YER039C-A_p

Putative protein of unknown function; YER039C-A is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YER039C-A / YER039C-A

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:4.43|P-value:3.01E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:3.52|P-value:1.59E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:4.16|P-value:1.04E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:3.34|P-value:3.21E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.24|P-value:4.59E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:4.08|P-value:1.52E-5 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.40|P-value:2.56E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.42|P-value:2.41E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.22|P-value:4.93E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.53|P-value:1.55E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:4.58|P-value:1.42E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:4.03|P-value:1.89E-5 ID:SGTC_814|Compound:3342-0569|FD-Score:3.03|P-value:9.71E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:4.91|P-value:2.65E-7 ID:SGTC_845|Compound:0330-0138|FD-Score:3.10|P-value:7.76E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.69|P-value:8.12E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.21|P-value:5.07E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.09|P-value:7.83E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.67|P-value:8.87E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.12|P-value:7.04E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.78|P-value:5.67E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:4.34|P-value:4.63E-6 ID:SGTC_1678|Compound:st019265|FD-Score:3.59|P-value:1.20E-4 ID:SGTC_1708|Compound:st033234|FD-Score:4.10|P-value:1.36E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.10|P-value:7.70E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.39|P-value:2.64E-4 ID:SGTC_1866|Compound:st057638|FD-Score:3.12|P-value:7.13E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.33|P-value:4.88E-6 ID:SGTC_1916|Compound:st067606|FD-Score:4.22|P-value:7.93E-6 ID:SGTC_2016|Compound:5121758|FD-Score:-3.25|P-value:4.43E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.56|P-value:1.39E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.36|P-value:2.93E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.31|P-value:3.55E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.29|P-value:3.80E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.12|P-value:7.10E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.35|P-value:3.14E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.17|P-value:5.91E-4 ID:SGTC_2295|Compound:7971645|FD-Score:-3.23|P-value:4.71E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.39|P-value:2.69E-4 ID:SGTC_2299|Compound:7976368|FD-Score:5.14|P-value:7.54E-8 ID:SGTC_2308|Compound:7584454|FD-Score:3.42|P-value:2.34E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.71|P-value:7.57E-5 ID:SGTC_2692|Compound:st077426|FD-Score:3.31|P-value:3.58E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.22|P-value:4.93E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.08|P-value:8.26E-4 ID:SGTC_2873|Compound:9040596|FD-Score:4.50|P-value:2.08E-6 ID:SGTC_3067|Compound:9117431|FD-Score:-4.00|P-value:2.14E-5 ID:SGTC_3189|Compound:9110682|FD-Score:3.24|P-value:4.57E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.35|P-value:3.13E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:4.43|P-value:3.01E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:3.52|P-value:1.59E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:4.16|P-value:1.04E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:3.34|P-value:3.21E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.24|P-value:4.59E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:4.08|P-value:1.52E-5 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.40|P-value:2.56E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.42|P-value:2.41E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.22|P-value:4.93E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.53|P-value:1.55E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:4.58|P-value:1.42E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:4.03|P-value:1.89E-5 ID:SGTC_814|Compound:3342-0569|FD-Score:3.03|P-value:9.71E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:4.91|P-value:2.65E-7 ID:SGTC_845|Compound:0330-0138|FD-Score:3.10|P-value:7.76E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.69|P-value:8.12E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.21|P-value:5.07E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.09|P-value:7.83E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.67|P-value:8.87E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.12|P-value:7.04E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.78|P-value:5.67E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:4.34|P-value:4.63E-6 ID:SGTC_1678|Compound:st019265|FD-Score:3.59|P-value:1.20E-4 ID:SGTC_1708|Compound:st033234|FD-Score:4.10|P-value:1.36E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.10|P-value:7.70E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.39|P-value:2.64E-4 ID:SGTC_1866|Compound:st057638|FD-Score:3.12|P-value:7.13E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.33|P-value:4.88E-6 ID:SGTC_1916|Compound:st067606|FD-Score:4.22|P-value:7.93E-6 ID:SGTC_2016|Compound:5121758|FD-Score:-3.25|P-value:4.43E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.56|P-value:1.39E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.36|P-value:2.93E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.31|P-value:3.55E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.29|P-value:3.80E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.12|P-value:7.10E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.35|P-value:3.14E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.17|P-value:5.91E-4 ID:SGTC_2295|Compound:7971645|FD-Score:-3.23|P-value:4.71E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.39|P-value:2.69E-4 ID:SGTC_2299|Compound:7976368|FD-Score:5.14|P-value:7.54E-8 ID:SGTC_2308|Compound:7584454|FD-Score:3.42|P-value:2.34E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.71|P-value:7.57E-5 ID:SGTC_2692|Compound:st077426|FD-Score:3.31|P-value:3.58E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.22|P-value:4.93E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.08|P-value:8.26E-4 ID:SGTC_2873|Compound:9040596|FD-Score:4.50|P-value:2.08E-6 ID:SGTC_3067|Compound:9117431|FD-Score:-4.00|P-value:2.14E-5 ID:SGTC_3189|Compound:9110682|FD-Score:3.24|P-value:4.57E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.35|P-value:3.13E-4

Top fitness defect scores for YER039C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2299 7976368 5.14 114.9 µM 7.54E-8 12 1.40E-7
2 SGTC_833 3852-0053 4.91 558.0 µM 2.65E-7 6 4.66E-7
3 SGTC_1094 duloxetine 4.67 25.4 µM 8.87E-7 RPP1 & pyrimidine depletion 6 1.48E-6
4 SGTC_716 1683-5115 4.58 658.0 µM 1.42E-6 8 2.34E-6
5 SGTC_2873 9040596 4.50 71.4 µM 2.08E-6 33 3.36E-6
6 SGTC_61 0978-8327 4.43 98.6 µM 3.01E-6 ergosterol biosynthesis 21 4.78E-6
7 SGTC_1586 deoxycorticosterone acetate 4.34 53.7 µM 4.63E-6 4 7.22E-6
8 SGTC_1915 st067105 4.33 30.6 µM 4.88E-6 RNA pol III & RNase P/MRP 33 7.60E-6
9 SGTC_1916 st067606 4.22 49.2 µM 7.93E-6 28 1.21E-5
10 SGTC_166 k072-0058 4.16 166.4 µM 1.04E-5 DNA intercalators 27 1.57E-5
11 SGTC_1708 st033234 4.10 31.8 µM 1.36E-5 14 2.03E-5
12 SGTC_362 0310-0100 4.08 9.0 µM 1.52E-5 RPP1 & pyrimidine depletion 30 2.26E-5
13 SGTC_784 4579-0127 4.03 173.0 µM 1.89E-5 21 2.78E-5
14 SGTC_1495 4469-0029 3.78 237.0 µM 5.67E-5 119 7.96E-5
15 SGTC_2406 ethylparaben 3.71 405.7 µM 7.57E-5 53 1.05E-4
16 SGTC_941 3237-0776 3.69 460.0 µM 8.12E-5 23 1.12E-4
17 SGTC_1678 st019265 3.59 80.2 µM 1.20E-4 60S ribosome export 32 1.64E-4
18 SGTC_2019 4016004 3.56 108.0 µM 1.39E-4 42 1.89E-4
19 SGTC_595 3909-8003 3.53 73.7 µM 1.55E-4 23 2.09E-4
20 SGTC_136 0097-0015 3.52 404.5 µM 1.59E-4 60S ribosome export 35 2.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.70E-10 YBR087W RFC5 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.093 7.19E-8 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.091 1.18E-7 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.087 4.95E-7 YPL026C SKS1 hom Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
0.081 2.33E-6 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.080 3.52E-6 YIL139C REV7 hom Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.079 4.79E-6 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.078 6.61E-6 YBL049W MOH1 hom Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase
0.078 6.81E-6 YPL070W MUK1 hom Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation
0.076 9.89E-6 YHR094C HXT1 hom Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication
0.070 4.39E-5 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.070 4.75E-5 YER155C BEM2 hom Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence
0.070 5.23E-5 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.069 6.43E-5 YJL157C FAR1 hom Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.069 6.84E-5 YPL110C GDE1 hom Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes