YER036C / ARB1

ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YER036C / ARB1

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:5.00|P-value:1.91E-8 ID:SGTC_69|Compound:0096-0274|FD-Score:2.93|P-value:6.80E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.06|P-value:3.13E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-2.79|P-value:8.74E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-6.17|P-value:3.37E-12 ID:SGTC_417|Compound:st075190|FD-Score:3.41|P-value:9.30E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-2.86|P-value:6.79E-4 ID:SGTC_500|Compound:h-89|FD-Score:-2.83|P-value:7.70E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.03|P-value:4.60E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.29|P-value:1.53E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.10|P-value:3.44E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:2.90|P-value:7.65E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-4.02|P-value:3.55E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:3.56|P-value:4.65E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.95|P-value:7.10E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.08|P-value:3.66E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.61|P-value:3.67E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:-2.82|P-value:7.88E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:2.98|P-value:5.46E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.34|P-value:9.25E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.92|P-value:6.85E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.02|P-value:4.67E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.11|P-value:3.28E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:-2.77|P-value:9.69E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.04|P-value:4.32E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.07|P-value:3.86E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-2.81|P-value:8.10E-4 ID:SGTC_2041|Compound:5107442|FD-Score:-2.99|P-value:4.03E-4 ID:SGTC_2138|Compound:5575593|FD-Score:3.25|P-value:1.84E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.32|P-value:1.39E-4 ID:SGTC_2328|Compound:6201408|FD-Score:2.84|P-value:9.42E-4 ID:SGTC_2337|Compound:9009472|FD-Score:2.93|P-value:6.64E-4 ID:SGTC_2371|Compound:9071574|FD-Score:-3.92|P-value:6.10E-6 ID:SGTC_2381|Compound:9035592|FD-Score:-2.81|P-value:8.17E-4 ID:SGTC_2384|Compound:9036245|FD-Score:4.03|P-value:4.72E-6 ID:SGTC_2397|Compound:5161689|FD-Score:-3.54|P-value:3.81E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.32|P-value:1.35E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.14|P-value:2.89E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-4.15|P-value:1.85E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:5.23|P-value:4.27E-9 ID:SGTC_2776|Compound:terbinafine|FD-Score:2.87|P-value:8.55E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.23|P-value:1.97E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.35|P-value:1.18E-4 ID:SGTC_2884|Compound:9058502|FD-Score:2.94|P-value:6.51E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-2.96|P-value:4.53E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-5.00|P-value:1.24E-8 ID:SGTC_2931|Compound:9014674|FD-Score:3.22|P-value:2.13E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.00|P-value:5.06E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.21|P-value:2.18E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.68|P-value:2.70E-5 ID:SGTC_3097|Compound:9117246|FD-Score:2.85|P-value:9.17E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.60|P-value:4.01E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-2.82|P-value:8.03E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.42|P-value:8.99E-5 ID:SGTC_3245|Compound:9134821|FD-Score:-2.95|P-value:4.71E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.31|P-value:1.44E-4 ID:SGTC_57|Compound:miconazole|FD-Score:5.00|P-value:1.91E-8 ID:SGTC_69|Compound:0096-0274|FD-Score:2.93|P-value:6.80E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.06|P-value:3.13E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-2.79|P-value:8.74E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-6.17|P-value:3.37E-12 ID:SGTC_417|Compound:st075190|FD-Score:3.41|P-value:9.30E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-2.86|P-value:6.79E-4 ID:SGTC_500|Compound:h-89|FD-Score:-2.83|P-value:7.70E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.03|P-value:4.60E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.29|P-value:1.53E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.10|P-value:3.44E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:2.90|P-value:7.65E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-4.02|P-value:3.55E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:3.56|P-value:4.65E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.95|P-value:7.10E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.08|P-value:3.66E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.61|P-value:3.67E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:-2.82|P-value:7.88E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:2.98|P-value:5.46E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.34|P-value:9.25E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.92|P-value:6.85E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.02|P-value:4.67E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.11|P-value:3.28E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:-2.77|P-value:9.69E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.04|P-value:4.32E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.07|P-value:3.86E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-2.81|P-value:8.10E-4 ID:SGTC_2041|Compound:5107442|FD-Score:-2.99|P-value:4.03E-4 ID:SGTC_2138|Compound:5575593|FD-Score:3.25|P-value:1.84E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.32|P-value:1.39E-4 ID:SGTC_2328|Compound:6201408|FD-Score:2.84|P-value:9.42E-4 ID:SGTC_2337|Compound:9009472|FD-Score:2.93|P-value:6.64E-4 ID:SGTC_2371|Compound:9071574|FD-Score:-3.92|P-value:6.10E-6 ID:SGTC_2381|Compound:9035592|FD-Score:-2.81|P-value:8.17E-4 ID:SGTC_2384|Compound:9036245|FD-Score:4.03|P-value:4.72E-6 ID:SGTC_2397|Compound:5161689|FD-Score:-3.54|P-value:3.81E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.32|P-value:1.35E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.14|P-value:2.89E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-4.15|P-value:1.85E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:5.23|P-value:4.27E-9 ID:SGTC_2776|Compound:terbinafine|FD-Score:2.87|P-value:8.55E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.23|P-value:1.97E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.35|P-value:1.18E-4 ID:SGTC_2884|Compound:9058502|FD-Score:2.94|P-value:6.51E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-2.96|P-value:4.53E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-5.00|P-value:1.24E-8 ID:SGTC_2931|Compound:9014674|FD-Score:3.22|P-value:2.13E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.00|P-value:5.06E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.21|P-value:2.18E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.68|P-value:2.70E-5 ID:SGTC_3097|Compound:9117246|FD-Score:2.85|P-value:9.17E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.60|P-value:4.01E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-2.82|P-value:8.03E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.42|P-value:8.99E-5 ID:SGTC_3245|Compound:9134821|FD-Score:-2.95|P-value:4.71E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.31|P-value:1.44E-4

Top fitness defect scores for YER036C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2563 tomatine 5.23 8.5 µM 4.27E-9 7 8.30E-8 0.37
2 SGTC_57 miconazole 5.00 162.5 nM 1.91E-8 ergosterol depletion effects on membrane 17 2.86E-7 0.09
3 SGTC_2384 9036245 4.03 200.0 µM 4.72E-6 2 2.74E-5 0.17
4 SGTC_1038 k292-0204 3.95 154.0 µM 7.10E-6 5 3.84E-5 0.04
5 SGTC_2997 9067075 3.68 71.4 µM 2.70E-5 unfolded protein response 25 1.16E-4 0.08
6 SGTC_1234 0326-0494 3.61 15.5 µM 3.67E-5 5 1.50E-4 0.15
7 SGTC_3129 9127257 3.60 49.5 µM 4.01E-5 8 1.62E-4 0.15
8 SGTC_939 1165-0479 3.56 45.3 µM 4.65E-5 9 1.83E-4 0.10
9 SGTC_3165 9101544 3.42 49.5 µM 8.99E-5 10 3.17E-4 0.14
10 SGTC_417 st075190 3.41 100.0 µM 9.30E-5 4 3.26E-4 0.11
11 SGTC_2820 7989630 3.35 71.4 µM 1.18E-4 ERG2 7 3.97E-4 0.09
12 SGTC_2453 5731132 3.32 22.2 µM 1.35E-4 11 4.46E-4 0.02
13 SGTC_2293 7624732 3.32 200.0 µM 1.39E-4 15 4.56E-4 0.19
14 SGTC_3293 9120939 3.31 62.0 µM 1.44E-4 17 4.70E-4 0.09
15 SGTC_746 1095-0025 3.29 46.6 µM 1.53E-4 RSC & ERG11 13 4.94E-4 0.07
16 SGTC_2138 5575593 3.25 77.7 µM 1.84E-4 5 5.75E-4 0.37
17 SGTC_2778 tioconazole 3.23 65.1 nM 1.97E-4 ergosterol depletion effects on membrane 43 6.10E-4 0.02
18 SGTC_2931 9014674 3.22 55.7 µM 2.13E-4 9 6.50E-4 0.08
19 SGTC_2994 9053520 3.21 71.4 µM 2.18E-4 RPP1 & pyrimidine depletion 16 6.63E-4 0.20
20 SGTC_2466 5983409 3.14 37.1 µM 2.89E-4 17 8.38E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.14E-16 YPL021W ECM23 hom Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
0.121 1.70E-12 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.119 4.28E-12 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.114 4.27E-11 YPL117C IDI1 het Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability
0.111 1.07E-10 YGL233W SEC15 het Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase
0.110 1.45E-10 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.101 3.98E-9 YER008C SEC3 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress
0.096 2.37E-8 YNL243W SLA2 hom Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo
0.092 8.57E-8 YLL037W_d YLL037W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor
0.090 1.65E-7 YDR299W BFR2 het Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
0.090 1.79E-7 YBR102C EXO84 het Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate
0.089 2.38E-7 YMR218C TRS130 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
0.087 4.36E-7 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.086 5.29E-7 YCL031C RRP7 het Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress
0.086 5.46E-7 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation