YER039C / HVG1

Protein of unknown function, has homology to Vrg4p

Zygosity: Homozygous strain
fixedexpanded
Profile for YER039C / HVG1

Click on Significant Values for Screen Details ID:SGTC_85|Compound:0868-0259|FD-Score:3.16|P-value:8.95E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.24|P-value:7.13E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:6.04|P-value:1.23E-9 ID:SGTC_149|Compound:3970-0822|FD-Score:-6.31|P-value:2.49E-10 ID:SGTC_154|Compound:3389-1638|FD-Score:4.34|P-value:9.07E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:-6.15|P-value:6.96E-10 ID:SGTC_162|Compound:k030-0015|FD-Score:-3.17|P-value:9.01E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.71|P-value:1.30E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:5.16|P-value:1.74E-7 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.95|P-value:4.81E-5 ID:SGTC_579|Compound:4491-1009|FD-Score:4.76|P-value:1.33E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.46|P-value:3.28E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:4.89|P-value:6.84E-7 ID:SGTC_889|Compound:0919-1524|FD-Score:3.39|P-value:4.09E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.35|P-value:4.69E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:-4.82|P-value:1.01E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:3.22|P-value:7.44E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.69|P-value:1.33E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.22|P-value:7.35E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.37|P-value:4.31E-4 ID:SGTC_1625|Compound:st003711|FD-Score:5.99|P-value:1.64E-9 ID:SGTC_1626|Compound:st003712|FD-Score:-5.86|P-value:3.96E-9 ID:SGTC_1689|Compound:st020265|FD-Score:3.59|P-value:1.95E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.56|P-value:2.21E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.55|P-value:2.32E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.35|P-value:4.62E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.24|P-value:7.02E-4 ID:SGTC_2429|Compound:5902844|FD-Score:-3.41|P-value:3.96E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.26|P-value:6.57E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-4.21|P-value:1.66E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.55|P-value:2.40E-4 ID:SGTC_2696|Compound:st077691|FD-Score:-3.55|P-value:2.35E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.77|P-value:9.92E-5 ID:SGTC_2795|Compound:7780010|FD-Score:4.26|P-value:1.27E-5 ID:SGTC_2965|Compound:9082772|FD-Score:4.63|P-value:2.40E-6 ID:SGTC_3041|Compound:9091929|FD-Score:-3.40|P-value:4.07E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.30|P-value:5.52E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.69|P-value:1.38E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.32|P-value:5.25E-4 ID:SGTC_3310|Compound:9130229|FD-Score:4.10|P-value:2.53E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:3.16|P-value:8.95E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.24|P-value:7.13E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:6.04|P-value:1.23E-9 ID:SGTC_149|Compound:3970-0822|FD-Score:-6.31|P-value:2.49E-10 ID:SGTC_154|Compound:3389-1638|FD-Score:4.34|P-value:9.07E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:-6.15|P-value:6.96E-10 ID:SGTC_162|Compound:k030-0015|FD-Score:-3.17|P-value:9.01E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.71|P-value:1.30E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:5.16|P-value:1.74E-7 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.95|P-value:4.81E-5 ID:SGTC_579|Compound:4491-1009|FD-Score:4.76|P-value:1.33E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.46|P-value:3.28E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:4.89|P-value:6.84E-7 ID:SGTC_889|Compound:0919-1524|FD-Score:3.39|P-value:4.09E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.35|P-value:4.69E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:-4.82|P-value:1.01E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:3.22|P-value:7.44E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.69|P-value:1.33E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.22|P-value:7.35E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.37|P-value:4.31E-4 ID:SGTC_1625|Compound:st003711|FD-Score:5.99|P-value:1.64E-9 ID:SGTC_1626|Compound:st003712|FD-Score:-5.86|P-value:3.96E-9 ID:SGTC_1689|Compound:st020265|FD-Score:3.59|P-value:1.95E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.56|P-value:2.21E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.55|P-value:2.32E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.35|P-value:4.62E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.24|P-value:7.02E-4 ID:SGTC_2429|Compound:5902844|FD-Score:-3.41|P-value:3.96E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.26|P-value:6.57E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-4.21|P-value:1.66E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.55|P-value:2.40E-4 ID:SGTC_2696|Compound:st077691|FD-Score:-3.55|P-value:2.35E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.77|P-value:9.92E-5 ID:SGTC_2795|Compound:7780010|FD-Score:4.26|P-value:1.27E-5 ID:SGTC_2965|Compound:9082772|FD-Score:4.63|P-value:2.40E-6 ID:SGTC_3041|Compound:9091929|FD-Score:-3.40|P-value:4.07E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.30|P-value:5.52E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.69|P-value:1.38E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.32|P-value:5.25E-4 ID:SGTC_3310|Compound:9130229|FD-Score:4.10|P-value:2.53E-5

Top fitness defect scores for YER039C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_147 4466-0538 6.04 29.2 µM 1.23E-9 ergosterol biosynthesis 4 7.60E-10
2 SGTC_1625 st003711 5.99 30.1 µM 1.64E-9 calcium & mitochondrial duress 9 1.02E-9
3 SGTC_196 k015-0023 5.16 18.1 µM 1.74E-7 PDR1 9 1.22E-7
4 SGTC_739 1486-1183 4.89 203.0 µM 6.84E-7 9 4.99E-7
5 SGTC_579 4491-1009 4.76 110.0 µM 1.33E-6 60S ribosome export 8 9.84E-7
6 SGTC_2965 9082772 4.63 38.6 µM 2.40E-6 mitochondrial response to ROS 26 1.81E-6
7 SGTC_154 3389-1638 4.34 511.1 µM 9.07E-6 18 7.08E-6
8 SGTC_2795 7780010 4.26 54.5 µM 1.27E-5 19 1.00E-5
9 SGTC_3310 9130229 4.10 44.1 µM 2.53E-5 Golgi 22 2.03E-5
10 SGTC_218 alverine citrate 3.95 93.8 µM 4.81E-5 fatty acid desaturase (OLE1) 32 3.92E-5
11 SGTC_2730 imipramine 3.77 71.3 µM 9.92E-5 33 8.23E-5
12 SGTC_1450 4112-4260 3.69 37.6 µM 1.33E-4 calcium & mitochondrial duress 37 1.11E-4
13 SGTC_1689 st020265 3.59 53.5 µM 1.95E-4 21 1.64E-4
14 SGTC_1799 st045822 3.56 46.1 µM 2.21E-4 22 1.87E-4
15 SGTC_1942 st076330 3.55 65.2 µM 2.32E-4 41 1.96E-4
16 SGTC_889 0919-1524 3.39 82.7 µM 4.09E-4 31 3.52E-4
17 SGTC_1590 st077108 3.37 57.8 µM 4.31E-4 14 3.71E-4
18 SGTC_2015 5119600 3.35 184.0 µM 4.62E-4 48 3.98E-4
19 SGTC_916 4466-0038 3.35 42.0 nM 4.69E-4 cell wall 105 4.04E-4
20 SGTC_3308 9128332 3.32 17.6 µM 5.25E-4 plasma membrane duress 107 4.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.27E-14 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.101 4.13E-9 YGL249W ZIP2 hom Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.095 3.02E-8 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.091 1.36E-7 YHL014C YLF2 hom Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.090 1.54E-7 YBR019C GAL10 hom UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
0.086 5.78E-7 YOR016C ERP4 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.083 1.46E-6 YMR251W-A HOR7 hom Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication
0.078 6.41E-6 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.075 1.55E-5 YER110C KAP123 hom Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
0.075 1.55E-5 YPR143W RRP15 het Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.073 2.40E-5 YPL149W ATG5 hom Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation
0.072 2.80E-5 YKR105C_p VBA5_p hom Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p
0.071 3.63E-5 YDR133C_d YDR133C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
0.071 4.16E-5 YIL007C NAS2 hom Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress
0.071 4.35E-5 YHR043C DOG2 hom 2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, paralogous to DOG1, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed