YER027C / GAL83

One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YER027C / GAL83

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.35|P-value:6.23E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:5.01|P-value:4.82E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:3.33|P-value:5.48E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.68|P-value:1.50E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:3.56|P-value:2.46E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:4.60|P-value:3.48E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:4.06|P-value:3.56E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:3.54|P-value:2.65E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.70|P-value:1.46E-4 ID:SGTC_499|Compound:genistein|FD-Score:-3.54|P-value:3.27E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:-4.22|P-value:2.32E-5 ID:SGTC_510|Compound:ag-490|FD-Score:-4.23|P-value:2.27E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:3.19|P-value:8.85E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.52|P-value:3.55E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.23|P-value:7.66E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.36|P-value:6.05E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.25|P-value:8.87E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.72|P-value:1.68E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:-4.82|P-value:1.64E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:5.03|P-value:4.38E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.16|P-value:2.34E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.95|P-value:5.46E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.58|P-value:2.84E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.91|P-value:6.59E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.64|P-value:2.84E-6 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.99|P-value:4.75E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:-3.55|P-value:3.16E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:-3.38|P-value:5.70E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.25|P-value:8.83E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.44|P-value:3.71E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.01|P-value:5.55E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.70|P-value:2.89E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:3.73|P-value:1.31E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.17|P-value:9.57E-4 ID:SGTC_1866|Compound:st057638|FD-Score:5.83|P-value:6.46E-9 ID:SGTC_1876|Compound:myriocin|FD-Score:3.86|P-value:7.85E-5 ID:SGTC_2376|Compound:9072922|FD-Score:3.16|P-value:9.71E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.40|P-value:5.40E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.65|P-value:2.23E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.09|P-value:3.28E-7 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.27|P-value:8.23E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.29|P-value:7.63E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.23|P-value:9.57E-4 ID:SGTC_2915|Compound:7971052|FD-Score:3.30|P-value:6.08E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.39|P-value:4.52E-4 ID:SGTC_3034|Compound:9090421|FD-Score:3.18|P-value:9.17E-4 ID:SGTC_3036|Compound:9090181|FD-Score:-3.21|P-value:0.00100 ID:SGTC_3209|Compound:9113616|FD-Score:-3.79|P-value:1.29E-4 ID:SGTC_3342|Compound:9147791|FD-Score:4.11|P-value:2.95E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.35|P-value:6.23E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:5.01|P-value:4.82E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:3.33|P-value:5.48E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.68|P-value:1.50E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:3.56|P-value:2.46E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:4.60|P-value:3.48E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:4.06|P-value:3.56E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:3.54|P-value:2.65E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.70|P-value:1.46E-4 ID:SGTC_499|Compound:genistein|FD-Score:-3.54|P-value:3.27E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:-4.22|P-value:2.32E-5 ID:SGTC_510|Compound:ag-490|FD-Score:-4.23|P-value:2.27E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:3.19|P-value:8.85E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.52|P-value:3.55E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.23|P-value:7.66E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.36|P-value:6.05E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.25|P-value:8.87E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.72|P-value:1.68E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:-4.82|P-value:1.64E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:5.03|P-value:4.38E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.16|P-value:2.34E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.95|P-value:5.46E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.58|P-value:2.84E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.91|P-value:6.59E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.64|P-value:2.84E-6 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.99|P-value:4.75E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:-3.55|P-value:3.16E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:-3.38|P-value:5.70E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.25|P-value:8.83E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.44|P-value:3.71E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.01|P-value:5.55E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.70|P-value:2.89E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:3.73|P-value:1.31E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.17|P-value:9.57E-4 ID:SGTC_1866|Compound:st057638|FD-Score:5.83|P-value:6.46E-9 ID:SGTC_1876|Compound:myriocin|FD-Score:3.86|P-value:7.85E-5 ID:SGTC_2376|Compound:9072922|FD-Score:3.16|P-value:9.71E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.40|P-value:5.40E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.65|P-value:2.23E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.09|P-value:3.28E-7 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.27|P-value:8.23E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.29|P-value:7.63E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.23|P-value:9.57E-4 ID:SGTC_2915|Compound:7971052|FD-Score:3.30|P-value:6.08E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.39|P-value:4.52E-4 ID:SGTC_3034|Compound:9090421|FD-Score:3.18|P-value:9.17E-4 ID:SGTC_3036|Compound:9090181|FD-Score:-3.21|P-value:0.00100 ID:SGTC_3209|Compound:9113616|FD-Score:-3.79|P-value:1.29E-4 ID:SGTC_3342|Compound:9147791|FD-Score:4.11|P-value:2.95E-5

Top fitness defect scores for YER027C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1866 st057638 5.83 64.0 µM 6.46E-9 1 2.84E-9
2 SGTC_103 0844-0104 5.68 51.8 µM 1.50E-8 ERAD & cell cycle 81 6.88E-9
3 SGTC_2584 androsterone 5.09 48.7 µM 3.28E-7 cell wall 79 1.77E-7
4 SGTC_1128 3448-9350 5.03 235.0 µM 4.38E-7 10 2.41E-7
5 SGTC_67 0335-0847 5.01 266.0 µM 4.82E-7 ubiquinone biosynthesis & proteasome 86 2.66E-7
6 SGTC_1186 1319-0216 4.64 26.0 µM 2.84E-6 9 1.72E-6
7 SGTC_259 usnic acid 4.60 108.9 µM 3.48E-6 7 2.13E-6
8 SGTC_1134 3477-0009 4.16 42.5 µM 2.34E-5 42 1.58E-5
9 SGTC_3342 9147791 4.11 14.5 µM 2.95E-5 13 2.01E-5
10 SGTC_266 formosanin C 4.06 406.0 nM 3.56E-5 sphingolipid biosynthesis & PDR1 65 2.45E-5
11 SGTC_1219 1469-0211 3.99 33.1 µM 4.75E-5 20 3.32E-5
12 SGTC_1161 k007-0610 3.95 110.0 µM 5.46E-5 ERAD & cell cycle 121 3.84E-5
13 SGTC_1185 1319-0113 3.91 81.3 µM 6.59E-5 DNA damage response 10 4.69E-5
14 SGTC_1876 myriocin 3.86 605.0 nM 7.85E-5 36 5.63E-5
15 SGTC_1568 digitonin 3.73 820.0 nM 1.31E-4 sphingolipid biosynthesis & PDR1 40 9.62E-5
16 SGTC_495 decylubiquinone 3.70 155.0 µM 1.46E-4 copper-dependent oxidative stress 32 1.08E-4
17 SGTC_142 0335-0849 3.56 62.7 µM 2.46E-4 ubiquinone biosynthesis & proteasome 151 1.87E-4
18 SGTC_384 k007-0144 3.54 5.2 µM 2.65E-4 ERAD & cell cycle 76 2.02E-4
19 SGTC_1245 0418-0076 3.44 17.2 µM 3.71E-4 ERG2 48 2.87E-4
20 SGTC_2970 9090938 3.39 41.9 µM 4.52E-4 RNA processing & uracil transport 72 3.53E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.241 1.73E-45 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.200 1.86E-31 YJR091C JSN1 hom Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
0.189 2.40E-28 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.185 3.70E-27 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.184 4.70E-27 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.180 9.90E-26 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.173 5.36E-24 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.172 1.43E-23 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.170 2.85E-23 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.169 6.82E-23 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.165 5.24E-22 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.165 7.33E-22 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.163 2.19E-21 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.163 2.37E-21 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.162 2.92E-21 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation