YER037W / PHM8

Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p

Zygosity: Homozygous strain
fixedexpanded
Profile for YER037W / PHM8

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:3.55|P-value:2.92E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.40|P-value:4.99E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.36|P-value:7.44E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.59|P-value:3.39E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:4.52|P-value:6.27E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:4.23|P-value:2.12E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:4.15|P-value:2.96E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.53|P-value:3.17E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.91|P-value:7.72E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.05|P-value:4.48E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:4.54|P-value:5.75E-6 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.23|P-value:8.62E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.19|P-value:9.89E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:4.37|P-value:1.22E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.32|P-value:6.38E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.20|P-value:9.69E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.40|P-value:6.46E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-3.41|P-value:6.14E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.93|P-value:7.23E-5 ID:SGTC_1847|Compound:st056231|FD-Score:4.26|P-value:1.88E-5 ID:SGTC_1850|Compound:st056238|FD-Score:4.39|P-value:1.10E-5 ID:SGTC_1897|Compound:st060201|FD-Score:6.33|P-value:5.12E-10 ID:SGTC_1906|Compound:st060206|FD-Score:4.01|P-value:5.31E-5 ID:SGTC_1932|Compound:st074806|FD-Score:4.45|P-value:8.33E-6 ID:SGTC_2282|Compound:7944268|FD-Score:-4.83|P-value:2.23E-6 ID:SGTC_2317|Compound:5986382|FD-Score:4.67|P-value:3.28E-6 ID:SGTC_2318|Compound:6029776|FD-Score:4.27|P-value:1.80E-5 ID:SGTC_2323|Compound:6148992|FD-Score:3.84|P-value:1.01E-4 ID:SGTC_2328|Compound:6201408|FD-Score:4.96|P-value:8.52E-7 ID:SGTC_2345|Compound:9052315|FD-Score:4.03|P-value:4.91E-5 ID:SGTC_2391|Compound:6285546|FD-Score:-3.31|P-value:8.65E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.20|P-value:9.55E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-4.98|P-value:1.14E-6 ID:SGTC_2591|Compound:skatole|FD-Score:4.71|P-value:2.69E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.37|P-value:7.08E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.38|P-value:1.62E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.39|P-value:5.15E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.51|P-value:3.37E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.66|P-value:1.96E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-4.21|P-value:3.28E-5 ID:SGTC_2833|Compound:9001315|FD-Score:4.72|P-value:2.61E-6 ID:SGTC_2952|Compound:9073731|FD-Score:3.47|P-value:3.86E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.83|P-value:1.04E-4 ID:SGTC_3232|Compound:9132874|FD-Score:-3.32|P-value:8.28E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.55|P-value:2.92E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.40|P-value:4.99E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.36|P-value:7.44E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.59|P-value:3.39E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:4.52|P-value:6.27E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:4.23|P-value:2.12E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:4.15|P-value:2.96E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.53|P-value:3.17E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.91|P-value:7.72E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.05|P-value:4.48E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:4.54|P-value:5.75E-6 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.23|P-value:8.62E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.19|P-value:9.89E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:4.37|P-value:1.22E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.32|P-value:6.38E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.20|P-value:9.69E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.40|P-value:6.46E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-3.41|P-value:6.14E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.93|P-value:7.23E-5 ID:SGTC_1847|Compound:st056231|FD-Score:4.26|P-value:1.88E-5 ID:SGTC_1850|Compound:st056238|FD-Score:4.39|P-value:1.10E-5 ID:SGTC_1897|Compound:st060201|FD-Score:6.33|P-value:5.12E-10 ID:SGTC_1906|Compound:st060206|FD-Score:4.01|P-value:5.31E-5 ID:SGTC_1932|Compound:st074806|FD-Score:4.45|P-value:8.33E-6 ID:SGTC_2282|Compound:7944268|FD-Score:-4.83|P-value:2.23E-6 ID:SGTC_2317|Compound:5986382|FD-Score:4.67|P-value:3.28E-6 ID:SGTC_2318|Compound:6029776|FD-Score:4.27|P-value:1.80E-5 ID:SGTC_2323|Compound:6148992|FD-Score:3.84|P-value:1.01E-4 ID:SGTC_2328|Compound:6201408|FD-Score:4.96|P-value:8.52E-7 ID:SGTC_2345|Compound:9052315|FD-Score:4.03|P-value:4.91E-5 ID:SGTC_2391|Compound:6285546|FD-Score:-3.31|P-value:8.65E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.20|P-value:9.55E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-4.98|P-value:1.14E-6 ID:SGTC_2591|Compound:skatole|FD-Score:4.71|P-value:2.69E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.37|P-value:7.08E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.38|P-value:1.62E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.39|P-value:5.15E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.51|P-value:3.37E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.66|P-value:1.96E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-4.21|P-value:3.28E-5 ID:SGTC_2833|Compound:9001315|FD-Score:4.72|P-value:2.61E-6 ID:SGTC_2952|Compound:9073731|FD-Score:3.47|P-value:3.86E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.83|P-value:1.04E-4 ID:SGTC_3232|Compound:9132874|FD-Score:-3.32|P-value:8.28E-4

Top fitness defect scores for YER037W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1897 st060201 6.33 15.0 µM 5.12E-10 mitochondrial processes 4 1.19E-10
2 SGTC_2328 6201408 4.96 200.0 µM 8.52E-7 9 3.60E-7
3 SGTC_2833 9001315 4.72 45.5 µM 2.61E-6 amide catabolism 34 1.20E-6
4 SGTC_2591 skatole 4.71 100.0 µM 2.69E-6 17 1.24E-6
5 SGTC_2317 5986382 4.67 200.0 µM 3.28E-6 5 1.54E-6
6 SGTC_1405 3909-7894 4.54 12.0 µM 5.75E-6 60S ribosome export 6 2.82E-6
7 SGTC_538 2922-0838 4.52 53.3 µM 6.27E-6 Golgi 21 3.09E-6
8 SGTC_1932 st074806 4.45 40.9 µM 8.33E-6 15 4.20E-6
9 SGTC_1850 st056238 4.39 17.0 µM 1.10E-5 RPP1 & pyrimidine depletion 12 5.64E-6
10 SGTC_1441 4106-0040 4.37 13.0 µM 1.22E-5 7 6.32E-6
11 SGTC_2318 6029776 4.27 164.0 µM 1.80E-5 17 9.65E-6
12 SGTC_1847 st056231 4.26 15.0 µM 1.88E-5 29 1.01E-5
13 SGTC_754 3474-0146 4.23 171.0 µM 2.12E-5 copper-dependent oxidative stress 20 1.15E-5
14 SGTC_950 1165-0508 4.15 94.1 µM 2.96E-5 25 1.65E-5
15 SGTC_1331 1472-0049 4.05 76.2 µM 4.48E-5 17 2.57E-5
16 SGTC_2345 9052315 4.03 157.4 µM 4.91E-5 20 2.83E-5
17 SGTC_1906 st060206 4.01 94.7 µM 5.31E-5 18 3.08E-5
18 SGTC_1845 st056753 3.93 3.0 µM 7.23E-5 TSC3-RPN4 36 4.30E-5
19 SGTC_1149 3909-7961 3.91 23.3 µM 7.72E-5 19 4.61E-5
20 SGTC_2323 6148992 3.84 148.3 µM 1.01E-4 41 6.17E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.22E-13 YER143W DDI1 hom DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains
0.078 5.67E-6 YBR027C_d YBR027C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.074 1.74E-5 YPR001W CIT3 hom Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
0.074 1.87E-5 YOL046C_d YOL046C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W
0.073 2.53E-5 YNL095C_p YNL095C_p hom Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication
0.070 4.81E-5 YPL022W RAD1 hom Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
0.070 5.35E-5 YKL188C PXA2 hom Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder
0.069 6.27E-5 YJL033W HCA4 het DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
0.067 1.13E-4 YFR041C ERJ5 hom Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response
0.067 1.15E-4 YOR028C CIN5 hom Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication
0.065 1.50E-4 YGL058W RAD6 hom Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p
0.065 1.54E-4 YGR264C MES1 het Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
0.065 1.56E-4 YOR219C STE13 hom Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor
0.064 2.24E-4 YPL007C TFC8 het One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90
0.064 2.31E-4 YPL001W HAT1 hom Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair