YER048C / CAJ1

Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YER048C / CAJ1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.79|P-value:9.35E-10 ID:SGTC_65|Compound:0798-0905|FD-Score:3.91|P-value:2.45E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:4.11|P-value:9.93E-6 ID:SGTC_90|Compound:0870-0863|FD-Score:3.46|P-value:1.60E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.19|P-value:5.16E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-4.68|P-value:6.94E-7 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.38|P-value:2.43E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.28|P-value:5.04E-6 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.35|P-value:2.77E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.11|P-value:9.87E-6 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.12|P-value:9.66E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.16|P-value:5.75E-4 ID:SGTC_442|Compound:cape|FD-Score:3.63|P-value:8.22E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.56|P-value:1.08E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:9.71|P-value:4.19E-24 ID:SGTC_780|Compound:0109-0199|FD-Score:7.35|P-value:1.29E-14 ID:SGTC_845|Compound:0330-0138|FD-Score:3.74|P-value:5.14E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:3.89|P-value:2.63E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:-4.24|P-value:6.24E-6 ID:SGTC_1022|Compound:4477-0945|FD-Score:-4.30|P-value:4.59E-6 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.50|P-value:1.53E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.28|P-value:3.21E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.85|P-value:3.17E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.06|P-value:7.40E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.55|P-value:1.13E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.30|P-value:3.40E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.83|P-value:3.51E-5 ID:SGTC_1677|Compound:st019204|FD-Score:-3.28|P-value:3.64E-4 ID:SGTC_1706|Compound:st031321|FD-Score:4.58|P-value:1.01E-6 ID:SGTC_1739|Compound:st037196|FD-Score:3.45|P-value:1.66E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.17|P-value:7.48E-6 ID:SGTC_1767|Compound:st044992|FD-Score:4.22|P-value:6.01E-6 ID:SGTC_1831|Compound:st055328|FD-Score:4.15|P-value:8.38E-6 ID:SGTC_1870|Compound:st057514|FD-Score:-4.07|P-value:1.38E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:13.10|P-value:2.00E-42 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.68|P-value:6.67E-5 ID:SGTC_1884|Compound:5633444|FD-Score:5.00|P-value:1.06E-7 ID:SGTC_1889|Compound:st059080|FD-Score:2.98|P-value:9.63E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.13|P-value:6.25E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.24|P-value:4.16E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.98|P-value:2.00E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-4.16|P-value:8.89E-6 ID:SGTC_2225|Compound:6654152|FD-Score:3.07|P-value:7.08E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:-3.33|P-value:3.01E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.21|P-value:4.18E-4 ID:SGTC_2327|Compound:6189656|FD-Score:4.57|P-value:1.07E-6 ID:SGTC_2328|Compound:6201408|FD-Score:-4.74|P-value:5.13E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.33|P-value:2.99E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.53|P-value:2.73E-23 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.20|P-value:4.42E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.35|P-value:3.19E-6 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.73|P-value:6.03E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.46|P-value:1.63E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.55|P-value:1.25E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.51|P-value:1.33E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.91|P-value:1.99E-7 ID:SGTC_3213|Compound:9129884|FD-Score:3.44|P-value:1.75E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.24|P-value:3.86E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.79|P-value:9.35E-10 ID:SGTC_65|Compound:0798-0905|FD-Score:3.91|P-value:2.45E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:4.11|P-value:9.93E-6 ID:SGTC_90|Compound:0870-0863|FD-Score:3.46|P-value:1.60E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.19|P-value:5.16E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-4.68|P-value:6.94E-7 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.38|P-value:2.43E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.28|P-value:5.04E-6 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.35|P-value:2.77E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.11|P-value:9.87E-6 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.12|P-value:9.66E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.16|P-value:5.75E-4 ID:SGTC_442|Compound:cape|FD-Score:3.63|P-value:8.22E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.56|P-value:1.08E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:9.71|P-value:4.19E-24 ID:SGTC_780|Compound:0109-0199|FD-Score:7.35|P-value:1.29E-14 ID:SGTC_845|Compound:0330-0138|FD-Score:3.74|P-value:5.14E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:3.89|P-value:2.63E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:-4.24|P-value:6.24E-6 ID:SGTC_1022|Compound:4477-0945|FD-Score:-4.30|P-value:4.59E-6 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.50|P-value:1.53E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.28|P-value:3.21E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.85|P-value:3.17E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.06|P-value:7.40E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.55|P-value:1.13E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.30|P-value:3.40E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.83|P-value:3.51E-5 ID:SGTC_1677|Compound:st019204|FD-Score:-3.28|P-value:3.64E-4 ID:SGTC_1706|Compound:st031321|FD-Score:4.58|P-value:1.01E-6 ID:SGTC_1739|Compound:st037196|FD-Score:3.45|P-value:1.66E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.17|P-value:7.48E-6 ID:SGTC_1767|Compound:st044992|FD-Score:4.22|P-value:6.01E-6 ID:SGTC_1831|Compound:st055328|FD-Score:4.15|P-value:8.38E-6 ID:SGTC_1870|Compound:st057514|FD-Score:-4.07|P-value:1.38E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:13.10|P-value:2.00E-42 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.68|P-value:6.67E-5 ID:SGTC_1884|Compound:5633444|FD-Score:5.00|P-value:1.06E-7 ID:SGTC_1889|Compound:st059080|FD-Score:2.98|P-value:9.63E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.13|P-value:6.25E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.24|P-value:4.16E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.98|P-value:2.00E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-4.16|P-value:8.89E-6 ID:SGTC_2225|Compound:6654152|FD-Score:3.07|P-value:7.08E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:-3.33|P-value:3.01E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.21|P-value:4.18E-4 ID:SGTC_2327|Compound:6189656|FD-Score:4.57|P-value:1.07E-6 ID:SGTC_2328|Compound:6201408|FD-Score:-4.74|P-value:5.13E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.33|P-value:2.99E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.53|P-value:2.73E-23 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.20|P-value:4.42E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.35|P-value:3.19E-6 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.73|P-value:6.03E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.46|P-value:1.63E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.55|P-value:1.25E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.51|P-value:1.33E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.91|P-value:1.99E-7 ID:SGTC_3213|Compound:9129884|FD-Score:3.44|P-value:1.75E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.24|P-value:3.86E-4

Top fitness defect scores for YER048C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1872 amphotericin b 13.10 148.0 nM 2.00E-42 RNA pol III & RNase P/MRP 1 1.11E-39
2 SGTC_779 1360-0071 9.71 233.0 µM 4.19E-24 fatty acid desaturase (OLE1) 2 1.40E-22
3 SGTC_2688 kanamycin b 9.53 96.7 µM 2.73E-23 calcium & mitochondrial duress 34 8.05E-22
4 SGTC_780 0109-0199 7.35 192.0 µM 1.29E-14 1 1.00E-13
5 SGTC_58 0957-0393 5.79 9.0 µM 9.35E-10 cell wall 222 3.46E-9
6 SGTC_1884 5633444 5.00 25.0 µM 1.06E-7 redox potentiating 33 2.85E-7
7 SGTC_1706 st031321 4.58 10.0 µM 1.01E-6 TSC3-RPN4 10 2.35E-6
8 SGTC_2327 6189656 4.57 200.0 µM 1.07E-6 13 2.48E-6
9 SGTC_467 ro 31-8220 4.56 72.8 µM 1.08E-6 calcium & mitochondrial duress 54 2.50E-6
10 SGTC_2765 myclobutanil 4.35 7.7 µM 3.19E-6 azole & statin 39 6.86E-6
11 SGTC_1767 st044992 4.22 70.3 µM 6.01E-6 17 1.24E-5
12 SGTC_1742 st038235 4.17 28.9 µM 7.48E-6 mitochondrial stress 110 1.52E-5
13 SGTC_1831 st055328 4.15 12.0 µM 8.38E-6 heme biosynthesis & mitochondrial translocase 17 1.69E-5
14 SGTC_265 mycophenolic acid 4.12 32.9 µM 9.66E-6 RPP1 & pyrimidine depletion 14 1.93E-5
15 SGTC_255 tunicamycin 4.11 200.5 nM 9.87E-6 unfolded protein response 66 1.97E-5
16 SGTC_81 0411-0046 4.11 10.0 µM 9.93E-6 21 1.98E-5
17 SGTC_65 0798-0905 3.91 35.0 µM 2.45E-5 calcium & mitochondrial duress 86 4.62E-5
18 SGTC_912 3474-0017 3.89 2.2 µM 2.63E-5 24 4.93E-5
19 SGTC_1156 4092-0367 3.85 4.9 µM 3.17E-5 23 5.87E-5
20 SGTC_1340 1486-1359 3.83 257.0 µM 3.51E-5 24 6.46E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.243 1.99E-46 YBR167C POP7 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.179 1.55E-25 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.177 7.34E-25 YDR276C PMP3 hom Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
0.170 3.62E-23 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.159 2.03E-20 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.148 6.93E-18 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.142 1.58E-16 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.141 2.18E-16 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.136 3.10E-15 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.135 3.66E-15 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.132 1.84E-14 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.131 3.19E-14 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.131 3.20E-14 YBR048W RPS11B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
0.122 1.16E-12 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.120 2.78E-12 YDL213C NOP6 hom rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes