YER038W-A_d

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria

Zygosity: Homozygous strain
fixedexpanded
Profile for YER038W-A / YER038W-A

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:5.32|P-value:6.84E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.15|P-value:8.10E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.15|P-value:7.96E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.23|P-value:7.11E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.90|P-value:5.64E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.47|P-value:2.55E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:4.41|P-value:6.37E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-4.33|P-value:7.60E-6 ID:SGTC_661|Compound:1304-0007|FD-Score:4.40|P-value:6.54E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:-3.55|P-value:1.90E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.83|P-value:6.33E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:4.06|P-value:2.97E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:-5.10|P-value:1.78E-7 ID:SGTC_807|Compound:1315-0151|FD-Score:-5.25|P-value:7.83E-8 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.17|P-value:7.61E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.49|P-value:2.81E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.80|P-value:8.62E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.38|P-value:7.22E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.77|P-value:8.25E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.76|P-value:8.58E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.20|P-value:7.73E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.43|P-value:3.42E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.41|P-value:3.22E-4 ID:SGTC_1792|Compound:st045773|FD-Score:-3.18|P-value:7.22E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-3.51|P-value:2.19E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.99|P-value:3.32E-5 ID:SGTC_2280|Compound:7785178|FD-Score:4.01|P-value:3.66E-5 ID:SGTC_2287|Compound:7945887|FD-Score:4.01|P-value:3.66E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.94|P-value:4.79E-5 ID:SGTC_2427|Compound:5545055|FD-Score:5.53|P-value:2.12E-8 ID:SGTC_2437|Compound:5741531|FD-Score:3.58|P-value:2.01E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.49|P-value:2.41E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.11|P-value:9.11E-4 ID:SGTC_2849|Compound:9019321|FD-Score:6.64|P-value:2.23E-11 ID:SGTC_2923|Compound:7992654|FD-Score:-3.26|P-value:5.59E-4 ID:SGTC_2969|Compound:9091408|FD-Score:4.08|P-value:2.71E-5 ID:SGTC_2974|Compound:9094440|FD-Score:5.82|P-value:4.05E-9 ID:SGTC_2979|Compound:9012552|FD-Score:4.08|P-value:2.63E-5 ID:SGTC_3047|Compound:9092122|FD-Score:-3.90|P-value:4.81E-5 ID:SGTC_3056|Compound:9094900|FD-Score:3.44|P-value:3.38E-4 ID:SGTC_3057|Compound:9095946|FD-Score:6.18|P-value:4.38E-10 ID:SGTC_3232|Compound:9132874|FD-Score:-3.37|P-value:3.73E-4 ID:SGTC_3236|Compound:9132701|FD-Score:-3.60|P-value:1.56E-4 ID:SGTC_3237|Compound:9133362|FD-Score:-3.78|P-value:7.85E-5 ID:SGTC_3240|Compound:9133527|FD-Score:-3.67|P-value:1.20E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.36|P-value:3.83E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.53|P-value:3.66E-6 ID:SGTC_6|Compound:0844-0013|FD-Score:5.32|P-value:6.84E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.15|P-value:8.10E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.15|P-value:7.96E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.23|P-value:7.11E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.90|P-value:5.64E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.47|P-value:2.55E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:4.41|P-value:6.37E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-4.33|P-value:7.60E-6 ID:SGTC_661|Compound:1304-0007|FD-Score:4.40|P-value:6.54E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:-3.55|P-value:1.90E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.83|P-value:6.33E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:4.06|P-value:2.97E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:-5.10|P-value:1.78E-7 ID:SGTC_807|Compound:1315-0151|FD-Score:-5.25|P-value:7.83E-8 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.17|P-value:7.61E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.49|P-value:2.81E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.80|P-value:8.62E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.38|P-value:7.22E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.77|P-value:8.25E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.76|P-value:8.58E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.20|P-value:7.73E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.43|P-value:3.42E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.41|P-value:3.22E-4 ID:SGTC_1792|Compound:st045773|FD-Score:-3.18|P-value:7.22E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-3.51|P-value:2.19E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.99|P-value:3.32E-5 ID:SGTC_2280|Compound:7785178|FD-Score:4.01|P-value:3.66E-5 ID:SGTC_2287|Compound:7945887|FD-Score:4.01|P-value:3.66E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.94|P-value:4.79E-5 ID:SGTC_2427|Compound:5545055|FD-Score:5.53|P-value:2.12E-8 ID:SGTC_2437|Compound:5741531|FD-Score:3.58|P-value:2.01E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.49|P-value:2.41E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.11|P-value:9.11E-4 ID:SGTC_2849|Compound:9019321|FD-Score:6.64|P-value:2.23E-11 ID:SGTC_2923|Compound:7992654|FD-Score:-3.26|P-value:5.59E-4 ID:SGTC_2969|Compound:9091408|FD-Score:4.08|P-value:2.71E-5 ID:SGTC_2974|Compound:9094440|FD-Score:5.82|P-value:4.05E-9 ID:SGTC_2979|Compound:9012552|FD-Score:4.08|P-value:2.63E-5 ID:SGTC_3047|Compound:9092122|FD-Score:-3.90|P-value:4.81E-5 ID:SGTC_3056|Compound:9094900|FD-Score:3.44|P-value:3.38E-4 ID:SGTC_3057|Compound:9095946|FD-Score:6.18|P-value:4.38E-10 ID:SGTC_3232|Compound:9132874|FD-Score:-3.37|P-value:3.73E-4 ID:SGTC_3236|Compound:9132701|FD-Score:-3.60|P-value:1.56E-4 ID:SGTC_3237|Compound:9133362|FD-Score:-3.78|P-value:7.85E-5 ID:SGTC_3240|Compound:9133527|FD-Score:-3.67|P-value:1.20E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.36|P-value:3.83E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.53|P-value:3.66E-6

Top fitness defect scores for YER038W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2849 9019321 6.64 13.0 µM 2.23E-11 8 1.54E-11
2 SGTC_3057 9095946 6.18 49.5 µM 4.38E-10 Golgi 2 3.15E-10
3 SGTC_2974 9094440 5.82 9.7 µM 4.05E-9 ergosterol biosynthesis 15 3.00E-9
4 SGTC_2427 5545055 5.53 42.8 µM 2.12E-8 2 1.61E-8
5 SGTC_6 0844-0013 5.32 19.8 µM 6.84E-8 26 5.26E-8
6 SGTC_3293 9120939 4.53 62.0 µM 3.66E-6 7 2.98E-6
7 SGTC_505 gw-5074 4.41 63.9 µM 6.37E-6 44 5.23E-6
8 SGTC_661 1304-0007 4.40 33.6 µM 6.54E-6 15 5.37E-6
9 SGTC_1131 3454-3128 4.38 32.3 µM 7.22E-6 25 5.93E-6
10 SGTC_2979 9012552 4.08 45.5 µM 2.63E-5 5 2.21E-5
11 SGTC_2969 9091408 4.08 28.7 µM 2.71E-5 22 2.27E-5
12 SGTC_802 4112-3352 4.06 742.0 µM 2.97E-5 22 2.49E-5
13 SGTC_2287 7945887 4.01 168.8 µM 3.66E-5 8 3.08E-5
14 SGTC_2280 7785178 4.01 200.0 µM 3.66E-5 9 3.08E-5
15 SGTC_2425 5628681 3.94 7.8 µM 4.79E-5 24 4.04E-5
16 SGTC_393 acivicin 3.90 6.2 µM 5.64E-5 23 4.78E-5
17 SGTC_1125 tnp00248 3.80 1.3 µM 8.62E-5 33 7.34E-5
18 SGTC_2437 5741531 3.58 144.2 µM 2.01E-4 52 1.73E-4
19 SGTC_1023 4482-3888 3.49 16.0 µM 2.81E-4 TSC3-RPN4 29 2.43E-4
20 SGTC_3056 9094900 3.44 49.5 µM 3.38E-4 38 2.93E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 9.21E-11 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.111 1.15E-10 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.110 1.97E-10 YLR421C RPN13 hom Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.108 4.11E-10 YEL016C NPP2 hom Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication
0.105 1.18E-9 YDL137W ARF2 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication
0.102 3.02E-9 YPR035W GLN1 het Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.101 4.68E-9 YEL023C_p YEL023C_p hom Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
0.096 2.62E-8 YLR210W CLB4 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
0.096 2.65E-8 YHR035W_p YHR035W_p hom Putative protein of unknown function; not an essential gene
0.095 3.18E-8 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.094 4.46E-8 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.094 5.45E-8 YHR138C YHR138C hom Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress
0.092 8.85E-8 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.092 1.06E-7 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.088 3.15E-7 YLL052C AQY2 hom Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains