD-Score:4.15|P-value:3.72E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.40|P-value:5.23E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.64|P-value:2.61E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.47|P-value:8.19E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:3.48|P-value:4.58E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:-3.23|P-value:8.95E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.60|P-value:2.92E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.79|P-value:2.33E-6 ID:SGTC_634|Compound:1611-4317|FD-Score:-4.24|P-value:2.14E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:4.40|P-value:1.34E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:3.35|P-value:6.95E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:5.18|P-value:3.74E-7 ID:SGTC_967|Compound:1306-0166|FD-Score:5.06|P-value:6.68E-7 ID:SGTC_989|Compound:1501-0895|FD-Score:-3.43|P-value:4.63E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.16|P-value:3.62E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.96|P-value:7.76E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.78|P-value:1.53E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.38|P-value:6.32E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.10|P-value:4.62E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.52|P-value:3.94E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-4.32|P-value:1.53E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.99|P-value:5.99E-5 ID:SGTC_1618|Compound:st003135|FD-Score:3.86|P-value:1.16E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.95|P-value:8.13E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-3.55|P-value:3.02E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.42|P-value:1.19E-5 ID:SGTC_1991|Compound:st073000|FD-Score:4.31|P-value:1.97E-5 ID:SGTC_2055|Compound:5235184|FD-Score:4.89|P-value:1.46E-6 ID:SGTC_2150|Compound:5556613|FD-Score:4.81|P-value:2.17E-6 ID:SGTC_2341|Compound:7987486|FD-Score:5.19|P-value:3.60E-7 ID:SGTC_2343|Compound:7990716|FD-Score:-3.80|P-value:1.23E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.76|P-value:1.65E-4 ID:SGTC_2365|Compound:9042475|FD-Score:5.99|P-value:5.24E-9 ID:SGTC_2368|Compound:9071271|FD-Score:4.13|P-value:4.06E-5 ID:SGTC_2444|Compound:5485484|FD-Score:4.31|P-value:1.95E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.79|P-value:2.41E-6 ID:SGTC_2551|Compound:apiole|FD-Score:-3.36|P-value:5.82E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.71|P-value:1.98E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.67|P-value:2.02E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-3.54|P-value:3.20E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.01|P-value:6.60E-5 ID:SGTC_2981|Compound:9013952|FD-Score:-3.52|P-value:3.41E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.21|P-value:2.97E-5 ID:SGTC_3054|Compound:9094397|FD-Score:4.24|P-value:2.62E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.98|P-value:7.34E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.47|P-value:4.71E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.37|P-value:1.44E-7 ID:SGTC_3266|Compound:9136860|FD-Score:-3.54|P-value:3.22E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.39|P-value:6.13E-4 ID:SGTC_251|Compound:melphalan|FD-Score:4.15|P-value:3.72E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.40|P-value:5.23E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.64|P-value:2.61E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.47|P-value:8.19E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:3.48|P-value:4.58E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:-3.23|P-value:8.95E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.60|P-value:2.92E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.79|P-value:2.33E-6 ID:SGTC_634|Compound:1611-4317|FD-Score:-4.24|P-value:2.14E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:4.40|P-value:1.34E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:3.35|P-value:6.95E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:5.18|P-value:3.74E-7 ID:SGTC_967|Compound:1306-0166|FD-Score:5.06|P-value:6.68E-7 ID:SGTC_989|Compound:1501-0895|FD-Score:-3.43|P-value:4.63E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.16|P-value:3.62E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.96|P-value:7.76E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.78|P-value:1.53E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.38|P-value:6.32E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.10|P-value:4.62E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.52|P-value:3.94E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-4.32|P-value:1.53E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.99|P-value:5.99E-5 ID:SGTC_1618|Compound:st003135|FD-Score:3.86|P-value:1.16E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.95|P-value:8.13E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-3.55|P-value:3.02E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.42|P-value:1.19E-5 ID:SGTC_1991|Compound:st073000|FD-Score:4.31|P-value:1.97E-5 ID:SGTC_2055|Compound:5235184|FD-Score:4.89|P-value:1.46E-6 ID:SGTC_2150|Compound:5556613|FD-Score:4.81|P-value:2.17E-6 ID:SGTC_2341|Compound:7987486|FD-Score:5.19|P-value:3.60E-7 ID:SGTC_2343|Compound:7990716|FD-Score:-3.80|P-value:1.23E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.76|P-value:1.65E-4 ID:SGTC_2365|Compound:9042475|FD-Score:5.99|P-value:5.24E-9 ID:SGTC_2368|Compound:9071271|FD-Score:4.13|P-value:4.06E-5 ID:SGTC_2444|Compound:5485484|FD-Score:4.31|P-value:1.95E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.79|P-value:2.41E-6 ID:SGTC_2551|Compound:apiole|FD-Score:-3.36|P-value:5.82E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.71|P-value:1.98E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.67|P-value:2.02E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-3.54|P-value:3.20E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.01|P-value:6.60E-5 ID:SGTC_2981|Compound:9013952|FD-Score:-3.52|P-value:3.41E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.21|P-value:2.97E-5 ID:SGTC_3054|Compound:9094397|FD-Score:4.24|P-value:2.62E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.98|P-value:7.34E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.47|P-value:4.71E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.37|P-value:1.44E-7 ID:SGTC_3266|Compound:9136860|FD-Score:-3.54|P-value:3.22E-4

Top fitness defect scores for YER026C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2365 9042475 5.99 200.0 µM 5.24E-9 10 1.08E-9
2 SGTC_3211 9128781 5.37 49.5 µM 1.44E-7 28 3.95E-8
3 SGTC_2341 7987486 5.19 176.7 µM 3.60E-7 5 1.07E-7
4 SGTC_925 2064-1272 5.18 59.6 µM 3.74E-7 6 1.12E-7
5 SGTC_967 1306-0166 5.06 352.0 µM 6.68E-7 11 2.10E-7
6 SGTC_2055 5235184 4.89 200.0 µM 1.46E-6 ERG2 13 4.93E-7
7 SGTC_2150 5556613 4.81 200.0 µM 2.17E-6 5 7.54E-7
8 SGTC_602 3130-1533 4.79 38.1 µM 2.33E-6 6 8.16E-7
9 SGTC_2540 epiandrosterone 4.79 100.0 µM 2.41E-6 35 8.47E-7
10 SGTC_1920 st075728 4.42 45.7 µM 1.19E-5 12 4.83E-6
11 SGTC_644 1498-1197 4.40 63.3 µM 1.34E-5 9 5.46E-6
12 SGTC_2444 5485484 4.31 36.4 µM 1.95E-5 25 8.23E-6
13 SGTC_1991 st073000 4.31 8.9 µM 1.97E-5 NEO1 65 8.30E-6
14 SGTC_3054 9094397 4.24 49.5 µM 2.62E-5 fatty acid desaturase (OLE1) 24 1.13E-5
15 SGTC_2997 9067075 4.21 71.4 µM 2.97E-5 unfolded protein response 47 1.30E-5
16 SGTC_1050 3232-1156 4.16 69.3 µM 3.62E-5 RSC complex & mRNA processing 15 1.61E-5
17 SGTC_251 melphalan 4.15 456.5 µM 3.72E-5 DNA damage response 17 1.66E-5
18 SGTC_2368 9071271 4.13 200.0 µM 4.06E-5 28 1.82E-5
19 SGTC_1202 1988-0068 4.10 29.6 µM 4.62E-5 RNA processing & uracil transport 22 2.10E-5
20 SGTC_2921 7974240 4.01 10.7 µM 6.60E-5 52 3.10E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.77E-15 YPR153W YPR153W hom Putative protein of unknown function
0.130 3.98E-14 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.106 7.20E-10 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.103 2.28E-9 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.096 2.53E-8 YPR139C LOA1 hom Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA
0.093 6.96E-8 YBR255W MTC4 hom Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.091 1.40E-7 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.090 2.02E-7 YKL143W LTV1 hom Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
0.089 2.59E-7 YOR103C OST2 het Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.088 3.73E-7 YKL147C_d YKL147C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
0.085 9.20E-7 YJL088W ARG3 hom Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
0.083 1.38E-6 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.083 1.52E-6 YMR216C SKY1 hom SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
0.079 4.06E-6 YKL132C RMA1 hom Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.078 5.88E-6 YHR039C MSC7 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids