YER047C / SAP1

Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system

Zygosity: Homozygous strain
fixedexpanded
Profile for YER047C / SAP1

Click on Significant Values for Screen Details ID:SGTC_100|Compound:0086-0128|FD-Score:-3.31|P-value:5.02E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:-4.38|P-value:7.43E-6 ID:SGTC_881|Compound:0833-0569|FD-Score:4.89|P-value:1.05E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:3.57|P-value:2.77E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.84|P-value:9.98E-5 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.14|P-value:2.98E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.22|P-value:9.32E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.47|P-value:3.89E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.48|P-value:3.77E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:-4.20|P-value:1.62E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-5.04|P-value:3.11E-7 ID:SGTC_1683|Compound:st010134|FD-Score:3.83|P-value:1.05E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.29|P-value:7.47E-4 ID:SGTC_1842|Compound:st055362|FD-Score:4.01|P-value:5.06E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.53|P-value:3.18E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.88|P-value:8.45E-5 ID:SGTC_1968|Compound:st069590|FD-Score:4.95|P-value:7.60E-7 ID:SGTC_2055|Compound:5235184|FD-Score:3.24|P-value:8.61E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-4.61|P-value:2.62E-6 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.64|P-value:2.13E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.43|P-value:4.57E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-4.18|P-value:1.73E-5 ID:SGTC_2483|Compound:5729050|FD-Score:-3.18|P-value:8.04E-4 ID:SGTC_2488|Compound:5268135|FD-Score:-3.41|P-value:3.57E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.29|P-value:7.40E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.30|P-value:7.15E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.27|P-value:7.82E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-5.06|P-value:2.85E-7 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.70|P-value:1.71E-4 ID:SGTC_3340|Compound:9146634|FD-Score:5.45|P-value:5.99E-8 ID:SGTC_3348|Compound:9149464|FD-Score:3.74|P-value:1.44E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.31|P-value:5.02E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:-4.38|P-value:7.43E-6 ID:SGTC_881|Compound:0833-0569|FD-Score:4.89|P-value:1.05E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:3.57|P-value:2.77E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.84|P-value:9.98E-5 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.14|P-value:2.98E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.22|P-value:9.32E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.47|P-value:3.89E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.48|P-value:3.77E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:-4.20|P-value:1.62E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-5.04|P-value:3.11E-7 ID:SGTC_1683|Compound:st010134|FD-Score:3.83|P-value:1.05E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.29|P-value:7.47E-4 ID:SGTC_1842|Compound:st055362|FD-Score:4.01|P-value:5.06E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.53|P-value:3.18E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.88|P-value:8.45E-5 ID:SGTC_1968|Compound:st069590|FD-Score:4.95|P-value:7.60E-7 ID:SGTC_2055|Compound:5235184|FD-Score:3.24|P-value:8.61E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-4.61|P-value:2.62E-6 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.64|P-value:2.13E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.43|P-value:4.57E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-4.18|P-value:1.73E-5 ID:SGTC_2483|Compound:5729050|FD-Score:-3.18|P-value:8.04E-4 ID:SGTC_2488|Compound:5268135|FD-Score:-3.41|P-value:3.57E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.29|P-value:7.40E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.30|P-value:7.15E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.27|P-value:7.82E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-5.06|P-value:2.85E-7 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.70|P-value:1.71E-4 ID:SGTC_3340|Compound:9146634|FD-Score:5.45|P-value:5.99E-8 ID:SGTC_3348|Compound:9149464|FD-Score:3.74|P-value:1.44E-4

Top fitness defect scores for YER047C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3340 9146634 5.45 11.1 µM 5.99E-8 2 2.55E-8
2 SGTC_1968 st069590 4.95 43.6 µM 7.60E-7 6 3.67E-7
3 SGTC_881 0833-0569 4.89 170.0 µM 1.05E-6 7 5.15E-7
4 SGTC_1148 3909-7663 4.14 27.7 µM 2.98E-5 12 1.73E-5
5 SGTC_1842 st055362 4.01 61.2 µM 5.06E-5 14 3.01E-5
6 SGTC_1964 st076914 3.88 61.0 µM 8.45E-5 RPP1 & pyrimidine depletion 22 5.15E-5
7 SGTC_1133 3473-0247 3.84 50.0 µM 9.98E-5 RSC complex & mRNA processing 54 6.14E-5
8 SGTC_1683 st010134 3.83 710.0 nM 1.05E-4 35 6.47E-5
9 SGTC_3348 9149464 3.74 3.5 µM 1.44E-4 18 9.04E-5
10 SGTC_2775 cyproheptadine 3.70 69.6 µM 1.71E-4 23 1.08E-4
11 SGTC_2417 cerulenin 3.64 830.0 nM 2.13E-4 39 1.36E-4
12 SGTC_932 2857-0803 3.57 154.0 µM 2.77E-4 39 1.79E-4
13 SGTC_1951 sophoraflavanone G 3.53 9.2 µM 3.18E-4 RNA processing & uracil transport 46 2.08E-4
14 SGTC_1366 1683-0113 3.48 21.9 µM 3.77E-4 20 2.48E-4
15 SGTC_1342 1486-1464 3.47 234.0 µM 3.89E-4 28 2.57E-4
16 SGTC_2475 5812728 3.43 15.0 µM 4.57E-4 mitochondrial processes 37 3.03E-4
17 SGTC_2501 sodium tetradecyl sulfate 3.30 13.4 µM 7.15E-4 60 4.86E-4
18 SGTC_2495 cafestol 3.29 54.5 µM 7.40E-4 Golgi 51 5.04E-4
19 SGTC_1724 st037281 3.29 8.3 µM 7.47E-4 73 5.09E-4
20 SGTC_2581 avocatin a 3.27 64.0 µM 7.82E-4 sphingolipid biosynthesis & PDR1 76 5.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 3.73E-9 YJR141W_p YJR141W_p het Essential protein of unknown function
0.089 2.43E-7 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.081 2.83E-6 YCR105W ADH7 hom NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
0.079 4.06E-6 YGR053C_p YGR053C_p hom Putative protein of unknown function
0.079 4.70E-6 YIR011C STS1 het Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation
0.079 4.88E-6 YNL071W LAT1 hom Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
0.077 8.66E-6 YEL018W EAF5 hom Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex
0.071 3.83E-5 YNL054W VAC7 hom Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock
0.071 4.00E-5 YGL164C YRB30 hom RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes
0.070 4.43E-5 YDL113C ATG20 hom Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
0.070 5.46E-5 YHR107C CDC12 het Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells
0.069 6.09E-5 YHR101C BIG1 het Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan
0.068 7.83E-5 YBR228W SLX1 hom Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
0.066 1.29E-4 YLR191W PEX13 hom Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
0.066 1.33E-4 YPL001W HAT1 hom Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair