YER044C-A / MEI4

Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores

Zygosity: Homozygous strain
fixedexpanded
Profile for YER044C-A / MEI4

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.09|P-value:8.83E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.29|P-value:4.51E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.43|P-value:4.34E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:6.40|P-value:7.56E-11 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.36|P-value:5.56E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:6.81|P-value:5.12E-12 ID:SGTC_165|Compound:k038-0023|FD-Score:4.70|P-value:1.19E-6 ID:SGTC_305|Compound:1682-2595|FD-Score:3.61|P-value:1.39E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.21|P-value:5.88E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.51|P-value:2.00E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.42|P-value:2.76E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.06|P-value:2.26E-5 ID:SGTC_448|Compound:monastrol|FD-Score:3.59|P-value:1.48E-4 ID:SGTC_476|Compound:mead acid|FD-Score:3.25|P-value:5.19E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.07|P-value:3.70E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.73|P-value:1.44E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:4.21|P-value:1.16E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.28|P-value:4.57E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:-3.33|P-value:6.26E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:4.79|P-value:7.78E-7 ID:SGTC_858|Compound:0438-0351|FD-Score:3.22|P-value:5.76E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.52|P-value:2.76E-6 ID:SGTC_1140|Compound:3229-1848|FD-Score:-4.06|P-value:3.92E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:5.59|P-value:1.07E-8 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.35|P-value:3.61E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.23|P-value:1.05E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.14|P-value:7.43E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.07|P-value:9.42E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.92|P-value:3.93E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.20|P-value:9.63E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.95|P-value:3.58E-5 ID:SGTC_1672|Compound:st016598|FD-Score:5.15|P-value:1.20E-7 ID:SGTC_1720|Compound:st037298|FD-Score:3.13|P-value:7.77E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.10|P-value:8.67E-4 ID:SGTC_1913|Compound:st060213|FD-Score:4.21|P-value:1.15E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.15|P-value:7.35E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.38|P-value:3.18E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.75|P-value:8.09E-5 ID:SGTC_2009|Compound:4012297|FD-Score:-3.51|P-value:3.23E-4 ID:SGTC_2067|Compound:5224629|FD-Score:-6.03|P-value:1.76E-9 ID:SGTC_2097|Compound:5376186|FD-Score:-3.50|P-value:3.33E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.68|P-value:1.04E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.11|P-value:8.36E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-4.29|P-value:1.46E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.51|P-value:2.04E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.84|P-value:6.04E-7 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-4.11|P-value:3.18E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-6.20|P-value:6.24E-10 ID:SGTC_2935|Compound:9038016|FD-Score:4.37|P-value:5.70E-6 ID:SGTC_3297|Compound:9117502|FD-Score:3.85|P-value:5.40E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.09|P-value:8.83E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.29|P-value:4.51E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.43|P-value:4.34E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:6.40|P-value:7.56E-11 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.36|P-value:5.56E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:6.81|P-value:5.12E-12 ID:SGTC_165|Compound:k038-0023|FD-Score:4.70|P-value:1.19E-6 ID:SGTC_305|Compound:1682-2595|FD-Score:3.61|P-value:1.39E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.21|P-value:5.88E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.51|P-value:2.00E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.42|P-value:2.76E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.06|P-value:2.26E-5 ID:SGTC_448|Compound:monastrol|FD-Score:3.59|P-value:1.48E-4 ID:SGTC_476|Compound:mead acid|FD-Score:3.25|P-value:5.19E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.07|P-value:3.70E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.73|P-value:1.44E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:4.21|P-value:1.16E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.28|P-value:4.57E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:-3.33|P-value:6.26E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:4.79|P-value:7.78E-7 ID:SGTC_858|Compound:0438-0351|FD-Score:3.22|P-value:5.76E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.52|P-value:2.76E-6 ID:SGTC_1140|Compound:3229-1848|FD-Score:-4.06|P-value:3.92E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:5.59|P-value:1.07E-8 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.35|P-value:3.61E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.23|P-value:1.05E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.14|P-value:7.43E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.07|P-value:9.42E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.92|P-value:3.93E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.20|P-value:9.63E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.95|P-value:3.58E-5 ID:SGTC_1672|Compound:st016598|FD-Score:5.15|P-value:1.20E-7 ID:SGTC_1720|Compound:st037298|FD-Score:3.13|P-value:7.77E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.10|P-value:8.67E-4 ID:SGTC_1913|Compound:st060213|FD-Score:4.21|P-value:1.15E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.15|P-value:7.35E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.38|P-value:3.18E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.75|P-value:8.09E-5 ID:SGTC_2009|Compound:4012297|FD-Score:-3.51|P-value:3.23E-4 ID:SGTC_2067|Compound:5224629|FD-Score:-6.03|P-value:1.76E-9 ID:SGTC_2097|Compound:5376186|FD-Score:-3.50|P-value:3.33E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.68|P-value:1.04E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.11|P-value:8.36E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-4.29|P-value:1.46E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.51|P-value:2.04E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.84|P-value:6.04E-7 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-4.11|P-value:3.18E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-6.20|P-value:6.24E-10 ID:SGTC_2935|Compound:9038016|FD-Score:4.37|P-value:5.70E-6 ID:SGTC_3297|Compound:9117502|FD-Score:3.85|P-value:5.40E-5

Top fitness defect scores for YER044C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_159 3970-0959 6.81 50.0 µM 5.12E-12 18 4.97E-12
2 SGTC_61 0978-8327 6.40 98.6 µM 7.56E-11 ergosterol biosynthesis 5 7.56E-11
3 SGTC_1157 4092-0394 5.59 27.6 µM 1.07E-8 8 1.12E-8
4 SGTC_1672 st016598 5.15 6.5 µM 1.20E-7 endomembrane recycling 39 1.29E-7
5 SGTC_2450 5739737 4.84 12.9 µM 6.04E-7 7 6.55E-7
6 SGTC_855 0428-0020 4.79 25.0 µM 7.78E-7 Golgi 13 8.45E-7
7 SGTC_165 k038-0023 4.70 64.4 µM 1.19E-6 ubiquinone biosynthesis & proteasome 54 1.29E-6
8 SGTC_1081 sertraline 4.52 6.0 µM 2.76E-6 60S ribosome export 22 3.03E-6
9 SGTC_2935 9038016 4.37 30.0 µM 5.70E-6 11 6.27E-6
10 SGTC_1370 2001-0092 4.23 44.6 µM 1.05E-5 21 1.16E-5
11 SGTC_1913 st060213 4.21 96.1 µM 1.15E-5 22 1.27E-5
12 SGTC_652 0437-0092 4.21 114.0 µM 1.16E-5 8 1.28E-5
13 SGTC_400 oxethazaine 4.06 37.5 µM 2.26E-5 calcium & mitochondrial duress 20 2.50E-5
14 SGTC_1530 rhein 3.95 70.4 µM 3.58E-5 18 3.98E-5
15 SGTC_1489 4065-0444 3.92 182.0 µM 3.93E-5 21 4.36E-5
16 SGTC_3297 9117502 3.85 71.4 µM 5.40E-5 10 6.01E-5
17 SGTC_1990 st072050 3.75 59.8 µM 8.09E-5 16 9.02E-5
18 SGTC_2099 5377090 3.68 177.4 µM 1.04E-4 29 1.16E-4
19 SGTC_305 1682-2595 3.61 20.8 µM 1.39E-4 RNA processing & uracil transport 32 1.55E-4
20 SGTC_448 monastrol 3.59 171.0 µM 1.48E-4 14 1.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 4.22E-10 YGR001C_p YGR001C_p hom Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
0.107 5.94E-10 YOR025W HST3 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.103 2.44E-9 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.099 8.73E-9 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.099 9.45E-9 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.092 9.15E-8 YDR005C MAF1 hom Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.091 1.16E-7 YDR482C CWC21 hom Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p
0.090 2.06E-7 YOR296W_p YOR296W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene
0.087 4.04E-7 YDR001C NTH1 hom Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
0.085 7.50E-7 YDL198C GGC1 hom Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family
0.085 8.50E-7 YDR239C YDR239C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.084 9.88E-7 YJR119C JHD2 hom JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation
0.083 1.60E-6 YNR069C BSC5 hom Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro
0.079 4.07E-6 YOR027W STI1 hom Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop
0.079 4.35E-6 YDL128W VCX1 hom Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter