YER041W / YEN1

Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YER041W / YEN1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:4.40|P-value:2.74E-6 ID:SGTC_29|Compound:0299-0004|FD-Score:3.71|P-value:6.42E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:9.25|P-value:5.30E-22 ID:SGTC_58|Compound:0957-0393|FD-Score:7.47|P-value:5.50E-15 ID:SGTC_64|Compound:000l-0018|FD-Score:19.60|P-value:1.83E-91 ID:SGTC_67|Compound:0335-0847|FD-Score:4.49|P-value:1.72E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:3.05|P-value:8.16E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:13.60|P-value:1.86E-45 ID:SGTC_103|Compound:0844-0104|FD-Score:22.90|P-value:9.82E-125 ID:SGTC_107|Compound:0358-0022|FD-Score:8.44|P-value:1.34E-18 ID:SGTC_137|Compound:0438-0332|FD-Score:9.62|P-value:1.21E-23 ID:SGTC_142|Compound:0335-0849|FD-Score:9.81|P-value:1.74E-24 ID:SGTC_149|Compound:3970-0822|FD-Score:3.04|P-value:8.49E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:17.40|P-value:1.47E-72 ID:SGTC_196|Compound:k015-0023|FD-Score:3.74|P-value:5.55E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:7.57|P-value:2.52E-15 ID:SGTC_210|Compound:3551-0445|FD-Score:3.83|P-value:3.77E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:8.48|P-value:9.06E-19 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:-3.14|P-value:5.72E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.70|P-value:6.59E-5 ID:SGTC_253|Compound:dyclonine|FD-Score:3.93|P-value:2.42E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.16|P-value:5.37E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.97|P-value:2.00E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:3.52|P-value:1.36E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.56|P-value:1.15E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.52|P-value:1.35E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-4.14|P-value:8.87E-6 ID:SGTC_533|Compound:1222-0222|FD-Score:4.56|P-value:1.25E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:4.95|P-value:1.51E-7 ID:SGTC_654|Compound:1124-0271|FD-Score:3.67|P-value:7.41E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.57|P-value:1.10E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:5.35|P-value:1.59E-8 ID:SGTC_710|Compound:3448-4187|FD-Score:3.23|P-value:4.30E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:14.30|P-value:6.88E-50 ID:SGTC_852|Compound:0418-0143|FD-Score:4.16|P-value:8.59E-6 ID:SGTC_886|Compound:0866-0150|FD-Score:-3.05|P-value:7.75E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.84|P-value:3.62E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:4.75|P-value:4.52E-7 ID:SGTC_984|Compound:1492-0255|FD-Score:3.50|P-value:1.50E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.19|P-value:4.82E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.32|P-value:2.99E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:12.80|P-value:4.48E-40 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.21|P-value:6.82E-6 ID:SGTC_1294|Compound:1000-1494|FD-Score:18.00|P-value:5.01E-78 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.58|P-value:1.08E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.63|P-value:8.82E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.31|P-value:3.09E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-5.07|P-value:7.51E-8 ID:SGTC_1526|Compound:st051518|FD-Score:5.30|P-value:2.14E-8 ID:SGTC_1860|Compound:st056228|FD-Score:-3.64|P-value:7.99E-5 ID:SGTC_1968|Compound:st069590|FD-Score:3.52|P-value:1.36E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.42|P-value:2.02E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.39|P-value:2.31E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-4.51|P-value:1.52E-6 ID:SGTC_2429|Compound:5902844|FD-Score:9.59|P-value:1.67E-23 ID:SGTC_2430|Compound:5571206|FD-Score:3.32|P-value:3.07E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.97|P-value:2.01E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:6.09|P-value:1.47E-10 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.42|P-value:2.02E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.09|P-value:1.15E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.02|P-value:9.05E-4 ID:SGTC_2811|Compound:7967822|FD-Score:4.40|P-value:2.67E-6 ID:SGTC_2821|Compound:7996764|FD-Score:-3.09|P-value:6.84E-4 ID:SGTC_2905|Compound:7799065|FD-Score:3.31|P-value:3.10E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.08|P-value:7.38E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.62|P-value:8.85E-7 ID:SGTC_3059|Compound:1327-0034|FD-Score:7.13|P-value:8.27E-14 ID:SGTC_3060|Compound:1327-0027|FD-Score:5.89|P-value:5.76E-10 ID:SGTC_3063|Compound:1327-0034|FD-Score:6.42|P-value:1.61E-11 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.35|P-value:2.69E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.28|P-value:3.42E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.02|P-value:8.95E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:4.40|P-value:2.74E-6 ID:SGTC_29|Compound:0299-0004|FD-Score:3.71|P-value:6.42E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:9.25|P-value:5.30E-22 ID:SGTC_58|Compound:0957-0393|FD-Score:7.47|P-value:5.50E-15 ID:SGTC_64|Compound:000l-0018|FD-Score:19.60|P-value:1.83E-91 ID:SGTC_67|Compound:0335-0847|FD-Score:4.49|P-value:1.72E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:3.05|P-value:8.16E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:13.60|P-value:1.86E-45 ID:SGTC_103|Compound:0844-0104|FD-Score:22.90|P-value:9.82E-125 ID:SGTC_107|Compound:0358-0022|FD-Score:8.44|P-value:1.34E-18 ID:SGTC_137|Compound:0438-0332|FD-Score:9.62|P-value:1.21E-23 ID:SGTC_142|Compound:0335-0849|FD-Score:9.81|P-value:1.74E-24 ID:SGTC_149|Compound:3970-0822|FD-Score:3.04|P-value:8.49E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:17.40|P-value:1.47E-72 ID:SGTC_196|Compound:k015-0023|FD-Score:3.74|P-value:5.55E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:7.57|P-value:2.52E-15 ID:SGTC_210|Compound:3551-0445|FD-Score:3.83|P-value:3.77E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:8.48|P-value:9.06E-19 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:-3.14|P-value:5.72E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.70|P-value:6.59E-5 ID:SGTC_253|Compound:dyclonine|FD-Score:3.93|P-value:2.42E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.16|P-value:5.37E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.97|P-value:2.00E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:3.52|P-value:1.36E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.56|P-value:1.15E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.52|P-value:1.35E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-4.14|P-value:8.87E-6 ID:SGTC_533|Compound:1222-0222|FD-Score:4.56|P-value:1.25E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:4.95|P-value:1.51E-7 ID:SGTC_654|Compound:1124-0271|FD-Score:3.67|P-value:7.41E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.57|P-value:1.10E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:5.35|P-value:1.59E-8 ID:SGTC_710|Compound:3448-4187|FD-Score:3.23|P-value:4.30E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:14.30|P-value:6.88E-50 ID:SGTC_852|Compound:0418-0143|FD-Score:4.16|P-value:8.59E-6 ID:SGTC_886|Compound:0866-0150|FD-Score:-3.05|P-value:7.75E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.84|P-value:3.62E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:4.75|P-value:4.52E-7 ID:SGTC_984|Compound:1492-0255|FD-Score:3.50|P-value:1.50E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.19|P-value:4.82E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.32|P-value:2.99E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:12.80|P-value:4.48E-40 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.21|P-value:6.82E-6 ID:SGTC_1294|Compound:1000-1494|FD-Score:18.00|P-value:5.01E-78 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.58|P-value:1.08E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.63|P-value:8.82E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.31|P-value:3.09E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-5.07|P-value:7.51E-8 ID:SGTC_1526|Compound:st051518|FD-Score:5.30|P-value:2.14E-8 ID:SGTC_1860|Compound:st056228|FD-Score:-3.64|P-value:7.99E-5 ID:SGTC_1968|Compound:st069590|FD-Score:3.52|P-value:1.36E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.42|P-value:2.02E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.39|P-value:2.31E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-4.51|P-value:1.52E-6 ID:SGTC_2429|Compound:5902844|FD-Score:9.59|P-value:1.67E-23 ID:SGTC_2430|Compound:5571206|FD-Score:3.32|P-value:3.07E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.97|P-value:2.01E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:6.09|P-value:1.47E-10 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.42|P-value:2.02E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.09|P-value:1.15E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.02|P-value:9.05E-4 ID:SGTC_2811|Compound:7967822|FD-Score:4.40|P-value:2.67E-6 ID:SGTC_2821|Compound:7996764|FD-Score:-3.09|P-value:6.84E-4 ID:SGTC_2905|Compound:7799065|FD-Score:3.31|P-value:3.10E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.08|P-value:7.38E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.62|P-value:8.85E-7 ID:SGTC_3059|Compound:1327-0034|FD-Score:7.13|P-value:8.27E-14 ID:SGTC_3060|Compound:1327-0027|FD-Score:5.89|P-value:5.76E-10 ID:SGTC_3063|Compound:1327-0034|FD-Score:6.42|P-value:1.61E-11 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.35|P-value:2.69E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.28|P-value:3.42E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.02|P-value:8.95E-4

Top fitness defect scores for YER041W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 22.90 51.8 µM 9.82E-125 ERAD & cell cycle 2 1.04E-116
2 SGTC_64 000l-0018 19.60 272.1 µM 1.83E-91 ubiquinone biosynthesis & proteasome 12 1.28E-85
3 SGTC_1294 1000-1494 18.00 117.0 µM 5.01E-78 5 4.61E-73
4 SGTC_158 k038-0087 17.40 26.4 µM 1.47E-72 ubiquinone biosynthesis & proteasome 9 5.92E-68
5 SGTC_794 k038-0031 14.30 316.0 µM 6.88E-50 ubiquinone biosynthesis & proteasome 4 9.14E-47
6 SGTC_86 0417-1630 13.60 471.9 µM 1.86E-45 ubiquinone biosynthesis & proteasome 22 1.27E-42
7 SGTC_1161 k007-0610 12.80 110.0 µM 4.48E-40 ERAD & cell cycle 9 1.36E-37
8 SGTC_142 0335-0849 9.81 62.7 µM 1.74E-24 ubiquinone biosynthesis & proteasome 30 5.11E-23
9 SGTC_137 0438-0332 9.62 85.4 µM 1.21E-23 ubiquinone biosynthesis & proteasome 25 3.15E-22
10 SGTC_2429 5902844 9.59 64.4 µM 1.67E-23 1 4.24E-22
11 SGTC_36 0335-0881 9.25 14.2 µM 5.30E-22 ubiquinone biosynthesis & proteasome 23 1.08E-20
12 SGTC_216 k038-0035 8.48 28.4 µM 9.06E-19 ubiquinone biosynthesis & proteasome 11 1.14E-17
13 SGTC_107 0358-0022 8.44 2.7 µM 1.34E-18 SWF1 & branched chain AA biosynthesis 9 1.63E-17
14 SGTC_200 k038-0079 7.57 37.5 µM 2.52E-15 ubiquinone biosynthesis & proteasome 17 1.90E-14
15 SGTC_58 0957-0393 7.47 9.0 µM 5.50E-15 cell wall 145 3.93E-14
16 SGTC_3059 1327-0034 7.13 3.0 µM 8.27E-14 22 4.96E-13
17 SGTC_3063 1327-0034 6.42 4.0 µM 1.61E-11 17 6.91E-11
18 SGTC_2536 dehydroabietamide 6.09 32.0 µM 1.47E-10 4 5.48E-10
19 SGTC_3060 1327-0027 5.89 12.5 µM 5.76E-10 19 1.96E-9
20 SGTC_673 1082-0474 5.35 110.0 µM 1.59E-8 RSC complex & mRNA processing 28 4.38E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.735 0 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.698 0 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.648 0 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.644 0 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.633 0 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.628 0 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.627 0 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.586 3.19E-308 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.532 4.83E-244 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.474 1.99E-187 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.464 2.17E-178 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.460 4.21E-175 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.457 1.46E-172 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.451 1.78E-167 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.448 1.70E-165 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2