YER038C / KRE29

Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance

Zygosity: Heterozygous strain
fixedexpanded
Profile for YER038C / KRE29

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:4.65|P-value:5.27E-7 ID:SGTC_22|Compound:0964-0034|FD-Score:3.11|P-value:5.40E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.63|P-value:7.02E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:-6.06|P-value:9.88E-11 ID:SGTC_376|Compound:3970-0862|FD-Score:3.25|P-value:3.20E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.34|P-value:2.30E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:3.22|P-value:3.59E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:4.46|P-value:1.45E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:3.06|P-value:6.61E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.87|P-value:2.38E-5 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.47|P-value:1.37E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.28|P-value:2.82E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.39|P-value:1.83E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-9.64|P-value:2.21E-24 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.07|P-value:6.24E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.10|P-value:8.57E-6 ID:SGTC_1449|Compound:4112-4002|FD-Score:-3.13|P-value:5.13E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:-3.21|P-value:3.76E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-2.97|P-value:9.03E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:5.30|P-value:1.31E-8 ID:SGTC_1496|Compound:4469-0713|FD-Score:4.24|P-value:4.26E-6 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.40|P-value:1.77E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-4.28|P-value:3.53E-6 ID:SGTC_1703|Compound:st026983|FD-Score:-3.43|P-value:1.58E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.86|P-value:2.48E-5 ID:SGTC_1884|Compound:5633444|FD-Score:3.97|P-value:1.51E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-2.96|P-value:9.61E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.19|P-value:4.12E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.30|P-value:3.23E-6 ID:SGTC_2054|Compound:5233173|FD-Score:-3.78|P-value:3.68E-5 ID:SGTC_2064|Compound:5220758|FD-Score:-3.19|P-value:4.10E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.05|P-value:6.74E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.39|P-value:1.86E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.47|P-value:1.32E-6 ID:SGTC_2383|Compound:9036125|FD-Score:-4.28|P-value:3.52E-6 ID:SGTC_2386|Compound:9075165|FD-Score:-3.29|P-value:2.73E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:5.78|P-value:6.63E-10 ID:SGTC_2421|Compound:5690543|FD-Score:3.61|P-value:7.56E-5 ID:SGTC_2445|Compound:5742597|FD-Score:3.35|P-value:2.16E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.75|P-value:4.11E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.24|P-value:3.30E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.12|P-value:5.21E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-3.81|P-value:3.11E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.09|P-value:5.94E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.58|P-value:8.63E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.21|P-value:3.77E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.27|P-value:3.03E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.13|P-value:5.12E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.05|P-value:6.84E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.49|P-value:1.23E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-2.95|P-value:9.73E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.83|P-value:2.92E-5 ID:SGTC_2913|Compound:7966556|FD-Score:3.18|P-value:4.21E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.22|P-value:3.63E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.25|P-value:3.23E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.82|P-value:2.13E-7 ID:SGTC_3137|Compound:9097352|FD-Score:3.35|P-value:2.18E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-2.97|P-value:8.98E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.39|P-value:1.88E-4 ID:SGTC_3326|Compound:9140064|FD-Score:5.15|P-value:3.14E-8 ID:SGTC_11|Compound:0438-0307|FD-Score:4.65|P-value:5.27E-7 ID:SGTC_22|Compound:0964-0034|FD-Score:3.11|P-value:5.40E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.63|P-value:7.02E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:-6.06|P-value:9.88E-11 ID:SGTC_376|Compound:3970-0862|FD-Score:3.25|P-value:3.20E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.34|P-value:2.30E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:3.22|P-value:3.59E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:4.46|P-value:1.45E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:3.06|P-value:6.61E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.87|P-value:2.38E-5 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.47|P-value:1.37E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.28|P-value:2.82E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.39|P-value:1.83E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-9.64|P-value:2.21E-24 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.07|P-value:6.24E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.10|P-value:8.57E-6 ID:SGTC_1449|Compound:4112-4002|FD-Score:-3.13|P-value:5.13E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:-3.21|P-value:3.76E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-2.97|P-value:9.03E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:5.30|P-value:1.31E-8 ID:SGTC_1496|Compound:4469-0713|FD-Score:4.24|P-value:4.26E-6 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.40|P-value:1.77E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-4.28|P-value:3.53E-6 ID:SGTC_1703|Compound:st026983|FD-Score:-3.43|P-value:1.58E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.86|P-value:2.48E-5 ID:SGTC_1884|Compound:5633444|FD-Score:3.97|P-value:1.51E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-2.96|P-value:9.61E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.19|P-value:4.12E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.30|P-value:3.23E-6 ID:SGTC_2054|Compound:5233173|FD-Score:-3.78|P-value:3.68E-5 ID:SGTC_2064|Compound:5220758|FD-Score:-3.19|P-value:4.10E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.05|P-value:6.74E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.39|P-value:1.86E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.47|P-value:1.32E-6 ID:SGTC_2383|Compound:9036125|FD-Score:-4.28|P-value:3.52E-6 ID:SGTC_2386|Compound:9075165|FD-Score:-3.29|P-value:2.73E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:5.78|P-value:6.63E-10 ID:SGTC_2421|Compound:5690543|FD-Score:3.61|P-value:7.56E-5 ID:SGTC_2445|Compound:5742597|FD-Score:3.35|P-value:2.16E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.75|P-value:4.11E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.24|P-value:3.30E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.12|P-value:5.21E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-3.81|P-value:3.11E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.09|P-value:5.94E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.58|P-value:8.63E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.21|P-value:3.77E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.27|P-value:3.03E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.13|P-value:5.12E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.05|P-value:6.84E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.49|P-value:1.23E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-2.95|P-value:9.73E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.83|P-value:2.92E-5 ID:SGTC_2913|Compound:7966556|FD-Score:3.18|P-value:4.21E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.22|P-value:3.63E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.25|P-value:3.23E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.82|P-value:2.13E-7 ID:SGTC_3137|Compound:9097352|FD-Score:3.35|P-value:2.18E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-2.97|P-value:8.98E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.39|P-value:1.88E-4 ID:SGTC_3326|Compound:9140064|FD-Score:5.15|P-value:3.14E-8

Top fitness defect scores for YER038C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 5.78 200.0 µM 6.63E-10 2 3.81E-9 1.88
2 SGTC_1479 0549-0158 5.30 134.0 µM 1.31E-8 1 5.75E-8 0.91
3 SGTC_3326 9140064 5.15 16.4 µM 3.14E-8 1 1.28E-7 0.36
4 SGTC_11 0438-0307 4.65 1.3 µM 5.27E-7 2 1.66E-6 0.17
5 SGTC_2370 9071495 4.47 200.0 µM 1.32E-6 mitochondrial processes 5 3.83E-6 0.17
6 SGTC_975 1335-0046 4.46 28.5 µM 1.45E-6 RPP1 & pyrimidine depletion 4 4.17E-6 0.28
7 SGTC_1919 st067113 4.30 52.3 µM 3.23E-6 TSC3-RPN4 7 8.66E-6 0.10
8 SGTC_1496 4469-0713 4.24 57.4 µM 4.26E-6 3 1.12E-5 0.62
9 SGTC_1446 4239-0190 4.10 62.0 µM 8.57E-6 8 2.11E-5 0.42
10 SGTC_1884 5633444 3.97 25.0 µM 1.51E-5 redox potentiating 16 3.53E-5 0.16
11 SGTC_1237 0330-0133 3.87 46.1 µM 2.38E-5 ergosterol biosynthesis 10 5.35E-5 0.11
12 SGTC_1864 st057645 3.86 30.4 µM 2.48E-5 amide catabolism 3 5.56E-5 0.35
13 SGTC_2882 9058044 3.83 58.4 µM 2.92E-5 7 6.44E-5 0.02
14 SGTC_2486 5283202 3.75 22.4 µM 4.11E-5 2 8.80E-5 0.09
15 SGTC_2421 5690543 3.61 90.7 µM 7.56E-5 5 1.53E-4 0.03
16 SGTC_2574 2',4'-dihydroxychalcone 3.58 14.6 µM 8.63E-5 16 1.73E-4 0.03
17 SGTC_2705 st078069 3.49 42.8 µM 1.23E-4 7 2.39E-4 0.11
18 SGTC_1273 0849-0096 3.47 14.1 µM 1.37E-4 RPP1 & pyrimidine depletion 11 2.65E-4 0.11
19 SGTC_1286 0929-0070 3.39 131.0 µM 1.83E-4 7 3.44E-4 0.13
20 SGTC_3292 9120825 3.39 59.8 µM 1.88E-4 6 3.53E-4 0.16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 3.06E-18 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.146 2.39E-17 YFR031C SMC2 het Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
0.138 8.18E-16 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.134 8.26E-15 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.131 2.91E-14 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.127 1.35E-13 YHR118C ORC6 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
0.126 2.33E-13 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.114 3.15E-11 YMR218C TRS130 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
0.114 3.23E-11 YER093C TSC11 het Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain
0.114 3.24E-11 YKL153W_d YKL153W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
0.111 9.82E-11 YMR270C RRN9 het Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
0.102 2.99E-9 YDR498C SEC20 het Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p
0.099 8.35E-9 YIR011C STS1 het Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation
0.096 2.73E-8 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.095 3.17E-8 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition