YER034W

Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YER034W / YER034W

Click on Significant Values for Screen Details

Top fitness defect scores for YER034W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3207 9114163 6.69 49.5 µM 5.74E-11 2 1.09E-11
2 SGTC_2598 perillyl alcohol 6.08 100.0 µM 2.38E-9 6 5.96E-10
3 SGTC_3190 9110366 5.84 49.5 µM 9.52E-9 1 2.64E-9
4 SGTC_2441 5730946 5.40 39.1 µM 1.02E-7 5 3.37E-8
5 SGTC_2603 homopterocarpin 5.26 100.0 µM 2.05E-7 10 7.16E-8
6 SGTC_2907 7721985 5.23 69.9 µM 2.36E-7 4 8.33E-8
7 SGTC_1901 st060216 5.00 58.6 µM 7.35E-7 12 2.82E-7
8 SGTC_196 k015-0023 4.68 18.1 µM 3.36E-6 PDR1 12 1.44E-6
9 SGTC_2443 5493264 4.50 126.7 µM 7.39E-6 13 3.36E-6
10 SGTC_369 0957-0393 4.42 4.5 µM 1.07E-5 cell wall signaling 14 5.01E-6
11 SGTC_1638 st008370 4.06 60.6 µM 4.65E-5 ergosterol biosynthesis 29 2.42E-5
12 SGTC_1021 4476-0760 3.86 85.3 µM 1.03E-4 30 5.66E-5
13 SGTC_197 4544-0043 3.80 41.6 µM 1.29E-4 endomembrane recycling 51 7.25E-5
14 SGTC_2062 5245942 3.80 200.0 µM 1.31E-4 25 7.38E-5
15 SGTC_583 1488-1091 3.78 88.9 µM 1.39E-4 22 7.80E-5
16 SGTC_425 3825-7017 3.69 13.1 µM 1.95E-4 31 1.13E-4
17 SGTC_3213 9129884 3.61 49.5 µM 2.56E-4 26 1.51E-4
18 SGTC_3224 9130643 3.58 49.5 µM 2.86E-4 RPP1 & pyrimidine depletion 38 1.70E-4
19 SGTC_3232 9132874 3.56 49.5 µM 3.08E-4 RPP1 & pyrimidine depletion 24 1.84E-4
20 SGTC_3181 9108277 3.54 49.5 µM 3.37E-4 iron homeostasis 29 2.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 4.61E-12 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.117 1.18E-11 YER007C-A TMA20 hom Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress
0.094 4.43E-8 YER181C_d YER181C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies
0.094 4.95E-8 YOR129C AFI1 hom Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p
0.093 6.72E-8 YDL078C MDH3 hom Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
0.092 8.26E-8 YPL213W LEA1 hom Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein
0.085 8.58E-7 YJL061W NUP82 het Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p)
0.081 2.39E-6 YDL241W_p YDL241W_p hom Putative protein of unknown function; YDL241W is not an essential gene
0.080 3.50E-6 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 4.58E-6 YIL113W SDP1 hom Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
0.079 5.23E-6 YJR008W MHO1 hom Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility
0.077 7.05E-6 YGR141W VPS62 hom Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins
0.077 7.33E-6 YGR130C YGR130C hom Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
0.077 8.44E-6 YDR061W_p YDR061W_p hom Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
0.075 1.39E-5 YGR127W_p YGR127W_p hom Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response