HIPHOP chemogenomics database
YER031C / YPT31 
Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YER031C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.607 | 0 | YJL204C | RCY1 | hom | F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth |
| 0.581 | 7.26E-302 | YDL226C | GCS1 | hom | ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p |
| 0.546 | 5.79E-259 | YJL207C | LAA1 | hom | AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene |
| 0.509 | 1.58E-220 | YCR094W | CDC50 | hom | Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication |
| 0.504 | 2.55E-215 | YFL034W_p | YFL034W_p | hom | Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk |
| 0.467 | 3.46E-181 | YMR071C | TVP18 | hom | Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments |
| 0.456 | 1.30E-171 | YKL135C | APL2 | hom | Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress |
| 0.400 | 9.59E-129 | YOR070C | GYP1 | hom | Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion |
| 0.376 | 2.73E-112 | YDL090C | RAM1 | hom | Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit |
| 0.373 | 8.53E-111 | YOR039W | CKB2 | hom | Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase |
| 0.365 | 1.15E-105 | YNL267W | PIK1 | het | Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton |
| 0.355 | 1.79E-100 | YGL199C_d | YGL199C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W |
| 0.355 | 2.96E-100 | YGL019W | CKB1 | hom | Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases |
| 0.353 | 6.93E-99 | YHL019C | APM2 | hom | Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport |
| 0.336 | 4.67E-89 | YOR115C | TRS33 | hom | One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic |