YER043C / SAH1

S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor

Zygosity: Heterozygous strain
fixedexpanded
Profile for YER043C / SAH1

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:-5.28|P-value:2.20E-9 ID:SGTC_116|Compound:0155-0182|FD-Score:-6.13|P-value:4.53E-12 ID:SGTC_175|Compound:3793-3120|FD-Score:4.05|P-value:2.45E-6 ID:SGTC_197|Compound:4544-0043|FD-Score:-2.83|P-value:8.73E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:2.88|P-value:5.50E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:2.82|P-value:6.96E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.63|P-value:2.12E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:3.01|P-value:3.26E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.34|P-value:7.90E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:-3.02|P-value:4.13E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:2.84|P-value:6.45E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.10|P-value:2.32E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:2.87|P-value:5.92E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.13|P-value:2.06E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.67|P-value:2.33E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:4.80|P-value:3.24E-8 ID:SGTC_1634|Compound:st006576|FD-Score:3.18|P-value:1.60E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.12|P-value:2.12E-4 ID:SGTC_1711|Compound:st032263|FD-Score:-3.04|P-value:3.83E-4 ID:SGTC_1739|Compound:st037196|FD-Score:2.98|P-value:3.82E-4 ID:SGTC_1810|Compound:st050138|FD-Score:2.84|P-value:6.66E-4 ID:SGTC_1813|Compound:st051246|FD-Score:2.80|P-value:7.72E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.11|P-value:2.23E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.90|P-value:5.41E-6 ID:SGTC_2054|Compound:5233173|FD-Score:-2.85|P-value:8.06E-4 ID:SGTC_2254|Compound:7938975|FD-Score:2.80|P-value:7.71E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-2.85|P-value:8.30E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.02|P-value:4.13E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.23|P-value:1.33E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-2.95|P-value:5.54E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.15|P-value:1.84E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.19|P-value:1.58E-4 ID:SGTC_3040|Compound:9091894|FD-Score:2.77|P-value:8.45E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-2.90|P-value:6.72E-4 ID:SGTC_3306|Compound:9127676|FD-Score:2.74|P-value:9.58E-4 ID:SGTC_3313|Compound:9133968|FD-Score:2.80|P-value:7.57E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-5.28|P-value:2.20E-9 ID:SGTC_116|Compound:0155-0182|FD-Score:-6.13|P-value:4.53E-12 ID:SGTC_175|Compound:3793-3120|FD-Score:4.05|P-value:2.45E-6 ID:SGTC_197|Compound:4544-0043|FD-Score:-2.83|P-value:8.73E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:2.88|P-value:5.50E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:2.82|P-value:6.96E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.63|P-value:2.12E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:3.01|P-value:3.26E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.34|P-value:7.90E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:-3.02|P-value:4.13E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:2.84|P-value:6.45E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.10|P-value:2.32E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:2.87|P-value:5.92E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.13|P-value:2.06E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.67|P-value:2.33E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:4.80|P-value:3.24E-8 ID:SGTC_1634|Compound:st006576|FD-Score:3.18|P-value:1.60E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.12|P-value:2.12E-4 ID:SGTC_1711|Compound:st032263|FD-Score:-3.04|P-value:3.83E-4 ID:SGTC_1739|Compound:st037196|FD-Score:2.98|P-value:3.82E-4 ID:SGTC_1810|Compound:st050138|FD-Score:2.84|P-value:6.66E-4 ID:SGTC_1813|Compound:st051246|FD-Score:2.80|P-value:7.72E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.11|P-value:2.23E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.90|P-value:5.41E-6 ID:SGTC_2054|Compound:5233173|FD-Score:-2.85|P-value:8.06E-4 ID:SGTC_2254|Compound:7938975|FD-Score:2.80|P-value:7.71E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-2.85|P-value:8.30E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.02|P-value:4.13E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.23|P-value:1.33E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-2.95|P-value:5.54E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.15|P-value:1.84E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.19|P-value:1.58E-4 ID:SGTC_3040|Compound:9091894|FD-Score:2.77|P-value:8.45E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-2.90|P-value:6.72E-4 ID:SGTC_3306|Compound:9127676|FD-Score:2.74|P-value:9.58E-4 ID:SGTC_3313|Compound:9133968|FD-Score:2.80|P-value:7.57E-4

Top fitness defect scores for YER043C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1568 digitonin 4.80 820.0 nM 3.24E-8 sphingolipid biosynthesis & PDR1 9 7.97E-7 0.27
2 SGTC_175 3793-3120 4.05 23.7 µM 2.45E-6 3 2.55E-5 0.07
3 SGTC_1944 st076371 3.90 56.9 µM 5.41E-6 3 4.80E-5 0.02
4 SGTC_453 enantio-paf c16 3.63 10.0 µM 2.12E-5 24 1.43E-4 0.04
5 SGTC_822 1487-0950 3.34 154.0 µM 7.90E-5 6 4.12E-4 0.06
6 SGTC_2563 tomatine 3.23 8.5 µM 1.33E-4 21 6.28E-4 0.12
7 SGTC_2837 9008476 3.19 45.5 µM 1.58E-4 12 7.20E-4 0.01
8 SGTC_1634 st006576 3.18 41.0 µM 1.60E-4 TSC3-RPN4 14 7.25E-4 0.17
9 SGTC_2811 7967822 3.15 32.5 µM 1.84E-4 13 8.13E-4 0.04
10 SGTC_907 3448-6986 3.13 75.5 µM 2.06E-4 14 8.89E-4 0.07
11 SGTC_1695 st026914 3.12 34.5 µM 2.12E-4 8 9.12E-4 0.01
12 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.11 70.1 µM 2.23E-4 11 9.49E-4 0.05
13 SGTC_886 0866-0150 3.10 153.0 µM 2.32E-4 10 9.79E-4 0.01
14 SGTC_621 3584-0052 3.01 32.1 µM 3.26E-4 14 0.00129 0.03
15 SGTC_1739 st037196 2.98 92.5 µM 3.82E-4 13 0.00146 0.01
16 SGTC_286 k060-0067 2.88 22.9 µM 5.50E-4 tubulin folding & SWR complex 19 0.00196 0.01
17 SGTC_893 0958-0369 2.87 48.9 µM 5.92E-4 15 0.00208 0.05
18 SGTC_839 0122-0028 2.84 230.0 µM 6.45E-4 RSC complex & mRNA processing 61 0.00223 0.01
19 SGTC_1810 st050138 2.84 53.0 µM 6.66E-4 PDR1 13 0.00229 0.03
20 SGTC_354 2783-3500 2.82 4.9 µM 6.96E-4 cell wall 50 0.00237 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.195 5.90E-30 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.181 5.52E-26 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.171 1.92E-23 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.166 4.30E-22 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.163 2.78E-21 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.161 7.74E-21 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.160 8.92E-21 YFR027W ECO1 het Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.157 4.99E-20 YKL152C GPM1 het Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.151 1.20E-18 YGR209C TRX2 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.141 1.83E-16 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.135 4.86E-15 YNL163C RIA1 het Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
0.135 4.86E-15 YMR049C ERB1 het Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1
0.131 3.20E-14 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.123 8.65E-13 YGL111W NSA1 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.123 8.68E-13 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases