YER040W / GLN3

Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source

Zygosity: Homozygous strain
fixedexpanded
Profile for YER040W / GLN3

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:4.27|P-value:9.99E-6 ID:SGTC_114|Compound:0364-0001|FD-Score:4.90|P-value:5.03E-7 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.24|P-value:7.39E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:6.02|P-value:9.98E-10 ID:SGTC_130|Compound:0136-0219|FD-Score:3.84|P-value:6.15E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.67|P-value:1.22E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:-3.41|P-value:4.18E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.09|P-value:9.94E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.17|P-value:7.42E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:-3.66|P-value:1.64E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.21|P-value:6.56E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.00|P-value:3.21E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.82|P-value:6.62E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:3.12|P-value:8.93E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:4.32|P-value:8.13E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:3.23|P-value:6.09E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.65|P-value:1.30E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:-3.47|P-value:3.32E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.31|P-value:8.41E-6 ID:SGTC_712|Compound:r015-0009|FD-Score:3.51|P-value:2.18E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.60|P-value:1.57E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.73|P-value:9.37E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.72|P-value:9.79E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:5.64|P-value:9.65E-9 ID:SGTC_993|Compound:3909-8757|FD-Score:3.91|P-value:4.58E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:5.73|P-value:5.54E-9 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.40|P-value:3.36E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.36|P-value:6.67E-6 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.22|P-value:6.25E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.21|P-value:1.33E-5 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.34|P-value:4.13E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.75|P-value:1.05E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.90|P-value:4.90E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:5.68|P-value:7.42E-9 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.89|P-value:4.99E-5 ID:SGTC_1633|Compound:st005664|FD-Score:4.72|P-value:1.23E-6 ID:SGTC_1635|Compound:st007035|FD-Score:-3.63|P-value:1.86E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.43|P-value:3.03E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-4.88|P-value:7.89E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.38|P-value:4.68E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.16|P-value:7.61E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.25|P-value:1.20E-7 ID:SGTC_1959|Compound:st077091|FD-Score:3.30|P-value:4.81E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.37|P-value:3.73E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:5.13|P-value:1.59E-7 ID:SGTC_2322|Compound:7413319|FD-Score:-3.42|P-value:4.04E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:5.32|P-value:5.72E-8 ID:SGTC_2437|Compound:5741531|FD-Score:-4.04|P-value:3.58E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:5.23|P-value:8.95E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.46|P-value:3.79E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.18|P-value:7.34E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.13|P-value:8.65E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.91|P-value:4.68E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:3.38|P-value:3.61E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.18|P-value:9.26E-4 ID:SGTC_2784|Compound:7567673|FD-Score:4.96|P-value:3.82E-7 ID:SGTC_2980|Compound:9014342|FD-Score:-5.37|P-value:6.16E-8 ID:SGTC_2982|Compound:9019404|FD-Score:-3.30|P-value:6.04E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.25|P-value:7.32E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.93|P-value:4.25E-5 ID:SGTC_3006|Compound:9075424|FD-Score:-3.32|P-value:5.78E-4 ID:SGTC_3015|Compound:9080845|FD-Score:-3.73|P-value:1.28E-4 ID:SGTC_3047|Compound:9092122|FD-Score:4.59|P-value:2.31E-6 ID:SGTC_3052|Compound:9092717|FD-Score:3.15|P-value:8.12E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.33|P-value:5.59E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.30|P-value:4.68E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-4.00|P-value:4.25E-5 ID:SGTC_3|Compound:0833-0587|FD-Score:4.27|P-value:9.99E-6 ID:SGTC_114|Compound:0364-0001|FD-Score:4.90|P-value:5.03E-7 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.24|P-value:7.39E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:6.02|P-value:9.98E-10 ID:SGTC_130|Compound:0136-0219|FD-Score:3.84|P-value:6.15E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.67|P-value:1.22E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:-3.41|P-value:4.18E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.09|P-value:9.94E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.17|P-value:7.42E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:-3.66|P-value:1.64E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.21|P-value:6.56E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.00|P-value:3.21E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.82|P-value:6.62E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:3.12|P-value:8.93E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:4.32|P-value:8.13E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:3.23|P-value:6.09E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.65|P-value:1.30E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:-3.47|P-value:3.32E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.31|P-value:8.41E-6 ID:SGTC_712|Compound:r015-0009|FD-Score:3.51|P-value:2.18E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.60|P-value:1.57E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.73|P-value:9.37E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.72|P-value:9.79E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:5.64|P-value:9.65E-9 ID:SGTC_993|Compound:3909-8757|FD-Score:3.91|P-value:4.58E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:5.73|P-value:5.54E-9 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.40|P-value:3.36E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.36|P-value:6.67E-6 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.22|P-value:6.25E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.21|P-value:1.33E-5 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.34|P-value:4.13E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.75|P-value:1.05E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.90|P-value:4.90E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:5.68|P-value:7.42E-9 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.89|P-value:4.99E-5 ID:SGTC_1633|Compound:st005664|FD-Score:4.72|P-value:1.23E-6 ID:SGTC_1635|Compound:st007035|FD-Score:-3.63|P-value:1.86E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.43|P-value:3.03E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-4.88|P-value:7.89E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.38|P-value:4.68E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.16|P-value:7.61E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.25|P-value:1.20E-7 ID:SGTC_1959|Compound:st077091|FD-Score:3.30|P-value:4.81E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.37|P-value:3.73E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:5.13|P-value:1.59E-7 ID:SGTC_2322|Compound:7413319|FD-Score:-3.42|P-value:4.04E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:5.32|P-value:5.72E-8 ID:SGTC_2437|Compound:5741531|FD-Score:-4.04|P-value:3.58E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:5.23|P-value:8.95E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.46|P-value:3.79E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.18|P-value:7.34E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.13|P-value:8.65E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.91|P-value:4.68E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:3.38|P-value:3.61E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.18|P-value:9.26E-4 ID:SGTC_2784|Compound:7567673|FD-Score:4.96|P-value:3.82E-7 ID:SGTC_2980|Compound:9014342|FD-Score:-5.37|P-value:6.16E-8 ID:SGTC_2982|Compound:9019404|FD-Score:-3.30|P-value:6.04E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.25|P-value:7.32E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.93|P-value:4.25E-5 ID:SGTC_3006|Compound:9075424|FD-Score:-3.32|P-value:5.78E-4 ID:SGTC_3015|Compound:9080845|FD-Score:-3.73|P-value:1.28E-4 ID:SGTC_3047|Compound:9092122|FD-Score:4.59|P-value:2.31E-6 ID:SGTC_3052|Compound:9092717|FD-Score:3.15|P-value:8.12E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.33|P-value:5.59E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.30|P-value:4.68E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-4.00|P-value:4.25E-5

Top fitness defect scores for YER040W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_118 0083-0097 6.02 135.3 µM 9.98E-10 translation 23 8.78E-10
2 SGTC_1029 k015-0030 5.73 64.7 µM 5.54E-9 6 4.98E-9
3 SGTC_1421 4029-0249 5.68 71.4 µM 7.42E-9 3 6.69E-9
4 SGTC_991 3996-0057 5.64 64.7 µM 9.65E-9 2 8.73E-9
5 SGTC_2420 aureobasidin a 5.32 50.0 nM 5.72E-8 17 5.29E-8
6 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 5.23 54.6 µM 8.95E-8 RPP1 & pyrimidine depletion 11 8.32E-8
7 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 5.13 49.5 µM 1.59E-7 6 1.49E-7
8 SGTC_2784 7567673 4.96 72.7 µM 3.82E-7 iron homeostasis 15 3.61E-7
9 SGTC_114 0364-0001 4.90 490.3 µM 5.03E-7 18 4.77E-7
10 SGTC_1327 1436-0082 4.75 2.2 µM 1.05E-6 10 1.00E-6
11 SGTC_1633 st005664 4.72 67.9 µM 1.23E-6 16 1.18E-6
12 SGTC_3047 9092122 4.59 49.5 µM 2.31E-6 10 2.23E-6
13 SGTC_1106 tegaserod maleate 4.36 11.7 µM 6.67E-6 11 6.51E-6
14 SGTC_502 l-744,832 4.32 89.3 µM 8.13E-6 calcium & mitochondrial duress 30 7.95E-6
15 SGTC_673 1082-0474 4.31 110.0 µM 8.41E-6 RSC complex & mRNA processing 52 8.23E-6
16 SGTC_3 0833-0587 4.27 95.6 µM 9.99E-6 redox potentiating 15 9.80E-6
17 SGTC_1154 4088-0362 4.21 150.0 µM 1.33E-5 16 1.30E-5
18 SGTC_420 mitomycin C 4.00 81.9 mM 3.21E-5 16 3.19E-5
19 SGTC_3004 9076122 3.93 71.4 µM 4.25E-5 17 4.23E-5
20 SGTC_993 3909-8757 3.91 62.7 µM 4.58E-5 26 4.55E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.68E-15 YNL135C FPR1 hom Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
0.120 2.55E-12 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.114 4.06E-11 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.104 1.40E-9 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.100 5.51E-9 YJL117W PHO86 hom Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress
0.096 2.35E-8 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.096 2.86E-8 YFL021W GAT1 hom Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
0.091 1.13E-7 YJL102W MEF2 hom Mitochondrial elongation factor involved in translational elongation
0.086 6.95E-7 YGL127C SOH1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
0.085 7.65E-7 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.084 1.07E-6 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.083 1.66E-6 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.083 1.66E-6 YNL204C SPS18 hom Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation
0.082 1.86E-6 YNL199C GCR2 hom Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p
0.079 4.82E-6 YOL164W BDS1 hom Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources